Gene Symbol | mel-26 |
Entrez Gene ID | 172737 |
Full Name | Protein maternal effect lethal 26 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » mel-26 cDNA ORF clone
Gene Symbol | mel-26 |
Entrez Gene ID | 172737 |
Full Name | Protein maternal effect lethal 26 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_060048.8 | NP_492449.2 | Protein maternal effect lethal 26 |
NM_001276534.1 | NP_001263463.1 | Protein maternal effect lethal 26 |
NM_060048.9 | NP_492449.2 | Protein maternal effect lethal 26 |
NM_001276534.2 | NP_001263463.1 | Protein maternal effect lethal 26 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
study demonstrates that the level of MEI-1 protein is reduced in an unc-89 mutant, indicating that the normal role of UNC-89 is to inhibit the CUL-3/MEL-26 complex toward MEI-1 in striated muscle
Title: UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.
MEI-1 is the only essential target for MEL-26, and possibly for the E3 ubiquitin ligase CUL-3, but the upstream ubiquitin ligase activating enzyme RFL-1 has additional essential targets
Title: Levels of the ubiquitin ligase substrate adaptor MEL-26 are inversely correlated with MEI-1/katanin microtubule-severing activity during both meiosis and mitosis.
FIGL-1 by the CUL-3MEL-26 E3 ligase spatially restricts FIGL-1 function to mitotic cells, where it is required for correct progression through mitosis.
Title: The AAA-ATPase FIGL-1 controls mitotic progression, and its levels are regulated by the CUL-3MEL-26 E3 ligase in the C. elegans germ line.
KO8F11.3 regulates mel-26 in the helminth embryo.
Title: CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo.
MEL-26 not only acts as a substrate-specific adaptor within the MEL-26/CUL-3 complex, but also promotes cytokinesis by a CUL-3- and microtubule-independent mechanism.
Title: The BTB protein MEL-26 promotes cytokinesis in C. elegans by a CUL-3-independent mechanism.
The following mel-26 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the mel-26 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa335375 | |
Clone ID Related Accession (Same CDS sequence) | NM_060048.8 , NM_060048.9 | |
Accession Version | NM_060048.8 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Protein maternal effect lethal 26 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Jun 26, 2012 this sequence version replaced NM_060048.7. COMPLETENESS: incomplete on both ends. |
1 | ATGGAACCAC GAATCGATGG AGGAGTATTC ATCGGAGGAA TCGGAAATTC GGGAAATGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_492449.2 |
CDS | 1..1188 |
Translation |
Target ORF information:
Target ORF information:
|
NM_060048.8 |
1 | ATGGAACCAC GAATCGATGG AGGAGTATTC ATCGGAGGAA TCGGAAATTC GGGAAATGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa335375 | |
Clone ID Related Accession (Same CDS sequence) | NM_060048.8 , NM_060048.9 | |
Accession Version | NM_060048.9 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1188bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Protein maternal effect lethal 26 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_060048.8. |
1 | ATGGAACCAC GAATCGATGG AGGAGTATTC ATCGGAGGAA TCGGAAATTC GGGAAATGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_492449.2 |
CDS | 6..1193 |
Translation |
Target ORF information:
Target ORF information:
|
NM_060048.9 |
1 | ATGGAACCAC GAATCGATGG AGGAGTATTC ATCGGAGGAA TCGGAAATTC GGGAAATGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa350859 | |
Clone ID Related Accession (Same CDS sequence) | NM_001276534.1 , NM_001276534.2 | |
Accession Version | NM_001276534.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Protein maternal effect lethal 26 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). COMPLETENESS: incomplete on both ends. |
1 | ATGGAACCAC GAATCGATGG AGGAGTATTC ATCGGAGGAA TCGGAAATTC GGGAAATGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001263463.1 |
CDS | 1..1200 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001276534.1 |
1 | ATGGAACCAC GAATCGATGG AGGAGTATTC ATCGGAGGAA TCGGAAATTC GGGAAATGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa350859 | |
Clone ID Related Accession (Same CDS sequence) | NM_001276534.1 , NM_001276534.2 | |
Accession Version | NM_001276534.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1200bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Protein maternal effect lethal 26 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_001276534.1. |
1 | ATGGAACCAC GAATCGATGG AGGAGTATTC ATCGGAGGAA TCGGAAATTC GGGAAATGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001263463.1 |
CDS | 6..1205 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001276534.2 |
1 | ATGGAACCAC GAATCGATGG AGGAGTATTC ATCGGAGGAA TCGGAAATTC GGGAAATGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |