Gene Symbol | mei-1 |
Entrez Gene ID | 172612 |
Full Name | Meiotic spindle formation protein mei-1 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
ORF » Species Summary » Caenorhabditis elegans » mei-1 cDNA ORF clone
Gene Symbol | mei-1 |
Entrez Gene ID | 172612 |
Full Name | Meiotic spindle formation protein mei-1 |
Gene Type | protein-coding |
Organism | Caenorhabditis elegans |
mRNA | Protein | Name |
---|---|---|
NM_059856.7 | NP_492257.1 | Meiotic spindle formation protein mei-1 |
NM_181993.5 | NP_871793.1 | Meiotic spindle formation protein mei-1 |
NM_059856.6 | NP_492257.1 | Meiotic spindle formation protein mei-1 |
NM_181993.6 | NP_871793.1 | Meiotic spindle formation protein mei-1 |
Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The reconstructions show that katanin cycles between open spiral and closed ring conformations, depending on the ATP occupancy of a gating protomer that tenses or relaxes interprotomer interfaces.
Title: Katanin spiral and ring structures shed light on power stroke for microtubule severing.
mei-1 and aspm-1 promote oocyte meiotic spindle pole assembly
Title: Caenorhabditis elegans oocyte meiotic spindle pole assembly requires microtubule severing and the calponin homology domain protein ASPM-1.
Purified MEI-1/MEI-2 complexes preferentially sever at intersections between two microtubules and directly bundle microtubules in vitro.
Title: Katanin maintains meiotic metaphase chromosome alignment and spindle structure in vivo and has multiple effects on microtubules in vitro.
The phosphorylation of MEI-1 may ensure temporal activation of the katanin complex during meiosis, whereas CRL3(MEL-26)-mediated degradation of both MEI-1 and its activator PPFR-1 ensure efficient katanin inactivation in the transition to mitosis.
Title: Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation.
study demonstrates that the level of MEI-1 protein is reduced in an unc-89 mutant, indicating that the normal role of UNC-89 is to inhibit the CUL-3/MEL-26 complex toward MEI-1 in striated muscle
Title: UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans.
The following mei-1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the mei-1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCa335638 | |
Clone ID Related Accession (Same CDS sequence) | NM_059856.7 , NM_059856.6 | |
Accession Version | NM_059856.7 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Meiotic spindle formation protein mei-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_059856.6. |
1 | ATGAATGGGG ATGTGCAGTC AGTCATTCGC GGATATCTGG AGCGAGCCCA AGTCGCGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_492257.1 |
CDS | 2..1420 |
Translation |
Target ORF information:
Target ORF information:
|
NM_059856.7 |
1 | ATGAATGGGG ATGTGCAGTC AGTCATTCGC GGATATCTGG AGCGAGCCCA AGTCGCGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa335638 | |
Clone ID Related Accession (Same CDS sequence) | NM_059856.7 , NM_059856.6 | |
Accession Version | NM_059856.6 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1419bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Meiotic spindle formation protein mei-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Jun 26, 2012 this sequence version replaced NM_059856.5. COMPLETENESS: incomplete on both ends. |
1 | ATGAATGGGG ATGTGCAGTC AGTCATTCGC GGATATCTGG AGCGAGCCCA AGTCGCGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_492257.1 |
CDS | 1..1419 |
Translation |
Target ORF information:
Target ORF information:
|
NM_059856.6 |
1 | ATGAATGGGG ATGTGCAGTC AGTCATTCGC GGATATCTGG AGCGAGCCCA AGTCGCGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa336282 | |
Clone ID Related Accession (Same CDS sequence) | NM_181993.5 , NM_181993.6 | |
Accession Version | NM_181993.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1428bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-08 | |
Organism | Caenorhabditis elegans | |
Product | Meiotic spindle formation protein mei-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Jun 26, 2012 this sequence version replaced NM_181993.4. COMPLETENESS: incomplete on both ends. |
1 | ATGAATGGGG ATGTGCAGTC AGTCATTCGC GGATATCTGG AGCGAGCCCA AGTCGCGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_871793.1 |
CDS | 1..1428 |
Translation |
Target ORF information:
Target ORF information:
|
NM_181993.5 |
1 | ATGAATGGGG ATGTGCAGTC AGTCATTCGC GGATATCTGG AGCGAGCCCA AGTCGCGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCa336282 | |
Clone ID Related Accession (Same CDS sequence) | NM_181993.5 , NM_181993.6 | |
Accession Version | NM_181993.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1428bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-17 | |
Organism | Caenorhabditis elegans | |
Product | Meiotic spindle formation protein mei-1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003279). On Sep 4, 2019 this sequence version replaced NM_181993.5. |
1 | ATGAATGGGG ATGTGCAGTC AGTCATTCGC GGATATCTGG AGCGAGCCCA AGTCGCGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_871793.1 |
CDS | 2..1429 |
Translation |
Target ORF information:
Target ORF information:
|
NM_181993.6 |
1 | ATGAATGGGG ATGTGCAGTC AGTCATTCGC GGATATCTGG AGCGAGCCCA AGTCGCGAAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Genome sequence of the nematode C. elegans: a platform for investigating biology. |