The following ADAMTS5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ADAMTS5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OBa44534 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001166515.1 | |
| Accession Version | NM_001166515.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2805bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-30 | |
| Organism | Bos taurus(cattle) | |
| Product | A disintegrin and metalloproteinase with thrombospondin motifs 5 precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from NKLS02000001.1. On Oct 27, 2009 this sequence version replaced XM_589193.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMN03145422, SAMN03145425 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGCTGCTCG GGTGGGCGGC CCTGATGCTG TGCGCGCTCC GCCTGCCCCC GGTGGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001159987.1 |
| CDS | 1..2805 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001166515.1 |
1 | ATGCTGCTCG GGTGGGCGGC CCTGATGCTG TGCGCGCTCC GCCTGCCCCC GGTGGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OBa45512 | |
| Clone ID Related Accession (Same CDS sequence) | XM_024993812.1 | |
| Accession Version | XM_024993812.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2268bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2018-05-06 | |
| Organism | Bos taurus(cattle) | |
| Product | A disintegrin and metalloproteinase with thrombospondin motifs 5 isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037328.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGCTGCTCG GGTGGGCGGC CCTGATGCTG TGCGCGCTCC GCCTGCCCCC GGTGGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_024849580.1 |
| CDS | 829..3096 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_024993812.1 |
1 | ATGCTGCTCG GGTGGGCGGC CCTGATGCTG TGCGCGCTCC GCCTGCCCCC GGTGGCCGCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
MMPs are less efficient than ADAMTS5 in cleaving aggrecan core protein. |
Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production. |
Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5. |
A whole-genome assembly of the domestic cow, Bos taurus. |
Alpha2-macroglobulin is a novel substrate for ADAMTS-4 and ADAMTS-5 and represents an endogenous inhibitor of these enzymes. |
