MMP2 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	MMP2
Entrez Gene ID	282872
Full Name	matrix metallopeptidase 2
General protein information	Preferred Names matrix metallopeptidase 2 Names 72 kDa type IV collagenase 72 kDa gelatinase MMP-2 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) matrix metalloproteinase 2 (72 KDa type IV collagenase) matrix metalloproteinase-2
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174745.2	NP_777170.1	72 kDa type IV collagenase precursor

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Mmp2	NP_112316.2
Danio rerio (zebrafish)	mmp2	NP_932333.1
Bos taurus (cattle)	MMP2	NP_777170.1
Pan troglodytes (chimpanzee)	MMP2	XP_001167520.2
Gallus gallus (chicken)	MMP2	NP_989751.1
Canis lupus familiaris (dog)	MMP2	XP_535300.4
Mus musculus (house mouse)	Mmp2	NP_032636.1
Homo sapiens (human)	MMP2	NP_004521.1
	MMP2	XP_001087939.1
Xenopus tropicalis (tropical clawed frog)	mmp2	NP_001015789.1

Gene Ontology
Bibliography

Related articles in PubMed

Differential free fatty acid receptor-1 (FFAR1/GPR40) signalling is associated with gene expression or gelatinase granule release in bovine neutrophils.
Mena SJ, Manosalva C, Carretta MD, Teuber S, Olmo I, Burgos RA, Hidalgo MA
Innate immunity22(6)479-89(2016 08)

Cross talk between MMP2-Spm-Cer-S1P and ERK1/2 in proliferation of pulmonary artery smooth muscle cells under angiotensin II stimulation.
Chowdhury A, Sarkar J, Pramanik PK, Chakraborti T, Chakraborti S
Archives of biochemistry and biophysics60391-101(2016 Aug)

Expression of MMP-1, -2, and -8 in longissimus dorsi muscle and their relationship with meat quality traits in cattle.
Qi YX, Zhang XH, Wang YQ, Pang YZ, Zhang ZB, Zhang TL, Zhang ZX
Genetics and molecular research : GMR15(1)15017593(2016 Mar)

Study on matrix metalloproteinase 1 and 2 gene expression and NO in dairy cows with ovarian cysts.
Mutlag AM, Wang X, Yang Z, Meng J, Wang X, Zhang J, Qin Z, Wang G, Li J
Animal reproduction science1521-7(2015 Jan)

Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy.
Santos JM, Tewari S, Lin JY, Kowluru RA
Biochemical and biophysical research communications438(4)760-4(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study shows that differential FFAR1 signaling is associated with gene expression or gelatinase granule release in bovine neutrophils
Title: Differential free fatty acid receptor-1 (FFAR1/GPR40) signalling is associated with gene expression or gelatinase granule release in bovine neutrophils.

NADPH oxidase plays an important role in proMMP-2 expression and activation and MMP-2 mediated SMC proliferation occurs through the involvement of Spm-Cer-S1P signaling axis under ANG II stimulation of PASMCs
Title: Cross talk between MMP2-Spm-Cer-S1P and ERK1/2 in proliferation of pulmonary artery smooth muscle cells under angiotensin II stimulation.

The expression patterns of MMP1, MMP2, and MMP8 were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2, and MMP8 expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2, and MMP8 were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.
Title: Expression of MMP-1, -2, and -8 in longissimus dorsi muscle and their relationship with meat quality traits in cattle.

The results showed that a decrease in MMP-1 and MMP-2 gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.
Title: Study on matrix metalloproteinase 1 and 2 gene expression and NO in dairy cows with ovarian cysts.

Activation of cytosolic MMP-9 and MMP-2 was investigated in the retinal endothelial cells incubated in high glucose for 6-96 h, and correlated with their mitochondrial accumulation and mitochondrial damage.
Title: Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy.

The following MMP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41766	NM_174745.2 Latest version!	Bos taurus matrix metallopeptidase 2 (MMP2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MMP2 ( NM_174745.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_777170.1 Bos taurus matrix metallopeptidase 2 (MMP2), mRNA.

Price & Availability↑

CloneID	OBa41766
Clone ID Related Accession (Same CDS sequence)	NM_174745.2
Accession Version	NM_174745.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1986bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Bos taurus(cattle)
Product	72 kDa type IV collagenase precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF290428.1. On Jun 3, 2003 this sequence version replaced NM_174745.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF290428.1, BC149404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END##

ATGACCGAGG CGCGAGTGTC CCGGGGCGCG CTGGCCGCCC TTCTGCGGGC GCTCTGCGCC 
CTGGGCTGCC TGTTGGGCCG TGCCGCCGCC GCGCCGTCGC CCATCATCAA ATTTCCCGGC 
GATGTCGCCC CCAAAACGGA CAAAGAGTTG GCTGTGCAAT ACCTAAACAC CTTCTACGGC 
TGCCCCAAGG AGAGCTGTAA CTTGTTTGTG CTGAAGGACA CCCTGAAGAA GATGCAGAAG 
TTCTTCGGGT TACCCCAGAC AGGTGAACTG GACCAGAGCA CCATTGAGAC CATGCGGAAG 
CCGCGCTGTG GCAACCCCGA CGTGGCCAAC TACAACTTCT TCCCCCGAAA GCCCAAGTGG 
GACAAGAACC AGATCACATA CAGGATCATT GGCTACACAC CTGATCTGGA CCCCCAGACA 
GTGGATGATG CCTTCGCTCG TGCCTTCCAA GTCTGGAGCG ATGTGACTCC GCTACGGTTT 
TCTCGGATCC ATGATGGAGA GGCTGACATC ATGATCAACT TTGGCCGCTG GGAGCATGGA 
GATGGGTACC CTTTTGATGG CAAAGACGGG CTCCTGGCTC ATGCCTTCGC CCCGGGCCCT 
GGAGTTGGGG GAGATTCCCA CTTTGATGAC GATGAGCTGC GGACCCTGGG AGAAGGACAA 
GTGGTCCGTG TGAAGTACGG GAATGCTGAC GGGGAATATT GCAAGTTCCC CTTCCGGTTC 
AACGGCAAGG AGTACACCAG CTGCACAGAC ACAGGCCGCA GCGATGGCTT CCTCTGGTGT 
TCCACCACAT ACAACTTTGA CAAGGACGGC AAGTATGGCT TCTGCCCCCA TGAAGCCCTG 
TTCACCATGG GCGGCAACGC CGACGGACAG CCCTGCAAGT TCCCGTTCCG CTTCCAGGGC 
ACGTCTTACG ACAGTTGCAC CACGGAGGGC CGCACGGACG GCTACCGCTG GTGTGGCACC 
ACCGAGGACT ACGACCGCGA CAAGGAGTAC GGCTTCTGCC CGGAGACCGC CATGTCCACT 
GTGGGCGGGA ACTCGGAAGG TGCCCCATGT GTCCTCCCCT TCACCTTCCT GGGCAACAAG 
CACGAGAGCT GCACCAGCGC TGGCCGCAGT GATGGGAAGT TGTGGTGTGC GACCACCTCC 
AACTACGATG ATGACCGCAA GTGGGGCTTC TGCCCCGACC AAGGGTACAG CCTGTTCCTG 
GTGGCAGCCC ATGAGTTTGG CCATGCAATG GGGCTGGAGC ACTCACAGGA CCCTGGAGCC 
CTGATGGCGC CCATTTATAC CTACACCAAG AACTTCCGCC TGTCCCATGA TGACATCCAG 
GGCATCCAAG AACTCTATGG GGCCTCCCCT GACATTGATA CTGGCACCGG CCCCACCCCA 
ACCCTGGGCC CCGTCACTCC TGAGCTCTGC AAACAGGACA TCGTCTTCGA CGGCATCTCT 
CAGATCCGTG GGGAGATCTT CTTCTTCAAG GACCGATTCA TCTGGCGAAC AGTGACACCA 
CGTGACAAGC CCACAGGGCC CCTGCTGGTA GCCACATTCT GGCCTGAGCT GCCGGAAAAG 
ATCGATGCTG TGTACGAAGA CCCACAGGAG GAGAAGGCTG TGTTCTTTGC AGGGAACGAA 
TACTGGGTCT ATTCAGCCAG CACCCTGGAG CGAGGGTACC CCAAGCCACT GACCAGCCTG 
GGGCTCCCCC CTGGTGTCCA GAAGGTGGAT GCTGCCTTTA ACTGGAGCAA GAACAAGAAG 
ACGTACATCT TCGCCGGAGA CAAATTCTGG AGATACAATG AGGTGAAGAA GAAAATGGAT 
CCTGGCTTCC CCAAGCTCAT CGCCGATGCC TGGAACGCCA TCCCTGATAA CCTGGATGCT 
GTGGTGGACC TGCAGGGCGG GGGTCACAGC TACTTCTTCA AGGGCGCCTA TTACCTGAAG 
TTGGAGAACC AAAGTCTGAA GAGCGTGAAG TTCGGAAGCA TCAAATCCGA TTGGCTGGGC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_777170.1
CDS	182..2167
Translation	MTEARVSRGALAALLRALCALGCLLGRAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGELDQSTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPQTVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGPGVGGDSHFDDDELRTLGEGQVVRVKYGNADGEYCKFPFRFNGKEYTSCTDTGRSDGFLWCSTTYNFDKDGKYGFCPHEALFTMGGNADGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKEYGFCPETAMSTVGGNSEGAPCVLPFTFLGNKHESCTSAGRSDGKLWCATTSNYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSHDDIQGIQELYGASPDIDTGTGPTPTLGPVTPELCKQDIVFDGISQIRGEIFFFKDRFIWRTVTPRDKPTGPLLVATFWPELPEKIDAVYEDPQEEKAVFFAGNEYWVYSASTLERGYPKPLTSLGLPPGVQKVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC

Target ORF information:

RefSeq Version	NM_174745.2
Organism	Bos taurus(cattle)
Definition	Bos taurus matrix metallopeptidase 2 (MMP2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174745.2

ORF Insert Sequence:

ATGACCGAGG CGCGAGTGTC CCGGGGCGCG CTGGCCGCCC TTCTGCGGGC GCTCTGCGCC 
CTGGGCTGCC TGTTGGGCCG TGCCGCCGCC GCGCCGTCGC CCATCATCAA ATTTCCCGGC 
GATGTCGCCC CCAAAACGGA CAAAGAGTTG GCTGTGCAAT ACCTAAACAC CTTCTACGGC 
TGCCCCAAGG AGAGCTGTAA CTTGTTTGTG CTGAAGGACA CCCTGAAGAA GATGCAGAAG 
TTCTTCGGGT TACCCCAGAC AGGTGAACTG GACCAGAGCA CCATTGAGAC CATGCGGAAG 
CCGCGCTGTG GCAACCCCGA CGTGGCCAAC TACAACTTCT TCCCCCGAAA GCCCAAGTGG 
GACAAGAACC AGATCACATA CAGGATCATT GGCTACACAC CTGATCTGGA CCCCCAGACA 
GTGGATGATG CCTTCGCTCG TGCCTTCCAA GTCTGGAGCG ATGTGACTCC GCTACGGTTT 
TCTCGGATCC ATGATGGAGA GGCTGACATC ATGATCAACT TTGGCCGCTG GGAGCATGGA 
GATGGGTACC CTTTTGATGG CAAAGACGGG CTCCTGGCTC ATGCCTTCGC CCCGGGCCCT 
GGAGTTGGGG GAGATTCCCA CTTTGATGAC GATGAGCTGC GGACCCTGGG AGAAGGACAA 
GTGGTCCGTG TGAAGTACGG GAATGCTGAC GGGGAATATT GCAAGTTCCC CTTCCGGTTC 
AACGGCAAGG AGTACACCAG CTGCACAGAC ACAGGCCGCA GCGATGGCTT CCTCTGGTGT 
TCCACCACAT ACAACTTTGA CAAGGACGGC AAGTATGGCT TCTGCCCCCA TGAAGCCCTG 
TTCACCATGG GCGGCAACGC CGACGGACAG CCCTGCAAGT TCCCGTTCCG CTTCCAGGGC 
ACGTCTTACG ACAGTTGCAC CACGGAGGGC CGCACGGACG GCTACCGCTG GTGTGGCACC 
ACCGAGGACT ACGACCGCGA CAAGGAGTAC GGCTTCTGCC CGGAGACCGC CATGTCCACT 
GTGGGCGGGA ACTCGGAAGG TGCCCCATGT GTCCTCCCCT TCACCTTCCT GGGCAACAAG 
CACGAGAGCT GCACCAGCGC TGGCCGCAGT GATGGGAAGT TGTGGTGTGC GACCACCTCC 
AACTACGATG ATGACCGCAA GTGGGGCTTC TGCCCCGACC AAGGGTACAG CCTGTTCCTG 
GTGGCAGCCC ATGAGTTTGG CCATGCAATG GGGCTGGAGC ACTCACAGGA CCCTGGAGCC 
CTGATGGCGC CCATTTATAC CTACACCAAG AACTTCCGCC TGTCCCATGA TGACATCCAG 
GGCATCCAAG AACTCTATGG GGCCTCCCCT GACATTGATA CTGGCACCGG CCCCACCCCA 
ACCCTGGGCC CCGTCACTCC TGAGCTCTGC AAACAGGACA TCGTCTTCGA CGGCATCTCT 
CAGATCCGTG GGGAGATCTT CTTCTTCAAG GACCGATTCA TCTGGCGAAC AGTGACACCA 
CGTGACAAGC CCACAGGGCC CCTGCTGGTA GCCACATTCT GGCCTGAGCT GCCGGAAAAG 
ATCGATGCTG TGTACGAAGA CCCACAGGAG GAGAAGGCTG TGTTCTTTGC AGGGAACGAA 
TACTGGGTCT ATTCAGCCAG CACCCTGGAG CGAGGGTACC CCAAGCCACT GACCAGCCTG 
GGGCTCCCCC CTGGTGTCCA GAAGGTGGAT GCTGCCTTTA ACTGGAGCAA GAACAAGAAG 
ACGTACATCT TCGCCGGAGA CAAATTCTGG AGATACAATG AGGTGAAGAA GAAAATGGAT 
CCTGGCTTCC CCAAGCTCAT CGCCGATGCC TGGAACGCCA TCCCTGATAA CCTGGATGCT 
GTGGTGGACC TGCAGGGCGG GGGTCACAGC TACTTCTTCA AGGGCGCCTA TTACCTGAAG 
TTGGAGAACC AAAGTCTGAA GAGCGTGAAG TTCGGAAGCA TCAAATCCGA TTGGCTGGGC 
TGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Differential free fatty acid receptor-1 (FFAR1/GPR40) signalling is associated with gene expression or gelatinase granule release in bovine neutrophils.
Innate immunity22(6)479-89(2016 08)
Mena SJ,Manosalva C,Carretta MD,Teuber S,Olmo I,Burgos RA,Hidalgo MA

Cross talk between MMP2-Spm-Cer-S1P and ERK1/2 in proliferation of pulmonary artery smooth muscle cells under angiotensin II stimulation.
Archives of biochemistry and biophysics60391-101(2016 Aug)
Chowdhury A,Sarkar J,Pramanik PK,Chakraborti T,Chakraborti S

Expression of MMP-1, -2, and -8 in longissimus dorsi muscle and their relationship with meat quality traits in cattle.
Genetics and molecular research : GMR15(1)15017593(2016 Mar)
Qi YX,Zhang XH,Wang YQ,Pang YZ,Zhang ZB,Zhang TL,Zhang ZX

Study on matrix metalloproteinase 1 and 2 gene expression and NO in dairy cows with ovarian cysts.
Animal reproduction science1521-7(2015 Jan)
Mutlag AM,Wang X,Yang Z,Meng J,Wang X,Zhang J,Qin Z,Wang G,Li J

Interrelationship between activation of matrix metalloproteinases and mitochondrial dysfunction in the development of diabetic retinopathy.
Biochemical and biophysical research communications438(4)760-4(2013 Sep)
Santos JM,Tewari S,Lin JY,Kowluru RA

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MMP2 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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