MYO10 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	MYO10
Entrez Gene ID	281935
Full Name	myosin X
General protein information	Preferred Names myosin X Names unconventional myosin-X unconventional myosin-10 unconventionnal myosin-X
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174394.2	NP_776819.1	unconventional myosin-X

Pathways from BioSystems

Homologies

Homo sapiens (human)	MYO10	NP_036466.2
Canis lupus familiaris (dog)	MYO10	XP_005619480.1
Rattus norvegicus (Norway rat)	Myo10	NP_001101127.1
Mus musculus (house mouse)	Myo10	NP_062345.2
Pan troglodytes (chimpanzee)	MYO10	XP_001175408.2
Gallus gallus (chicken)	MYO10	XP_419000.4
Danio rerio (zebrafish)	myo10	XP_005171458.1
Bos taurus (cattle)	MYO10	NP_776819.1

Gene Ontology
Bibliography

Related articles in PubMed

A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip.
Baboolal TG, Mashanov GI, Nenasheva TA, Peckham M, Molloy JE
The Journal of biological chemistry291(43)22373-22385(2016 Oct)

Stable single ?-helices are constant force springs in proteins.
Wolny M, Batchelor M, Knight PJ, Paci E, Dougan L, Peckham M
The Journal of biological chemistry289(40)27825-35(2014 Oct)

Myosin-10 produces its power-stroke in two phases and moves processively along a single actin filament under low load.
Takagi Y, Farrow RE, Billington N, Nagy A, Batters C, Yang Y, Sellers JR, Molloy JE
Proceedings of the National Academy of Sciences of the United States of America111(18)E1833-42(2014 May)

Phospholipid-dependent regulation of the motor activity of myosin X.
Umeki N, Jung HS, Sakai T, Sato O, Ikebe R, Ikebe M
Nature structural & molecular biology18(7)783-8(2011 Jun)

PtdIns(3,4,5)P? is a regulator of myosin-X localization and filopodia formation.
Plantard L, Arjonen A, Lock JG, Nurani G, Ivaska J, Str?mblad S
Journal of cell science123(Pt 20)3525-34(2010 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip.
Title: A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip.

Single alpha-helices domain of MYO10 unfolds progressively as the length is increased and refolds progressively as the length is reduced.
Title: Stable single ?-helices are constant force springs in proteins.

At low optical trap loads, we observed staircase-like processive movements of myosin-10 interacting with the actin filament, consisting of up to six approximately 35-nm steps per binding interaction.
Title: Myosin-10 produces its power-stroke in two phases and moves processively along a single actin filament under low load.

Myosin X is monomeric and the band 4.1-ezrin-radixin-moesin (FERM) and pleckstrin homology (PH) domains bind to the head intramolecularly, forming an inhibited conformation.
Title: Phospholipid-dependent regulation of the motor activity of myosin X.

the structural features of the motor and the track that allow myosin X to recognize actin filament bundles
Title: The stepping pattern of myosin X is adapted for processive motility on bundled actin.

The following MYO10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYO10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa42149	NM_174394.2 Latest version!	Bos taurus myosin X (MYO10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	30	$1161.30 $1659.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYO10 ( NM_174394.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776819.1 Bos taurus myosin X (MYO10), mRNA.

Price & Availability↑

CloneID	OBa42149
Clone ID Related Accession (Same CDS sequence)	NM_174394.2
Accession Version	NM_174394.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 6159bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	unconventional myosin-X
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U55042.1. On or before Mar 29, 2005 this sequence version replaced XM_614341.1, NM_174394.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U55042.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145413, SAMN03145414 [ECO:0000348] ##Evidence-Data-END##

ATGGACAACT TCTTCCCCGA GGGAACACGG GTCTGGCTGA GAGAAAACGG CCAGCATTTC 
CCCAGTACCG TAAACTCCTG CGCGGAGGGC GTTGTGGTGT TCCAGACGGA CTATGGTCAG 
GTATTCACGT ACAAGCAGAG CACAATTACA CACCAGAAGG TGATGCCTAT GCAGCCCACG 
GATGAGGAGG GCGTGGATGA CATGGCCACC CTGACAGAGC TCCACGGGGG TGCCATCATG 
CACAACTTGT ACCAGCGCTA CAAGAGAAAC CAAATCTATA CCTACATCGG CTCCATCATT 
GCCTCCGTGA ACCCCTACAA GACCATCACG GGCCTGTACT CGAGGGACGC CGTGGATCGC 
TACAGCAGGT GCCACCTGGG TGAGCTGCCC CCCCACGTCT TCGCCATCGC CAACGAGTGC 
TACCGCTGCC TGTGGAAGCG CCACGACAAC CAGTGCGTGC TCATCAGTGG TGAAAGTGGC 
GCAGGGAAAA CCGAGAGCAC GAAGCTGATC CTCAAGTTTT TATCAGCCAT CAGTCAGCAG 
TCTGTGGACT TGTCCTCGAA GGAGAAGACC TCATCTGTCG AGCAAGCCAT TCTTGAGAGC 
AGCCCCATCA TGGAAGCCTT TGGCAATGCC AAGACCGTGT ACAACAATAA CTCCAGTCGC 
TTCGGGAAGT TTGTTCAGCT GAACATCGGC CAGAAGGGAA ACATCCAGGG CGGGAGAATT 
GTAGATTATT TATTAGAAAA AAACCGAGTA GTAAGGCAAA ACCCCGGGGA AAGGAATTAT 
CACATATTCT ATGCGCTGCT GGCAGGGCTA GGACATGAAG AGAGAGAAGA ATTTTATTTA 
TCTGTGCCAG AAAACTACCA CTACTTGAAT CAGTCTGGAT GTGTGACAGA CAGGACAATC 
AGTGACCAGG AATCCTTTAG GGAAGTAATT ATGGCGATGG AGGTCATGCA GTTTAGCAAG 
GAAGAAGTTC GGGAAGTGTT GAGGTTGCTT GCTGGTATAT TACATCTCGG GAACATAGAA 
TTTATCACTG CTGGTGGGGC GCAAGTTTCC TTCAAAACGG CCTTGGGCAG GTCTGCAGAG 
TTACTTGGGC TGGACCCGGC ACAGCTCACG GATGCCTTGA CCCAGAGGTC CATGTTCCTC 
CGGGGGGAGG AGATCCTTAC ACCTCTCAAC GTTCAGCAGG CGGCAGACAG CAGGGACTCC 
TTGGCCATGG CACTTTACGC ACGCTGCTTC GAGTGGGTGA TCAAGAAGAT CAACAGCAGG 
ATCAAAGGCA AAGATGACTT CAAGTCTATT GGCATCTTGG ACATCTTTGG ATTTGAAAAC 
TTTGAGGTGA ATCACTTTGA GCAGTTCAAT ATAAACTATG CAAACGAGAA ACTTCAGGAA 
TATTTCAACA AGCATATCTT TTCTTTAGAA CAACTGGAAT ATAGTAGAGA AGGCTTAGTG 
TGGGAAGATA TTGACTGGAT AGACAATGGA GAATGCCTGG ACTTGATTGA GAAGAAACTT 
GGTCTCCTAG CCCTTATCAA TGAAGAAAGC CATTTTCCTC AAGCCACTGA TAGCACCTTA 
TTGGAAAAGT TGCACAATCA GCATGCTAAT AACCACTTTT ACGTGAAGCC TAGAGTTGCA 
GTCAACAATT TTGGAGTGAA ACACTATGCT GGAGAGGTTC AGTATGACGT GCGGGGCATC 
TTGGAGAAGA ACAGGGATAC CTTCAGGGAC GATCTTCTCA ACCTTCTGAG AGAAAGCCGA 
TTCGACTTCA TCTACGACCT CTTCGAACAC GTTTCCAGCC GCAATAATCA GGATACCTTG 
AAATGCGGAA GCAAACACCG GCGGCCCACG GTCAGCTCGC AGTTCAAGGA CTCCCTGCAT 
TCCTTAATGG CAACGCTAAG CGCCTCTAAT CCTTTCTTTG TTCGCTGTAT CAAGCCAAAC 
ATGCAGAAGA TGCCTGACCA GTTTGACCAG GCAGTCGTGG TCAACCAGCT GCGGTACTCG 
GGGATGCTGG AGACGGTCAG GATCCGGAAA GCTGGCTATG CCGTCCGGAG ACCCTTCCAG 
GACTTTTACA AAAGGTATAA GGTGCTGATG AGGAACGTGG CGCTGCCTGA GGACATCAGG 
GGCAAGTGCA CGGCCCTGCT GCAGCTCTAT GATGCCTCCA ACAGTGAGTG GCAACTGGGG 
AAGACAAAGG TGTTCCTTCG TGAGTCCTTG GAGCAGAAAC TGGAGAAGCG ACAGGAAGAG 
GAGGTGACGC GGGCGGCCAT GGTGATCCGG GCCCACGTCT TGGGCTACTT GGCAAGAAAG 
CAATACAAGA AGGTCCTTGA TTGTGTAGTG ATCATACAGA AGAACTACAG GGCCTTCCTC 
CTGAGGAGGA GATTTTTGCA CCTGAAAAAA GCAGCTGTGG TTTTCCAGAA GCAACTCCGA 
GGTCAGATTG CCAGAAGAGT TTACAGACAA CTGCTGGCAG AGAAACGAGC AGAGGAGGAA 
AAGAGGAAAC GGGAAGAGGA AGAAAAGAGG AAACGGGAGG AGGAGGAAAG AGAAAGAGAG 
AGGGAACGAA GAGAAGCGGA GCTCCGCGCC CAACAGGAGG AAGCAGCCCG GAAGCAGCGG 
GAACTGGAAG CCTTGCAGCA GGAGAGTCAG AGGGCAGCGG AGCTGAGCCG GGAGCTGGAG 
AAGCAGAAGG AGAACAAGCA GGTGGAGGAG ATCCTGCGGC TGGAGAAGGA AATCGAGGAC 
CTGCAGCGCA TGAAGGAGCG GCAGGAGCTG TCCCTGACCG AGGCGTCCCT GCAAAAGCTG 
CAGCAGCTGC GGGATGAAGA GCTGCGGCGG CTGGAGGACG AGGCCTGCCG CGCCGCCCAG 
GAGTTCCTGG AGTCGCTCAA CTTCGACGAG ATCGACGAGT GCGTCCGCAA CATTGAGCGC 
TCCCTGTCGG TGGGGAGCGG GTGCACAGGC GAGCAGGGCG CCGGGGCGGA GAAGCCCAGC 
TTCAACTTCA GCCAGCCCTA CCCAGAGGAG GAGGAGGTGG ATGAGGGCTT CGAGGCTGAC 
GACGATGCGT TCAAGGACTC GCCCAACCCC AGCGAGCACG GCCACTCAGA CCAGCGCACC 
AGCGGCATCC GGACCAGCGA CGAGTCCTCG GAGGAGGACC CCTACATGAA CGACACCGTG 
GTGCCCACCA GCCCCAGCGC TGACAGCACC GTGCTGCTGG CCCCCTCGGA GCACGACTCC 
TCCGCCGGGG AGCCCACCTA CTGCCTGCCC CAGACCCCGG GGGCCCTGCC CGCCCCAGAG 
GGCGACTACG ATTACGATCA AGATGACTAC GAGGACGGGG CCATCACCTC CGGCAGCAGC 
GTGACCTTCT CCAACTCCTG CAGCAGCCAG TGGTCCCCAG ACTACCGATG CTCCGTGGGC 
ACCTACAACA GCTCGGGGGC CTACCGGTTC AGCTCGGAGG GCGCTCAGTC CTCGTTTGAA 
GATAGTGAAG AGGACTTCGA TTCTCGGTTT GATACAGACG ACGAGCTTTC GTACCGGCGG 
GACTCTGTGT ACAGCTGTGT CACGCTGCCT TACTTCCATA GCTTCCTGTA CATGAAAGGT 
GGCCTCATGA ACTCCTGGAA GCGCCGCTGG TGCGTGCTCA AGGACGAGAC GTTCCTGTGG 
TTCCGCTCCA AGCAGGAGGC CCTCAAGCAA GGCTGGCTGC ACAAGAAGGG TGGCGGCTCC 
TCCACCCTAT CCAGGAGAAA CTGGAAGAAG CGCTGGTTTG TCCTCCGCCA GGCCAAGCTG 
ATGTACTTCG AGAACGACAG CGAGGAGAAG CTCAAGGGCA CCGTGGAGGT CCGGGCGGCC 
AAGGAGATCA TAGATAACAC CAGCAAAGAG AACGGGATTG ACATCATCAT GGCCGACAGG 
ACCTTCCATC TGATTGCAGA ATCCCCGGAA GACGCCAGCC AGTGGTTCAG TGTGCTGAGT 
CAGGTCCACG CATCCACAGA CCAGGAGATT CGGGAGATGC ATGATGAGCA GGCAAACCCA 
CAAAACGCTG TGGGCACTTT GGATGTGGGG CTGATCGATT CTGTGTGCGC CTCGGACAGC 
CCAGATAGAC CTAACTCATT CGTGATCATC ACGGCCAACC GGGTGCTTCA CTGCAACGCC 
GACACGCCGG AGGAAATGCA CCACTGGATA ACGCTGCTGC AGAGATCCAA GGGCGATACC 
AGAGTGGAGG GCCAGGAGTT CATAGTGAGA GGGTGGTTGC ACAAAGAAGT GAAAAACAGT 
CCGAAGATGT CGTCCCTGAA ACTGAAGAAA CGGTGGTTTG TGCTCACGCA CAATTCCTTG 
GATTACTACA AGAGCTCGGA GAAGAACGCT CTGAAGTTGG GCACCCTGGT TCTCAATAGT 
CTTTGTTCGG TCGTCCCACC TGATGAGAAG ATCTTTAAAG AGACAGGCTA CTGGAACGTC 
ACCGTGTACG GACGCAAGCA CTGCTACCGG CTCTACACCA AGCTGCTCAA CGAGGCCACC 
AGGTGGTCCA GCGCCATTCA AAACGTGACG GACACCAAGG CCCCAATTGA CACGCCCACG 
CAGCAGCTGA TTCAAGATAT CAAGGAGAAC TGCCTGAACT CGGACGTGGT GGAGCAGATA 
TACAAGCGGA ATCCCATCCT GAGGCACACC CACCACCCAC TGCACTCGCC ACTCCTGCCC 
CTGCCCTACG GAGACATCAA CCTCAACTTG CTCAAAGACA AGGGCTACAC GACGCTTCAG 
GACGAAGCCA TCAAGATATT CAACTCCCTC CAGCAGCTGG AGTCCATGTC CGACCCTATT 
CCCATCATCC AGGGCATCCT CCAGACGGGG CACGACCTCC GGCCTCTGCG AGACGAGCTG 
TACTGCCAGC TCATCAAGCA GACCAACAAG GTGCCGCACC CGGGCAGCGT GGGCAACCTC 
TGCAGCTGGC AGATCCTCAC CTGCCTGAGC TGCACCTTCC TGCCCAGCCG CGGGATCCTC 
AAGTACCTCA AGTTCCACCT GAGAAGGATA CGGGAACAGT TTCCAGGAAC TGAGATGGAA 
AAATATGCCC TCTTCATTTA CGAATCTCTT AAGAAAACCA AATGCAGAGA GTTTGTGCCT 
TCGCGAGATG AGATAGAAGC TCTGATCCAT CGGCAAGAGA TGACGTCCAC GGTGCACTGC 
CACGGTGGGG GCTCCTGCAA GATCACTGTC AACTCCCACA CCACGGCCGG GGAGGTGGTG 
GAGAAGCTGA TCCGAGGCCT GGCCATGGAG GACAGCAGAA ACATGTTCGC ACTCTTTGAG 
TACAACGGAC ACGTCGATAA AGCCATCGAG AGCAGGACCA TCGTAGCAGA TGTGTTAGCA 
AAGTTTGAAA AGCTGGCCGC CACTTCAGAG GTGGGCGAGC AGCCCTGGAA ATTCTACTTC 
AAACTTTACT GCTTCCTGGA CACAGACAAC GTGCCAAAAG ACAGCGTGGA ATTCGCCTTT 
ATGTTTGAAC AGGCCCACGA AGCCGTCATC CATGGCCACT ACCCGGCCCC CGAGGAGAAC 
CTGCAGGTGC TGGCTGCCCT GCGGCTCCAG TATCTGCAGG GGGATTACGC ACCGCACGCC 
CCGGTACCGC CCCTCGAGGA GGTCTACTCG CTGCAGAGGC TCAAGGCCCG CATCAGCCAA 
TCCACCAAGA GCTTCACGCC GGGGGAGCGG CTGGAGAAGA GGCGCACGAG CTTCCTGGAG 
GGGACCCTGC GGCGGAGCTT CCGGACGGGC TCCGCGATAC GGCAGAAGGC AGAGGAGGAG 
CAGATGGTGG ACATGTGGGT CAAGGAGGAG GTGTGCTCCG CGCGGGCCAG CATCCTGGAC 
AAGTGGAAGA AGTTCCAGGG CATGAGCCAG GAACAGGCCA TGGCCAAGTA CATGGCCTTG 
ATCAAGGAGT GGCCTGGGTA CGGGTCGACG CTCTTCGACG TGGAGTGCAA GGAAGGTGGC 
TTTCCCCAGG ACCTCTGGCT GGGCGTCAGC GCCGATGCGG TCTCTGTCTA CAAGCGTGGG 
GAGGGGAGGC CATTGGAAGT CTTCCAGTAC GAACACATCC TCTCCTTCGG TGCCCCCCTG 
GCCAACACCT ACAAGATCGT CGTCGATGAG AGGGAGCTGC TCTTTGAAAC CAGTGAGGTG 
GTGGACGTGG CCAAGCTCAT GAAAGCCTAC ATCAGCATGA TCGTGAAGAA GCGCTACAGC 
ACCTCGCGCT CCGTGAGCAG CCAGGGCAGC TCCAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776819.1
CDS	223..6381
Translation	MDNFFPEGTRVWLRENGQHFPSTVNSCAEGVVVFQTDYGQVFTYKQSTITHQKVMPMQPTDEEGVDDMATLTELHGGAIMHNLYQRYKRNQIYTYIGSIIASVNPYKTITGLYSRDAVDRYSRCHLGELPPHVFAIANECYRCLWKRHDNQCVLISGESGAGKTESTKLILKFLSAISQQSVDLSSKEKTSSVEQAILESSPIMEAFGNAKTVYNNNSSRFGKFVQLNIGQKGNIQGGRIVDYLLEKNRVVRQNPGERNYHIFYALLAGLGHEEREEFYLSVPENYHYLNQSGCVTDRTISDQESFREVIMAMEVMQFSKEEVREVLRLLAGILHLGNIEFITAGGAQVSFKTALGRSAELLGLDPAQLTDALTQRSMFLRGEEILTPLNVQQAADSRDSLAMALYARCFEWVIKKINSRIKGKDDFKSIGILDIFGFENFEVNHFEQFNINYANEKLQEYFNKHIFSLEQLEYSREGLVWEDIDWIDNGECLDLIEKKLGLLALINEESHFPQATDSTLLEKLHNQHANNHFYVKPRVAVNNFGVKHYAGEVQYDVRGILEKNRDTFRDDLLNLLRESRFDFIYDLFEHVSSRNNQDTLKCGSKHRRPTVSSQFKDSLHSLMATLSASNPFFVRCIKPNMQKMPDQFDQAVVVNQLRYSGMLETVRIRKAGYAVRRPFQDFYKRYKVLMRNVALPEDIRGKCTALLQLYDASNSEWQLGKTKVFLRESLEQKLEKRQEEEVTRAAMVIRAHVLGYLARKQYKKVLDCVVIIQKNYRAFLLRRRFLHLKKAAVVFQKQLRGQIARRVYRQLLAEKRAEEEKRKREEEEKRKREEEERERERERREAELRAQQEEAARKQRELEALQQESQRAAELSRELEKQKENKQVEEILRLEKEIEDLQRMKERQELSLTEASLQKLQQLRDEELRRLEDEACRAAQEFLESLNFDEIDECVRNIERSLSVGSGCTGEQGAGAEKPSFNFSQPYPEEEEVDEGFEADDDAFKDSPNPSEHGHSDQRTSGIRTSDESSEEDPYMNDTVVPTSPSADSTVLLAPSEHDSSAGEPTYCLPQTPGALPAPEGDYDYDQDDYEDGAITSGSSVTFSNSCSSQWSPDYRCSVGTYNSSGAYRFSSEGAQSSFEDSEEDFDSRFDTDDELSYRRDSVYSCVTLPYFHSFLYMKGGLMNSWKRRWCVLKDETFLWFRSKQEALKQGWLHKKGGGSSTLSRRNWKKRWFVLRQAKLMYFENDSEEKLKGTVEVRAAKEIIDNTSKENGIDIIMADRTFHLIAESPEDASQWFSVLSQVHASTDQEIREMHDEQANPQNAVGTLDVGLIDSVCASDSPDRPNSFVIITANRVLHCNADTPEEMHHWITLLQRSKGDTRVEGQEFIVRGWLHKEVKNSPKMSSLKLKKRWFVLTHNSLDYYKSSEKNALKLGTLVLNSLCSVVPPDEKIFKETGYWNVTVYGRKHCYRLYTKLLNEATRWSSAIQNVTDTKAPIDTPTQQLIQDIKENCLNSDVVEQIYKRNPILRHTHHPLHSPLLPLPYGDINLNLLKDKGYTTLQDEAIKIFNSLQQLESMSDPIPIIQGILQTGHDLRPLRDELYCQLIKQTNKVPHPGSVGNLCSWQILTCLSCTFLPSRGILKYLKFHLRRIREQFPGTEMEKYALFIYESLKKTKCREFVPSRDEIEALIHRQEMTSTVHCHGGGSCKITVNSHTTAGEVVEKLIRGLAMEDSRNMFALFEYNGHVDKAIESRTIVADVLAKFEKLAATSEVGEQPWKFYFKLYCFLDTDNVPKDSVEFAFMFEQAHEAVIHGHYPAPEENLQVLAALRLQYLQGDYAPHAPVPPLEEVYSLQRLKARISQSTKSFTPGERLEKRRTSFLEGTLRRSFRTGSAIRQKAEEEQMVDMWVKEEVCSARASILDKWKKFQGMSQEQAMAKYMALIKEWPGYGSTLFDVECKEGGFPQDLWLGVSADAVSVYKRGEGRPLEVFQYEHILSFGAPLANTYKIVVDERELLFETSEVVDVAKLMKAYISMIVKKRYSTSRSVSSQGSSR

Target ORF information:

RefSeq Version	NM_174394.2
Organism	Bos taurus(cattle)
Definition	Bos taurus myosin X (MYO10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174394.2

ORF Insert Sequence:

ATGGACAACT TCTTCCCCGA GGGAACACGG GTCTGGCTGA GAGAAAACGG CCAGCATTTC 
CCCAGTACCG TAAACTCCTG CGCGGAGGGC GTTGTGGTGT TCCAGACGGA CTATGGTCAG 
GTATTCACGT ACAAGCAGAG CACAATTACA CACCAGAAGG TGATGCCTAT GCAGCCCACG 
GATGAGGAGG GCGTGGATGA CATGGCCACC CTGACAGAGC TCCACGGGGG TGCCATCATG 
CACAACTTGT ACCAGCGCTA CAAGAGAAAC CAAATCTATA CCTACATCGG CTCCATCATT 
GCCTCCGTGA ACCCCTACAA GACCATCACG GGCCTGTACT CGAGGGACGC CGTGGATCGC 
TACAGCAGGT GCCACCTGGG TGAGCTGCCC CCCCACGTCT TCGCCATCGC CAACGAGTGC 
TACCGCTGCC TGTGGAAGCG CCACGACAAC CAGTGCGTGC TCATCAGTGG TGAAAGTGGC 
GCAGGGAAAA CCGAGAGCAC GAAGCTGATC CTCAAGTTTT TATCAGCCAT CAGTCAGCAG 
TCTGTGGACT TGTCCTCGAA GGAGAAGACC TCATCTGTCG AGCAAGCCAT TCTTGAGAGC 
AGCCCCATCA TGGAAGCCTT TGGCAATGCC AAGACCGTGT ACAACAATAA CTCCAGTCGC 
TTCGGGAAGT TTGTTCAGCT GAACATCGGC CAGAAGGGAA ACATCCAGGG CGGGAGAATT 
GTAGATTATT TATTAGAAAA AAACCGAGTA GTAAGGCAAA ACCCCGGGGA AAGGAATTAT 
CACATATTCT ATGCGCTGCT GGCAGGGCTA GGACATGAAG AGAGAGAAGA ATTTTATTTA 
TCTGTGCCAG AAAACTACCA CTACTTGAAT CAGTCTGGAT GTGTGACAGA CAGGACAATC 
AGTGACCAGG AATCCTTTAG GGAAGTAATT ATGGCGATGG AGGTCATGCA GTTTAGCAAG 
GAAGAAGTTC GGGAAGTGTT GAGGTTGCTT GCTGGTATAT TACATCTCGG GAACATAGAA 
TTTATCACTG CTGGTGGGGC GCAAGTTTCC TTCAAAACGG CCTTGGGCAG GTCTGCAGAG 
TTACTTGGGC TGGACCCGGC ACAGCTCACG GATGCCTTGA CCCAGAGGTC CATGTTCCTC 
CGGGGGGAGG AGATCCTTAC ACCTCTCAAC GTTCAGCAGG CGGCAGACAG CAGGGACTCC 
TTGGCCATGG CACTTTACGC ACGCTGCTTC GAGTGGGTGA TCAAGAAGAT CAACAGCAGG 
ATCAAAGGCA AAGATGACTT CAAGTCTATT GGCATCTTGG ACATCTTTGG ATTTGAAAAC 
TTTGAGGTGA ATCACTTTGA GCAGTTCAAT ATAAACTATG CAAACGAGAA ACTTCAGGAA 
TATTTCAACA AGCATATCTT TTCTTTAGAA CAACTGGAAT ATAGTAGAGA AGGCTTAGTG 
TGGGAAGATA TTGACTGGAT AGACAATGGA GAATGCCTGG ACTTGATTGA GAAGAAACTT 
GGTCTCCTAG CCCTTATCAA TGAAGAAAGC CATTTTCCTC AAGCCACTGA TAGCACCTTA 
TTGGAAAAGT TGCACAATCA GCATGCTAAT AACCACTTTT ACGTGAAGCC TAGAGTTGCA 
GTCAACAATT TTGGAGTGAA ACACTATGCT GGAGAGGTTC AGTATGACGT GCGGGGCATC 
TTGGAGAAGA ACAGGGATAC CTTCAGGGAC GATCTTCTCA ACCTTCTGAG AGAAAGCCGA 
TTCGACTTCA TCTACGACCT CTTCGAACAC GTTTCCAGCC GCAATAATCA GGATACCTTG 
AAATGCGGAA GCAAACACCG GCGGCCCACG GTCAGCTCGC AGTTCAAGGA CTCCCTGCAT 
TCCTTAATGG CAACGCTAAG CGCCTCTAAT CCTTTCTTTG TTCGCTGTAT CAAGCCAAAC 
ATGCAGAAGA TGCCTGACCA GTTTGACCAG GCAGTCGTGG TCAACCAGCT GCGGTACTCG 
GGGATGCTGG AGACGGTCAG GATCCGGAAA GCTGGCTATG CCGTCCGGAG ACCCTTCCAG 
GACTTTTACA AAAGGTATAA GGTGCTGATG AGGAACGTGG CGCTGCCTGA GGACATCAGG 
GGCAAGTGCA CGGCCCTGCT GCAGCTCTAT GATGCCTCCA ACAGTGAGTG GCAACTGGGG 
AAGACAAAGG TGTTCCTTCG TGAGTCCTTG GAGCAGAAAC TGGAGAAGCG ACAGGAAGAG 
GAGGTGACGC GGGCGGCCAT GGTGATCCGG GCCCACGTCT TGGGCTACTT GGCAAGAAAG 
CAATACAAGA AGGTCCTTGA TTGTGTAGTG ATCATACAGA AGAACTACAG GGCCTTCCTC 
CTGAGGAGGA GATTTTTGCA CCTGAAAAAA GCAGCTGTGG TTTTCCAGAA GCAACTCCGA 
GGTCAGATTG CCAGAAGAGT TTACAGACAA CTGCTGGCAG AGAAACGAGC AGAGGAGGAA 
AAGAGGAAAC GGGAAGAGGA AGAAAAGAGG AAACGGGAGG AGGAGGAAAG AGAAAGAGAG 
AGGGAACGAA GAGAAGCGGA GCTCCGCGCC CAACAGGAGG AAGCAGCCCG GAAGCAGCGG 
GAACTGGAAG CCTTGCAGCA GGAGAGTCAG AGGGCAGCGG AGCTGAGCCG GGAGCTGGAG 
AAGCAGAAGG AGAACAAGCA GGTGGAGGAG ATCCTGCGGC TGGAGAAGGA AATCGAGGAC 
CTGCAGCGCA TGAAGGAGCG GCAGGAGCTG TCCCTGACCG AGGCGTCCCT GCAAAAGCTG 
CAGCAGCTGC GGGATGAAGA GCTGCGGCGG CTGGAGGACG AGGCCTGCCG CGCCGCCCAG 
GAGTTCCTGG AGTCGCTCAA CTTCGACGAG ATCGACGAGT GCGTCCGCAA CATTGAGCGC 
TCCCTGTCGG TGGGGAGCGG GTGCACAGGC GAGCAGGGCG CCGGGGCGGA GAAGCCCAGC 
TTCAACTTCA GCCAGCCCTA CCCAGAGGAG GAGGAGGTGG ATGAGGGCTT CGAGGCTGAC 
GACGATGCGT TCAAGGACTC GCCCAACCCC AGCGAGCACG GCCACTCAGA CCAGCGCACC 
AGCGGCATCC GGACCAGCGA CGAGTCCTCG GAGGAGGACC CCTACATGAA CGACACCGTG 
GTGCCCACCA GCCCCAGCGC TGACAGCACC GTGCTGCTGG CCCCCTCGGA GCACGACTCC 
TCCGCCGGGG AGCCCACCTA CTGCCTGCCC CAGACCCCGG GGGCCCTGCC CGCCCCAGAG 
GGCGACTACG ATTACGATCA AGATGACTAC GAGGACGGGG CCATCACCTC CGGCAGCAGC 
GTGACCTTCT CCAACTCCTG CAGCAGCCAG TGGTCCCCAG ACTACCGATG CTCCGTGGGC 
ACCTACAACA GCTCGGGGGC CTACCGGTTC AGCTCGGAGG GCGCTCAGTC CTCGTTTGAA 
GATAGTGAAG AGGACTTCGA TTCTCGGTTT GATACAGACG ACGAGCTTTC GTACCGGCGG 
GACTCTGTGT ACAGCTGTGT CACGCTGCCT TACTTCCATA GCTTCCTGTA CATGAAAGGT 
GGCCTCATGA ACTCCTGGAA GCGCCGCTGG TGCGTGCTCA AGGACGAGAC GTTCCTGTGG 
TTCCGCTCCA AGCAGGAGGC CCTCAAGCAA GGCTGGCTGC ACAAGAAGGG TGGCGGCTCC 
TCCACCCTAT CCAGGAGAAA CTGGAAGAAG CGCTGGTTTG TCCTCCGCCA GGCCAAGCTG 
ATGTACTTCG AGAACGACAG CGAGGAGAAG CTCAAGGGCA CCGTGGAGGT CCGGGCGGCC 
AAGGAGATCA TAGATAACAC CAGCAAAGAG AACGGGATTG ACATCATCAT GGCCGACAGG 
ACCTTCCATC TGATTGCAGA ATCCCCGGAA GACGCCAGCC AGTGGTTCAG TGTGCTGAGT 
CAGGTCCACG CATCCACAGA CCAGGAGATT CGGGAGATGC ATGATGAGCA GGCAAACCCA 
CAAAACGCTG TGGGCACTTT GGATGTGGGG CTGATCGATT CTGTGTGCGC CTCGGACAGC 
CCAGATAGAC CTAACTCATT CGTGATCATC ACGGCCAACC GGGTGCTTCA CTGCAACGCC 
GACACGCCGG AGGAAATGCA CCACTGGATA ACGCTGCTGC AGAGATCCAA GGGCGATACC 
AGAGTGGAGG GCCAGGAGTT CATAGTGAGA GGGTGGTTGC ACAAAGAAGT GAAAAACAGT 
CCGAAGATGT CGTCCCTGAA ACTGAAGAAA CGGTGGTTTG TGCTCACGCA CAATTCCTTG 
GATTACTACA AGAGCTCGGA GAAGAACGCT CTGAAGTTGG GCACCCTGGT TCTCAATAGT 
CTTTGTTCGG TCGTCCCACC TGATGAGAAG ATCTTTAAAG AGACAGGCTA CTGGAACGTC 
ACCGTGTACG GACGCAAGCA CTGCTACCGG CTCTACACCA AGCTGCTCAA CGAGGCCACC 
AGGTGGTCCA GCGCCATTCA AAACGTGACG GACACCAAGG CCCCAATTGA CACGCCCACG 
CAGCAGCTGA TTCAAGATAT CAAGGAGAAC TGCCTGAACT CGGACGTGGT GGAGCAGATA 
TACAAGCGGA ATCCCATCCT GAGGCACACC CACCACCCAC TGCACTCGCC ACTCCTGCCC 
CTGCCCTACG GAGACATCAA CCTCAACTTG CTCAAAGACA AGGGCTACAC GACGCTTCAG 
GACGAAGCCA TCAAGATATT CAACTCCCTC CAGCAGCTGG AGTCCATGTC CGACCCTATT 
CCCATCATCC AGGGCATCCT CCAGACGGGG CACGACCTCC GGCCTCTGCG AGACGAGCTG 
TACTGCCAGC TCATCAAGCA GACCAACAAG GTGCCGCACC CGGGCAGCGT GGGCAACCTC 
TGCAGCTGGC AGATCCTCAC CTGCCTGAGC TGCACCTTCC TGCCCAGCCG CGGGATCCTC 
AAGTACCTCA AGTTCCACCT GAGAAGGATA CGGGAACAGT TTCCAGGAAC TGAGATGGAA 
AAATATGCCC TCTTCATTTA CGAATCTCTT AAGAAAACCA AATGCAGAGA GTTTGTGCCT 
TCGCGAGATG AGATAGAAGC TCTGATCCAT CGGCAAGAGA TGACGTCCAC GGTGCACTGC 
CACGGTGGGG GCTCCTGCAA GATCACTGTC AACTCCCACA CCACGGCCGG GGAGGTGGTG 
GAGAAGCTGA TCCGAGGCCT GGCCATGGAG GACAGCAGAA ACATGTTCGC ACTCTTTGAG 
TACAACGGAC ACGTCGATAA AGCCATCGAG AGCAGGACCA TCGTAGCAGA TGTGTTAGCA 
AAGTTTGAAA AGCTGGCCGC CACTTCAGAG GTGGGCGAGC AGCCCTGGAA ATTCTACTTC 
AAACTTTACT GCTTCCTGGA CACAGACAAC GTGCCAAAAG ACAGCGTGGA ATTCGCCTTT 
ATGTTTGAAC AGGCCCACGA AGCCGTCATC CATGGCCACT ACCCGGCCCC CGAGGAGAAC 
CTGCAGGTGC TGGCTGCCCT GCGGCTCCAG TATCTGCAGG GGGATTACGC ACCGCACGCC 
CCGGTACCGC CCCTCGAGGA GGTCTACTCG CTGCAGAGGC TCAAGGCCCG CATCAGCCAA 
TCCACCAAGA GCTTCACGCC GGGGGAGCGG CTGGAGAAGA GGCGCACGAG CTTCCTGGAG 
GGGACCCTGC GGCGGAGCTT CCGGACGGGC TCCGCGATAC GGCAGAAGGC AGAGGAGGAG 
CAGATGGTGG ACATGTGGGT CAAGGAGGAG GTGTGCTCCG CGCGGGCCAG CATCCTGGAC 
AAGTGGAAGA AGTTCCAGGG CATGAGCCAG GAACAGGCCA TGGCCAAGTA CATGGCCTTG 
ATCAAGGAGT GGCCTGGGTA CGGGTCGACG CTCTTCGACG TGGAGTGCAA GGAAGGTGGC 
TTTCCCCAGG ACCTCTGGCT GGGCGTCAGC GCCGATGCGG TCTCTGTCTA CAAGCGTGGG 
GAGGGGAGGC CATTGGAAGT CTTCCAGTAC GAACACATCC TCTCCTTCGG TGCCCCCCTG 
GCCAACACCT ACAAGATCGT CGTCGATGAG AGGGAGCTGC TCTTTGAAAC CAGTGAGGTG 
GTGGACGTGG CCAAGCTCAT GAAAGCCTAC ATCAGCATGA TCGTGAAGAA GCGCTACAGC 
ACCTCGCGCT CCGTGAGCAG CCAGGGCAGC TCCAGGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A Combination of Diffusion and Active Translocation Localizes Myosin 10 to the Filopodial Tip.
The Journal of biological chemistry291(43)22373-22385(2016 Oct)
Baboolal TG,Mashanov GI,Nenasheva TA,Peckham M,Molloy JE

Stable single ?-helices are constant force springs in proteins.
The Journal of biological chemistry289(40)27825-35(2014 Oct)
Wolny M,Batchelor M,Knight PJ,Paci E,Dougan L,Peckham M

Myosin-10 produces its power-stroke in two phases and moves processively along a single actin filament under low load.
Proceedings of the National Academy of Sciences of the United States of America111(18)E1833-42(2014 May)
Takagi Y,Farrow RE,Billington N,Nagy A,Batters C,Yang Y,Sellers JR,Molloy JE

Phospholipid-dependent regulation of the motor activity of myosin X.
Nature structural & molecular biology18(7)783-8(2011 Jun)
Umeki N,Jung HS,Sakai T,Sato O,Ikebe R,Ikebe M

PtdIns(3,4,5)P? is a regulator of myosin-X localization and filopodia formation.
Journal of cell science123(Pt 20)3525-34(2010 Oct)
Plantard L,Arjonen A,Lock JG,Nurani G,Ivaska J,Str?mblad S

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MYO10 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

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