MMP13 cDNA ORF clone, Bos taurus(cattle)

Cyclic compression-induced p38 activation and subsequent MMP13 expression requires Rho/ROCK activity in bovine cartilage explants.
Nakagawa K, Teramura T, Takehara T, Onodera Y, Hamanishi C, Akagi M, Fukuda K
Inflammation research : official journal of the European Histamine Research Society ... [et al.]61(10)1093-100(2012 Oct)

Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction.
Litherland GJ, Elias MS, Hui W, Macdonald CD, Catterall JB, Barter MJ, Farren MJ, Jefferson M, Rowan AD
The Journal of biological chemistry285(29)22414-25(2010 Jul)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

[Type II collagen fragment capacity to induce collagen cleavage and hypertrophy of articular chondrocyte].
Chetkina EV, Pul AR
Vestnik Rossiiskoi akademii meditsinskikh nauk(5)15-21(2008)

Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis.
Tchetina EV, Kobayashi M, Yasuda T, Meijers T, Pidoux I, Poole AR
Matrix biology : journal of the International Society for Matrix Biology26(4)247-58(2007 May)

p38 phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
Title: Cyclic compression-induced p38 activation and subsequent MMP13 expression requires Rho/ROCK activity in bovine cartilage explants.

These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
Title: Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction.

At high but naturally occurring concentrations the collagen peptide CB12-II induced an increase in the expressions of MMP-13 and cleavage of type II collagen by collagenase in the mid zone and also in the superficial zone.
Title: [Type II collagen fragment capacity to induce collagen cleavage and hypertrophy of articular chondrocyte].

MMP-13 and collagenase have roles in chondrocyte hypertrophy induced by type II collagen
Title: Chondrocyte hypertrophy can be induced by a cryptic sequence of type II collagen and is accompanied by the induction of MMP-13 and collagenase activity: implications for development and arthritis.

involvement of p38 MAP kinase in the hyaluronan oligosaccharide induction of MMP-13
Title: Hyaluronan oligosaccharides induce matrix metalloproteinase 13 via transcriptional activation of NFkappaB and p38 MAP kinase in articular chondrocytes.