IFNB1 cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	IFNB1
Entrez Gene ID	281845
Full Name	interferon, beta 1, fibroblast
Synonyms	IFNb
Gene Type	protein-coding
Organism	Bos taurus(cattle)
Genome	Chromosome: 8 Map Location: 8q15

mRNA and Protein(s)

mRNA	Protein	Name
NM_174350.1	NP_776775.1	interferon beta-1 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	LOC616977	XP_005209956.1
Bos taurus (cattle)	LOC784249	XP_005209957.1
Bos taurus (cattle)	LOC784525	XP_002689586.1
Bos taurus (cattle)	LOC100337470	XP_002689583.1
Bos taurus (cattle)	IL6	NP_001015617.1
Bos taurus (cattle)	LOC525550	XP_002689587.1
Bos taurus (cattle)	IFNB1	NP_776775.1
Bos taurus (cattle)	LOC100848709	XP_005209960.1
Bos taurus (cattle)	IFNB3	NP_001107769.1

Gene Ontology
Bibliography

Related articles in PubMed

Type 2 BVDV N
Alkheraif AA, Topliff CL, Reddy J, Massilamany C, Donis RO, Meyers G, Eskridge KM, Kelling CL
Virology507123-134(2017 07)

Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.
Singh N, Ram?rez-Carvajal L, de Los Santos T, Golding MC, Long CR
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research36(1)37-47(2016 Jan)

ICP27 protein encoded by bovine herpesvirus type 1 (bICP27) interferes with promoter activity of the bovine genes encoding beta interferon 1 (IFN-?1) and IFN-?3.
da Silva LF, Sinani D, Jones C
Virus research169(1)162-8(2012 Oct)

Cytoplasmic localized infected cell protein 0 (bICP0) encoded by bovine herpesvirus 1 inhibits ? interferon promoter activity and reduces IRF3 (interferon response factor 3) protein levels.
da Silva LF, Gaudreault N, Jones C
Virus research160(1-2)143-9(2011 Sep)

Infection of cultured bovine cells with bovine herpesvirus 1 (BHV-1) or Sendai virus induces different beta interferon subtypes.
da Silva LF, Jones C
Virus research157(1)54-60(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BVDV2-E significantly increased IFN-beta activity compared to BVDV2-wt.
Title: Type 2 BVDV N

The data confirm the involvement of EHMT2 in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 inhibition.
Title: Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.

The authors provide evidence that ICP27 protein encoded by bovine herpesvirus type 1, a viral early protein that shuttles between the nucleus and cytoplasm inhibits transcriptional activity of two bovine IFN-beta gene promoters (IFN-beta1 and IFN-beta3).
Title: ICP27 protein encoded by bovine herpesvirus type 1 (bICP27) interferes with promoter activity of the bovine genes encoding beta interferon 1 (IFN-?1) and IFN-?3.

The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 degradation.
Title: Cytoplasmic localized infected cell protein 0 (bICP0) encoded by bovine herpesvirus 1 inhibits ? interferon promoter activity and reduces IRF3 (interferon response factor 3) protein levels.

These studies provide evidence that virus infection differentially stimulates expression of the three bovine IFN-beta genes.
Title: Infection of cultured bovine cells with bovine herpesvirus 1 (BHV-1) or Sendai virus induces different beta interferon subtypes.

The following IFNB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa42750	NM_174350.1 Latest version!	Bos taurus interferon, beta 1, fibroblast (IFNB1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$104.30 $149.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone	40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

IFNB1 ( NM_174350.1 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776775.1 Bos taurus interferon, beta 1, fibroblast (IFNB1), mRNA.

Price & Availability↑

CloneID	OBa42750
Clone ID Related Accession (Same CDS sequence)	NM_174350.1
Accession Version	NM_174350.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Bos taurus(cattle)
Product	interferon beta-1 precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M15477.1.

ATGACCTACC GGTGCCTCCT CCAGATGGTT CTCCTGCTGT GTTTCTCCAC CACAGCTCTT 
TCCAGGAGCT ACAGCTTGCT TCGATTCCAA CAACGTCAGA GCCTTAAAGA GTGTCAGAAA 
CTCCTGGGGC AGTTACCTTC AACTTCTCAA CATTGCCTCG AGGCCAGGAT GGACTTCCAG 
ATGCCTGAGG AGATGAAGCA AGAACAGCAG TTCCAGAAGG AAGATGCCAT ATTGGTCATG 
TATGAGGTGC TCCAGCACAT CTTCGGCATT CTCACCAGAG ACTTCTCCAG CACTGGCTGG 
TCTGAGACCA TCATCGAGGA CCTCCTTAAG GAACTCTATT GGCAGATGAA TCGTCTGCAG 
CCAATCCAGA AGGAAATAAT GCAGAAGCAA AACTCCACTA CGGAAGACAC GATCGTTCCC 
CACCTAGGGA AATATTACTT CAACCTCATG CAGTACCTGG AGTCCAAGGA GTACGACAGG 
TGTGCCTGGA CAGTCGTGCA AGTGCAAATA CTCACGAACG TTTCTTTCCT GATGAGACTA 
ACAGGTTACG TCCGTGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776775.1
CDS	77..637
Translation	MTYRCLLQMVLLLCFSTTALSRSYSLLRFQQRQSLKECQKLLGQLPSTSQHCLEARMDFQMPEEMKQEQQFQKEDAILVMYEVLQHIFGILTRDFSSTGWSETIIEDLLKELYWQMNRLQPIQKEIMQKQNSTTEDTIVPHLGKYYFNLMQYLESKEYDRCAWTVVQVQILTNVSFLMRLTGYVRD

Target ORF information:

RefSeq Version	NM_174350.1
Organism	Bos taurus(cattle)
Definition	Bos taurus interferon, beta 1, fibroblast (IFNB1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174350.1

ORF Insert Sequence:

ATGACCTACC GGTGCCTCCT CCAGATGGTT CTCCTGCTGT GTTTCTCCAC CACAGCTCTT 
TCCAGGAGCT ACAGCTTGCT TCGATTCCAA CAACGTCAGA GCCTTAAAGA GTGTCAGAAA 
CTCCTGGGGC AGTTACCTTC AACTTCTCAA CATTGCCTCG AGGCCAGGAT GGACTTCCAG 
ATGCCTGAGG AGATGAAGCA AGAACAGCAG TTCCAGAAGG AAGATGCCAT ATTGGTCATG 
TATGAGGTGC TCCAGCACAT CTTCGGCATT CTCACCAGAG ACTTCTCCAG CACTGGCTGG 
TCTGAGACCA TCATCGAGGA CCTCCTTAAG GAACTCTATT GGCAGATGAA TCGTCTGCAG 
CCAATCCAGA AGGAAATAAT GCAGAAGCAA AACTCCACTA CGGAAGACAC GATCGTTCCC 
CACCTAGGGA AATATTACTT CAACCTCATG CAGTACCTGG AGTCCAAGGA GTACGACAGG 
TGTGCCTGGA CAGTCGTGCA AGTGCAAATA CTCACGAACG TTTCTTTCCT GATGAGACTA 
ACAGGTTACG TCCGTGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Type 2 BVDV N
Virology507123-134(2017 07)
Alkheraif AA,Topliff CL,Reddy J,Massilamany C,Donis RO,Meyers G,Eskridge KM,Kelling CL

Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research36(1)37-47(2016 Jan)
Singh N,Ram?rez-Carvajal L,de Los Santos T,Golding MC,Long CR

ICP27 protein encoded by bovine herpesvirus type 1 (bICP27) interferes with promoter activity of the bovine genes encoding beta interferon 1 (IFN-?1) and IFN-?3.
Virus research169(1)162-8(2012 Oct)
da Silva LF,Sinani D,Jones C

Cytoplasmic localized infected cell protein 0 (bICP0) encoded by bovine herpesvirus 1 inhibits ? interferon promoter activity and reduces IRF3 (interferon response factor 3) protein levels.
Virus research160(1-2)143-9(2011 Sep)
da Silva LF,Gaudreault N,Jones C

Infection of cultured bovine cells with bovine herpesvirus 1 (BHV-1) or Sendai virus induces different beta interferon subtypes.
Virus research157(1)54-60(2011 Apr)
da Silva LF,Jones C

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IFNB1 cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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