Gene Symbol | IFNB1 |
Entrez Gene ID | 281845 |
Full Name | interferon, beta 1, fibroblast |
Synonyms | IFNb |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
Genome |
ORF » Species Summary » Bos taurus » IFNB1 cDNA ORF clone
Gene Symbol | IFNB1 |
Entrez Gene ID | 281845 |
Full Name | interferon, beta 1, fibroblast |
Synonyms | IFNb |
Gene Type | protein-coding |
Organism | Bos taurus(cattle) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_174350.1 | NP_776775.1 | interferon beta-1 precursor |
Bos taurus (cattle) | LOC616977 | XP_005209956.1 |
Bos taurus (cattle) | LOC784249 | XP_005209957.1 |
Bos taurus (cattle) | LOC784525 | XP_002689586.1 |
Bos taurus (cattle) | LOC100337470 | XP_002689583.1 |
Bos taurus (cattle) | IL6 | NP_001015617.1 |
Bos taurus (cattle) | LOC525550 | XP_002689587.1 |
Bos taurus (cattle) | IFNB1 | NP_776775.1 |
Bos taurus (cattle) | LOC100848709 | XP_005209960.1 |
Bos taurus (cattle) | IFNB3 | NP_001107769.1 |
Type 2 BVDV N
Alkheraif AA, Topliff CL, Reddy J, Massilamany C, Donis RO, Meyers G, Eskridge KM, Kelling CL
Virology507123-134(2017 07)
Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.
Singh N, Ram?rez-Carvajal L, de Los Santos T, Golding MC, Long CR
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research36(1)37-47(2016 Jan)
ICP27 protein encoded by bovine herpesvirus type 1 (bICP27) interferes with promoter activity of the bovine genes encoding beta interferon 1 (IFN-?1) and IFN-?3.
da Silva LF, Sinani D, Jones C
Virus research169(1)162-8(2012 Oct)
Cytoplasmic localized infected cell protein 0 (bICP0) encoded by bovine herpesvirus 1 inhibits ? interferon promoter activity and reduces IRF3 (interferon response factor 3) protein levels.
da Silva LF, Gaudreault N, Jones C
Virus research160(1-2)143-9(2011 Sep)
Infection of cultured bovine cells with bovine herpesvirus 1 (BHV-1) or Sendai virus induces different beta interferon subtypes.
da Silva LF, Jones C
Virus research157(1)54-60(2011 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
BVDV2-E significantly increased IFN-beta activity compared to BVDV2-wt.
Title: Type 2 BVDV N
The data confirm the involvement of EHMT2 in the epigenetic regulation of IFN-b and demonstrate the activation of a general antiviral state after EHMT2 inhibition.
Title: Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells.
The authors provide evidence that ICP27 protein encoded by bovine herpesvirus type 1, a viral early protein that shuttles between the nucleus and cytoplasm inhibits transcriptional activity of two bovine IFN-beta gene promoters (IFN-beta1 and IFN-beta3).
Title: ICP27 protein encoded by bovine herpesvirus type 1 (bICP27) interferes with promoter activity of the bovine genes encoding beta interferon 1 (IFN-?1) and IFN-?3.
The authors demonstrate that bovine herpesvirus 1 bICP0 effectively inhibits bovine IFN-beta promoter activity and induces IRF3 degradation.
Title: Cytoplasmic localized infected cell protein 0 (bICP0) encoded by bovine herpesvirus 1 inhibits ? interferon promoter activity and reduces IRF3 (interferon response factor 3) protein levels.
These studies provide evidence that virus infection differentially stimulates expression of the three bovine IFN-beta genes.
Title: Infection of cultured bovine cells with bovine herpesvirus 1 (BHV-1) or Sendai virus induces different beta interferon subtypes.
The following IFNB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the IFNB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OBa42750 | |
Clone ID Related Accession (Same CDS sequence) | NM_174350.1 | |
Accession Version | NM_174350.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 561bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Bos taurus(cattle) | |
Product | interferon beta-1 precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M15477.1. |
1 | ATGACCTACC GGTGCCTCCT CCAGATGGTT CTCCTGCTGT GTTTCTCCAC CACAGCTCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_776775.1 |
CDS | 77..637 |
Translation |
Target ORF information:
Target ORF information:
|
NM_174350.1 |
1 | ATGACCTACC GGTGCCTCCT CCAGATGGTT CTCCTGCTGT GTTTCTCCAC CACAGCTCTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Type 2 BVDV N |
Inhibition of EHMT2 Induces a Robust Antiviral Response Against Foot-and-Mouth Disease and Vesicular Stomatitis Virus Infections in Bovine Cells. |
ICP27 protein encoded by bovine herpesvirus type 1 (bICP27) interferes with promoter activity of the bovine genes encoding beta interferon 1 (IFN-?1) and IFN-?3. |
Cytoplasmic localized infected cell protein 0 (bICP0) encoded by bovine herpesvirus 1 inhibits ? interferon promoter activity and reduces IRF3 (interferon response factor 3) protein levels. |
Infection of cultured bovine cells with bovine herpesvirus 1 (BHV-1) or Sendai virus induces different beta interferon subtypes. |