CTSB cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CTSB
Entrez Gene ID	281105
Full Name	cathepsin B
Synonyms	CATB
General protein information	Preferred Names cathepsin B Names cathepsin B BCSB
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
XM_024995434.1	XP_024851202.1	cathepsin B isoform X1
XM_005209822.3	XP_005209879.1	cathepsin B isoform X1
XM_015472394.1	XP_015327880.1	cathepsin B isoform X2
XM_005209822.4	XP_005209879.1	cathepsin B isoform X1
NM_174031.2	NP_776456.1	cathepsin B precursor
XM_010807696.2	XP_010805998.1	cathepsin B isoform X1
XM_010807696.3	XP_010805998.1	cathepsin B isoform X1
XM_024995435.1	XP_024851203.1	cathepsin B isoform X2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	CTSB	NP_776456.1
Gallus gallus (chicken)	CTSB	XP_004935955.1
Danio rerio (zebrafish)	ctsba	NP_998501.1
Homo sapiens (human)	CTSB	NP_680090.1
Canis lupus familiaris (dog)	CTSB	XP_543203.3
Rattus norvegicus (Norway rat)	Ctsb	NP_072119.2
Arabidopsis thaliana (thale cress)	AT1G02300	NP_563647.1
Oryza sativa (rice)	Os05g0310500	NP_001174338.1
Pan troglodytes (chimpanzee)	CTSB	XP_003317965.1
Xenopus tropicalis (tropical clawed frog)	ctsb	NP_989225.1
Drosophila melanogaster (fruit fly)	CtsB1	NP_572920.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004533	XP_313835.5
Arabidopsis thaliana (thale cress)	AT1G02305	NP_563648.1
	CTSB	XP_002805301.1
Mus musculus (house mouse)	Ctsb	NP_031824.1
Arabidopsis thaliana (thale cress)	AT4G01610	NP_567215.1

Gene Ontology
Bibliography

Related articles in PubMed

Cathepsins S, B and L with aminopeptidases display ?-secretase activity associated with the pathogenesis of Alzheimer's disease.
Schechter I, Ziv E
Biological chemistry392(6)555-69(2011 Apr)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells.
Im E, Venkatakrishnan A, Kazlauskas A
Molecular biology of the cell16(8)3488-500(2005 Aug)

The inactivation of bovine cathepsin B by novel N-chloro-acetyl-dipeptides: application of the Houghten 'tea bag' methodology to inhibitor synthesis.
Gilmore BF, Harriott P, Walker B
Biochemical and biophysical research communications333(4)1284-8(2005 Aug)

Cathepsin B stability, but not activity, is affected in cysteine:cystine redox buffers.
Pillay CS, Dennison C
Biological chemistry383(7-8)1199-204(2002 Jul-Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The cathepsin B deserves further evaluation as therapeutic targets to develop disease modifying drugs to treat Alzheimer's disease.
Title: Cathepsins S, B and L with aminopeptidases display ?-secretase activity associated with the pathogenesis of Alzheimer's disease.

Overexpressing cathepsin B reduced the Vascular Endothelial Growth Factor-dependent tube response
Title: Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells.

The peptides, all of which contain a C-terminal free acid, were tested as inactivators of bovine cathepsin B, in an attempt at exploiting the known and, amongst the cysteine proteinases, unique carboxy dipeptidyl peptidase activity of the protease.
Title: The inactivation of bovine cathepsin B by novel N-chloro-acetyl-dipeptides: application of the Houghten 'tea bag' methodology to inhibitor synthesis.

evidence shows cathepsin B activity may not be redox regulated; however, the stability of the enzyme at neutral pH is dependent on redox potential, and on the presence of oxidising agents.
Title: Cathepsin B stability, but not activity, is affected in cysteine:cystine redox buffers.

The following CTSB gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CTSB cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OBa43507	NM_174031.2 Latest version!	Bos taurus cathepsin B (CTSB), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OBa21834	XM_024995434.1 Latest version!	Bos taurus cathepsin B (CTSB), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OBa21834	XM_005209822.4 Latest version!	Bos taurus cathepsin B (CTSB), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OBa21834	XM_010807696.3 Latest version!	Bos taurus cathepsin B (CTSB), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OBa236917	XM_024995435.1 Latest version!	Bos taurus cathepsin B (CTSB), transcript variant X5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
OBa91183	XM_015472394.1 Latest version!	Bos taurus cathepsin B (CTSB), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00
View Old Accession Versions >>
OBa21834	XM_005209822.3	Bos taurus cathepsin B (CTSB), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
OBa21834	XM_010807696.2	Bos taurus cathepsin B (CTSB), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CTSB ( NM_174031.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776456.1 Bos taurus cathepsin B (CTSB), mRNA.

Price & Availability↑

CloneID	OBa43507
Clone ID Related Accession (Same CDS sequence)	NM_174031.2
Accession Version	NM_174031.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1008bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Bos taurus(cattle)
Product	cathepsin B precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from L06075.1. On Jun 10, 2007 this sequence version replaced NM_174031.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L06075.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145412, SAMN03145413 [ECO:0000348] ##Evidence-Data-END##

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCAG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGGGTGTA CCAGCACGTC TCTGGAGAGA TTATGGGAGG CCACGCCATC 
CGCATCCTAG GCTGGGGAGT GGAGAACGGC ACCCCCTACT GGCTGGTCGG CAACTCCTGG 
AACACTGATT GGGGTGACAA TGGCTTCTTC AAAATCCTCA GAGGACAGGA CCACTGTGGA 
ATCGAGTCGG AAATCGTGGC TGGAATGCCG TGCACTCATC AGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776456.1
CDS	1..1008
Translation	MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY

Target ORF information:

RefSeq Version	NM_174031.2
Organism	Bos taurus(cattle)
Definition	Bos taurus cathepsin B (CTSB), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174031.2

ORF Insert Sequence:

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCAG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGGGTGTA CCAGCACGTC TCTGGAGAGA TTATGGGAGG CCACGCCATC 
CGCATCCTAG GCTGGGGAGT GGAGAACGGC ACCCCCTACT GGCTGGTCGG CAACTCCTGG 
AACACTGATT GGGGTGACAA TGGCTTCTTC AAAATCCTCA GAGGACAGGA CCACTGTGGA 
ATCGAGTCGG AAATCGTGGC TGGAATGCCG TGCACTCATC AGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSB ( XM_024995434.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024851202.1 Bos taurus cathepsin B (CTSB), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OBa21834
Clone ID Related Accession (Same CDS sequence)	XM_024995434.1 , XM_005209822.3 , XM_005209822.4 , XM_010807696.2 , XM_010807696.3
Accession Version	XM_024995434.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1008bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	cathepsin B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037335.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCCG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGGGTGTA CCAGCACGTC TCTGGAGAGA TTATGGGAGG CCACGCCATC 
CGCATCCTAG GCTGGGGAGT GGAGAACGGC ACCCCCTACT GGCTGGTCGG CAACTCCTGG 
AACACTGATT GGGGTGACAA TGGCTTCTTC AAAATCCTCA GAGGACAGGA CCACTGTGGA 
ATCGAGTCGG AAATCGTGGC TGGAATGCCG TGCACTCATC AGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024851202.1
CDS	80..1087
Translation	MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY

Target ORF information:

RefSeq Version	XM_024995434.1
Organism	Bos taurus(cattle)
Definition	Bos taurus cathepsin B (CTSB), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024995434.1

ORF Insert Sequence:

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCCG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGGGTGTA CCAGCACGTC TCTGGAGAGA TTATGGGAGG CCACGCCATC 
CGCATCCTAG GCTGGGGAGT GGAGAACGGC ACCCCCTACT GGCTGGTCGG CAACTCCTGG 
AACACTGATT GGGGTGACAA TGGCTTCTTC AAAATCCTCA GAGGACAGGA CCACTGTGGA 
ATCGAGTCGG AAATCGTGGC TGGAATGCCG TGCACTCATC AGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSB ( XM_005209822.3 ) cDNA ORF clone, Bos taurus(cattle) -> XP_005209879.1 Bos taurus cathepsin B (CTSB), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OBa21834
Clone ID Related Accession (Same CDS sequence)	XM_024995434.1 , XM_005209822.3 , XM_005209822.4 , XM_010807696.2 , XM_010807696.3
Accession Version	XM_005209822.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1008bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-01-25
Organism	Bos taurus(cattle)
Product	cathepsin B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104073.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_005209822.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCCG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGGGTGTA CCAGCACGTC TCTGGAGAGA TTATGGGAGG CCACGCCATC 
CGCATCCTAG GCTGGGGAGT GGAGAACGGC ACCCCCTACT GGCTGGTCGG CAACTCCTGG 
AACACTGATT GGGGTGACAA TGGCTTCTTC AAAATCCTCA GAGGACAGGA CCACTGTGGA 
ATCGAGTCGG AAATCGTGGC TGGAATGCCG TGCACTCATC AGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005209879.1
CDS	150..1157
Translation	MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY

Target ORF information:

RefSeq Version	XM_005209822.3
Organism	Bos taurus(cattle)
Definition	Bos taurus cathepsin B (CTSB), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005209822.3

ORF Insert Sequence:

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCCG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGGGTGTA CCAGCACGTC TCTGGAGAGA TTATGGGAGG CCACGCCATC 
CGCATCCTAG GCTGGGGAGT GGAGAACGGC ACCCCCTACT GGCTGGTCGG CAACTCCTGG 
AACACTGATT GGGGTGACAA TGGCTTCTTC AAAATCCTCA GAGGACAGGA CCACTGTGGA 
ATCGAGTCGG AAATCGTGGC TGGAATGCCG TGCACTCATC AGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSB ( XM_005209822.4 ) cDNA ORF clone, Bos taurus(cattle) -> XP_005209879.1 Bos taurus cathepsin B (CTSB), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OBa21834
Clone ID Related Accession (Same CDS sequence)	XM_024995434.1 , XM_005209822.3 , XM_005209822.4 , XM_010807696.2 , XM_010807696.3
Accession Version	XM_005209822.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1008bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	cathepsin B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037335.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_005209822.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCCG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGGGTGTA CCAGCACGTC TCTGGAGAGA TTATGGGAGG CCACGCCATC 
CGCATCCTAG GCTGGGGAGT GGAGAACGGC ACCCCCTACT GGCTGGTCGG CAACTCCTGG 
AACACTGATT GGGGTGACAA TGGCTTCTTC AAAATCCTCA GAGGACAGGA CCACTGTGGA 
ATCGAGTCGG AAATCGTGGC TGGAATGCCG TGCACTCATC AGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005209879.1
CDS	178..1185
Translation	MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY

Target ORF information:

RefSeq Version	XM_005209822.4
Organism	Bos taurus(cattle)
Definition	Bos taurus cathepsin B (CTSB), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005209822.4

ORF Insert Sequence:

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCCG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGGGTGTA CCAGCACGTC TCTGGAGAGA TTATGGGAGG CCACGCCATC 
CGCATCCTAG GCTGGGGAGT GGAGAACGGC ACCCCCTACT GGCTGGTCGG CAACTCCTGG 
AACACTGATT GGGGTGACAA TGGCTTCTTC AAAATCCTCA GAGGACAGGA CCACTGTGGA 
ATCGAGTCGG AAATCGTGGC TGGAATGCCG TGCACTCATC AGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSB ( XM_010807696.2 ) cDNA ORF clone, Bos taurus(cattle) -> XP_010805998.1 Bos taurus cathepsin B (CTSB), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OBa21834
Clone ID Related Accession (Same CDS sequence)	XM_024995434.1 , XM_005209822.3 , XM_005209822.4 , XM_010807696.2 , XM_010807696.3
Accession Version	XM_010807696.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1008bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-01-25
Organism	Bos taurus(cattle)
Product	cathepsin B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104073.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jan 26, 2016 this sequence version replaced XM_010807696.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCCG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGGGTGTA CCAGCACGTC TCTGGAGAGA TTATGGGAGG CCACGCCATC 
CGCATCCTAG GCTGGGGAGT GGAGAACGGC ACCCCCTACT GGCTGGTCGG CAACTCCTGG 
AACACTGATT GGGGTGACAA TGGCTTCTTC AAAATCCTCA GAGGACAGGA CCACTGTGGA 
ATCGAGTCGG AAATCGTGGC TGGAATGCCG TGCACTCATC AGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_010805998.1
CDS	266..1273
Translation	MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY

Target ORF information:

RefSeq Version	XM_010807696.2
Organism	Bos taurus(cattle)
Definition	Bos taurus cathepsin B (CTSB), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_010807696.2

ORF Insert Sequence:

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCCG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGGGTGTA CCAGCACGTC TCTGGAGAGA TTATGGGAGG CCACGCCATC 
CGCATCCTAG GCTGGGGAGT GGAGAACGGC ACCCCCTACT GGCTGGTCGG CAACTCCTGG 
AACACTGATT GGGGTGACAA TGGCTTCTTC AAAATCCTCA GAGGACAGGA CCACTGTGGA 
ATCGAGTCGG AAATCGTGGC TGGAATGCCG TGCACTCATC AGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSB ( XM_010807696.3 ) cDNA ORF clone, Bos taurus(cattle) -> XP_010805998.1 Bos taurus cathepsin B (CTSB), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OBa21834
Clone ID Related Accession (Same CDS sequence)	XM_024995434.1 , XM_005209822.3 , XM_005209822.4 , XM_010807696.2 , XM_010807696.3
Accession Version	XM_010807696.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1008bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	cathepsin B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037335.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On May 7, 2018 this sequence version replaced XM_010807696.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCCG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGGGTGTA CCAGCACGTC TCTGGAGAGA TTATGGGAGG CCACGCCATC 
CGCATCCTAG GCTGGGGAGT GGAGAACGGC ACCCCCTACT GGCTGGTCGG CAACTCCTGG 
AACACTGATT GGGGTGACAA TGGCTTCTTC AAAATCCTCA GAGGACAGGA CCACTGTGGA 
ATCGAGTCGG AAATCGTGGC TGGAATGCCG TGCACTCATC AGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_010805998.1
CDS	251..1258
Translation	MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY

Target ORF information:

RefSeq Version	XM_010807696.3
Organism	Bos taurus(cattle)
Definition	Bos taurus cathepsin B (CTSB), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_010807696.3

ORF Insert Sequence:

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCCG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGGGTGTA CCAGCACGTC TCTGGAGAGA TTATGGGAGG CCACGCCATC 
CGCATCCTAG GCTGGGGAGT GGAGAACGGC ACCCCCTACT GGCTGGTCGG CAACTCCTGG 
AACACTGATT GGGGTGACAA TGGCTTCTTC AAAATCCTCA GAGGACAGGA CCACTGTGGA 
ATCGAGTCGG AAATCGTGGC TGGAATGCCG TGCACTCATC AGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSB ( XM_024995435.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_024851203.1 Bos taurus cathepsin B (CTSB), transcript variant X5, mRNA.

Price & Availability↑

CloneID	OBa236917
Clone ID Related Accession (Same CDS sequence)	XM_024995435.1
Accession Version	XM_024995435.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-05-06
Organism	Bos taurus(cattle)
Product	cathepsin B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_037335.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Bos taurus Annotation Release 106 Annotation Version :: 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCCG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGCTTCTT CAAAATCCTC AGAGGACAGG ACCACTGTGG AATCGAGTCG 
GAAATCGTGG CTGGAATGCC GTGCACTCAT CAGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024851203.1
CDS	178..1056
Translation	MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCGAILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGFFKILRGQDHCGIESEIVAGMPCTHQY

Target ORF information:

RefSeq Version	XM_024995435.1
Organism	Bos taurus(cattle)
Definition	Bos taurus cathepsin B (CTSB), transcript variant X5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024995435.1

ORF Insert Sequence:

ATGTGGCGGC TCTTGGCCAC CCTCAGCTGC CTGCTGGTGC TGACCAGTGC CCGGAGCAGC 
CTGTATTTCC CGCCTCTGTC CGATGAGCTG GTCAACTTTG TTAACAAGCA AAACACCACT 
TGGAAGGCTG GACACAACTT CTACAACGTG GACCTGAGCT ATGTGAAGAA GCTGTGTGGC 
GCCATCCTGG GCGGGCCCAA GCTGCCCCAG AGAGATGCAT TTGCTGCGGA TGTGGTTCTG 
CCTGAAAGCT TCGATGCCCG GGAACAGTGG CCAAACTGCC CGACCATCAA AGAGATCAGA 
GATCAGGGAT CCTGTGGCTC CTGCTGGGCG TTCGGGGCTG TGGAAGCCAT TTCTGACCGG 
ATCTGCATCC ACAGCAATGG GCGTGTCAAC GTGGAGGTGT CCGCTGAGGA CATGCTGACC 
TGCTGTGGTG GCGAGTGTGG GGACGGCTGT AACGGCGGCT TCCCCTCTGG AGCCTGGAAC 
TTCTGGACAA AGAAAGGCTT AGTGTCCGGG GGCCTCTATA ACTCGCATGT AGGTTGCAGA 
CCGTACTCCA TCCCTCCCTG TGAGCACCAT GTGAACGGCT CCCGGCCCCC GTGCACCGGT 
GAGGGGGACA CCCCCAAGTG CAGCAAGACC TGTGAGCCCG GCTACAGCCC GTCCTACAAA 
GAAGACAAGC ATTTTGGATG CAGTTCCTAC AGCGTCGCCA ACAACGAGAA GGAGATCATG 
GCAGAGATCT ACAAAAATGG CCCAGTCGAG GGGGCCTTCT CTGTGTACTC GGACTTCCTG 
CTATACAAGT CTGGCTTCTT CAAAATCCTC AGAGGACAGG ACCACTGTGG AATCGAGTCG 
GAAATCGTGG CTGGAATGCC GTGCACTCAT CAGTACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CTSB ( XM_015472394.1 ) cDNA ORF clone, Bos taurus(cattle) -> XP_015327880.1 Bos taurus cathepsin B (CTSB), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OBa91183
Clone ID Related Accession (Same CDS sequence)	XM_015472394.1
Accession Version	XM_015472394.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 636bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-01-25
Organism	Bos taurus(cattle)
Product	cathepsin B isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003104073.1) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Bos taurus Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCGGGA ACAGTGGCCA AACTGCCCGA CCATCAAAGA GATCAGAGAT CAGGGATCCT 
GTGGCTCCTG CTGGCTGTAA CGGCGGCTTC CCCTCTGGAG CCTGGAACTT CTGGACAAAG 
AAAGGCTTAG TGTCCGGGGG CCTCTATAAC TCGCATGTAG GTTGCAGACC GTACTCCATC 
CCTCCCTGTG AGCACCATGT GAACGGCTCC CGGCCCCCGT GCACCGGTGA GGGGGACACC 
CCCAAGTGCA GCAAGACCTG TGAGCCCGGC TACAGCCCGT CCTACAAAGA AGACAAGCAT 
TTTGGATGCA GTTCCTACAG CGTCGCCAAC AACGAGAAGG AGATCATGGC AGAGATCTAC 
AAAAATGGCC CAGTCGAGGG GGCCTTCTCT GTGTACTCGG ACTTCCTGCT ATACAAGTCT 
GGGGTGTACC AGCACGTCTC TGGAGAGATT ATGGGAGGCC ACGCCATCCG CATCCTAGGC 
TGGGGAGTGG AGAACGGCAC CCCCTACTGG CTGGTCGGCA ACTCCTGGAA CACTGATTGG 
GGTGACAATG GCTTCTTCAA AATCCTCAGA GGACAGGACC ACTGTGGAAT CGAGTCGGAA 
ATCGTGGCTG GAATGCCGTG CACTCATCAG TACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_015327880.1
CDS	1..636
Translation	MPGNSGQTARPSKRSEIRDPVAPAGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSWNTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY

Target ORF information:

RefSeq Version	XM_015472394.1
Organism	Bos taurus(cattle)
Definition	Bos taurus cathepsin B (CTSB), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_015472394.1

ORF Insert Sequence:

ATGCCCGGGA ACAGTGGCCA AACTGCCCGA CCATCAAAGA GATCAGAGAT CAGGGATCCT 
GTGGCTCCTG CTGGCTGTAA CGGCGGCTTC CCCTCTGGAG CCTGGAACTT CTGGACAAAG 
AAAGGCTTAG TGTCCGGGGG CCTCTATAAC TCGCATGTAG GTTGCAGACC GTACTCCATC 
CCTCCCTGTG AGCACCATGT GAACGGCTCC CGGCCCCCGT GCACCGGTGA GGGGGACACC 
CCCAAGTGCA GCAAGACCTG TGAGCCCGGC TACAGCCCGT CCTACAAAGA AGACAAGCAT 
TTTGGATGCA GTTCCTACAG CGTCGCCAAC AACGAGAAGG AGATCATGGC AGAGATCTAC 
AAAAATGGCC CAGTCGAGGG GGCCTTCTCT GTGTACTCGG ACTTCCTGCT ATACAAGTCT 
GGGGTGTACC AGCACGTCTC TGGAGAGATT ATGGGAGGCC ACGCCATCCG CATCCTAGGC 
TGGGGAGTGG AGAACGGCAC CCCCTACTGG CTGGTCGGCA ACTCCTGGAA CACTGATTGG 
GGTGACAATG GCTTCTTCAA AATCCTCAGA GGACAGGACC ACTGTGGAAT CGAGTCGGAA 
ATCGTGGCTG GAATGCCGTG CACTCATCAG TACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Cathepsins S, B and L with aminopeptidases display ?-secretase activity associated with the pathogenesis of Alzheimer's disease.
Biological chemistry392(6)555-69(2011 Apr)
Schechter I,Ziv E

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Cathepsin B regulates the intrinsic angiogenic threshold of endothelial cells.
Molecular biology of the cell16(8)3488-500(2005 Aug)
Im E,Venkatakrishnan A,Kazlauskas A

The inactivation of bovine cathepsin B by novel N-chloro-acetyl-dipeptides: application of the Houghten 'tea bag' methodology to inhibitor synthesis.
Biochemical and biophysical research communications333(4)1284-8(2005 Aug)
Gilmore BF,Harriott P,Walker B

Cathepsin B stability, but not activity, is affected in cysteine:cystine redox buffers.
Biological chemistry383(7-8)1199-204(2002 Jul-Aug)
Pillay CS,Dennison C

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CTSB cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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