APL1C cDNA ORF clone, Anopheles gambiae str. PEST

The Anopheles gambiae genome: an update.
Mongin E, Louis C, Holt RA, Birney E, Collins FH
Trends in parasitology20(2)49-52(2004 Feb)

The genome sequence of the malaria mosquito Anopheles gambiae.
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Science (New York, N.Y.)298(5591)129-49(2002 Oct)

Full-length APL1A1 and APL1B form a stable complex with LRIM1. These results support a model in which APL1A1, APL1B and APL1C can all form an extended, flexible heterodimer with LRIM1, providing a repertoire of functional innate immune complexes to protect A. gambiae from a diverse array of pathogens.
Title: Biophysical analysis of anopheles gambiae leucine-rich repeat proteins APL1A1, APL1B [corrected] and APL1C and their interaction with LRIM1.

a cleaved form of TEP1 may act as a convertase for activation of other TEP1 molecules and that the LRIM1/APL1C heterodimer regulates formation of this TEP1 convertase.
Title: A heterodimeric complex of the LRR proteins LRIM1 and APL1C regulates complement-like immunity in Anopheles gambiae.

study shows 2 proteins that antagonize malaria infections, LRIM1 & APL1C, circulate in hemolymph as a complex which interacts with complement C3-like protein, TEP1, promoting its cleavage or stabilization & localization on Plasmodium berghei.
Title: Leucine-rich repeat protein complex activates mosquito complement in defense against Plasmodium parasites.

The authors show that LRIM1 and APL1 are required for binding of TEP1 to parasites.
Title: Two mosquito LRR proteins function as complement control factors in the TEP1-mediated killing of Plasmodium.