HSD11B1 cDNA ORF clone, Ovis aries(sheep)

Gene
Clones
gRNAs

Summary

Gene Symbol	HSD11B1
Entrez Gene ID	443409
Full Name	hydroxysteroid 11-beta dehydrogenase 1
Gene Type	protein-coding
Organism	Ovis aries(sheep)

mRNA and Protein(s)

mRNA	Protein	Name
XM_012186885.2	XP_012042275.1	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2
XM_012186882.2	XP_012042272.1	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1
XM_012186884.2	XP_012042274.1	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1
XM_027975569.1	XP_027831370.1	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1
XM_027975568.1	XP_027831369.1	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1
NM_001009395.2	NP_001009395.1	corticosteroid 11-beta-dehydrogenase isozyme 1
XM_012186882.1	XP_012042272.1	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1
XM_027975570.1	XP_027831371.1	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Biological Roles of Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1), HSD11B2, and Glucocorticoid Receptor (NR3C1) in Sheep Conceptus Elongation.
Brooks K, Burns G, Spencer TE
Biology of reproduction93(2)38(2015 Aug)

Endometrial HSD11B1 and cortisol regeneration in the ovine uterus: effects of pregnancy, interferon tau, and prostaglandins.
Dorniak P, Welsh TH Jr, Bazer FW, Spencer TE
Biology of reproduction86(4)124(2012 Apr)

HSD11B1, HSD11B2, PTGS2, and NR3C1 expression in the peri-implantation ovine uterus: effects of pregnancy, progesterone, and interferon tau.
Simmons RM, Satterfield MC, Welsh TH Jr, Bazer FW, Spencer TE
Biology of reproduction82(1)35-43(2010 Jan)

Intrauterine growth restriction and differential patterns of hepatic growth and expression of IGF1, PCK2, and HSDL1 mRNA in the sheep fetus in late gestation.
Gentili S, Morrison JL, McMillen IC
Biology of reproduction80(6)1121-7(2009 Jun)

Cloning of an ovine 11 beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development.
Yang K, Smith CL, Dales D, Hammond GL, Challis JR
Endocrinology131(5)2120-6(1992 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

These results support the idea that the effects of HSD11B1-derived cortisol on conceptus elongation are indirectly mediated by the endometrium and are not directly mediated through GR in the trophectoderm
Title: Biological Roles of Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1), HSD11B2, and Glucocorticoid Receptor (NR3C1) in Sheep Conceptus Elongation.

Studies support the idea that IFNT and PGs from the conceptus regulate endometrial HSD11B1 expression and activity that regenerates bioactive cortisol in the ovine uterus during early pregnancy to influence endometrial functions and conceptus elongation.
Title: Endometrial HSD11B1 and cortisol regeneration in the ovine uterus: effects of pregnancy, interferon tau, and prostaglandins.

Endometrial epithelial HSD11B1 expression is induced by progesterone as well as stimulated by interferon tau and PTGS2-derived prostaglandins.
Title: HSD11B1, HSD11B2, PTGS2, and NR3C1 expression in the peri-implantation ovine uterus: effects of pregnancy, progesterone, and interferon tau.

hepatic expression of 11beta-hydroxysteroid dehydrogenase type 1 increased in placental restriction-hypoxic reduced liver growth
Title: Intrauterine growth restriction and differential patterns of hepatic growth and expression of IGF1, PCK2, and HSDL1 mRNA in the sheep fetus in late gestation.

The following HSD11B1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HSD11B1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OSm00171	NM_001009395.2 Latest version!	Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OSm21833	XM_012186882.2 Latest version!	Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OSm21833	XM_027975569.1 Latest version!	Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OSm21833	XM_027975568.1 Latest version!	Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OSm21833	XM_012186884.2 Latest version!	Ovis aries hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OSm21833	XM_027975570.1 Latest version!	Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), transcript variant X4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
OSm21834	XM_012186885.2 Latest version!	Ovis aries hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
View Old Accession Versions >>
OSm21833	XM_012186882.1	Ovis aries hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

HSD11B1 ( NM_001009395.2 ) cDNA ORF clone, Ovis aries(sheep) -> NP_001009395.1 Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), mRNA.

Price & Availability↑

CloneID	OSm00171
Clone ID Related Accession (Same CDS sequence)	NM_001009395.2
Accession Version	NM_001009395.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Ovis aries(sheep)
Product	corticosteroid 11-beta-dehydrogenase isozyme 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X69561.1. On Dec 4, 2012 this sequence version replaced NM_001009395.1. ##Evidence-Data-START## Transcript exon combination :: X69561.1, EE789437.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA104494974, SAMEA104494976 [ECO:0000350] ##Evidence-Data-END##

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATCGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCGCA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AATGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAGCGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001009395.1
CDS	65..943
Translation	MAFMKKYLLPILGIFLAYYYYSANEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAHVVVTARSEESLKKVVSRCLELGAASAHYVAGTMENMTFAEQFVAKAGELVGGLDMLILNHINYTPLRVFSNDIHLLRRSLEVNLLSYVVLSTAALPMLKQTSGSIVVVSSVAGKIACPLAAAYSASKFALDGFFSSLRTEYEATKVNVSITLCILGLIDTDTAMKAVAGIYNAEASPKEECALEIIKGGALRQDEVYYDNSILTSLLLKNPGRKIMEFLSLKKYNMERFINN

Target ORF information:

RefSeq Version	NM_001009395.2
Organism	Ovis aries(sheep)
Definition	Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001009395.2

ORF Insert Sequence:

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATCGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCGCA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AATGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAGCGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSD11B1 ( XM_012186882.2 ) cDNA ORF clone, Ovis aries(sheep) -> XP_012042272.1 Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OSm21833
Clone ID Related Accession (Same CDS sequence)	XM_012186882.2 , XM_012186884.2 , XM_027975569.1 , XM_027975568.1 , XM_012186882.1 , XM_027975570.1
Accession Version	XM_012186882.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-05
Organism	Ovis aries(sheep)
Product	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040263.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Feb 6, 2019 this sequence version replaced XM_012186882.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_012042272.1
CDS	288..1166
Translation	MAFMKKYLLPILGIFLAYYYYSANEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAHVVVTARSEESLKKVVSRCLELGAASAHYVAGTMENMTFAEQFVAKAGELVGGLDMLILNHINYTPLRVFSNDIHLLRRSLEVNLLSYVVLSTAALPMLKQTNGSIVVVSSVAGKIACPLAAAYSASKFALDGFFSSLRTEYEATKVNVSITLCILGLIDTDTAMKAVAGIYNAEASPKEECALEIIKGGALRQDEVYYDNSILTSLLLKNPGRKIMEFLSLKKYNMERFINN

Target ORF information:

RefSeq Version	XM_012186882.2
Organism	Ovis aries(sheep)
Definition	Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_012186882.2

ORF Insert Sequence:

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSD11B1 ( XM_012186884.2 ) cDNA ORF clone, Ovis aries(sheep) -> XP_012042274.1 Ovis aries hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OSm21833
Clone ID Related Accession (Same CDS sequence)	XM_012186882.2 , XM_012186884.2 , XM_027975569.1 , XM_027975568.1 , XM_012186882.1 , XM_027975570.1
Accession Version	XM_012186884.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-12-16
Organism	Ovis aries(sheep)
Product	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639021.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 17, 2015 this sequence version replaced XM_012186884.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_012042274.1
CDS	734..1612
Translation	MAFMKKYLLPILGIFLAYYYYSANEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAHVVVTARSEESLKKVVSRCLELGAASAHYVAGTMENMTFAEQFVAKAGELVGGLDMLILNHINYTPLRVFSNDIHLLRRSLEVNLLSYVVLSTAALPMLKQTNGSIVVVSSVAGKIACPLAAAYSASKFALDGFFSSLRTEYEATKVNVSITLCILGLIDTDTAMKAVAGIYNAEASPKEECALEIIKGGALRQDEVYYDNSILTSLLLKNPGRKIMEFLSLKKYNMERFINN

Target ORF information:

RefSeq Version	XM_012186884.2
Organism	Ovis aries(sheep)
Definition	Ovis aries hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_012186884.2

ORF Insert Sequence:

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSD11B1 ( XM_027975569.1 ) cDNA ORF clone, Ovis aries(sheep) -> XP_027831370.1 Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OSm21833
Clone ID Related Accession (Same CDS sequence)	XM_012186882.2 , XM_012186884.2 , XM_027975569.1 , XM_027975568.1 , XM_012186882.1 , XM_027975570.1
Accession Version	XM_027975569.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-05
Organism	Ovis aries(sheep)
Product	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040263.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_027831370.1
CDS	928..1806
Translation	MAFMKKYLLPILGIFLAYYYYSANEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAHVVVTARSEESLKKVVSRCLELGAASAHYVAGTMENMTFAEQFVAKAGELVGGLDMLILNHINYTPLRVFSNDIHLLRRSLEVNLLSYVVLSTAALPMLKQTNGSIVVVSSVAGKIACPLAAAYSASKFALDGFFSSLRTEYEATKVNVSITLCILGLIDTDTAMKAVAGIYNAEASPKEECALEIIKGGALRQDEVYYDNSILTSLLLKNPGRKIMEFLSLKKYNMERFINN

Target ORF information:

RefSeq Version	XM_027975569.1
Organism	Ovis aries(sheep)
Definition	Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_027975569.1

ORF Insert Sequence:

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSD11B1 ( XM_027975568.1 ) cDNA ORF clone, Ovis aries(sheep) -> XP_027831369.1 Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OSm21833
Clone ID Related Accession (Same CDS sequence)	XM_012186882.2 , XM_012186884.2 , XM_027975569.1 , XM_027975568.1 , XM_012186882.1 , XM_027975570.1
Accession Version	XM_027975568.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-05
Organism	Ovis aries(sheep)
Product	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040263.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_027831369.1
CDS	568..1446
Translation	MAFMKKYLLPILGIFLAYYYYSANEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAHVVVTARSEESLKKVVSRCLELGAASAHYVAGTMENMTFAEQFVAKAGELVGGLDMLILNHINYTPLRVFSNDIHLLRRSLEVNLLSYVVLSTAALPMLKQTNGSIVVVSSVAGKIACPLAAAYSASKFALDGFFSSLRTEYEATKVNVSITLCILGLIDTDTAMKAVAGIYNAEASPKEECALEIIKGGALRQDEVYYDNSILTSLLLKNPGRKIMEFLSLKKYNMERFINN

Target ORF information:

RefSeq Version	XM_027975568.1
Organism	Ovis aries(sheep)
Definition	Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_027975568.1

ORF Insert Sequence:

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSD11B1 ( XM_012186882.1 ) cDNA ORF clone, Ovis aries(sheep) -> XP_012042272.1 Ovis aries hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OSm21833
Clone ID Related Accession (Same CDS sequence)	XM_012186882.2 , XM_012186884.2 , XM_027975569.1 , XM_027975568.1 , XM_012186882.1 , XM_027975570.1
Accession Version	XM_012186882.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-12-16
Organism	Ovis aries(sheep)
Product	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639021.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_012042272.1
CDS	3142..4020
Translation	MAFMKKYLLPILGIFLAYYYYSANEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAHVVVTARSEESLKKVVSRCLELGAASAHYVAGTMENMTFAEQFVAKAGELVGGLDMLILNHINYTPLRVFSNDIHLLRRSLEVNLLSYVVLSTAALPMLKQTNGSIVVVSSVAGKIACPLAAAYSASKFALDGFFSSLRTEYEATKVNVSITLCILGLIDTDTAMKAVAGIYNAEASPKEECALEIIKGGALRQDEVYYDNSILTSLLLKNPGRKIMEFLSLKKYNMERFINN

Target ORF information:

RefSeq Version	XM_012186882.1
Organism	Ovis aries(sheep)
Definition	Ovis aries hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_012186882.1

ORF Insert Sequence:

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSD11B1 ( XM_027975570.1 ) cDNA ORF clone, Ovis aries(sheep) -> XP_027831371.1 Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), transcript variant X4, mRNA.

Price & Availability↑

CloneID	OSm21833
Clone ID Related Accession (Same CDS sequence)	XM_012186882.2 , XM_012186884.2 , XM_027975569.1 , XM_027975568.1 , XM_012186882.1 , XM_027975570.1
Accession Version	XM_027975570.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 879bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-05
Organism	Ovis aries(sheep)
Product	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_040263.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Name :: Ovis aries Annotation Release 103 Annotation Version :: 103 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_027831371.1
CDS	397..1275
Translation	MAFMKKYLLPILGIFLAYYYYSANEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAHVVVTARSEESLKKVVSRCLELGAASAHYVAGTMENMTFAEQFVAKAGELVGGLDMLILNHINYTPLRVFSNDIHLLRRSLEVNLLSYVVLSTAALPMLKQTNGSIVVVSSVAGKIACPLAAAYSASKFALDGFFSSLRTEYEATKVNVSITLCILGLIDTDTAMKAVAGIYNAEASPKEECALEIIKGGALRQDEVYYDNSILTSLLLKNPGRKIMEFLSLKKYNMERFINN

Target ORF information:

RefSeq Version	XM_027975570.1
Organism	Ovis aries(sheep)
Definition	Ovis aries hydroxysteroid 11-beta dehydrogenase 1 (HSD11B1), transcript variant X4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_027975570.1

ORF Insert Sequence:

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGGGA AAATAGCTTG TCCACTTGCT 
GCTGCCTATT CTGCAAGCAA GTTTGCTCTG GATGGGTTCT TCTCCTCTCT CAGGACGGAA 
TATGAGGCGA CCAAGGTCAA TGTGTCAATC ACCCTCTGTA TTCTTGGCCT CATCGACACA 
GACACAGCCA TGAAGGCAGT TGCTGGGATA TACAATGCAG AAGCATCTCC AAAGGAAGAA 
TGTGCCCTGG AGATTATCAA AGGGGGAGCT CTGCGCCAAG ATGAAGTTTA TTATGACAAT 
TCAATCTTGA CTTCTCTCCT GCTGAAAAAT CCAGGAAGGA AGATCATGGA ATTTCTCTCC 
TTGAAGAAAT ATAATATGGA AAGATTTATA AACAACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

HSD11B1 ( XM_012186885.2 ) cDNA ORF clone, Ovis aries(sheep) -> XP_012042275.1 Ovis aries hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OSm21834
Clone ID Related Accession (Same CDS sequence)	XM_012186885.2
Accession Version	XM_012186885.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 735bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-12-16
Organism	Ovis aries(sheep)
Product	corticosteroid 11-beta-dehydrogenase isozyme 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_014639021.1) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Dec 17, 2015 this sequence version replaced XM_012186885.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Ovis aries Annotation Release 102 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.5 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGACA CAGCCATGAA GGCAGTTGCT 
GGGATATACA ATGCAGAAGC ATCTCCAAAG GAAGAATGTG CCCTGGAGAT TATCAAAGGG 
GGAGCTCTGC GCCAAGATGA AGTTTATTAT GACAATTCAA TCTTGACTTC TCTCCTGCTG 
AAAAATCCAG GAAGGAAGAT CATGGAATTT CTCTCCTTGA AGAAATATAA TATGGAAAGA 
TTTATAAACA ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_012042275.1
CDS	1493..2227
Translation	MAFMKKYLLPILGIFLAYYYYSANEEFRPEMLRGKRVIVTGASKGIGREMAYHLARMGAHVVVTARSEESLKKVVSRCLELGAASAHYVAGTMENMTFAEQFVAKAGELVGGLDMLILNHINYTPLRVFSNDIHLLRRSLEVNLLSYVVLSTAALPMLKQTNGSIVVVSSVADTAMKAVAGIYNAEASPKEECALEIIKGGALRQDEVYYDNSILTSLLLKNPGRKIMEFLSLKKYNMERFINN

Target ORF information:

RefSeq Version	XM_012186885.2
Organism	Ovis aries(sheep)
Definition	Ovis aries hydroxysteroid (11-beta) dehydrogenase 1 (HSD11B1), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_012186885.2

ORF Insert Sequence:

ATGGCTTTTA TGAAAAAATA CCTCCTCCCC ATTCTGGGGA TCTTCTTGGC CTACTACTAC 
TATTCTGCGA ATGAGGAATT CAGACCAGAG ATGCTTCGAG GAAAGAGAGT GATTGTCACG 
GGGGCCAGCA AGGGAATTGG AAGAGAAATG GCCTATCACC TGGCAAGGAT GGGAGCTCAC 
GTGGTAGTGA CAGCGAGGTC AGAAGAAAGT CTAAAGAAGG TGGTATCCCG CTGCCTGGAG 
CTGGGGGCGG CCTCAGCACA CTACGTGGCA GGCACCATGG AGAACATGAC CTTCGCAGAA 
CAATTTGTTG CCAAAGCTGG AGAGCTCGTG GGGGGACTTG ACATGCTCAT TCTCAACCAC 
ATCAACTATA CACCTTTGAG GGTGTTTAGC AACGACATCC ATCTCTTGCG CAGAAGCCTA 
GAGGTCAACC TCCTGAGTTA CGTGGTCCTG AGCACGGCCG CCTTGCCCAT GCTGAAGCAG 
ACCAACGGGA GCATTGTGGT CGTCTCCTCC GTAGCTGACA CAGCCATGAA GGCAGTTGCT 
GGGATATACA ATGCAGAAGC ATCTCCAAAG GAAGAATGTG CCCTGGAGAT TATCAAAGGG 
GGAGCTCTGC GCCAAGATGA AGTTTATTAT GACAATTCAA TCTTGACTTC TCTCCTGCTG 
AAAAATCCAG GAAGGAAGAT CATGGAATTT CTCTCCTTGA AGAAATATAA TATGGAAAGA 
TTTATAAACA ACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Biological Roles of Hydroxysteroid (11-Beta) Dehydrogenase 1 (HSD11B1), HSD11B2, and Glucocorticoid Receptor (NR3C1) in Sheep Conceptus Elongation.
Biology of reproduction93(2)38(2015 Aug)
Brooks K,Burns G,Spencer TE

Endometrial HSD11B1 and cortisol regeneration in the ovine uterus: effects of pregnancy, interferon tau, and prostaglandins.
Biology of reproduction86(4)124(2012 Apr)
Dorniak P,Welsh TH Jr,Bazer FW,Spencer TE

HSD11B1, HSD11B2, PTGS2, and NR3C1 expression in the peri-implantation ovine uterus: effects of pregnancy, progesterone, and interferon tau.
Biology of reproduction82(1)35-43(2010 Jan)
Simmons RM,Satterfield MC,Welsh TH Jr,Bazer FW,Spencer TE

Intrauterine growth restriction and differential patterns of hepatic growth and expression of IGF1, PCK2, and HSDL1 mRNA in the sheep fetus in late gestation.
Biology of reproduction80(6)1121-7(2009 Jun)
Gentili S,Morrison JL,McMillen IC

Cloning of an ovine 11 beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development.
Endocrinology131(5)2120-6(1992 Nov)
Yang K,Smith CL,Dales D,Hammond GL,Challis JR

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HSD11B1 cDNA ORF clone, Ovis aries(sheep)

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ORF Insert Sequence:

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Target ORF information:

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Target ORF information:

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ORF Insert Sequence:

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