CHGA cDNA ORF clone, Bos taurus(cattle)

Gene
Clones
gRNAs

Summary

Gene Symbol	CHGA
Entrez Gene ID	281070
Full Name	chromogranin A
General protein information	Preferred Names chromogranin A Names chromogranin-A SP-I cgA chromogranin A (parathyroid secretory protein 1) pituitary secretory protein I
Gene Type	protein-coding
Organism	Bos taurus(cattle)

mRNA and Protein(s)

mRNA	Protein	Name
NM_181005.2	NP_851348.1	chromogranin-A precursor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CHGA	XP_510135.3
Bos taurus (cattle)	CHGA	NP_851348.1
Homo sapiens (human)	CHGA	NP_001266.1
Canis lupus familiaris (dog)	CHGA	XP_005623224.1
Mus musculus (house mouse)	Chga	NP_031719.1
Rattus norvegicus (Norway rat)	Chga	NP_067687.2
	CHGA	XP_001092629.2

Gene Ontology
Bibliography

Related articles in PubMed

Identification of the Vasoconstriction-Inhibiting Factor (VIF), a Potent Endogenous Cofactor of Angiotensin II Acting on the Angiotensin II Type 2 Receptor.
Salem S, Jankowski V, Asare Y, Liehn E, Welker P, Raya-Bermudez A, Pineda-Martos C, Rodriguez M, Mu?oz-Casta?eda JR, Bruck H, Marx N, Machado FB, Staudt M, Heinze G, Zidek W, Jankowski J
Circulation131(16)1426-34(2015 Apr)

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart.
Mazza R, Gattuso A, Mannarino C, Brar BK, Barbieri SF, Tota B, Mahata SK
American journal of physiology. Heart and circulatory physiology295(1)H113-22(2008 Jul)

Aggregation of cateslytin beta-sheets on negatively charged lipids promotes rigid membrane domains. A new mode of action for antimicrobial peptides?
Jean-Fran?ois F, Castano S, Desbat B, Odaert B, Roux M, Metz-Boutigue MH, Dufourc EJ
Biochemistry47(24)6394-402(2008 Jun)

Subcellular distribution of chromogranins A and B in bovine adrenal chromaffin cells.
Huh YH, Bahk SJ, Ghee JY, Yoo SH
FEBS letters579(23)5145-51(2005 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Vasoconstriction-Inhibiting Factor (VIF), a degradation product of chromogranin A, is a vasoregulatory peptide that modulates the vasoconstrictive effects of angiotensin II by acting on the angiotensin II type 2 receptor.
Title: Identification of the Vasoconstriction-Inhibiting Factor (VIF), a Potent Endogenous Cofactor of Angiotensin II Acting on the Angiotensin II Type 2 Receptor.

Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart.
Title: Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart.

Cateslytin adopts a dominant beta-sheet character upon interaction with negatively charged membranes, whereas it is essentially unstructured in water as are most short linear antimicrobial peptides.
Title: Aggregation of cateslytin beta-sheets on negatively charged lipids promotes rigid membrane domains. A new mode of action for antimicrobial peptides?

determination of the subcellular distribution of chromogranins A and B in chromaffin cells; results suggest that chromogranins are at the center of intracellular Ca(2+) homeostasis in secretory cells
Title: Subcellular distribution of chromogranins A and B in bovine adrenal chromaffin cells.

significant species differences in vasoactivity of the N-terminal domain of ChgA
Title: Chromogranin A-derived peptides: interaction with the rat posterior cerebral artery.

The following CHGA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CHGA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa41761	NM_181005.2 Latest version!	Bos taurus chromogranin A (CHGA), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CHGA ( NM_181005.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_851348.1 Bos taurus chromogranin A (CHGA), mRNA.

Price & Availability↑

CloneID	OBa41761
Clone ID Related Accession (Same CDS sequence)	NM_181005.2
Accession Version	NM_181005.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1350bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	chromogranin-A precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U73523.1. On Jun 3, 2003 this sequence version replaced NM_181005.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U73523.1, BC105515.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145415, SAMN03145416 [ECO:0000348] ##Evidence-Data-END##

ATGCGCTCCG CCGCGGTCCT GGCGCTTCTG CTCTGCGCGG GGCAAGTCAT TGCCCTGCCT 
GTGAACAGCC CCATGAATAA AGGGGACACT GAGGTGATGA AGTGTATCGT CGAGGTCATC 
TCTGACACAC TCTCCAAGCC CAGCCCCATG CCAGTCAGCA AGGAGTGTTT TGAGACACTC 
CGAGGAGATG AACGGATCCT CTCAATCCTG CGACATCAGA ATTTGCTGAA AGAGCTCCAA 
GACCTCGCTC TCCAAGGAGC CAAGGAGCGG ACACATCAGC AGAAGAAGCA CAGCAGTTAC 
GAGGATGAAC TCTCAGAGGT GCTTGAGAAG CCGAACGACC AGGCCGAGCC GAAAGAGGTG 
ACAGAAGAGG TGTCCTCCAA GGATGCTGCA GAAAAAAGAG ACGATTTTAA AGAGGTGGAG 
AAGAGTGATG AAGACTCGGA CGGAGACAGG CCTCAGGCCT CCCCAGGGCT TGGGCCGGGG 
CCCAAGGTTG AGGAGGACAA CCAGGCCCCT GGGGAGGAGG AGGAGGCCCC CTCCAACGCC 
CACCCCCTAG CCAGCCTCCC CAGCCCGAAA TACCCAGGCC CACAGGCCAA GGAGGACAGC 
GAGGGTCCCT CCCAGGGTCC AGCCAGCAGG GAGAAGGGCC TGAGTGCAGA GCAAGGGAGG 
CAGACAGAGA GAGAAGAGGA GGAGGAGAAG TGGGAGGAGG CGGAGGCTAG AGAGAAGGCC 
GTCCCGGAGG AAGAAAGCCC GCCCACCGCA GCGTTTAAAC CCCCACCGAG CCTCGGCAAC 
AAGGAGACGC AGAGGGCTGC TCCAGGTTGG CCCGAGGATG GAGCCGGGAA GATGGGGGCT 
GAGGAGGCCA AGCCCCCTGA GGGGAAGGGG GAGTGGTCAC ACTCCCGGCA GGAGGAAGAG 
GAGATGGCAA GGGCCCCTCA AGTCCTCTTC CGTGGTGGGA AGAGCGGGGA GCCCGAGCAG 
GAGGAGCAGC TCTCCAAGGA GTGGGAGGAC GCCAAGCGAT GGAGCAAGAT GGACCAGCTG 
GCCAAGGAGC TGACGGCCGA GAAGCGGCTG GAGGGGGAGG AGGAGGAAGA GGAGGACCCC 
GACCGCTCCA TGAGGCTCTC CTTCCGGGCC CGGGGCTACG GCTTCAGGGG TCCCGGGCTG 
CAGCTGCGGC GAGGCTGGAG GCCGAACTCC CGGGAGGACA GCGTGGAGGC CGGCCTGCCC 
CTCCAGGTGC GCGGCTACCC GGAAGAGAAG AAGGAGGAGG AGGGCAGCGC CAACCGCAGA 
CCAGAGGACC AGGAGCTGGA GAGCTTGTCA GCCATCGAGG CAGAGCTGGA GAAGGTGGCC 
CACCAGCTGG AGGAGCTTCG GCGGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_851348.1
CDS	191..1540
Translation	MRSAAVLALLLCAGQVIALPVNSPMNKGDTEVMKCIVEVISDTLSKPSPMPVSKECFETLRGDERILSILRHQNLLKELQDLALQGAKERTHQQKKHSSYEDELSEVLEKPNDQAEPKEVTEEVSSKDAAEKRDDFKEVEKSDEDSDGDRPQASPGLGPGPKVEEDNQAPGEEEEAPSNAHPLASLPSPKYPGPQAKEDSEGPSQGPASREKGLSAEQGRQTEREEEEEKWEEAEAREKAVPEEESPPTAAFKPPPSLGNKETQRAAPGWPEDGAGKMGAEEAKPPEGKGEWSHSRQEEEEMARAPQVLFRGGKSGEPEQEEQLSKEWEDAKRWSKMDQLAKELTAEKRLEGEEEEEEDPDRSMRLSFRARGYGFRGPGLQLRRGWRPNSREDSVEAGLPLQVRGYPEEKKEEEGSANRRPEDQELESLSAIEAELEKVAHQLEELRRG

Target ORF information:

RefSeq Version	NM_181005.2
Organism	Bos taurus(cattle)
Definition	Bos taurus chromogranin A (CHGA), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_181005.2

ORF Insert Sequence:

ATGCGCTCCG CCGCGGTCCT GGCGCTTCTG CTCTGCGCGG GGCAAGTCAT TGCCCTGCCT 
GTGAACAGCC CCATGAATAA AGGGGACACT GAGGTGATGA AGTGTATCGT CGAGGTCATC 
TCTGACACAC TCTCCAAGCC CAGCCCCATG CCAGTCAGCA AGGAGTGTTT TGAGACACTC 
CGAGGAGATG AACGGATCCT CTCAATCCTG CGACATCAGA ATTTGCTGAA AGAGCTCCAA 
GACCTCGCTC TCCAAGGAGC CAAGGAGCGG ACACATCAGC AGAAGAAGCA CAGCAGTTAC 
GAGGATGAAC TCTCAGAGGT GCTTGAGAAG CCGAACGACC AGGCCGAGCC GAAAGAGGTG 
ACAGAAGAGG TGTCCTCCAA GGATGCTGCA GAAAAAAGAG ACGATTTTAA AGAGGTGGAG 
AAGAGTGATG AAGACTCGGA CGGAGACAGG CCTCAGGCCT CCCCAGGGCT TGGGCCGGGG 
CCCAAGGTTG AGGAGGACAA CCAGGCCCCT GGGGAGGAGG AGGAGGCCCC CTCCAACGCC 
CACCCCCTAG CCAGCCTCCC CAGCCCGAAA TACCCAGGCC CACAGGCCAA GGAGGACAGC 
GAGGGTCCCT CCCAGGGTCC AGCCAGCAGG GAGAAGGGCC TGAGTGCAGA GCAAGGGAGG 
CAGACAGAGA GAGAAGAGGA GGAGGAGAAG TGGGAGGAGG CGGAGGCTAG AGAGAAGGCC 
GTCCCGGAGG AAGAAAGCCC GCCCACCGCA GCGTTTAAAC CCCCACCGAG CCTCGGCAAC 
AAGGAGACGC AGAGGGCTGC TCCAGGTTGG CCCGAGGATG GAGCCGGGAA GATGGGGGCT 
GAGGAGGCCA AGCCCCCTGA GGGGAAGGGG GAGTGGTCAC ACTCCCGGCA GGAGGAAGAG 
GAGATGGCAA GGGCCCCTCA AGTCCTCTTC CGTGGTGGGA AGAGCGGGGA GCCCGAGCAG 
GAGGAGCAGC TCTCCAAGGA GTGGGAGGAC GCCAAGCGAT GGAGCAAGAT GGACCAGCTG 
GCCAAGGAGC TGACGGCCGA GAAGCGGCTG GAGGGGGAGG AGGAGGAAGA GGAGGACCCC 
GACCGCTCCA TGAGGCTCTC CTTCCGGGCC CGGGGCTACG GCTTCAGGGG TCCCGGGCTG 
CAGCTGCGGC GAGGCTGGAG GCCGAACTCC CGGGAGGACA GCGTGGAGGC CGGCCTGCCC 
CTCCAGGTGC GCGGCTACCC GGAAGAGAAG AAGGAGGAGG AGGGCAGCGC CAACCGCAGA 
CCAGAGGACC AGGAGCTGGA GAGCTTGTCA GCCATCGAGG CAGAGCTGGA GAAGGTGGCC 
CACCAGCTGG AGGAGCTTCG GCGGGGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Identification of the Vasoconstriction-Inhibiting Factor (VIF), a Potent Endogenous Cofactor of Angiotensin II Acting on the Angiotensin II Type 2 Receptor.
Circulation131(16)1426-34(2015 Apr)
Salem S,Jankowski V,Asare Y,Liehn E,Welker P,Raya-Bermudez A,Pineda-Martos C,Rodriguez M,Mu?oz-Casta?eda JR,Bruck H,Marx N,Machado FB,Staudt M,Heinze G,Zidek W,Jankowski J

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Catestatin (chromogranin A344-364) is a novel cardiosuppressive agent: inhibition of isoproterenol and endothelin signaling in the frog heart.
American journal of physiology. Heart and circulatory physiology295(1)H113-22(2008 Jul)
Mazza R,Gattuso A,Mannarino C,Brar BK,Barbieri SF,Tota B,Mahata SK

Aggregation of cateslytin beta-sheets on negatively charged lipids promotes rigid membrane domains. A new mode of action for antimicrobial peptides?
Biochemistry47(24)6394-402(2008 Jun)
Jean-Fran?ois F,Castano S,Desbat B,Odaert B,Roux M,Metz-Boutigue MH,Dufourc EJ

Subcellular distribution of chromogranins A and B in bovine adrenal chromaffin cells.
FEBS letters579(23)5145-51(2005 Sep)
Huh YH,Bahk SJ,Ghee JY,Yoo SH

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CHGA cDNA ORF clone, Bos taurus(cattle)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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