DMRT3 cDNA ORF clone, Equus caballus(horse)

Gene
Clones
gRNAs

Summary

Gene Symbol	DMRT3
Entrez Gene ID	100147177
Full Name	doublesex and mab-3 related transcription factor 3
Synonyms	DMRT3
Gene Type	protein-coding
Organism	Equus caballus(horse)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001317265.1	NP_001304194.1	doublesex and mab-3 related transcription factor 3

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

To pace or not to pace: a pilot study of four- and five-gaited Icelandic horses homozygous for the DMRT3 'Gait Keeper' mutation.
J?derkvist Fegraeus K, Hirschberg I, ?rnason T, Andersson L, Velie BD, Andersson LS, Lindgren G
Animal genetics48(6)694-697(2017 Dec)

The evolutionary history of the DMRT3 'Gait keeper' haplotype.
Staiger EA, Alm?n MS, Promerov? M, Brooks S, Cothran EG, Imsland F, J?derkvist Fegraeus K, Lindgren G, Mehrabani Yeganeh H, Mikko S, Vega-Pla JL, Tozaki T, Rubin CJ, Andersson L
Animal genetics48(5)551-559(2017 Oct)

Lack of significant associations with early career performance suggest no link between the DMRT3 "Gait Keeper" mutation and precocity in Coldblooded trotters.
J?derkvist Fegraeus K, Lawrence C, Pet?jist? K, Johansson MK, Wiklund M, Olsson C, Andersson L, Andersson LS, R?ed KH, Ihler CF, Strand E, Lindgren G, Velie BD
PloS one12(5)e0177351(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

In the Icelandic horse breed, No DMRT3 SNP demonstrated genome-wide significance, implying that the ability to pace goes beyond the presence of a single gene variant.
Title: To pace or not to pace: a pilot study of four- and five-gaited Icelandic horses homozygous for the DMRT3 'Gait Keeper' mutation.

the spectrum of gait phenotypes strongly associated with the DMRT3 stop mutation is a recently derived trait
Title: The evolutionary history of the DMRT3 'Gait keeper' haplotype.

Previous studies have shown that a mutation from cytosine (C) to adenine (A) in the doublesex and mab-3 related transcription factor 3 (DMRT3) gene has a major impact on harness racing performance of different breeds. The current study provides no evidence to support such an association with DMRT3 in Coldblooded trotters.
Title: Lack of significant associations with early career performance suggest no link between the DMRT3 "Gait Keeper" mutation and precocity in Coldblooded trotters.

There was not a significant difference in the frequency of the DMRT3 mutation when comparing 5-gaited American Saddlebred horses to other American Saddlebred horses
Title: Comparison of DMRT3 genotypes among American Saddlebred horses with reference to gait.

This work finds a clear rationale for using the genotype at DMRT3 for multitrait evaluation.
Title: Should we use the single nucleotide polymorphism linked to in genomic evaluation of French trotter?

The following DMRT3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DMRT3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHb39677	NM_001317265.1 Latest version!	Equus caballus doublesex and mab-3 related transcription factor 3 (DMRT3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DMRT3 ( NM_001317265.1 ) cDNA ORF clone, Equus caballus(horse) -> NP_001304194.1 Equus caballus doublesex and mab-3 related transcription factor 3 (DMRT3), mRNA.

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CloneID	OHb39677
Clone ID Related Accession (Same CDS sequence)	NM_001317265.1
Accession Version	NM_001317265.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1425bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Equus caballus(horse)
Product	doublesex and mab-3 related transcription factor 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JQ922371.1. On Nov 29, 2015 this sequence version replaced XM_014735431.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: JQ922370.1, JQ922371.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02711379, SAMN03890618 [ECO:0000348] ##Evidence-Data-END##

ATGAACGGCT ACGGTTCCCC CTACCTGTAC ATGGGCGGCC CGGTGTCGCA GCCGCCGCGG 
GCGCCCTTGC AGCGCACGCC CAAGTGCGCG CGCTGCCGCA ACCACGGGGT GCTGTCCTGG 
CTCAAGGGTC ACAAGCGCTA CTGCCGCTTC AAGGACTGCA CCTGCGAGAA GTGCATCCTC 
ATCATCGAGC GGCAGAGGGT CATGGCGGCG CAGGTGGCGC TGCGCCGGCA GCAAGCTAAC 
GAGAGCCTCG AGAGCCTCAT TCCCGACTCG CTGCGTGCTC TGCCCGGCCC CCCGCCGCCG 
GGGGACGCCG CCGCTGCCGC CCCGCAGCCG CCGCCCACCT CGCAGCCGTC TCAGCCGCCG 
CCGCCGCAGC GTCCCGCCGC CGAGTTGGCT GCGGCCGCCG CGCTGCGCTG GGCCACCGAG 
CCGCAGCCCG GGGCGCTGCA GGCGCAGCTC GCCAAGCCAG ATTTGACTGA GGAGCGACTT 
GGGGACGGCA GCTCCGCAGA CAACACAGAG ACCTTCAGCG ACAAAGACAC CGACCAGAGG 
AGCTCCCCAG ATGTGGTGAA AAGTAAGGGC TGCTTCACCC CGGAGAGCCC CGAGGTCGTG 
TCTGTGGATG AAGGCGGGTA TGCGGTCCAG AAGAACGGAG GCACCTCCGA GAGCCGCCCC 
GACAGTCCCA AGTACCACGG GGAACAGAAT CACCTCCTGA TCGAGGGCCC CTCGGGGACC 
GTTTCTCTGC CCTTCAGCTT GAAAGCCAAC AGACCGCCCC TGGAAGTGTT AAAAAAAATC 
TTCCCCAACC AGAAGCCCAC GGTGCTGGAG CTCATCCTGA AGGGCTGTGG GGGCGACCTG 
GTGAGCGCCG TGGAGGTCCT CCTCTCCAGC CGCTCCTCGG CCTCGGCCGC CGACCGAACT 
TCGGCAGAGC CCGAGAGCCT CGTGTTGCCC TCCAACGGGC ACATCTTTGA ACACACCTTG 
AGCTCATACC CCATCTCCTC TTCCAAATGG TCCGTGGGAT CGGCCTTCAG GGTCCCAGAC 
ACGTTGAGGT TTTCCGCAGA CTCTAGTAAC GTTGTCCCCA ACCCCTTGGC CGTGCCCCTG 
CAGCATCCTT TCCCCCAGCC GCCCCGGTAC CCTCTGATGC TGAGGAATAC TTTGGCAAGA 
AACCAGTCGA GCCCCTTCCT GCCCAATGAT GTCACCCTGT GGAACACCAT GACGCTGCAG 
CAGCAGTACC AGCTGAGGTC CCAGTACGTC AGCCCTTTCC CCGGGAGCTC GCCCAGCGTC 
TTCAGAAGCT CGCCTGTCCT TCCCACGCGC GCCCCCGAAG ACCCTCGGAT CTCCATCCCT 
GACGATGGGT GTCCGATTGT GTCAAAGCAG TCTCTTTACA CCGAGGATGA CTATGACGAG 
AGGTCCGACT CCTCAGACTC TAGAATACTC AACACATCAT CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304194.1
CDS	39..1463
Translation	MNGYGSPYLYMGGPVSQPPRAPLQRTPKCARCRNHGVLSWLKGHKRYCRFKDCTCEKCILIIERQRVMAAQVALRRQQANESLESLIPDSLRALPGPPPPGDAAAAAPQPPPTSQPSQPPPPQRPAAELAAAAALRWATEPQPGALQAQLAKPDLTEERLGDGSSADNTETFSDKDTDQRSSPDVVKSKGCFTPESPEVVSVDEGGYAVQKNGGTSESRPDSPKYHGEQNHLLIEGPSGTVSLPFSLKANRPPLEVLKKIFPNQKPTVLELILKGCGGDLVSAVEVLLSSRSSASAADRTSAEPESLVLPSNGHIFEHTLSSYPISSSKWSVGSAFRVPDTLRFSADSSNVVPNPLAVPLQHPFPQPPRYPLMLRNTLARNQSSPFLPNDVTLWNTMTLQQQYQLRSQYVSPFPGSSPSVFRSSPVLPTRAPEDPRISIPDDGCPIVSKQSLYTEDDYDERSDSSDSRILNTSS

Target ORF information:

RefSeq Version	NM_001317265.1
Organism	Equus caballus(horse)
Definition	Equus caballus doublesex and mab-3 related transcription factor 3 (DMRT3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317265.1

ORF Insert Sequence:

ATGAACGGCT ACGGTTCCCC CTACCTGTAC ATGGGCGGCC CGGTGTCGCA GCCGCCGCGG 
GCGCCCTTGC AGCGCACGCC CAAGTGCGCG CGCTGCCGCA ACCACGGGGT GCTGTCCTGG 
CTCAAGGGTC ACAAGCGCTA CTGCCGCTTC AAGGACTGCA CCTGCGAGAA GTGCATCCTC 
ATCATCGAGC GGCAGAGGGT CATGGCGGCG CAGGTGGCGC TGCGCCGGCA GCAAGCTAAC 
GAGAGCCTCG AGAGCCTCAT TCCCGACTCG CTGCGTGCTC TGCCCGGCCC CCCGCCGCCG 
GGGGACGCCG CCGCTGCCGC CCCGCAGCCG CCGCCCACCT CGCAGCCGTC TCAGCCGCCG 
CCGCCGCAGC GTCCCGCCGC CGAGTTGGCT GCGGCCGCCG CGCTGCGCTG GGCCACCGAG 
CCGCAGCCCG GGGCGCTGCA GGCGCAGCTC GCCAAGCCAG ATTTGACTGA GGAGCGACTT 
GGGGACGGCA GCTCCGCAGA CAACACAGAG ACCTTCAGCG ACAAAGACAC CGACCAGAGG 
AGCTCCCCAG ATGTGGTGAA AAGTAAGGGC TGCTTCACCC CGGAGAGCCC CGAGGTCGTG 
TCTGTGGATG AAGGCGGGTA TGCGGTCCAG AAGAACGGAG GCACCTCCGA GAGCCGCCCC 
GACAGTCCCA AGTACCACGG GGAACAGAAT CACCTCCTGA TCGAGGGCCC CTCGGGGACC 
GTTTCTCTGC CCTTCAGCTT GAAAGCCAAC AGACCGCCCC TGGAAGTGTT AAAAAAAATC 
TTCCCCAACC AGAAGCCCAC GGTGCTGGAG CTCATCCTGA AGGGCTGTGG GGGCGACCTG 
GTGAGCGCCG TGGAGGTCCT CCTCTCCAGC CGCTCCTCGG CCTCGGCCGC CGACCGAACT 
TCGGCAGAGC CCGAGAGCCT CGTGTTGCCC TCCAACGGGC ACATCTTTGA ACACACCTTG 
AGCTCATACC CCATCTCCTC TTCCAAATGG TCCGTGGGAT CGGCCTTCAG GGTCCCAGAC 
ACGTTGAGGT TTTCCGCAGA CTCTAGTAAC GTTGTCCCCA ACCCCTTGGC CGTGCCCCTG 
CAGCATCCTT TCCCCCAGCC GCCCCGGTAC CCTCTGATGC TGAGGAATAC TTTGGCAAGA 
AACCAGTCGA GCCCCTTCCT GCCCAATGAT GTCACCCTGT GGAACACCAT GACGCTGCAG 
CAGCAGTACC AGCTGAGGTC CCAGTACGTC AGCCCTTTCC CCGGGAGCTC GCCCAGCGTC 
TTCAGAAGCT CGCCTGTCCT TCCCACGCGC GCCCCCGAAG ACCCTCGGAT CTCCATCCCT 
GACGATGGGT GTCCGATTGT GTCAAAGCAG TCTCTTTACA CCGAGGATGA CTATGACGAG 
AGGTCCGACT CCTCAGACTC TAGAATACTC AACACATCAT CTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

To pace or not to pace: a pilot study of four- and five-gaited Icelandic horses homozygous for the DMRT3 'Gait Keeper' mutation.
Animal genetics48(6)694-697(2017 Dec)
J?derkvist Fegraeus K,Hirschberg I,?rnason T,Andersson L,Velie BD,Andersson LS,Lindgren G

The evolutionary history of the DMRT3 'Gait keeper' haplotype.
Animal genetics48(5)551-559(2017 Oct)
Staiger EA,Alm?n MS,Promerov? M,Brooks S,Cothran EG,Imsland F,J?derkvist Fegraeus K,Lindgren G,Mehrabani Yeganeh H,Mikko S,Vega-Pla JL,Tozaki T,Rubin CJ,Andersson L

Lack of significant associations with early career performance suggest no link between the DMRT3 "Gait Keeper" mutation and precocity in Coldblooded trotters.
PloS one12(5)e0177351(2017)
J?derkvist Fegraeus K,Lawrence C,Pet?jist? K,Johansson MK,Wiklund M,Olsson C,Andersson L,Andersson LS,R?ed KH,Ihler CF,Strand E,Lindgren G,Velie BD

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DMRT3 cDNA ORF clone, Equus caballus(horse)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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