MCPH1 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene
Clones
gRNAs

Summary

Gene Symbol	MCPH1
Entrez Gene ID	106999655
Full Name	microcephalin 1
Gene Type	protein-coding
Organism	Macaca mulatta(Rhesus monkey)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001318176.1	NP_001305105.1	microcephalin

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Zimin AV, Cornish AS, Maudhoo MD, Gibbs RM, Zhang X, Pandey S, Meehan DT, Wipfler K, Bosinger SE, Johnson ZP, Tharp GK, Mar?ais G, Roberts M, Ferguson B, Fox HS, Treangen T, Salzberg SL, Yorke JA, Norgren RB Jr
Biology direct9(1)20(2014 Oct)

Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans.
Shi L, Li M, Lin Q, Qi X, Su B
BMC biology1162(2013 May)

Identification and functional characterization of a primate-specific E2F1 binding motif regulating MCPH1 expression.
Shi L, Su B
The FEBS journal279(3)491-503(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The divergence of MCPH1 protein sequences under Darwinian positive selection led to functional modifications, providing a possible molecular mechanism of how MCPH1 contributed to brain enlargement during primate evolution and human origin.
Title: Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans.

sequence comparison of vertebrate species suggested that the identified E2F1 binding motif is primate specific, consistent with the previous observation of rapid evolution of MCPH1 protein sequence in primates
Title: Identification and functional characterization of a primate-specific E2F1 binding motif regulating MCPH1 expression.

The following MCPH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MCPH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OMb57560	NM_001318176.1 Latest version!	Macaca mulatta microcephalin 1 (MCPH1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MCPH1 ( NM_001318176.1 ) cDNA ORF clone, Macaca mulatta(Rhesus monkey) -> NP_001305105.1 Macaca mulatta microcephalin 1 (MCPH1), mRNA.

Price & Availability↑

CloneID	OMb57560
Clone ID Related Accession (Same CDS sequence)	NM_001318176.1
Accession Version	NM_001318176.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2529bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-27
Organism	Macaca mulatta(Rhesus monkey)
Product	microcephalin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from JX194162.1. On Dec 26, 2015 this sequence version replaced XM_015144701.1. ##Evidence-Data-START## Transcript exon combination :: JX194162.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4688316, SAMEA4688317 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCCC CCATCCTGAA AGATGTAGTG GCCTATGTTG AAGTGTGGTC ATCCAATGGA 
ACGGAAAATT ATTCAAAGAC ATTTACAACA CAGCTTGTGG ATATGGGAGC AAAGGTTTCA 
AAAACTTTTA ACAAACAAGT AACTCACGTT ATCTTCAAAG ATGGCTACCA GAGCACTTGG 
GACAAAGCTC GAAAGAGAGG CGTAAAGCTC GTTTCAGTCC TCTGGGTTGA AAAATGCAGG 
ACAGCTGGAG CACACATTGA TGAATCGTTG TTCCCTGCAG CTAATACGAA TGAACACTTA 
CCAAGCCTAA TTAAAAAAAA ACGTAAATGT ATGCAGCCCA AAGATTTTAA TTTTAAAACA 
CCAGAAAATG ATAAGAGATT TCAGAAGAAA TTTGAGAAAA TGGCTAAAGA GCTACAAAGG 
CAAAAAACAA GTCTAGATGA TGATGTACCT ATTCTCTTAT TTGAATCTAA TGGTTCATTA 
ACATATAGTC CTACAATTAA AATTAATAGT AGTCACCACA GCGCAATGGA GAAGAGATTA 
CAAGAGATGA AGGAGAAAAG GGAAAATCTT TCCCCCACCT CTTCCCAAAT GATTCAACAG 
TCTCATGATA ATCCAAGTAA CTCTCTGTGT GAAGCACCTT TGAACATTTC ACATGATACT 
TTGTGTTCAG ATGAATCCAT TGCTGGTGGC TTACACTCGT CTTTTGATGA TCTTTGTGGA 
AACTCAGAAT GTGGAAATCA GGAAAGGAAG TTGGGAGGAT CCATTAATGA CACTAAAAGT 
GATATGTGTA TTTCTTCACT TGTATTGAAA ACAAATAATA CTCATTTATC ACCATCTTTC 
GCTCACCTTG ATAAATCAAG TCCTCAGAAA TTTCTGAGTA ATCTTTCAAA GGAAGAAATA 
AACTTGCAAA GAAACACTGT GGGTAAAATA GTCACCCCTG ACCAAAAGCA GGCTGCAGGT 
ATGTCTCAGG AGACGTTTGA AGAGAAGTAT CGTTTGTCTC CTACATTGTC TTCAACAAAA 
GGCCCCCTTT TGATACATTC AAGACCCAGG AGTTCCTCAG TAAAGAGAAA AAGAGTATCA 
TATGGCTTCC ATTCACCTCC AAAGGAAAAA TGCAAGAGAA AGAGGAGCAT CAGGAGATCT 
ATCATGCCGA GGCTGCAGCT GTGTAGGTCA GAAGGCAGCC TGCAGTGCAT GGCGGGACCT 
GCACTCGAGG CTCTTGGCTG TGGGGAGTCT TCGTATGATG ACTATTTTTC ACCTGATAAT 
CTTAAGGAAA GGAATTCAGA GAATCTTCCT CCCAAATCTC AGCTGCCATC AAACCCTGCT 
CAGTTCAGCT GCAGAAGTCT TTCTAAGAAG GAGAGAACAA GCATATTTGA AATGTCTGAT 
TTTTCCTGCG TTGGTAAAAA ACCCAGAACA GTTGACATTA CCAGTTTCAC AGCAAAAACC 
ATCTGCAGTC CTCAGAAAAC TGCAAGTGGA GAAGGCTGTG CAACTTTCAG TTGCGTGACT 
TCTGAGGAAT CCTCTGCCCC TGAAGAAACC TTAAGGTATT GTAGACAGGC TGGGCCTCAG 
CAGAAAGAAG ACGCATGGCC AGAGGGCAAT GGCTTTTCTT ACACCATTGA GGACCCTGCT 
CTTCCAAAAG GACATGATGG TGATTTAACT CCTTTCGAAG GAATCCTTAA AGAAGTGAAA 
GAAGCGGTTG GTCTGAAAAG CACACAGGAC AAAGGTACCA CTTCCAAAMT ATCAAACTCC 
TCTGAAGGCG AAGCCCCGAG TGAACATGAG CCACGTTCTG TAGTTGACTG TAACGTGGAG 
AGGTCTGCAG AAGAAAAGGA AAACTTACCT GGAGGATACA GTGGAAGTGT TAAAAATAGA 
CCAACAAGGC GTGATGTTTT AGATGGCTCA TGTGACAGCT TTAAGGACCT CATCAAACCT 
CATGAGGAAC TGAAGAAAAG TGGGAAAGGC AAAAAGCCAA CAAGAACATT AGTCATGACA 
AGCATGCCAT CTGAAAAGCA GAATGTCGTC ATCCAGGTTG TGGATAAATT GAAAGGCTTT 
TCAATTGCAC CAGACGTCTG TGAGACCACG ACTCACGTGC TTTCCGGGAA GCCACTTCGC 
ACCCTGAATG TGCTGCTGGG AATCGCGCGT GGCTGCTGGG TTCTCTCTTA TGATTGGGTG 
CTGTGGTCTT TAGAATCGGG TCAATGGATT TCTGAGGAGC CATTCGAACT GTCTAATCAC 
TTCCCTGCAG CTCCTCTGTG CCGAAGGGAG TGCCACTTGT CTGCAGGGCC GTACCGCGGA 
ATCCTCTTTG CCGACCAGCC AGTGATGTTT GTCTCGCCTG CCAGCAGCCC CCCCGTGGCC 
AAGCTCTGTG AACTAGTCCA CCTGTGCGGA GGCCGGGTCA GCCAAGTCCC CCGCCAGGCC 
AGCATCGTCA TCGGGCCCTA CAGCGGAAAG AAGAAAGCAA CAGTCAAGTA TCTGTCGGAG 
AAATGGGTCT TAGATTCCAT CACCCAGCAC AAGGTCTGTG CCTCTGAAAA CTACCTATTG 
CCACAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001305105.1
CDS	1..2529
Translation	MAAPILKDVVAYVEVWSSNGTENYSKTFTTQLVDMGAKVSKTFNKQVTHVIFKDGYQSTWDKARKRGVKLVSVLWVEKCRTAGAHIDESLFPAANTNEHLPSLIKKKRKCMQPKDFNFKTPENDKRFQKKFEKMAKELQRQKTSLDDDVPILLFESNGSLTYSPTIKINSSHHSAMEKRLQEMKEKRENLSPTSSQMIQQSHDNPSNSLCEAPLNISHDTLCSDESIAGGLHSSFDDLCGNSECGNQERKLGGSINDTKSDMCISSLVLKTNNTHLSPSFAHLDKSSPQKFLSNLSKEEINLQRNTVGKIVTPDQKQAAGMSQETFEEKYRLSPTLSSTKGPLLIHSRPRSSSVKRKRVSYGFHSPPKEKCKRKRSIRRSIMPRLQLCRSEGSLQCMAGPALEALGCGESSYDDYFSPDNLKERNSENLPPKSQLPSNPAQFSCRSLSKKERTSIFEMSDFSCVGKKPRTVDITSFTAKTICSPQKTASGEGCATFSCVTSEESSAPEETLRYCRQAGPQQKEDAWPEGNGFSYTIEDPALPKGHDGDLTPFEGILKEVKEAVGLKSTQDKGTTSKnullSNSSEGEAPSEHEPRSVVDCNVERSAEEKENLPGGYSGSVKNRPTRRDVLDGSCDSFKDLIKPHEELKKSGKGKKPTRTLVMTSMPSEKQNVVIQVVDKLKGFSIAPDVCETTTHVLSGKPLRTLNVLLGIARGCWVLSYDWVLWSLESGQWISEEPFELSNHFPAAPLCRRECHLSAGPYRGILFADQPVMFVSPASSPPVAKLCELVHLCGGRVSQVPRQASIVIGPYSGKKKATVKYLSEKWVLDSITQHKVCASENYLLPQ

Target ORF information:

RefSeq Version	NM_001318176.1
Organism	Macaca mulatta(Rhesus monkey)
Definition	Macaca mulatta microcephalin 1 (MCPH1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001318176.1

ORF Insert Sequence:

ATGGCGGCCC CCATCCTGAA AGATGTAGTG GCCTATGTTG AAGTGTGGTC ATCCAATGGA 
ACGGAAAATT ATTCAAAGAC ATTTACAACA CAGCTTGTGG ATATGGGAGC AAAGGTTTCA 
AAAACTTTTA ACAAACAAGT AACTCACGTT ATCTTCAAAG ATGGCTACCA GAGCACTTGG 
GACAAAGCTC GAAAGAGAGG CGTAAAGCTC GTTTCAGTCC TCTGGGTTGA AAAATGCAGG 
ACAGCTGGAG CACACATTGA TGAATCGTTG TTCCCTGCAG CTAATACGAA TGAACACTTA 
CCAAGCCTAA TTAAAAAAAA ACGTAAATGT ATGCAGCCCA AAGATTTTAA TTTTAAAACA 
CCAGAAAATG ATAAGAGATT TCAGAAGAAA TTTGAGAAAA TGGCTAAAGA GCTACAAAGG 
CAAAAAACAA GTCTAGATGA TGATGTACCT ATTCTCTTAT TTGAATCTAA TGGTTCATTA 
ACATATAGTC CTACAATTAA AATTAATAGT AGTCACCACA GCGCAATGGA GAAGAGATTA 
CAAGAGATGA AGGAGAAAAG GGAAAATCTT TCCCCCACCT CTTCCCAAAT GATTCAACAG 
TCTCATGATA ATCCAAGTAA CTCTCTGTGT GAAGCACCTT TGAACATTTC ACATGATACT 
TTGTGTTCAG ATGAATCCAT TGCTGGTGGC TTACACTCGT CTTTTGATGA TCTTTGTGGA 
AACTCAGAAT GTGGAAATCA GGAAAGGAAG TTGGGAGGAT CCATTAATGA CACTAAAAGT 
GATATGTGTA TTTCTTCACT TGTATTGAAA ACAAATAATA CTCATTTATC ACCATCTTTC 
GCTCACCTTG ATAAATCAAG TCCTCAGAAA TTTCTGAGTA ATCTTTCAAA GGAAGAAATA 
AACTTGCAAA GAAACACTGT GGGTAAAATA GTCACCCCTG ACCAAAAGCA GGCTGCAGGT 
ATGTCTCAGG AGACGTTTGA AGAGAAGTAT CGTTTGTCTC CTACATTGTC TTCAACAAAA 
GGCCCCCTTT TGATACATTC AAGACCCAGG AGTTCCTCAG TAAAGAGAAA AAGAGTATCA 
TATGGCTTCC ATTCACCTCC AAAGGAAAAA TGCAAGAGAA AGAGGAGCAT CAGGAGATCT 
ATCATGCCGA GGCTGCAGCT GTGTAGGTCA GAAGGCAGCC TGCAGTGCAT GGCGGGACCT 
GCACTCGAGG CTCTTGGCTG TGGGGAGTCT TCGTATGATG ACTATTTTTC ACCTGATAAT 
CTTAAGGAAA GGAATTCAGA GAATCTTCCT CCCAAATCTC AGCTGCCATC AAACCCTGCT 
CAGTTCAGCT GCAGAAGTCT TTCTAAGAAG GAGAGAACAA GCATATTTGA AATGTCTGAT 
TTTTCCTGCG TTGGTAAAAA ACCCAGAACA GTTGACATTA CCAGTTTCAC AGCAAAAACC 
ATCTGCAGTC CTCAGAAAAC TGCAAGTGGA GAAGGCTGTG CAACTTTCAG TTGCGTGACT 
TCTGAGGAAT CCTCTGCCCC TGAAGAAACC TTAAGGTATT GTAGACAGGC TGGGCCTCAG 
CAGAAAGAAG ACGCATGGCC AGAGGGCAAT GGCTTTTCTT ACACCATTGA GGACCCTGCT 
CTTCCAAAAG GACATGATGG TGATTTAACT CCTTTCGAAG GAATCCTTAA AGAAGTGAAA 
GAAGCGGTTG GTCTGAAAAG CACACAGGAC AAAGGTACCA CTTCCAAAMT ATCAAACTCC 
TCTGAAGGCG AAGCCCCGAG TGAACATGAG CCACGTTCTG TAGTTGACTG TAACGTGGAG 
AGGTCTGCAG AAGAAAAGGA AAACTTACCT GGAGGATACA GTGGAAGTGT TAAAAATAGA 
CCAACAAGGC GTGATGTTTT AGATGGCTCA TGTGACAGCT TTAAGGACCT CATCAAACCT 
CATGAGGAAC TGAAGAAAAG TGGGAAAGGC AAAAAGCCAA CAAGAACATT AGTCATGACA 
AGCATGCCAT CTGAAAAGCA GAATGTCGTC ATCCAGGTTG TGGATAAATT GAAAGGCTTT 
TCAATTGCAC CAGACGTCTG TGAGACCACG ACTCACGTGC TTTCCGGGAA GCCACTTCGC 
ACCCTGAATG TGCTGCTGGG AATCGCGCGT GGCTGCTGGG TTCTCTCTTA TGATTGGGTG 
CTGTGGTCTT TAGAATCGGG TCAATGGATT TCTGAGGAGC CATTCGAACT GTCTAATCAC 
TTCCCTGCAG CTCCTCTGTG CCGAAGGGAG TGCCACTTGT CTGCAGGGCC GTACCGCGGA 
ATCCTCTTTG CCGACCAGCC AGTGATGTTT GTCTCGCCTG CCAGCAGCCC CCCCGTGGCC 
AAGCTCTGTG AACTAGTCCA CCTGTGCGGA GGCCGGGTCA GCCAAGTCCC CCGCCAGGCC 
AGCATCGTCA TCGGGCCCTA CAGCGGAAAG AAGAAAGCAA CAGTCAAGTA TCTGTCGGAG 
AAATGGGTCT TAGATTCCAT CACCCAGCAC AAGGTCTGTG CCTCTGAAAA CTACCTATTG 
CCACAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A new rhesus macaque assembly and annotation for next-generation sequencing analyses.
Biology direct9(1)20(2014 Oct)
Zimin AV,Cornish AS,Maudhoo MD,Gibbs RM,Zhang X,Pandey S,Meehan DT,Wipfler K,Bosinger SE,Johnson ZP,Tharp GK,Mar?ais G,Roberts M,Ferguson B,Fox HS,Treangen T,Salzberg SL,Yorke JA,Norgren RB Jr

Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans.
BMC biology1162(2013 May)
Shi L,Li M,Lin Q,Qi X,Su B

Identification and functional characterization of a primate-specific E2F1 binding motif regulating MCPH1 expression.
The FEBS journal279(3)491-503(2012 Feb)
Shi L,Su B

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MCPH1 cDNA ORF clone, Macaca mulatta(Rhesus monkey)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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