| Gene Symbol | CDKN2A |
| Entrez Gene ID | 395077 |
| Full Name | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Gallus gallus(chicken) |
| Summary | This gene encodes a protein similar to one of two mammalian cyclin-dependent kinase inhibitor proteins which regulate the activity of cyclin-dependent protein kinases CDK4 and CDK6 which further cell cycle progression through G1. The protein encoded by this gene is similar to the mammalian ARF (alternate reading frame) protein which functions as a cyclin-dependent kinase inhibitor and participates in regulation of the p53 cell cycle pathway. The first exon of the mammalian ARF transcript is referred to as beta. The mammalian gene which encodes ARF can also produce a transcript encoding an unrelated protein known as p16INK4a which participates in the regulation of the retinoblastoma pathway. The p16INK4a transcript contains an alternate first exon referred to as alpha, however, this transcript contains the same two downstream exons found in the ARF transcript. Sequence related to the alpha exon has not been found in the chicken genome and a p16INK4a transcript has not been detected, however, there is a duplication of exon two which suggests that the function of p16INK4a is provided by a protein from a different gene located nearby on chromosome Z. Although the protein encoded by this gene is smaller than the mammalian ARF protein, it has been shown to function in p53 regulation. [provided by RefSeq, Dec 2008]. |
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