GPX1 cDNA ORF clone, Gallus gallus(chicken)

Gene
Clones
gRNAs

Summary

Gene Symbol	GPX1
Entrez Gene ID	100857115
Full Name	glutathione peroxidase 1
Synonyms	GPx-1
General protein information	Preferred Names glutathione peroxidase 1 Names glutathione peroxidase 1 cytosolic glutathione peroxidase-1
Gene Type	protein-coding
Organism	Gallus gallus(chicken)
Summary	The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Other studies indicate that H2O2 is also essential for growth-factor mediated signal transduction, mitochondrial function, and maintenance of thiol redox-balance; therefore, by limiting H2O2 accumulation, glutathione peroxidases are also involved in modulating these processes. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is the most abundant, is ubiquitously expressed and localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. It is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. [provided by RefSeq, Jul 2016].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001277853.2	NP_001264782.2	glutathione peroxidase 1

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	gpx1a	NP_001007282.2
Homo sapiens (human)	GPX1	NP_000572.2
Pan troglodytes (chimpanzee)	GPX1	NP_001070980.2
Canis lupus familiaris (dog)	GPX1	NP_001108591.1
Bos taurus (cattle)	GPX1	NP_776501.1
Danio rerio (zebrafish)	gpx1b	NP_001004634.2
Xenopus tropicalis (tropical clawed frog)	gpx1	NP_001015740.2
Mus musculus (house mouse)	Gpx1	NP_032186.2
Rattus norvegicus (Norway rat)	Gpx1	NP_110453.3
Gallus gallus (chicken)	GPX1	NP_001264782.1
	GPX1	NP_001152770.1

Gene Ontology
Bibliography

Related articles in PubMed

Glutathione Peroxidase 1, Selenoprotein K, and Selenoprotein H May Play Important Roles in Chicken Testes in Response to Selenium Deficiency.
Gao Y, Zhang J, Huang X, Zhang G
Biological trace element research179(2)271-276(2017 Oct)

Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels.
Xu JX, Zhang C, Cao CY, Zhu SY, Li H, Sun YC, Li JL
Biological trace element research170(2)438-48(2016 Apr)

Effect of selenium sources on the expression of cellular glutathione peroxidase and cytoplasmic thioredoxin reductase in the liver and kidney of broiler breeders and their offspring.
Yuan D, Zhan XA, Wang YX
Poultry science91(4)936-42(2012 Apr)

A comprehensive collection of chicken cDNAs.
Boardman PE, Sanz-Ezquerro J, Overton IM, Burt DW, Bosch E, Fong WT, Tickle C, Brown WR, Wilson SA, Hubbard SJ
Current biology : CB12(22)1965-9(2002 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Dietary low Se downregulated the mRNA expressions of Gpx1-4, Txnrd3, Sepn1, Selw, Sepx1, Selh, and SEPSECS.
Title: Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels.

The following GPX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OGa86424	NM_001277853.2 Latest version!	Gallus gallus glutathione peroxidase 1 (GPX1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GPX1 ( NM_001277853.2 ) cDNA ORF clone, Gallus gallus(chicken) -> NP_001264782.2 Gallus gallus glutathione peroxidase 1 (GPX1), mRNA.

Price & Availability↑

CloneID	OGa86424
Clone ID Related Accession (Same CDS sequence)	NM_001277853.2
Accession Version	NM_001277853.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 588bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-07-14
Organism	Gallus gallus(chicken)
Product	glutathione peroxidase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU139763.1, BU123885.1, CR353639.1, BX934103.2 and BU356939.1. On Jul 21, 2016 this sequence version replaced NM_001277853.1. ##RefSeq-Attributes-START## protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCAGCGA CGGGGCTGGC GGGCATCTTA GCGCGGCCGC TGGGCGCGGC TGAGCCGCTG 
GCGCTGAGCT CGCTGCGGGG CAAAGTGCTG CTGGTGGTCA ACGTGGCGTC GCTCTGAGGC 
ACCACCACGC GCGACTTCCT GCAGCTCAAC GAGCTGCAGC AGCGCTACGG GCCCCGCGGG 
CTGCGCGTGC TCGGCTTCCC CTGCAACCAA TTCGGGCACC AGGAGAACGC CACCAACGAG 
GAGATCCTGC GCTCGCTGGA GTACGTGCGG CCCGGCAACG GCTTCAAACC CAACTTCACC 
ATGTTCGAGA AGTGCGAGGT GAACGGGAAG GGCGCTCACC CGCTGTTCGC CTTCCTGAGA 
GAGGCGCTGC CCTTCCCGCA CGACGACCCC TCGGCGCTGA TGACCAACCC GCAGTACATC 
ATCTGGTCGC CGGTGTGCCG CAACGACGTC TCCTGGAACT TCGAGAAGTT CCTCGTGGGC 
CCCGACGGCG TCCCCTTCCG CCGCTACAGC CGCCACTTCG AGACCATCAA ACTGCAGGAC 
GACATCGAGC TGCTGCTCCA GAAGGTGCCC AAGGAGGCTC TGCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001264782.2
CDS	53..640
Translation	MAATGLAGILARPLGAAEPLALSSLRGKVLLVVNVASL*GTTTRDFLQLNELQQRYGPRGLRVLGFPCNQFGHQENATNEEILRSLEYVRPGNGFKPNFTMFEKCEVNGKGAHPLFAFLREALPFPHDDPSALMTNPQYIIWSPVCRNDVSWNFEKFLVGPDGVPFRRYSRHFETIKLQDDIELLLQKVPKEALQ

Target ORF information:

RefSeq Version	NM_001277853.2
Organism	Gallus gallus(chicken)
Definition	Gallus gallus glutathione peroxidase 1 (GPX1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001277853.2

ORF Insert Sequence:

ATGGCAGCGA CGGGGCTGGC GGGCATCTTA GCGCGGCCGC TGGGCGCGGC TGAGCCGCTG 
GCGCTGAGCT CGCTGCGGGG CAAAGTGCTG CTGGTGGTCA ACGTGGCGTC GCTCTGAGGC 
ACCACCACGC GCGACTTCCT GCAGCTCAAC GAGCTGCAGC AGCGCTACGG GCCCCGCGGG 
CTGCGCGTGC TCGGCTTCCC CTGCAACCAA TTCGGGCACC AGGAGAACGC CACCAACGAG 
GAGATCCTGC GCTCGCTGGA GTACGTGCGG CCCGGCAACG GCTTCAAACC CAACTTCACC 
ATGTTCGAGA AGTGCGAGGT GAACGGGAAG GGCGCTCACC CGCTGTTCGC CTTCCTGAGA 
GAGGCGCTGC CCTTCCCGCA CGACGACCCC TCGGCGCTGA TGACCAACCC GCAGTACATC 
ATCTGGTCGC CGGTGTGCCG CAACGACGTC TCCTGGAACT TCGAGAAGTT CCTCGTGGGC 
CCCGACGGCG TCCCCTTCCG CCGCTACAGC CGCCACTTCG AGACCATCAA ACTGCAGGAC 
GACATCGAGC TGCTGCTCCA GAAGGTGCCC AAGGAGGCTC TGCAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Glutathione Peroxidase 1, Selenoprotein K, and Selenoprotein H May Play Important Roles in Chicken Testes in Response to Selenium Deficiency.
Biological trace element research179(2)271-276(2017 Oct)
Gao Y,Zhang J,Huang X,Zhang G

Dietary Selenium Status Regulates the Transcriptions of Selenoproteome and Activities of Selenoenzymes in Chicken Kidney at Low or Super-nutritional Levels.
Biological trace element research170(2)438-48(2016 Apr)
Xu JX,Zhang C,Cao CY,Zhu SY,Li H,Sun YC,Li JL

Effect of selenium sources on the expression of cellular glutathione peroxidase and cytoplasmic thioredoxin reductase in the liver and kidney of broiler breeders and their offspring.
Poultry science91(4)936-42(2012 Apr)
Yuan D,Zhan XA,Wang YX

A comprehensive collection of chicken cDNAs.
Current biology : CB12(22)1965-9(2002 Nov)
Boardman PE,Sanz-Ezquerro J,Overton IM,Burt DW,Bosch E,Fong WT,Tickle C,Brown WR,Wilson SA,Hubbard SJ

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GPX1 cDNA ORF clone, Gallus gallus(chicken)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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