lin-39 cDNA ORF clone, Caenorhabditis elegans

Gene
Clones
gRNAs

Summary

Gene Symbol	lin-39
Entrez Gene ID	176068
Full Name	Homeobox protein lin-39
Gene Type	protein-coding
Organism	Caenorhabditis elegans

mRNA and Protein(s)

mRNA	Protein	Name
NM_001025993.3	NP_001021164.1	Homeobox protein lin-39
NM_001025993.2	NP_001021164.1	Homeobox protein lin-39

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.

Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the HOX protein LIN-39 regulates the vulval precursor cell cycle at two levels. First, LIN-39 acts as a permissive factor by maintaining the expression of the cell cycle machinery in the vulval precursor cells, keeping them competent to proliferate. Second, LIN-39 triggers the lateral NOTCH signaling pathway in the adjacent 2 degrees vulval precursor cells, which over comes the cell cycle inhibition by LIN-31 Forkhead.
Title: The C. elegans hox gene lin-39 controls cell cycle progression during vulval development.

Here we describe a nonautonomous role of mab-5 in regulating both QR and QL descendant migrations, a role masked by redundancy with lin-39 A third Hox gene, egl-5/Abdominal-B, also likely nonautonomously regulates Q descendant migrations.We find that increased levels of MAB-5 in body wall muscle (BWM) can drive the spon-1 promoter adjacent to the Q cells, and
Title: Nonautonomous Roles of MAB-5/Hox and the Secreted Basement Membrane Molecule SPON-1/F-Spondin in Caenorhabditis elegans Neuronal Migration.

Data indicate that the hypodermal fate regulator LIN-26, and the GATA factor ELT-6 positively regulate lin-39 expression in the embryonic precursors to the Vulval Precursor Cells (VPCs).
Title: Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6.

LIN-39 establishes neuroblast anterior polarity by binding to the mig-13 promoter and promoting mig-13 expression, whereas MAB-5 inhibits neuroblast anterior polarity by associating with the lin-39 promoter and downregulating lin-39 and mig-13 expression.
Title: Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.

Data show that the C. elegans hox gene lin-39 regulates epidermal morphogenesis via its novel target, the essential zinc finger protein VAB-23.
Title: LIN-39 and the EGFR/RAS/MAPK pathway regulate C. elegans vulval morphogenesis via the VAB-23 zinc finger protein.

The following lin-39 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the lin-39 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OCa340988	NM_001025993.3 Latest version!	Caenorhabditis elegans Homeobox protein lin-39 (lin-39), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OCa340988	NM_001025993.2	Caenorhabditis elegans Homeobox protein lin-39 (lin-39), partial mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$174.30 $249.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

lin-39 ( NM_001025993.3 ) cDNA ORF clone, Caenorhabditis elegans -> NP_001021164.1 Caenorhabditis elegans Homeobox protein lin-39 (lin-39), mRNA.

Price & Availability↑

CloneID	OCa340988
Clone ID Related Accession (Same CDS sequence)	NM_001025993.3 , NM_001025993.2
Accession Version	NM_001025993.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Caenorhabditis elegans
Product	Homeobox protein lin-39
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Sep 4, 2019 this sequence version replaced NM_001025993.2.

ATGACCACAT CAACATCACC GTCATCCACA GATGCACCGA GAGCTACAGC TCCTGAATCA 
AGCTCTTCGT CTTCATCCTC ATCTTCTTCA TCATCATCCA CATCTTCTGT GGGTGCATCT 
GGAATTCCAT CATCTTCTGA ATTATCGAGT ACAATTGGAT ATGATCCAAT GACAGCGTCT 
GCTGCACTTT CTGCTCATTT TGGAAGTTAT TATGATCCGA CTAGTTCTTC TCAAATTGCT 
TCATATTTTG CCTCAAGTCA AGGACTGGGA GGTCCTCAAT ATCCAATACT CGGAGATCAG 
TCACTATGCT ATAATCCATC AGTAACAAGT ACCCATCACG ACTGGAAGCA CCTGGAAGGA 
GACGATGATG ATGATAAGGA TGATGACAAG AAAGGCATCA GTGGTGATGA CGATGATATG 
GATAAGAATT CAGGCGGTGC AGTGTATCCA TGGATGACAC GTGTTCATTC AACTACAGGA 
GGTTCACGCG GCGAGAAGCG ACAACGAACA GCATACACAA GGAATCAAGT ATTAGAGCTG 
GAAAAGGAAT TTCATACACA CAAATATCTG ACGAGGAAGC GTAGAATTGA AGTAGCTCAT 
TCATTGATGC TTACCGAAAG ACAAGTCAAA ATTTGGTTTC AAAATCGACG AATGAAGCAC 
AAAAAAGAAA ATAAGGATAA ACCAATGACA CCTCCGATGA TGCCATTTGG TGCAAATCTA 
CCATTCGGTC CATTCCGGTT CCCACTTTTC AATCAATTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001021164.1
CDS	61..822
Translation	MTTSTSPSSTDAPRATAPESSSSSSSSSSSSSSTSSVGASGIPSSSELSSTIGYDPMTASAALSAHFGSYYDPTSSSQIASYFASSQGLGGPQYPILGDQSLCYNPSVTSTHHDWKHLEGDDDDDKDDDKKGISGDDDDMDKNSGGAVYPWMTRVHSTTGGSRGEKRQRTAYTRNQVLELEKEFHTHKYLTRKRRIEVAHSLMLTERQVKIWFQNRRMKHKKENKDKPMTPPMMPFGANLPFGPFRFPLFNQF

Target ORF information:

RefSeq Version	NM_001025993.3
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Homeobox protein lin-39 (lin-39), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025993.3

ORF Insert Sequence:

ATGACCACAT CAACATCACC GTCATCCACA GATGCACCGA GAGCTACAGC TCCTGAATCA 
AGCTCTTCGT CTTCATCCTC ATCTTCTTCA TCATCATCCA CATCTTCTGT GGGTGCATCT 
GGAATTCCAT CATCTTCTGA ATTATCGAGT ACAATTGGAT ATGATCCAAT GACAGCGTCT 
GCTGCACTTT CTGCTCATTT TGGAAGTTAT TATGATCCGA CTAGTTCTTC TCAAATTGCT 
TCATATTTTG CCTCAAGTCA AGGACTGGGA GGTCCTCAAT ATCCAATACT CGGAGATCAG 
TCACTATGCT ATAATCCATC AGTAACAAGT ACCCATCACG ACTGGAAGCA CCTGGAAGGA 
GACGATGATG ATGATAAGGA TGATGACAAG AAAGGCATCA GTGGTGATGA CGATGATATG 
GATAAGAATT CAGGCGGTGC AGTGTATCCA TGGATGACAC GTGTTCATTC AACTACAGGA 
GGTTCACGCG GCGAGAAGCG ACAACGAACA GCATACACAA GGAATCAAGT ATTAGAGCTG 
GAAAAGGAAT TTCATACACA CAAATATCTG ACGAGGAAGC GTAGAATTGA AGTAGCTCAT 
TCATTGATGC TTACCGAAAG ACAAGTCAAA ATTTGGTTTC AAAATCGACG AATGAAGCAC 
AAAAAAGAAA ATAAGGATAA ACCAATGACA CCTCCGATGA TGCCATTTGG TGCAAATCTA 
CCATTCGGTC CATTCCGGTT CCCACTTTTC AATCAATTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

lin-39 ( NM_001025993.2 ) cDNA ORF clone, Caenorhabditis elegans -> NP_001021164.1 Caenorhabditis elegans Homeobox protein lin-39 (lin-39), partial mRNA.

Price & Availability↑

CloneID	OCa340988
Clone ID Related Accession (Same CDS sequence)	NM_001025993.3 , NM_001025993.2
Accession Version	NM_001025993.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-08
Organism	Caenorhabditis elegans
Product	Homeobox protein lin-39
Comment	Comment: REVIEWED REFSEQ: This record has been curated by WormBase. This record is derived from an annotated genomic sequence (NC_003281). On Jun 26, 2012 this sequence version replaced NM_001025993.1. COMPLETENESS: incomplete on both ends.

ATGACCACAT CAACATCACC GTCATCCACA GATGCACCGA GAGCTACAGC TCCTGAATCA 
AGCTCTTCGT CTTCATCCTC ATCTTCTTCA TCATCATCCA CATCTTCTGT GGGTGCATCT 
GGAATTCCAT CATCTTCTGA ATTATCGAGT ACAATTGGAT ATGATCCAAT GACAGCGTCT 
GCTGCACTTT CTGCTCATTT TGGAAGTTAT TATGATCCGA CTAGTTCTTC TCAAATTGCT 
TCATATTTTG CCTCAAGTCA AGGACTGGGA GGTCCTCAAT ATCCAATACT CGGAGATCAG 
TCACTATGCT ATAATCCATC AGTAACAAGT ACCCATCACG ACTGGAAGCA CCTGGAAGGA 
GACGATGATG ATGATAAGGA TGATGACAAG AAAGGCATCA GTGGTGATGA CGATGATATG 
GATAAGAATT CAGGCGGTGC AGTGTATCCA TGGATGACAC GTGTTCATTC AACTACAGGA 
GGTTCACGCG GCGAGAAGCG ACAACGAACA GCATACACAA GGAATCAAGT ATTAGAGCTG 
GAAAAGGAAT TTCATACACA CAAATATCTG ACGAGGAAGC GTAGAATTGA AGTAGCTCAT 
TCATTGATGC TTACCGAAAG ACAAGTCAAA ATTTGGTTTC AAAATCGACG AATGAAGCAC 
AAAAAAGAAA ATAAGGATAA ACCAATGACA CCTCCGATGA TGCCATTTGG TGCAAATCTA 
CCATTCGGTC CATTCCGGTT CCCACTTTTC AATCAATTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001021164.1
CDS	1..762
Translation	MTTSTSPSSTDAPRATAPESSSSSSSSSSSSSSTSSVGASGIPSSSELSSTIGYDPMTASAALSAHFGSYYDPTSSSQIASYFASSQGLGGPQYPILGDQSLCYNPSVTSTHHDWKHLEGDDDDDKDDDKKGISGDDDDMDKNSGGAVYPWMTRVHSTTGGSRGEKRQRTAYTRNQVLELEKEFHTHKYLTRKRRIEVAHSLMLTERQVKIWFQNRRMKHKKENKDKPMTPPMMPFGANLPFGPFRFPLFNQF

Target ORF information:

RefSeq Version	NM_001025993.2
Organism	Caenorhabditis elegans
Definition	Caenorhabditis elegans Homeobox protein lin-39 (lin-39), partial mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001025993.2

ORF Insert Sequence:

ATGACCACAT CAACATCACC GTCATCCACA GATGCACCGA GAGCTACAGC TCCTGAATCA 
AGCTCTTCGT CTTCATCCTC ATCTTCTTCA TCATCATCCA CATCTTCTGT GGGTGCATCT 
GGAATTCCAT CATCTTCTGA ATTATCGAGT ACAATTGGAT ATGATCCAAT GACAGCGTCT 
GCTGCACTTT CTGCTCATTT TGGAAGTTAT TATGATCCGA CTAGTTCTTC TCAAATTGCT 
TCATATTTTG CCTCAAGTCA AGGACTGGGA GGTCCTCAAT ATCCAATACT CGGAGATCAG 
TCACTATGCT ATAATCCATC AGTAACAAGT ACCCATCACG ACTGGAAGCA CCTGGAAGGA 
GACGATGATG ATGATAAGGA TGATGACAAG AAAGGCATCA GTGGTGATGA CGATGATATG 
GATAAGAATT CAGGCGGTGC AGTGTATCCA TGGATGACAC GTGTTCATTC AACTACAGGA 
GGTTCACGCG GCGAGAAGCG ACAACGAACA GCATACACAA GGAATCAAGT ATTAGAGCTG 
GAAAAGGAAT TTCATACACA CAAATATCTG ACGAGGAAGC GTAGAATTGA AGTAGCTCAT 
TCATTGATGC TTACCGAAAG ACAAGTCAAA ATTTGGTTTC AAAATCGACG AATGAAGCAC 
AAAAAAGAAA ATAAGGATAA ACCAATGACA CCTCCGATGA TGCCATTTGG TGCAAATCTA 
CCATTCGGTC CATTCCGGTT CCCACTTTTC AATCAATTCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome sequence of the nematode C. elegans: a platform for investigating biology.
Science (New York, N.Y.)282(5396)2012-8(1998 Dec)

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lin-39 cDNA ORF clone, Caenorhabditis elegans

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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