MEP2 cDNA ORF clone, Saccharomyces cerevisiae S288C

The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.
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Nature387(6632 Suppl)93-8(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

X-ray crystal structures are being reported of the Mep2 orthologues from Saccharomyces cerevisiae and Candida albicans showing that under nitrogen-sufficient conditions the transporters are not phosphorylated and present in closed, inactive conformations.
Title: Structural basis for Mep2 ammonium transceptor activation by phosphorylation.

Mep2-like proteins are nutrient sensing transceptors that govern cellular differentiation
Title: A Mep2-dependent transcriptional profile links permease function to gene expression during pseudohyphal growth in Saccharomyces cerevisiae.

The growth impairment of cells lacking Npr1 on many nitrogen sources is shared by cells deprived of the three Mep proteins and is a consequence of deficient ammonium retrieval.
Title: The yeast ammonium transport protein Mep2 and its positive regulator, the Npr1 kinase, play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium.

an ammonium permease MEP2-based sensing mechanism for rapid activation of the protein kinase A pathway
Title: Ammonium permease-based sensing mechanism for rapid ammonium activation of the protein kinase A pathway in yeast.