Gene Symbol | gad8 |
Entrez Gene ID | 2539206 |
Full Name | AGC family protein kinase Gad8 |
Gene Type | protein-coding |
Organism | Schizosaccharomyces pombe(fission yeast) |
ORF » Species Summary » Schizosaccharomyces pombe » gad8 cDNA ORF clone
Gene Symbol | gad8 |
Entrez Gene ID | 2539206 |
Full Name | AGC family protein kinase Gad8 |
Gene Type | protein-coding |
Organism | Schizosaccharomyces pombe(fission yeast) |
mRNA | Protein | Name |
---|---|---|
NM_001023001.2 | NP_588010.1 | AGC family protein kinase Gad8 |
Homo sapiens (human) | SGK2 | NP_057360.2 |
Danio rerio (zebrafish) | sgk2a | NP_001107094.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_06599 | XP_003716929.1 |
SGK2 | XP_001083986.2 | |
Kluyveromyces lactis | KLLA0B12716g | XP_452097.1 |
Mus musculus (house mouse) | Sgk2 | NP_038759.1 |
Gallus gallus (chicken) | SGK2 | XP_004947056.1 |
Saccharomyces cerevisiae (baker's yeast) | YPK2 | NP_013822.1 |
Rattus norvegicus (Norway rat) | Sgk2 | NP_604458.1 |
Eremothecium gossypii | AGOS_ABL028W | NP_982919.2 |
Xenopus tropicalis (tropical clawed frog) | sgk2 | XP_002932914.2 |
Pan troglodytes (chimpanzee) | SGK2 | XP_001142856.2 |
Canis lupus familiaris (dog) | SGK2 | XP_005635135.1 |
Bos taurus (cattle) | SGK2 | NP_001069228.1 |
Saccharomyces cerevisiae (baker's yeast) | YPK1 | NP_012796.1 |
Schizosaccharomyces pombe (fission yeast) | gad8 | NP_588010.1 |
Neurospora crassa | NCU07280 | XP_962134.2 |
The genome sequence of Schizosaccharomyces pombe.
Wood V, Gwilliam R, Rajandream MA, Lyne M, Lyne R, Stewart A, Sgouros J, Peat N, Hayles J, Baker S, Basham D, Bowman S, Brooks K, Brown D, Brown S, Chillingworth T, Churcher C, Collins M, Connor R, Cronin A, Davis P, Feltwell T, Fraser A, Gentles S, Goble A, Hamlin N, Harris D, Hidalgo J, Hodgson G, Holroyd S, Hornsby T, Howarth S, Huckle EJ, Hunt S, Jagels K, James K, Jones L, Jones M, Leather S, McDonald S, McLean J, Mooney P, Moule S, Mungall K, Murphy L, Niblett D, Odell C, Oliver K, O'Neil S, Pearson D, Quail MA, Rabbinowitsch E, Rutherford K, Rutter S, Saunders D, Seeger K, Sharp S, Skelton J, Simmonds M, Squares R, Squares S, Stevens K, Taylor K, Taylor RG, Tivey A, Walsh S, Warren T, Whitehead S, Woodward J, Volckaert G, Aert R, Robben J, Grymonprez B, Weltjens I, Vanstreels E, Rieger M, Sch?fer M, M?ller-Auer S, Gabel C, Fuchs M, D?sterh?ft A, Fritzc C, Holzer E, Moestl D, Hilbert H, Borzym K, Langer I, Beck A, Lehrach H, Reinhardt R, Pohl TM, Eger P, Zimmermann W, Wedler H, Wambutt R, Purnelle B, Goffeau A, Cadieu E, Dr?ano S, Gloux S, Lelaure V, Mottier S, Galibert F, Aves SJ, Xiang Z, Hunt C, Moore K, Hurst SM, Lucas M, Rochet M, Gaillardin C, Tallada VA, Garzon A, Thode G, Daga RR, Cruzado L, Jimenez J, S?nchez M, del Rey F, Benito J, Dom?nguez A, Revuelta JL, Moreno S, Armstrong J, Forsburg SL, Cerutti L, Lowe T, McCombie WR, Paulsen I, Potashkin J, Shpakovski GV, Ussery D, Barrell BG, Nurse P, Cerrutti L
Nature415(6874)871-80(2002 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Increased PKC(Pck2) expression prevented Gad8-TORC2 binding and so reduced the TORC2-mediated phosphorylation of Gad8 serine 546 that activates Gad8.
Title: Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2.
findings highlight the significance of glucose availability in regulation of TORC2-Gad8 and indicate a novel link between the cAMP/PKA, Pmk1/MAPK, and TORC2-Gad8 signaling
Title: Glucose activates TORC2-Gad8 protein via positive regulation of the cAMP/cAMP-dependent protein kinase A (PKA) pathway and negative regulation of the Pmk1 protein-mitogen-activated protein kinase pathway.
The Gad8 kinase (AKT homologue) phosphorylates fission yeast Tor1 at threonine (T1972) to reduce activity.
Title: Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition.
Gad8 positively regulates expression of cyclin-dependent kinase inhibitor gene rum1+, which is essential for cell cycle arrest.
Title: Fission yeast TOR complex 2 activates the AGC-family Gad8 kinase essential for stress resistance and cell cycle control.
The following gad8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the gad8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSc99865 | |
Clone ID Related Accession (Same CDS sequence) | NM_001023001.2 | |
Accession Version | NM_001023001.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1710bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-04-02 | |
Organism | Schizosaccharomyces pombe(fission yeast) | |
Product | AGC family protein kinase Gad8 | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. This record is derived from an annotated genomic sequence (NC_003421). On Dec 10, 2012 this sequence version replaced NM_001023001.1. |
1 | ATGTCCTGGA AACTTACAAA GAAATTAAAA GAAACTCATC TAGCATCCGC TATTGGCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_588010.1 |
CDS | 661..2370 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001023001.2 |
1 | ATGTCCTGGA AACTTACAAA GAAATTAAAA GAAACTCATC TAGCATCCGC TATTGGCCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The genome sequence of Schizosaccharomyces pombe. |