CAD5 cDNA ORF clone, Arabidopsis thaliana(thale cress)

Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.
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Nature402(6763)769-77(1999 Dec)

Data show that disruption of the genes encoding both cinnamyl alcohol dehydrogenases CADC (At3g19450) and CADD (At4g34230) results in the atypical incorporation of hydroxycinnamaldehydes into lignin.
Title: Manipulation of Guaiacyl and Syringyl Monomer Biosynthesis in an Arabidopsis Cinnamyl Alcohol Dehydrogenase Mutant Results in Atypical Lignin Biosynthesis and Modified Cell Wall Structure.

Repressing both the CAD and the CCR activities results in sterility and dwarfism.
Title: The simultaneous repression of CCR and CAD, two enzymes of the lignin biosynthetic pathway, results in sterility and dwarfism in Arabidopsis thaliana.

These results suggest that AtGRP9 may be involved in lignin synthesis in response to salt stress as a result of its interaction with AtCAD5 in A. thaliana.
Title: Root and vascular tissue-specific expression of glycine-rich protein AtGRP9 and its interaction with AtCAD5, a cinnamyl alcohol dehydrogenase, in Arabidopsis thaliana.

determined the crystal structures of AtCAD5 in the apo-form and as a binary complex with NADP+, respectively, and modeled that of AtCAD4. The substrate-binding pockets of both AtCAD5 and AtCAD4 were also examined.
Title: Crystal structures and catalytic mechanism of the Arabidopsis cinnamyl alcohol dehydrogenases AtCAD5 and AtCAD4.