![OSM (227aa), Human OSM (227aa), Human](/product/documents/down?doc_name=Z03068_Activity.jpg&file=scm_files/productFile_notes/2018/04/17/9488055bac2b7fcce8f98ee5807e8a98.jpg)
ED₅₀< 10 ng/mL, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1× 10⁵ units/mg.
OSM (227aa), Human
Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, including IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and share a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor β or LIF Receptor β to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. On the other hand, OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells.
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