selenow1 cDNA ORF clone, Xenopus tropicalis(tropical clawed frog)

Gene
Clones
gRNAs

Summary

Gene Symbol	selenow1
Entrez Gene ID	100485593
Full Name	selenoprotein W1
Synonyms	selenow,selw,selw1,sepw,sepw1
General protein information	Preferred Names selenoprotein W1 Names selenoprotein W1 selenoprotein W selenoprotein W, 1
Gene Type	protein-coding
Organism	Xenopus tropicalis(tropical clawed frog)
Summary	This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is highly expressed in skeletal muscle and brain in mammals. It belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Studies in mouse show that this selenoprotein is involved in muscle growth and differentiation, and in the protection of neurons from oxidative stress during neuronal development. A paralog of this gene is found on chromosome 3 (GeneID:101731107). [provided by RefSeq, Aug 2017].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001304786.1	NP_001291715.2	selenoprotein W1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Composition and evolution of the vertebrate and mammalian selenoproteomes.
Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R, Hatfield DL, Gladyshev VN
PloS one7(3)e33066(2012)

Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species.
Gu QP, Beilstein MA, Vendeland SC, Lugade A, Ream W, Whanger PD
Gene193(2)187-96(1997 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following selenow1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the selenow1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OXa47210	NM_001304786.1 Latest version!	Xenopus tropicalis selenoprotein W1 (selenow1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

selenow1 ( NM_001304786.1 ) cDNA ORF clone, Xenopus tropicalis(tropical clawed frog) -> NP_001291715.2 Xenopus tropicalis selenoprotein W1 (selenow1), mRNA.

Price & Availability↑

CloneID	OXa47210
Clone ID Related Accession (Same CDS sequence)	NM_001304786.1
Accession Version	NM_001304786.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 258bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-21
Organism	Xenopus tropicalis(tropical clawed frog)
Product	selenoprotein W1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL782909.2 and CX803576.1. ##Evidence-Data-START## Transcript exon combination :: BX752099.1, AL803619.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00861992, SAMN00862003 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:9256076) protein contains selenocysteine :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGTGAAAG TTAACGTTGT GTACTGTGGT GCCTGAGGGT ACCTGTCCAA GTTTCGGCGG 
CTGAAGAAGG AACTGGAGCA ACGGTTCCCA GGCAAGCTGA GCATTGATGG CGAAGGAACC 
GAAAGAATGA CTGGATGGTT TGAAGTGAGC ATAAATGGAA AGCTGGTGCA CTCAAAAAAG 
AATGGGGATG GCTATGTGGA TAACGATGCC AAACTGCAGA AAATAATACT GGCTATTGAA 
GCTGCCCTTA AACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291715.2
CDS	129..386
Translation	MVKVNVVYCGA*GYLSKFRRLKKELEQRFPGKLSIDGEGTERMTGWFEVSINGKLVHSKKNGDGYVDNDAKLQKIILAIEAALKQ

Target ORF information:

RefSeq Version	NM_001304786.1
Organism	Xenopus tropicalis(tropical clawed frog)
Definition	Xenopus tropicalis selenoprotein W1 (selenow1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304786.1

ORF Insert Sequence:

ATGGTGAAAG TTAACGTTGT GTACTGTGGT GCCTGAGGGT ACCTGTCCAA GTTTCGGCGG 
CTGAAGAAGG AACTGGAGCA ACGGTTCCCA GGCAAGCTGA GCATTGATGG CGAAGGAACC 
GAAAGAATGA CTGGATGGTT TGAAGTGAGC ATAAATGGAA AGCTGGTGCA CTCAAAAAAG 
AATGGGGATG GCTATGTGGA TAACGATGCC AAACTGCAGA AAATAATACT GGCTATTGAA 
GCTGCCCTTA AACAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Composition and evolution of the vertebrate and mammalian selenoproteomes.
PloS one7(3)e33066(2012)
Mariotti M,Ridge PG,Zhang Y,Lobanov AV,Pringle TH,Guigo R,Hatfield DL,Gladyshev VN

Conserved features of selenocysteine insertion sequence (SECIS) elements in selenoprotein W cDNAs from five species.
Gene193(2)187-96(1997 Jul)
Gu QP,Beilstein MA,Vendeland SC,Lugade A,Ream W,Whanger PD

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selenow1 cDNA ORF clone, Xenopus tropicalis(tropical clawed frog)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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