bmp1.S cDNA ORF clone, Xenopus laevis(African clawed frog)

Gene
Clones
gRNAs

Summary

Gene Symbol	bmp1.S
Entrez Gene ID	399093
Full Name	bone morphogenetic protein 1 S homeolog
Synonyms	BMP-1,bmp1,bmp1-a,bmp1-b,bmp1.L,bmp1a,tld,tolloid,xbmp1,xtld
General protein information	Preferred Names bone morphogenetic protein 1 S homeolog Names bone morphogenetic protein 1 bone morphogenetic protein 1 L homeolog bone morphogenetic protein 1a
Gene Type	protein-coding
Organism	Xenopus laevis(African clawed frog)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001090275.2	NP_001083744.2	bone morphogenetic protein 1 precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases.
Bijakowski C, Vadon-Le Goff S, Delolme F, Bourhis JM, L?corch? P, Ruggiero F, Becker-Pauly C, Yiallouros I, St?cker W, Dive V, Hulmes DJ, Moali C
The Journal of biological chemistry287(40)33581-93(2012 Sep)

Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases.
Ploper D, Lee HX, De Robertis EM
Developmental biology352(2)317-28(2011 Apr)

Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation.
Inomata H, Haraguchi T, Sasai Y
Cell134(5)854-65(2008 Sep)

Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Klein SL, Strausberg RL, Wagner L, Pontius J, Clifton SW, Richardson P
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)

Is chordin a long-range- or short-range-acting factor? Roles for BMP1-related metalloproteases in chordin and BMP4 autofeedback loop regulation.
Blitz IL, Shimmi O, W?nnenberg-Stapleton K, O'Connor MB, Cho KW
Developmental biology223(1)120-38(2000 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases
Title: Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases.

Crescent is a new component of the dorsal-ventral patterning pathway, which functions as the dorsal counterpart of Sizzled, through the regulation of chordinases of the Tolloid family.
Title: Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases.

The following bmp1.S gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the bmp1.S cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OAf49132	NM_001090275.2 Latest version!	Xenopus laevis bone morphogenetic protein 1 S homeolog (bmp1.S), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$510.30 $729.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

bmp1.S ( NM_001090275.2 ) cDNA ORF clone, Xenopus laevis(African clawed frog) -> NP_001083744.2 Xenopus laevis bone morphogenetic protein 1 S homeolog (bmp1.S), mRNA.

Price & Availability↑

CloneID	OAf49132
Clone ID Related Accession (Same CDS sequence)	NM_001090275.2
Accession Version	NM_001090275.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2934bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-25
Organism	Xenopus laevis(African clawed frog)
Product	bone morphogenetic protein 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from D83476.1 and BC170427.1. On Apr 7, 2017 this sequence version replaced NM_001090275.1. ##Evidence-Data-START## Transcript exon combination :: D83476.1, BC170427.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00012418, SAMD00012419 [ECO:0000350] ##Evidence-Data-END##

ATGCCCTGGT TAGGCAGCCT CCCTTTACTC CTCTGCTGGG CATTGCTTGC AGGGATGCTC 
CATCTGGGAC AGGGGCAGGT ATTCATGGAC TATTCCTATG ATCTGGAGGA AGTAGTGGAA 
GAAACCATAG ATTACAAAGA CCCCTGCAAA GCTGCTGCAT TCTGGGGGGA CATTGCTCTG 
GATGAGGAAG ACTTGGCAAA CTTTAAAATT GACCGAATAG TAGATTTAAC AAAGCACACA 
ATACATACAG TCTCAGGTGC TGCAACCAAC ATCTCCAGGC CAGAGAAAGG CAGACGCACA 
CGGAAGGAAA GACGGCGCTC TCGAGAAAAG AGAGCCTCAA CATCCCGGCC TGAGAGGGTT 
TGGCCAGATG GCGTCATTCC TTATGTAATA AGTGGAAATT TTAGTGGCAG TCAGAGGGCA 
ATATTCCGGC AAGCAATGCG CCACTGGGAG AAGCACACGT GCGTCACTTT CCTGGAAAGG 
ACGGATGAGG ACAGTTATAT TGTTTTTACA TACAGACCAT GCGGATGCTG CTCTTATGTG 
GGCCGACGTG GTGGAGGCCC ACAAGCCATA TCAATTGGCA AAAACTGTGA CAAATTTGGC 
ATTGTTGTTC ATGAGTTGGG TCATGTGATA GGATTCTGGC ATGAACACAC CAGGCCCGAC 
CGGGACGATC ATGTGTCGAT CATCAGAGAG AATATTCAAC CGGGACAGGA GTATAACTTC 
TTGAAAATGG AGCCAGAAGA GGTTGAGTCC CTTGGGGAAA CATATGATTT TGACAGCATT 
ATGCACTACG CACGCAACAC CTTTTCCAGA GGGATTTTCC TGGACACCAT CCTTCCCAAA 
TATGATGTGA ATGGCGTGAG ACCTCCAATT GGCCAGAGAA CGCGGTTAAG TTCTGGAGAC 
GTTGCACAAG CCAGGAAGCT GTACAAGTGT CCAGCTTGCG GGGAGACTCT CCAAGACAGC 
CAGGGTAACT TCTCATCTCC TGGCTTCCCC AATGGATACT CTGCGTACAT GCATTGTGTT 
TGGCGACTGT CAGTCACTCC CGGGGAAAAG ATTATACTGA ACTTTACCTC TTTGGATCTG 
TACCGCAGCC GCCTCTGCTG GTATGACTAC ATTGAAGTCA GAGATGGTTT CTGGAAAAAG 
GCCCCACTCC GAGGGCGATT CTGCGGAGAC AAGATACCAG AGTCCATCAT ATCCACAGAG 
AGCCGTCTGT GGATTGAGTT CCGGAGCAGC AGCAACTGGG TGGGAAAAGG ATTCCAAGCA 
GTATATGAAG CACTGTGTGG TGGAGAAGTA AAGAAAGACT CTGGTCATAT CCAGTCCCCC 
AATTACCCTG ATGATTACAG ACCCAACAAG GCCTGTGTAT GGAAGCTCAG CGTGTCTGAA 
GGGTTCCATG TCGGAATCTC ATTCCAGTCC TTTGAGATTG AACGGCATGA CAGTTGCGCG 
TATGATTATC TGGAGATCCG AGATGGCAGC TCAGAAACTA GCCCGCTGGT TGGCCGTTTC 
TGTGGTTATG ACAAACCAGA TGACATTAAA AGCTCAACAA ACCAGCTATG GATTAAATTT 
GTATCTGATG GTTCAATCAA CAAGGCTGGC TTCTCACTTA ACTACTTCAA AGAGGTAGAT 
GAATGTTCCC GCCCTAATAA TGGAGGATGT GAGCAGCGTT GTGTAAACAC TCTGGGCAGC 
TACAAGTGTG CCTGTGATCC AGGATATGAA CTGGGACAGG ACAAGAAGTC CTGTGAAGCT 
GCCTGTGGTG GCTTCCTGAC CAAACTAAAT GGCTCAATCA ACAGCCCAGG ATGGCCCAAA 
GAGTATCCTC CAAACAAAAA CTGTATCTGG CAGCTGGTGG CCCCAACCCA GTATCGCATC 
TCACTCAAGT TTGATCAGTT TGAGACAGAA GGCAATGATG TGTGCAAATA TGATTTTGTG 
GAGGTTCGCA GTGGCCTAAC TTCAGACTCC AAACTGCACG GGAAGTTCTG TGGCTCTGAG 
CTCCCGGCGG TGATCACCTC CCAGTACAAT AACATGCGCA TTGAGTTCAA ATCTGATAAC 
ACTGTGTCTA AGAAAGGTTT CCAAGCAAAT TTCTTCTCAG ATAAGGACGA ATGTTCCCAG 
GATAATGGGG GCTGTCAGCA CGAGTGCACA AACACACTGG GAAGCTATAT CTGCCAATGT 
CGAAGTGGTT TTACCCTGCA CGAAAACAAG CATGACTGCA AGGAGGCTGG TTGTGACCAT 
AAAATGACGA GCAGCACTGG GACCATCTCG AGCCCTAACT GGCCAGATAA GTACCCAAGC 
AAGAAGATTT GCACTTGGCA AATTACAGCC ACGCCAGGCC ATCGTGTCAA ACTGACTGTG 
TCTGAAGTGG ACCTGGAGTC CCACCAAGAG TGTCTGTATG ACCACGTGGA GGTTTATACA 
GGGCGTAATG CACAGTCTCC CGTACTCACT CGCTTCTGTG GCAGTAAGAT TCCAGATCCC 
ATTATTTCTC CTGGCAACAC CATGTTCCTG AAGTTTATGT CTGACAACTC CGTGCAGAAG 
AGAGGCTTCC TAGGAGAGCT ATCATCAGTT TGTGGCGGCA CTCTTCATGC AGAAGTCCGT 
ACTCAGGATC TTTACTCCCA CGCCAAGTTA GGGGATGACA CACACCCTTC TGGCACAGAG 
TGTTTGTGGC ACATTGTGTC GGAGGCTGGT TATGGTGTGG AGCTGGTCTT CCAGAGCTTT 
GAGTTAGAAG AAGAACCAGA CTGCGGATAT GACTACATGG AATTGTATGA TGGTCCAGAT 
GAAGCAGCCC CTCGTCTGGG GAGGTTCTGT GGGTCAGGGC CCCCCGAGGA GGTGTACTCT 
GCTGGTGATG CATTGACGAT CAAGTTCCAC TCAGATGATA CAATCAATAA GAAGGGATTC 
CACGTTCGAT ATACCAGCAC CAAATTCCAG GACACTCTGC ACGCCCGCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001083744.2
CDS	114..3047
Translation	MPWLGSLPLLLCWALLAGMLHLGQGQVFMDYSYDLEEVVEETIDYKDPCKAAAFWGDIALDEEDLANFKIDRIVDLTKHTIHTVSGAATNISRPEKGRRTRKERRRSREKRASTSRPERVWPDGVIPYVISGNFSGSQRAIFRQAMRHWEKHTCVTFLERTDEDSYIVFTYRPCGCCSYVGRRGGGPQAISIGKNCDKFGIVVHELGHVIGFWHEHTRPDRDDHVSIIRENIQPGQEYNFLKMEPEEVESLGETYDFDSIMHYARNTFSRGIFLDTILPKYDVNGVRPPIGQRTRLSSGDVAQARKLYKCPACGETLQDSQGNFSSPGFPNGYSAYMHCVWRLSVTPGEKIILNFTSLDLYRSRLCWYDYIEVRDGFWKKAPLRGRFCGDKIPESIISTESRLWIEFRSSSNWVGKGFQAVYEALCGGEVKKDSGHIQSPNYPDDYRPNKACVWKLSVSEGFHVGISFQSFEIERHDSCAYDYLEIRDGSSETSPLVGRFCGYDKPDDIKSSTNQLWIKFVSDGSINKAGFSLNYFKEVDECSRPNNGGCEQRCVNTLGSYKCACDPGYELGQDKKSCEAACGGFLTKLNGSINSPGWPKEYPPNKNCIWQLVAPTQYRISLKFDQFETEGNDVCKYDFVEVRSGLTSDSKLHGKFCGSELPAVITSQYNNMRIEFKSDNTVSKKGFQANFFSDKDECSQDNGGCQHECTNTLGSYICQCRSGFTLHENKHDCKEAGCDHKMTSSTGTISSPNWPDKYPSKKICTWQITATPGHRVKLTVSEVDLESHQECLYDHVEVYTGRNAQSPVLTRFCGSKIPDPIISPGNTMFLKFMSDNSVQKRGFLGELSSVCGGTLHAEVRTQDLYSHAKLGDDTHPSGTECLWHIVSEAGYGVELVFQSFELEEEPDCGYDYMELYDGPDEAAPRLGRFCGSGPPEEVYSAGDALTIKFHSDDTINKKGFHVRYTSTKFQDTLHARK

Target ORF information:

RefSeq Version	NM_001090275.2
Organism	Xenopus laevis(African clawed frog)
Definition	Xenopus laevis bone morphogenetic protein 1 S homeolog (bmp1.S), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001090275.2

ORF Insert Sequence:

ATGCCCTGGT TAGGCAGCCT CCCTTTACTC CTCTGCTGGG CATTGCTTGC AGGGATGCTC 
CATCTGGGAC AGGGGCAGGT ATTCATGGAC TATTCCTATG ATCTGGAGGA AGTAGTGGAA 
GAAACCATAG ATTACAAAGA CCCCTGCAAA GCTGCTGCAT TCTGGGGGGA CATTGCTCTG 
GATGAGGAAG ACTTGGCAAA CTTTAAAATT GACCGAATAG TAGATTTAAC AAAGCACACA 
ATACATACAG TCTCAGGTGC TGCAACCAAC ATCTCCAGGC CAGAGAAAGG CAGACGCACA 
CGGAAGGAAA GACGGCGCTC TCGAGAAAAG AGAGCCTCAA CATCCCGGCC TGAGAGGGTT 
TGGCCAGATG GCGTCATTCC TTATGTAATA AGTGGAAATT TTAGTGGCAG TCAGAGGGCA 
ATATTCCGGC AAGCAATGCG CCACTGGGAG AAGCACACGT GCGTCACTTT CCTGGAAAGG 
ACGGATGAGG ACAGTTATAT TGTTTTTACA TACAGACCAT GCGGATGCTG CTCTTATGTG 
GGCCGACGTG GTGGAGGCCC ACAAGCCATA TCAATTGGCA AAAACTGTGA CAAATTTGGC 
ATTGTTGTTC ATGAGTTGGG TCATGTGATA GGATTCTGGC ATGAACACAC CAGGCCCGAC 
CGGGACGATC ATGTGTCGAT CATCAGAGAG AATATTCAAC CGGGACAGGA GTATAACTTC 
TTGAAAATGG AGCCAGAAGA GGTTGAGTCC CTTGGGGAAA CATATGATTT TGACAGCATT 
ATGCACTACG CACGCAACAC CTTTTCCAGA GGGATTTTCC TGGACACCAT CCTTCCCAAA 
TATGATGTGA ATGGCGTGAG ACCTCCAATT GGCCAGAGAA CGCGGTTAAG TTCTGGAGAC 
GTTGCACAAG CCAGGAAGCT GTACAAGTGT CCAGCTTGCG GGGAGACTCT CCAAGACAGC 
CAGGGTAACT TCTCATCTCC TGGCTTCCCC AATGGATACT CTGCGTACAT GCATTGTGTT 
TGGCGACTGT CAGTCACTCC CGGGGAAAAG ATTATACTGA ACTTTACCTC TTTGGATCTG 
TACCGCAGCC GCCTCTGCTG GTATGACTAC ATTGAAGTCA GAGATGGTTT CTGGAAAAAG 
GCCCCACTCC GAGGGCGATT CTGCGGAGAC AAGATACCAG AGTCCATCAT ATCCACAGAG 
AGCCGTCTGT GGATTGAGTT CCGGAGCAGC AGCAACTGGG TGGGAAAAGG ATTCCAAGCA 
GTATATGAAG CACTGTGTGG TGGAGAAGTA AAGAAAGACT CTGGTCATAT CCAGTCCCCC 
AATTACCCTG ATGATTACAG ACCCAACAAG GCCTGTGTAT GGAAGCTCAG CGTGTCTGAA 
GGGTTCCATG TCGGAATCTC ATTCCAGTCC TTTGAGATTG AACGGCATGA CAGTTGCGCG 
TATGATTATC TGGAGATCCG AGATGGCAGC TCAGAAACTA GCCCGCTGGT TGGCCGTTTC 
TGTGGTTATG ACAAACCAGA TGACATTAAA AGCTCAACAA ACCAGCTATG GATTAAATTT 
GTATCTGATG GTTCAATCAA CAAGGCTGGC TTCTCACTTA ACTACTTCAA AGAGGTAGAT 
GAATGTTCCC GCCCTAATAA TGGAGGATGT GAGCAGCGTT GTGTAAACAC TCTGGGCAGC 
TACAAGTGTG CCTGTGATCC AGGATATGAA CTGGGACAGG ACAAGAAGTC CTGTGAAGCT 
GCCTGTGGTG GCTTCCTGAC CAAACTAAAT GGCTCAATCA ACAGCCCAGG ATGGCCCAAA 
GAGTATCCTC CAAACAAAAA CTGTATCTGG CAGCTGGTGG CCCCAACCCA GTATCGCATC 
TCACTCAAGT TTGATCAGTT TGAGACAGAA GGCAATGATG TGTGCAAATA TGATTTTGTG 
GAGGTTCGCA GTGGCCTAAC TTCAGACTCC AAACTGCACG GGAAGTTCTG TGGCTCTGAG 
CTCCCGGCGG TGATCACCTC CCAGTACAAT AACATGCGCA TTGAGTTCAA ATCTGATAAC 
ACTGTGTCTA AGAAAGGTTT CCAAGCAAAT TTCTTCTCAG ATAAGGACGA ATGTTCCCAG 
GATAATGGGG GCTGTCAGCA CGAGTGCACA AACACACTGG GAAGCTATAT CTGCCAATGT 
CGAAGTGGTT TTACCCTGCA CGAAAACAAG CATGACTGCA AGGAGGCTGG TTGTGACCAT 
AAAATGACGA GCAGCACTGG GACCATCTCG AGCCCTAACT GGCCAGATAA GTACCCAAGC 
AAGAAGATTT GCACTTGGCA AATTACAGCC ACGCCAGGCC ATCGTGTCAA ACTGACTGTG 
TCTGAAGTGG ACCTGGAGTC CCACCAAGAG TGTCTGTATG ACCACGTGGA GGTTTATACA 
GGGCGTAATG CACAGTCTCC CGTACTCACT CGCTTCTGTG GCAGTAAGAT TCCAGATCCC 
ATTATTTCTC CTGGCAACAC CATGTTCCTG AAGTTTATGT CTGACAACTC CGTGCAGAAG 
AGAGGCTTCC TAGGAGAGCT ATCATCAGTT TGTGGCGGCA CTCTTCATGC AGAAGTCCGT 
ACTCAGGATC TTTACTCCCA CGCCAAGTTA GGGGATGACA CACACCCTTC TGGCACAGAG 
TGTTTGTGGC ACATTGTGTC GGAGGCTGGT TATGGTGTGG AGCTGGTCTT CCAGAGCTTT 
GAGTTAGAAG AAGAACCAGA CTGCGGATAT GACTACATGG AATTGTATGA TGGTCCAGAT 
GAAGCAGCCC CTCGTCTGGG GAGGTTCTGT GGGTCAGGGC CCCCCGAGGA GGTGTACTCT 
GCTGGTGATG CATTGACGAT CAAGTTCCAC TCAGATGATA CAATCAATAA GAAGGGATTC 
CACGTTCGAT ATACCAGCAC CAAATTCCAG GACACTCTGC ACGCCCGCAA GTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Sizzled is unique among secreted frizzled-related proteins for its ability to specifically inhibit bone morphogenetic protein-1 (BMP-1)/tolloid-like proteinases.
The Journal of biological chemistry287(40)33581-93(2012 Sep)
Bijakowski C,Vadon-Le Goff S,Delolme F,Bourhis JM,L?corch? P,Ruggiero F,Becker-Pauly C,Yiallouros I,St?cker W,Dive V,Hulmes DJ,Moali C

Dorsal-ventral patterning: Crescent is a dorsally secreted Frizzled-related protein that competitively inhibits Tolloid proteases.
Developmental biology352(2)317-28(2011 Apr)
Ploper D,Lee HX,De Robertis EM

Robust stability of the embryonic axial pattern requires a secreted scaffold for chordin degradation.
Cell134(5)854-65(2008 Sep)
Inomata H,Haraguchi T,Sasai Y

Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative.
Developmental dynamics : an official publication of the American Association of Anatomists225(4)384-91(2002 Dec)
Klein SL,Strausberg RL,Wagner L,Pontius J,Clifton SW,Richardson P

Is chordin a long-range- or short-range-acting factor? Roles for BMP1-related metalloproteases in chordin and BMP4 autofeedback loop regulation.
Developmental biology223(1)120-38(2000 Jul)
Blitz IL,Shimmi O,W?nnenberg-Stapleton K,O'Connor MB,Cho KW