| Gene Symbol | INSL3 |
| Entrez Gene ID | 397024 |
| Full Name | insulin like 3 |
| Synonyms | BLEYI-L,LEY I-L |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| Genome |
ORF » Species Summary » Sus scrofa » INSL3 cDNA ORF clone
| Gene Symbol | INSL3 |
| Entrez Gene ID | 397024 |
| Full Name | insulin like 3 |
| Synonyms | BLEYI-L,LEY I-L |
| Gene Type | protein-coding |
| Organism | Sus scrofa(pig) |
| Genome |
| mRNA | Protein | Name |
|---|---|---|
| NM_213970.1 | NP_999135.1 | insulin-like 3 precursor |
The Male Fetal Biomarker INSL3 Reveals Substantial Hormone Exchange between Fetuses in Early Pig Gestation.
Vernunft A, Ivell R, Heng K, Anand-Ivell R
PloS one11(3)e0152689(2016)
The insulin-like factor 3 (INSL3)-receptor (RXFP2) network functions as a germ cell survival/anti-apoptotic factor in boar testes.
Sagata D, Minagawa I, Kohriki H, Pitia AM, Uera N, Katakura Y, Sukigara H, Terada K, Shibata M, Park EY, Hasegawa Y, Sasada H, Kohsaka T
Endocrinology156(4)1523-39(2015 Apr)
Dynamics of insulin-like factor 3 and its receptor expression in boar testes.
Minagawa I, Sagata D, Pitia AM, Kohriki H, Shibata M, Sasada H, Hasegawa Y, Kohsaka T
The Journal of endocrinology220(3)247-61(2014 Mar)
Expression and localization of RLF/ INSL3 receptor RXFP2 in boar testes.
Kohsaka T, Sagata D, Minagawa I, Kohriki H, Pitia AM, Sugii Y, Morimoto M, Uera N, Shibata M, Sasada H, Hasegawa Y
Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia118(1 Suppl)23-5(2013)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This study thus provides evidence for substantial transfer of INSL3 between fetuses, and probably also across the placenta, emphasizing the vulnerability of the fetus to extrinsic hormonal influences within the uterus.
Title: The Male Fetal Biomarker INSL3 Reveals Substantial Hormone Exchange between Fetuses in Early Pig Gestation.
RXFP2 was expressed in boar meiotic and post-meiotic germ cells, where INSL3 neutralization led to increased germ cell apoptosis and reduced sperm output, suggesting that INSL3 acts as a survival/anti-apoptotic factor in maintaining sperm production.
Title: The insulin-like factor 3 (INSL3)-receptor (RXFP2) network functions as a germ cell survival/anti-apoptotic factor in boar testes.
Circulating INSL3 was shown to increase progressively during development
Title: Dynamics of insulin-like factor 3 and its receptor expression in boar testes.
The study suggests the existence of RLF/INSL3-RXFP2 signaling in germ cells of boars.
Title: Expression and localization of RLF/ INSL3 receptor RXFP2 in boar testes.
These results indicate that boar RLF/INSL3 is secreted from testicular Leydig cells as a B-C-A monomeric structure with full biological activity.
Title: Relaxin-like factor (RLF)/insulin-like peptide 3 (INSL3) is secreted from testicular Leydig cells as a monomeric protein comprising three domains B-C-A with full biological activity in boars.
The following INSL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the INSL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OSe00685 | |
| Clone ID Related Accession (Same CDS sequence) | NM_213970.1 | |
| Accession Version | NM_213970.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-19 | |
| Organism | Sus scrofa(pig) | |
| Product | insulin-like 3 precursor | |
| Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from X68369.1. ##Evidence-Data-START## Transcript exon combination :: X68369.1, FS687090.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01915391, SAMN01915392 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGACCCCC ACCCGCTCAC CTGGGCTCTA GTGCTGCTGG GCCCGGCCCT GGCACTCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_999135.1 |
| CDS | 6..401 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_213970.1 |
1 | ATGGACCCCC ACCCGCTCAC CTGGGCTCTA GTGCTGCTGG GCCCGGCCCT GGCACTCTCC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The Male Fetal Biomarker INSL3 Reveals Substantial Hormone Exchange between Fetuses in Early Pig Gestation. |
The insulin-like factor 3 (INSL3)-receptor (RXFP2) network functions as a germ cell survival/anti-apoptotic factor in boar testes. |
Dynamics of insulin-like factor 3 and its receptor expression in boar testes. |
Expression and localization of RLF/ INSL3 receptor RXFP2 in boar testes. |