GH1 cDNA ORF clone, Sus scrofa(pig)

Gene
Clones
gRNAs

Summary

Gene Symbol	GH1
Entrez Gene ID	396884
Full Name	growth hormone 1
Synonyms	GH,pGH
Gene Type	protein-coding
Organism	Sus scrofa(pig)
Genome	Chromosome: 12 Map Location: 12\|12p14

mRNA and Protein(s)

mRNA	Protein	Name
NM_213869.1	NP_999034.2	somatotropin precursor

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Missense mutations in the signal peptide of the porcine GH gene affect cellular synthesis and secretion.
Cheng Y, Liu S, Lu C, Wu Q, Li S, Fu H, Wang G, Lv C, Nie L, Zhang Y, Yu H, Hao L
Pituitary19(4)362-9(2016 Aug)

Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation.
Nieves-Martinez E, Sonntag WE, Wilson A, Donahue A, Molina DP, Brunso-Bechtold J, Nicolle MM
The Journal of endocrinology204(1)31-6(2010 Jan)

Effect of feeding allowance level on embryonic survival, IGF-1, insulin, GH, leptin and progesterone secretion in early pregnancy gilts.
De W, Ai-rong Z, Yan L, Sheng-yu X, Hai-yan G, Yong Z
Journal of animal physiology and animal nutrition93(5)577-85(2009 Oct)

Local feedback loop of ghrelin-GH in the pig ovary: action on estradiol secretion, aromatase activity and cell apoptosis.
Rak A, Gregoraszczuk E?
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society18(3)221-7(2008 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Missense mutations within the signal sequence influence the expression and the secretion of GH.
Title: Missense mutations in the signal peptide of the porcine GH gene affect cellular synthesis and secretion.

GH deficiency during adolescence has negative effects on learning and memory that emerge by middle-age unless prevented by GH supplementation.
Title: Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation.

These data demonstrated that feed allowance level has important consequence on embryo survival, embryo development and uterine development, possibly mediated by changes in concentrations of reproductive hormones.
Title: Effect of feeding allowance level on embryonic survival, IGF-1, insulin, GH, leptin and progesterone secretion in early pregnancy gilts.

ghrelin increased growth hormone secretion but not growth hormone synthesis by ovarian follicles
Title: Local feedback loop of ghrelin-GH in the pig ovary: action on estradiol secretion, aromatase activity and cell apoptosis.

Data indicate that the dual effects of cortistatin on growth hormone release parallel those of somatostatin and are probably mediated by the same receptor(s) and signaling pathway(s) for both peptides.
Title: Cortistatin mimics somatostatin by inducing a dual, dose-dependent stimulatory and inhibitory effect on growth hormone secretion in somatotropes.

The following GH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSe00676	NM_213869.1 Latest version!	Sus scrofa growth hormone 1 (GH1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$174.30 $249.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GH1 ( NM_213869.1 ) cDNA ORF clone, Sus scrofa(pig) -> NP_999034.2 Sus scrofa growth hormone 1 (GH1), mRNA.

Price & Availability↑

CloneID	OSe00676
Clone ID Related Accession (Same CDS sequence)	NM_213869.1
Accession Version	NM_213869.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 651bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Sus scrofa(pig)
Product	somatotropin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from U19787.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U19787.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN02389758, SAMN02389759 [ECO:0000348] ##Evidence-Data-END##

ATGGCTGCAG GCCCTCGGAC CTCCGTGCTC CTGGCTTTCG CCCTGCTCTG CCTGCCCTGG 
ACTCAGGAGG TGGGCGCCTT GGGAGCCATG CCCTTGTCCA GCCTATTTGC CAACGCCGTG 
CTCCGGGCCC AGCACCTGCA CCAACTGGCT GCCGACACCT ACAAGGAGTT TGACCGCCCC 
TACATCCCGG AGGGACAGAG GTACTCCATC CAGAACGCCC AGGCTGCCTT CTGCTTCTCG 
GAGACCATCC CGGCCCCCAC GGGCAAGGAC GAGGCCCAGC AGAGATCGGA CGTGGAGCTG 
CTGCGCTTCT CGCTGCTGCT CATCCAGTCG TGGCTCGGGC CCGTGCAGTT CCTCAGCAGG 
GTCTTCACCA ACAGCCTGGT GTTTGGCACC TCAGACCGCG TGTACGAGAA GCTGAAGGAC 
CTGGAGGAGG GCATCCAGGC CCTGATGCGG GAGCTGGAGG ATGGCAGCCC CCGGGCAGGA 
CAGATCCTCA AGCAAACCTA CGACAAATTT GACACAAACT TGCGCAGTGA TGACGCGCTG 
CTTAAGAACT ACGGGCTGCT CTCCTGCTTC AAGAAGGACC TGCACAAGGC TGAGACATAC 
CTGCGGGCTA TGAAGTGTCG CCGCTTCGTG GAGAGCAGCT GTGCCTTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_999034.2
CDS	128..778
Translation	MAAGPRTSVLLAFALLCLPWTQEVGALGAMPLSSLFANAVLRAQHLHQLAADTYKEFDRPYIPEGQRYSIQNAQAAFCFSETIPAPTGKDEAQQRSDVELLRFSLLLIQSWLGPVQFLSRVFTNSLVFGTSDRVYEKLKDLEEGIQALMRELEDGSPRAGQILKQTYDKFDTNLRSDDALLKNYGLLSCFKKDLHKAETYLRAMKCRRFVESSCAF

Target ORF information:

RefSeq Version	NM_213869.1
Organism	Sus scrofa(pig)
Definition	Sus scrofa growth hormone 1 (GH1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_213869.1

ORF Insert Sequence:

ATGGCTGCAG GCCCTCGGAC CTCCGTGCTC CTGGCTTTCG CCCTGCTCTG CCTGCCCTGG 
ACTCAGGAGG TGGGCGCCTT GGGAGCCATG CCCTTGTCCA GCCTATTTGC CAACGCCGTG 
CTCCGGGCCC AGCACCTGCA CCAACTGGCT GCCGACACCT ACAAGGAGTT TGACCGCCCC 
TACATCCCGG AGGGACAGAG GTACTCCATC CAGAACGCCC AGGCTGCCTT CTGCTTCTCG 
GAGACCATCC CGGCCCCCAC GGGCAAGGAC GAGGCCCAGC AGAGATCGGA CGTGGAGCTG 
CTGCGCTTCT CGCTGCTGCT CATCCAGTCG TGGCTCGGGC CCGTGCAGTT CCTCAGCAGG 
GTCTTCACCA ACAGCCTGGT GTTTGGCACC TCAGACCGCG TGTACGAGAA GCTGAAGGAC 
CTGGAGGAGG GCATCCAGGC CCTGATGCGG GAGCTGGAGG ATGGCAGCCC CCGGGCAGGA 
CAGATCCTCA AGCAAACCTA CGACAAATTT GACACAAACT TGCGCAGTGA TGACGCGCTG 
CTTAAGAACT ACGGGCTGCT CTCCTGCTTC AAGAAGGACC TGCACAAGGC TGAGACATAC 
CTGCGGGCTA TGAAGTGTCG CCGCTTCGTG GAGAGCAGCT GTGCCTTCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Missense mutations in the signal peptide of the porcine GH gene affect cellular synthesis and secretion.
Pituitary19(4)362-9(2016 Aug)
Cheng Y,Liu S,Lu C,Wu Q,Li S,Fu H,Wang G,Lv C,Nie L,Zhang Y,Yu H,Hao L

Early-onset GH deficiency results in spatial memory impairment in mid-life and is prevented by GH supplementation.
The Journal of endocrinology204(1)31-6(2010 Jan)
Nieves-Martinez E,Sonntag WE,Wilson A,Donahue A,Molina DP,Brunso-Bechtold J,Nicolle MM

Effect of feeding allowance level on embryonic survival, IGF-1, insulin, GH, leptin and progesterone secretion in early pregnancy gilts.
Journal of animal physiology and animal nutrition93(5)577-85(2009 Oct)
De W,Ai-rong Z,Yan L,Sheng-yu X,Hai-yan G,Yong Z

Local feedback loop of ghrelin-GH in the pig ovary: action on estradiol secretion, aromatase activity and cell apoptosis.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society18(3)221-7(2008 Jun)
Rak A,Gregoraszczuk E?