OAZ2 cDNA ORF clone, Sus scrofa(pig)

Gene
Clones
gRNAs

Summary

Gene Symbol	OAZ2
Entrez Gene ID	100144447
Full Name	ornithine decarboxylase antizyme 2
Gene Type	protein-coding
Organism	Sus scrofa(pig)
Summary	The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamine in cells. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis pathway; thus, completing the auto-regulatory circuit. This gene encodes antizyme 2, the second member of the antizyme family. Like antizyme 1, antizyme 2 has broad tissue distribution, inhibits ODC activity and polyamine uptake, and stimulates ODC degradation in vivo, however, it fails to promote ODC degradation in vitro. Antizyme 2 is expressed at lower levels than antizyme 1, but is evolutionary more conserved, suggesting it likely has an important biological role. Studies also show different subcellular localization of antizymes 1 and 2, indicating specific function for each antizyme in discrete compartments of the cell. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2014].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001301326.1	NP_001288255.1	ornithine decarboxylase antizyme 2 isoform 2
NM_001122995.2	NP_001116467.1	ornithine decarboxylase antizyme 2 isoform 1

Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Ivanov IP, Atkins JF
Nucleic acids research35(6)1842-58(2007)

PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences.
Uenishi H, Eguchi-Ogawa T, Shinkai H, Okumura N, Suzuki K, Toki D, Hamasima N, Awata T
Nucleic acids research35(Database issue)D650-3(2007 Jan)

PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries.
Uenishi H, Eguchi T, Suzuki K, Sawazaki T, Toki D, Shinkai H, Okumura N, Hamasima N, Awata T
Nucleic acids research32(Database issue)D484-8(2004 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following OAZ2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OAZ2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OSe101267	NM_001122995.2 Latest version!	Sus scrofa ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00
OSe101268	NM_001301326.1 Latest version!	Sus scrofa ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$104.30 $149.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OAZ2 ( NM_001122995.2 ) cDNA ORF clone, Sus scrofa(pig) -> NP_001116467.1 Sus scrofa ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OSe101267
Clone ID Related Accession (Same CDS sequence)	NM_001122995.2
Accession Version	NM_001122995.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-03-08
Organism	Sus scrofa(pig)
Product	ornithine decarboxylase antizyme 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP172930.1 and DR082583.1. On Aug 5, 2014 this sequence version replaced NM_001122995.1. Transcript Variant: This variant (1) encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BP172930.1, AK392493.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1487420, SAMEA1876824 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATAAACA CCCAGGACAG TAGTATCTTG CCTTTGAGTA ACTGTCCCCA GCTCCAGTGC 
TGCAGGCACA TTGTTCCGGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG CGGCAGGGAT CCTTCTGTCT CAGCTCTAAT ATATAAGGAC 
GAGAAGCTCA CTGTGACCCA GGACCTCCCT GTGAACGATG GAAAACCTCA CATCGTCCAC 
TTCCAGTATG AGGTCACCGA GGTGAAGGTC TCTTCCTGGG ATGCAGTCCT GTCCAGCCAG 
AGCCTGTTTG TAGAAATCCC AGATGGATTA TTAGCTGATG GGAGCAAAGA AGGATTGTTA 
GCACTGCTAG AGTTTGCTGA AGAGAAGATG AAAGTGAACT ATGTCTTCAT CTGCTTCAGG 
AAGGGCCGGG AAGACAGAGC TCCACTCCTG AAGACCTTCA GCTTCTTGGG CTTTGAGATT 
GTGCGTCCAG GTCATCCCTG TGTTCCCTCT CGGCCAGATG TGATGTTCAT GGTTTACCCC 
CTGGACCAGA ACTTGTCTGA TGAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001116467.1
CDS	join(176..271,273..746)
Translation	MINTQDSSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSVSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED

Target ORF information:

RefSeq Version	NM_001122995.2
Organism	Sus scrofa(pig)
Definition	Sus scrofa ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001122995.2

ORF Insert Sequence:

ATGATAAACA CCCAGGACAG TAGTATCTTG CCTTTGAGTA ACTGTCCCCA GCTCCAGTGC 
TGCAGGCACA TTGTTCCGGG GCCTCTGTGG TGCTCCGATG CCCCTCACCC ACTGTCGAAG 
ATCCCCGGTG GGCGAGGGGG CGGCAGGGAT CCTTCTGTCT CAGCTCTAAT ATATAAGGAC 
GAGAAGCTCA CTGTGACCCA GGACCTCCCT GTGAACGATG GAAAACCTCA CATCGTCCAC 
TTCCAGTATG AGGTCACCGA GGTGAAGGTC TCTTCCTGGG ATGCAGTCCT GTCCAGCCAG 
AGCCTGTTTG TAGAAATCCC AGATGGATTA TTAGCTGATG GGAGCAAAGA AGGATTGTTA 
GCACTGCTAG AGTTTGCTGA AGAGAAGATG AAAGTGAACT ATGTCTTCAT CTGCTTCAGG 
AAGGGCCGGG AAGACAGAGC TCCACTCCTG AAGACCTTCA GCTTCTTGGG CTTTGAGATT 
GTGCGTCCAG GTCATCCCTG TGTTCCCTCT CGGCCAGATG TGATGTTCAT GGTTTACCCC 
CTGGACCAGA ACTTGTCTGA TGAGGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

OAZ2 ( NM_001301326.1 ) cDNA ORF clone, Sus scrofa(pig) -> NP_001288255.1 Sus scrofa ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OSe101268
Clone ID Related Accession (Same CDS sequence)	NM_001301326.1
Accession Version	NM_001301326.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 567bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-03-08
Organism	Sus scrofa(pig)
Product	ornithine decarboxylase antizyme 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP172930.1, CK454400.1 and DR082583.1. Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: CK454400.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1487420, SAMEA1876826 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## ribosomal slippage :: inferred from conservation ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGATAAACA CCCAGGACAG TATCTTGCCT TTGAGTAACT GTCCCCAGCT CCAGTGCTGC 
AGGCACATTG TTCCGGGGCC TCTGTGGTGC TCCGATGCCC CTCACCCACT GTCGAAGATC 
CCCGGTGGGC GAGGGGGCGG CAGGGATCCT TCTGTCTCAG CTCTAATATA TAAGGACGAG 
AAGCTCACTG TGACCCAGGA CCTCCCTGTG AACGATGGAA AACCTCACAT CGTCCACTTC 
CAGTATGAGG TCACCGAGGT GAAGGTCTCT TCCTGGGATG CAGTCCTGTC CAGCCAGAGC 
CTGTTTGTAG AAATCCCAGA TGGATTATTA GCTGATGGGA GCAAAGAAGG ATTGTTAGCA 
CTGCTAGAGT TTGCTGAAGA GAAGATGAAA GTGAACTATG TCTTCATCTG CTTCAGGAAG 
GGCCGGGAAG ACAGAGCTCC ACTCCTGAAG ACCTTCAGCT TCTTGGGCTT TGAGATTGTG 
CGTCCAGGTC ATCCCTGTGT TCCCTCTCGG CCAGATGTGA TGTTCATGGT TTACCCCCTG 
GACCAGAACT TGTCTGATGA GGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288255.1
CDS	join(176..268,270..743)
Translation	MINTQDSILPLSNCPQLQCCRHIVPGPLWCSDAPHPLSKIPGGRGGGRDPSVSALIYKDEKLTVTQDLPVNDGKPHIVHFQYEVTEVKVSSWDAVLSSQSLFVEIPDGLLADGSKEGLLALLEFAEEKMKVNYVFICFRKGREDRAPLLKTFSFLGFEIVRPGHPCVPSRPDVMFMVYPLDQNLSDED

Target ORF information:

RefSeq Version	NM_001301326.1
Organism	Sus scrofa(pig)
Definition	Sus scrofa ornithine decarboxylase antizyme 2 (OAZ2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301326.1

ORF Insert Sequence:

ATGATAAACA CCCAGGACAG TATCTTGCCT TTGAGTAACT GTCCCCAGCT CCAGTGCTGC 
AGGCACATTG TTCCGGGGCC TCTGTGGTGC TCCGATGCCC CTCACCCACT GTCGAAGATC 
CCCGGTGGGC GAGGGGGCGG CAGGGATCCT TCTGTCTCAG CTCTAATATA TAAGGACGAG 
AAGCTCACTG TGACCCAGGA CCTCCCTGTG AACGATGGAA AACCTCACAT CGTCCACTTC 
CAGTATGAGG TCACCGAGGT GAAGGTCTCT TCCTGGGATG CAGTCCTGTC CAGCCAGAGC 
CTGTTTGTAG AAATCCCAGA TGGATTATTA GCTGATGGGA GCAAAGAAGG ATTGTTAGCA 
CTGCTAGAGT TTGCTGAAGA GAAGATGAAA GTGAACTATG TCTTCATCTG CTTCAGGAAG 
GGCCGGGAAG ACAGAGCTCC ACTCCTGAAG ACCTTCAGCT TCTTGGGCTT TGAGATTGTG 
CGTCCAGGTC ATCCCTGTGT TCCCTCTCGG CCAGATGTGA TGTTCATGGT TTACCCCCTG 
GACCAGAACT TGTCTGATGA GGACTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Ribosomal frameshifting in decoding antizyme mRNAs from yeast and protists to humans: close to 300 cases reveal remarkable diversity despite underlying conservation.
Nucleic acids research35(6)1842-58(2007)
Ivanov IP,Atkins JF

PEDE (Pig EST Data Explorer) has been expanded into Pig Expression Data Explorer, including 10 147 porcine full-length cDNA sequences.
Nucleic acids research35(Database issue)D650-3(2007 Jan)
Uenishi H,Eguchi-Ogawa T,Shinkai H,Okumura N,Suzuki K,Toki D,Hamasima N,Awata T

PEDE (Pig EST Data Explorer): construction of a database for ESTs derived from porcine full-length cDNA libraries.
Nucleic acids research32(Database issue)D484-8(2004 Jan)
Uenishi H,Eguchi T,Suzuki K,Sawazaki T,Toki D,Shinkai H,Okumura N,Hamasima N,Awata T

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OAZ2 cDNA ORF clone, Sus scrofa(pig)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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