Gene Symbol | PAB1 |
Entrez Gene ID | 856912 |
Full Name | polyadenylate-binding protein |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » PAB1 cDNA ORF clone
Gene Symbol | PAB1 |
Entrez Gene ID | 856912 |
Full Name | polyadenylate-binding protein |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001179055.1 | NP_011092.1 | polyadenylate-binding protein |
Canis lupus familiaris (dog) | PABPC1L | XP_534430.2 |
Bos taurus (cattle) | PABPC1L | XP_002692514.2 |
Danio rerio (zebrafish) | pabpc1l | NP_956133.1 |
Eremothecium gossypii | AGOS_AGR122C | NP_986788.1 |
Arabidopsis thaliana (thale cress) | PAB4 | NP_179916.1 |
Pan troglodytes (chimpanzee) | PABPC1L | XP_514668.2 |
Mus musculus (house mouse) | Pabpc1l | NP_001107551.1 |
Saccharomyces cerevisiae (baker's yeast) | PAB1 | NP_011092.1 |
Neurospora crassa | NCU04799 | XP_960425.1 |
Gallus gallus (chicken) | PABPC1L | XP_417367.2 |
Homo sapiens (human) | PABPC1L | NP_001118228.1 |
Rattus norvegicus (Norway rat) | Pabpc1l | XP_230831.6 |
Kluyveromyces lactis | KLLA0C17600g | XP_452986.1 |
Schizosaccharomyces pombe (fission yeast) | pabp | NP_593377.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_09505 | XP_003712237.1 |
Xenopus tropicalis (tropical clawed frog) | pabpc1l | NP_001005062.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome V.
Dietrich FS, Mulligan J, Hennessy K, Yelton MA, Allen E, Araujo R, Aviles E, Berno A, Brennan T, Carpenter J, Chen E, Cherry JM, Chung E, Duncan M, Guzman E, Hartzell G, Hunicke-Smith S, Hyman RW, Kayser A, Komp C, Lashkari D, Lew H, Lin D, Mosedale D, Davis RW
Nature387(6632 Suppl)78-81(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Two distal RNA recognition motif of Sbp1 bind to the poly(A) sequence in the 5'UTR of the Pab1 mRNA specifically and cooperatively while the central RGG domain of the protein interacts directly with Pab1.
Title: Sbp1 modulates the translation of Pab1 mRNA in a poly(A)- and RGG-dependent manner.
Study shows that Pab1 phase separates and gels in response to physiological thermal and pH stresses, a demixing process, which is modulated by the P domain but does not require it; Poly(A)-binding protein thus acts as a physiological stress sensor, exploiting phase separation to precisely mark stress onset, a broadly generalizable mechanism.
Title: Stress-Triggered Phase Separation Is an Adaptive, Evolutionarily Tuned Response.
In Saccharomyces cerevisiae the association of Pab1 with eRF3 negatively regulates translation termination.
Title: Interaction between the poly(A)-binding protein Pab1 and the eukaryotic release factor eRF3 regulates translation termination but not mRNA decay in Saccharomyces cerevisiae.
Closed-loop model of mRNA translation is prevalent for eIF4E/4G-bound but unexpectedly sparse for PAB1-bound mRNAs.
Title: Probing the closed-loop model of mRNA translation in living cells.
measured the contribution of each structural element in RRM2 domain to Pab1 performance, dissected the in vivo effects of mutations at known RNA-binding residues and other interaction sites, and identified non-RNA-binding residues essential to RRM2 function
Title: Deep mutational scanning of an RRM domain of the Saccharomyces cerevisiae poly(A)-binding protein.
The following PAB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PAB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi05660 | |
Clone ID Related Accession (Same CDS sequence) | NM_001179055.1 | |
Accession Version | NM_001179055.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | polyadenylate-binding protein | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001137). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGGCTGATA TTACTGATAA GACAGCTGAA CAATTGGAAA ACTTGAATAT TCAAGATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_011092.1 |
CDS | 1..1734 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001179055.1 |
1 | ATGGCTGATA TTACTGATAA GACAGCTGAA CAATTGGAAA ACTTGAATAT TCAAGATGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome V. |
Life with 6000 genes. |