Gene Symbol | MMS21 |
Entrez Gene ID | 856695 |
Full Name | SUMO ligase MMS21 |
Synonyms | NSE2,PSO10 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » MMS21 cDNA ORF clone
Gene Symbol | MMS21 |
Entrez Gene ID | 856695 |
Full Name | SUMO ligase MMS21 |
Synonyms | NSE2,PSO10 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001178834.3 | NP_010896.3 | SUMO ligase MMS21 |
Eremothecium gossypii | AGOS_AEL053C | NP_984808.1 |
Saccharomyces cerevisiae (baker's yeast) | MMS21 | NP_010896.3 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome V.
Dietrich FS, Mulligan J, Hennessy K, Yelton MA, Allen E, Araujo R, Aviles E, Berno A, Brennan T, Carpenter J, Chen E, Cherry JM, Chung E, Duncan M, Guzman E, Hartzell G, Hunicke-Smith S, Hyman RW, Kayser A, Komp C, Lashkari D, Lew H, Lin D, Mosedale D, Davis RW
Nature387(6632 Suppl)78-81(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
mms21RINGDelta mutant exhibits (1) reduced ribosomal RNA production; (2) nuclear accumulation of ribosomal proteins; (3) elevated Gcn4 translation, indicating translational stress; We identified RPL19A as a novel genetic suppressor of the mms21RINGDelta mutant; Deletion of a previously identified strong suppressor, MPH1, rescues both the accumulation of ribosome subunits and translational stress
Title: Mms21 SUMO Ligase Activity Promotes Nucleolar Function in Saccharomyces cerevisiae.
double-strand break relocation to the nuclear envelope depends on SUMOylation mediated by the E3 ligases Siz2 and Mms21
Title: PolySUMOylation by Siz2 and Mms21 triggers relocation of DNA breaks to nuclear pores through the Slx5/Slx8 STUbL.
Mms21 was phosophorylated during S-phase in a manner dependent on the DNA damage kinase Mec1. S260 S261 phosphorylation may positively regulate the SUMO ligase activity of Mms21 and promote genomic stability.
Title: Mec1-dependent phosphorylation of Mms21 modulates its SUMO ligase activity.
The Smc5/6-Mms21 complex operates as a large SUMO ligase in vivo during DNA repair.
Title: ATPase-dependent control of the Mms21 SUMO ligase during DNA repair.
We propose that the Smc5/6-Mms21 complex antagonizes toxic JMs by coordinating helicases and resolvases at D-Loops and HJs, respectively.
Title: Smc5/6-Mms21 prevents and eliminates inappropriate recombination intermediates in meiosis.
The following MMS21 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MMS21 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi05470 | |
Clone ID Related Accession (Same CDS sequence) | NM_001178834.3 | |
Accession Version | NM_001178834.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 804bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | SUMO ligase MMS21 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001137). On Jul 30, 2012 this sequence version replaced NM_001178834.2. ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGGCCTTGA ACGATAATCC TATACCCAAG TCAGTTCCTC TACACCCAAA ATCAGGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010896.3 |
CDS | 1..804 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001178834.3 |
1 | ATGGCCTTGA ACGATAATCC TATACCCAAG TCAGTTCCTC TACACCCAAA ATCAGGTAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome V. |
Life with 6000 genes. |