Gene Symbol | SPP1 |
Entrez Gene ID | 855965 |
Full Name | Spp1p |
Synonyms | CPS40,SAF41 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » SPP1 cDNA ORF clone
Gene Symbol | SPP1 |
Entrez Gene ID | 855965 |
Full Name | Spp1p |
Synonyms | CPS40,SAF41 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001183952.1 | NP_015187.1 | Spp1p |
Saccharomyces cerevisiae (baker's yeast) | SPP1 | NP_015187.1 |
Kluyveromyces lactis | KLLA0D07260g | XP_453385.1 |
Eremothecium gossypii | AGOS_ACR115W | NP_983517.2 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI.
Bussey H, Storms RK, Ahmed A, Albermann K, Allen E, Ansorge W, Araujo R, Aparicio A, Barrell B, Badcock K, Benes V, Botstein D, Bowman S, Br?ckner M, Carpenter J, Cherry JM, Chung E, Churcher C, Coster F, Davis K, Davis RW, Dietrich FS, Delius H, DiPaolo T, Hani J
Nature387(6632 Suppl)103-5(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Spp1 regulates the catalytic activity of the enzyme (Set1) and mediates its biological effect (meiotic DSB formation) independently of the single Set1 Complex.
Title: Spp1 at the crossroads of H3K4me3 regulation and meiotic recombination.
Spp1, a conserved member of the histone H3K4 methyltransferase Set1 complex, is required for normal levels of double strand breaks formation and is associated with chromosome axes during meiosis.
Title: Spp1, a member of the Set1 Complex, promotes meiotic DSB formation in promoters by tethering histone H3K4 methylation sites to chromosome axes.
findings show tethering of Spp1 (a component of the COMPASS complex), to recombinationally cold regions is sufficient to induce double-strand breaks (DSB); by interacting with H3K4me3 and Mer2, Spp1 promotes recruitment of potential meiotic DSB sites to the chromosomal axis
Title: The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination.
Data show that Tyr1052, a putative Phe/Tyr switch of Set1, plays an essential role in the regulation of H3K4 trimethylation by COMPASS and that the mutation to phenylalanine (Y1052F) suppresses the loss of Cps40 in H3K4 trimethylation levels.
Title: Regulation of H3K4 trimethylation via Cps40 (Spp1) of COMPASS is monoubiquitination independent: implication for a Phe/Tyr switch by the catalytic domain of Set1.
the origin recognition complex (ORC) mediates histone 3 lysine 4 methylation through cooperation with Spp1 in Saccharomyces cerevisiae
Title: Origin recognition complex (ORC) mediates histone 3 lysine 4 methylation through cooperation with Spp1 in Saccharomyces cerevisiae.
The following SPP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SPP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi04835 | |
Clone ID Related Accession (Same CDS sequence) | NM_001183952.1 | |
Accession Version | NM_001183952.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP |
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Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | Spp1p | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001148). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCATTAC CACAATGGTG TCCACCGCAT TCCACCTTAA AAAGAAATCC AACTACAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_015187.1 |
CDS | 1..1062 |
Translation |
Target ORF information:
Target ORF information:
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1 | ATGTCATTAC CACAATGGTG TCCACCGCAT TCCACCTTAA AAAGAAATCC AACTACAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI. |
Life with 6000 genes. |