Gene Symbol | SIT4 |
Entrez Gene ID | 851513 |
Full Name | type 2A-related serine/threonine-protein phosphatase SIT4 |
Synonyms | PPH1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » SIT4 cDNA ORF clone
Gene Symbol | SIT4 |
Entrez Gene ID | 851513 |
Full Name | type 2A-related serine/threonine-protein phosphatase SIT4 |
Synonyms | PPH1 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001180106.1 | NP_010236.1 | type 2A-related serine/threonine-protein phosphatase SIT4 |
Drosophila melanogaster (fruit fly) | PpV | NP_001259274.1 |
Saccharomyces cerevisiae (baker's yeast) | SIT4 | NP_010236.1 |
Xenopus tropicalis (tropical clawed frog) | ppp6c | NP_001017110.1 |
Homo sapiens (human) | PPP6C | NP_002712.1 |
Bos taurus (cattle) | PPP6C | NP_001124222.1 |
Rattus norvegicus (Norway rat) | Ppp6c | NP_598273.2 |
Gallus gallus (chicken) | PPP6C | NP_001073233.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003017 | XP_311859.5 |
Caenorhabditis elegans (roundworm) | pph-6 | NP_497714.2 |
Kluyveromyces lactis | KLLA0D03652g | XP_453227.1 |
Schizosaccharomyces pombe (fission yeast) | ppe1 | NP_588420.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_03911 | XP_003719961.1 |
Neurospora crassa | NCU03436 | XP_956722.1 |
Canis lupus familiaris (dog) | PPP6C | XP_851294.2 |
Eremothecium gossypii | AGOS_AER202C | NP_985059.1 |
Arabidopsis thaliana (thale cress) | AT1G50370 | NP_175454.1 |
Pan troglodytes (chimpanzee) | PPP6C | XP_003312329.1 |
Danio rerio (zebrafish) | ppp6c | NP_957299.1 |
Mus musculus (house mouse) | Ppp6c | NP_077171.1 |
Arabidopsis thaliana (thale cress) | FYPP3 | NP_188632.1 |
Oryza sativa (rice) | Os01g0691700 | NP_001043937.1 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.
Jacq C, Alt-M?rbe J, Andre B, Arnold W, Bahr A, Ballesta JP, Bargues M, Baron L, Becker A, Biteau N, Bl?cker H, Blugeon C, Boskovic J, Brandt P, Br?ckner M, Buitrago MJ, Coster F, Delaveau T, del Rey F, Dujon B, Eide LG, Garcia-Cantalejo JM, Goffeau A, Gomez-Peris A, Zaccaria P
Nature387(6632 Suppl)75-8(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
This pathway is functionally relevant to TORC1 signaling since the stress sensitivity of a nonessential TORC1 mutant (tco89Delta) to hydroxyurea and arsenic can be reversed by combining tco89Delta with either hst3Delta, hst4Delta, or sit4Delta Surprisingly, while hst3Delta or hst4Delta rescues the sensitivity tco89Delta has to low concentrations of the TORC1 inhibitor rapamycin, sit4Delta fails to do so
Title: Saccharomyces cerevisiae TORC1 Controls Histone Acetylation by Signaling Through the Sit4/PP6 Phosphatase to Regulate Sirtuin Deacetylase Nuclear Accumulation.
The results suggest that the phosphorylated Hxk2 functions downstream of Sit4 in the control of cell cycle, mitochondrial function, oxidative stress resistance and chronological lifespan.
Title: The ceramide-activated protein phosphatase Sit4p controls lifespan, mitochondrial function and cell cycle progression by regulating hexokinase 2 phosphorylation.
Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells.
Title: Ceramide signalling impinges on Sit4p and Hog1p to promote mitochondrial fission and mitophagy in Isc1p-deficient cells.
Results show that Sit4p and its mammalian orthologue, PP6, regulate traffic from the ER to the Golgi complex which is consistent with its role in coat recycling.
Title: Sit4p/PP6 regulates ER-to-Golgi traffic by controlling the dephosphorylation of COPII coat subunits.
These results suggest that the Pdc1p phosphorylation dependent on SIT4 occurs at residues that change the apparent affinity for thiamine pyrophosphate and pyruvate.
Title: Pyruvate decarboxylase activity is regulated by the Ser/Thr protein phosphatase Sit4p in the yeast Saccharomyces cerevisiae.
The following SIT4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SIT4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi01054 | |
Clone ID Related Accession (Same CDS sequence) | NM_001180106.1 | |
Accession Version | NM_001180106.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 936bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | type 2A-related serine/threonine-protein phosphatase SIT4 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001136). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGGTATCTA GAGGCCCCGA CGAATGGCTT GAAACAATAA AGAAATGCCA GGCGCTAACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_010236.1 |
CDS | 1..936 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001180106.1 |
1 | ATGGTATCTA GAGGCCCCGA CGAATGGCTT GAAACAATAA AGAAATGCCA GGCGCTAACT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. |
Life with 6000 genes. |