Gene Symbol | SSA1 |
Entrez Gene ID | 851259 |
Full Name | Hsp70 family ATPase SSA1 |
Synonyms | YG100 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » SSA1 cDNA ORF clone
Gene Symbol | SSA1 |
Entrez Gene ID | 851259 |
Full Name | Hsp70 family ATPase SSA1 |
Synonyms | YG100 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001178151.1 | NP_009396.2 | Hsp70 family ATPase SSA1 |
Danio rerio (zebrafish) | zgc:174006 | XP_005163979.1 |
Saccharomyces cerevisiae (baker's yeast) | SSA2 | NP_013076.1 |
Neurospora crassa | NCU09602 | XP_963366.1 |
Canis lupus familiaris (dog) | HSPA1L | XP_005627220.1 |
Mus musculus (house mouse) | Hspa1l | NP_038586.2 |
Eremothecium gossypii | AGOS_AFR114W | NP_985661.1 |
Danio rerio (zebrafish) | si:ch211-199o1.2 | NP_001093532.1 |
Danio rerio (zebrafish) | hsp70 | NP_571472.1 |
Arabidopsis thaliana (thale cress) | Hsp70b | NP_173055.1 |
Pan troglodytes (chimpanzee) | HSPA1L | XP_001160137.2 |
Rattus norvegicus (Norway rat) | Hspa1l | NP_997711.1 |
Saccharomyces cerevisiae (baker's yeast) | SSA1 | NP_009396.2 |
Magnaporthe oryzae (rice blast fungus) | MGG_06958 | XP_003709704.1 |
Homo sapiens (human) | HSPA1L | NP_005518.3 |
LOC716633 | XP_002803717.1 | |
Bos taurus (cattle) | HSPA1L | NP_001161367.1 |
Danio rerio (zebrafish) | hsp70.2 | XP_003198158.1 |
Danio rerio (zebrafish) | hsp70l | NP_001107061.1 |
Kluyveromyces lactis | KLLA0D04224g | XP_453252.1 |
Schizosaccharomyces pombe (fission yeast) | ssa1 | NP_593704.1 |
Schizosaccharomyces pombe (fission yeast) | ssa2 | NP_588421.1 |
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
The nucleotide sequence of chromosome I from Saccharomyces cerevisiae.
Bussey H, Kaback DB, Zhong W, Vo DT, Clark MW, Fortin N, Hall J, Ouellette BF, Keng T, Barton AB
Proceedings of the National Academy of Sciences of the United States of America92(9)3809-13(1995 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Molecular chaperones of the Hsp70 family, SSA1 and SSA2, assist in the assembly of 20S proteasomes.
Title: Molecular chaperones of the Hsp70 family assist in the assembly of 20S proteasomes.
The authors show here that both Escherichia coli ClpB and Saccharomyces cerevisiae Hsp104 cooperation with their cognate Hsp70 is crucial for efficient protein disaggregation and, in contrast to earlier claims, cannot be circumvented by activating M-domain mutations.
Title: Bacterial and Yeast AAA+ Disaggregases ClpB and Hsp104 Operate through Conserved Mechanism Involving Cooperation with Hsp70.
Ssa1 and Ssa2 are both necessary for the degradation of short-lived proteins. Ssa1 stably associates with its substrates and promotes their ubiquitylation.
Title: The requirements of yeast Hsp70 of SSA family for the ubiquitin-dependent degradation of short-lived and abnormal proteins.
We demonstrate that physiological levels of ADP highly limit Hsp104 activity. This inhibition, however, is moderated by the Hsp70 chaperone, which allows efficient disaggregation by supporting Hsp104 binding to aggregates but not to non-aggregated, disordered protein substrates.
Title: Adenosine diphosphate restricts the protein remodeling activity of the Hsp104 chaperone to Hsp70 assisted disaggregation.
yeast expressing P417L or P417S as the only copy of Ssa were temperature sensitive and exhibited defects in Ssa1-dependent protein translocation and misfolded protein degradation.
Title: Mutations in the Yeast Hsp70, Ssa1, at P417 Alter ATP Cycling, Interdomain Coupling, and Specific Chaperone Functions.
The following SSA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SSA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi00838 | |
Clone ID Related Accession (Same CDS sequence) | NM_001178151.1 | |
Accession Version | NM_001178151.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1929bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | Hsp70 family ATPase SSA1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001133). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCAAAAG CTGTCGGTAT TGATTTAGGT ACAACATACT CGTGTGTTGC TCACTTTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_009396.2 |
CDS | 1..1929 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001178151.1 |
1 | ATGTCAAAAG CTGTCGGTAT TGATTTAGGT ACAACATACT CGTGTGTTGC TCACTTTGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Life with 6000 genes. |
The nucleotide sequence of chromosome I from Saccharomyces cerevisiae. |