SEC61 cDNA ORF clone, Saccharomyces cerevisiae S288C

The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.
Johnston M, Hillier L, Riles L, Albermann K, Andr? B, Ansorge W, Benes V, Br?ckner M, Delius H, Dubois E, D?sterh?ft A, Entian KD, Floeth M, Goffeau A, Hebling U, Heumann K, Heuss-Neitzel D, Hilbert H, Hilger F, Kleine K, K?tter P, Louis EJ, Messenguy F, Mewes HW, Hoheisel JD
Nature387(6632 Suppl)87-90(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

Increased endoplasmic reticulum glutathione import triggers H2O2-dependent Bip oxidation through Ero1 reductive activation, which inhibits glutathione import in a negative regulatory loop.
Title: Endoplasmic Reticulum Transport of Glutathione by Sec61 Is Regulated by Ero1 and Bip.

These data suggest that the interaction between the proteasome 19S regulatory particle and the Sec61 channel is essential for the export of specific substrates from the endoplasmic reticulum to the cytosol for proteasomal degradation.
Title: Proteasome 19S RP binding to the Sec61 channel plays a key role in ERAD.

To map key residues in TM2b and TM7 in yeast Sec61 that modulate lateral gating activity, we performed alanine scanning and in vivo site-directed photocross-linking experiments.
Title: Structural and functional profiling of the lateral gate of the Sec61 translocon.

Loop 7 of Sec61 is required for initiation of posttranslational soluble protein import into and misfolded soluble protein export from the endoplasmic reticulum, suggesting a key role for L7 in transverse gating of the Sec61 channel.
Title: ERAD and protein import defects in a sec61 mutant lacking ER-lumenal loop 7.

A functional asymmetry exists within the SEC61 translocon caused by the residues forming the central constriction in the translocation pore.
Title: Functional asymmetry within the Sec61p translocon.