Gene Symbol | MLH1 |
Entrez Gene ID | 855203 |
Full Name | mismatch repair ATPase MLH1 |
Synonyms | PMS2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
ORF » Species Summary » Saccharomyces cerevisiae S288C » MLH1 cDNA ORF clone
Gene Symbol | MLH1 |
Entrez Gene ID | 855203 |
Full Name | mismatch repair ATPase MLH1 |
Synonyms | PMS2 |
Gene Type | protein-coding |
Organism | Saccharomyces cerevisiae S288C |
mRNA | Protein | Name |
---|---|---|
NM_001182671.1 | NP_013890.1 | mismatch repair ATPase MLH1 |
Rattus norvegicus (Norway rat) | Mlh1 | NP_112315.1 |
Drosophila melanogaster (fruit fly) | Mlh1 | NP_477022.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_07121 | XP_003715311.1 |
Oryza sativa (rice) | Os01g0958900 | NP_001045457.1 |
Xenopus tropicalis (tropical clawed frog) | mlh1 | XP_002933455.2 |
Pan troglodytes (chimpanzee) | MLH1 | XP_001170433.1 |
Canis lupus familiaris (dog) | MLH1 | XP_534219.2 |
Danio rerio (zebrafish) | mlh1 | NP_956953.1 |
Schizosaccharomyces pombe (fission yeast) | mlh1 | NP_596199.1 |
Neurospora crassa | NCU08309 | XP_962522.1 |
Gallus gallus (chicken) | MLH1 | XP_418828.1 |
Saccharomyces cerevisiae (baker's yeast) | MLH1 | NP_013890.1 |
Kluyveromyces lactis | KLLA0D09955g | XP_453504.1 |
Bos taurus (cattle) | MLH1 | NP_001069462.2 |
Mus musculus (house mouse) | Mlh1 | NP_081086.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP012192 | XP_320342.4 |
Homo sapiens (human) | MLH1 | NP_000240.1 |
Eremothecium gossypii | AGOS_AFL199C | NP_985351.1 |
Arabidopsis thaliana (thale cress) | MLH1 | NP_567345.2 |
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII.
Bowman S, Churcher C, Badcock K, Brown D, Chillingworth T, Connor R, Dedman K, Devlin K, Gentles S, Hamlin N, Hunt S, Jagels K, Lye G, Moule S, Odell C, Pearson D, Rajandream M, Rice P, Skelton J, Walsh S, Whitehead S, Barrell B
Nature387(6632 Suppl)90-3(1997 May)
Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Our observations provide a structure-function map for Mlh3 that reveals the importance of protein-protein interactions in regulating Mlh1-Mlh3's enzymatic activity. They also illustrate how defective meiotic components can alter the fate of meiotic recombination intermediates, providing new insights for how meiotic recombination pathways are regulated.
Title: mlh3 mutations in baker's yeast alter meiotic recombination outcomes by increasing noncrossover events genome-wide.
a comparative study of Msh2-Msh3 and Msh2-Msh6 for mispair binding, sliding clamp formation, and Mlh1-Pms1 recruitment
Title: Mispair-specific recruitment of the Mlh1-Pms1 complex identifies repair substrates of the Saccharomyces cerevisiae Msh2-Msh3 complex.
observations support a direct role for an Mlh1-Mlh3 endonuclease activity in resolving recombination intermediates and in DNA mismatch repair.
Title: Mlh1-Mlh3, a meiotic crossover and DNA mismatch repair factor, is a Msh2-Msh3-stimulated endonuclease.
Mlh1-Mlh3 prefers to bind the open unstacked Holliday junction form.
Title: The Saccharomyces cerevisiae Mlh1-Mlh3 heterodimer is an endonuclease that preferentially binds to Holliday junctions.
These studies establish that the Mlh1-Pms1 endonuclease is required for MMR in a previously uncharacterized Exo1-independent MMR pathway.
Title: Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway.
The following MLH1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MLH1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OSi04162 | |
Clone ID Related Accession (Same CDS sequence) | NM_001182671.1 | |
Accession Version | NM_001182671.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2310bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-31 | |
Organism | Saccharomyces cerevisiae S288C | |
Product | mismatch repair ATPase MLH1 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by SGD. This record is derived from an annotated genomic sequence (NC_001145). ##Genome-Annotation-Data-START## Annotation Provider :: SGD Annotation Status :: Full Annotation Annotation Version :: R64-2-1 URL :: http://www.yeastgenome.org/ ##Genome-Annotation-Data-END## COMPLETENESS: incomplete on both ends. |
1 | ATGTCTCTCA GAATAAAAGC ACTTGATGCA TCAGTGGTTA ACAAAATTGC TGCAGGTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_013890.1 |
CDS | 1..2310 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001182671.1 |
1 | ATGTCTCTCA GAATAAAAGC ACTTGATGCA TCAGTGGTTA ACAAAATTGC TGCAGGTGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIII. |
Life with 6000 genes. |