VPS21 cDNA ORF clone, Saccharomyces cerevisiae S288C

The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.
Dujon B, Albermann K, Aldea M, Alexandraki D, Ansorge W, Arino J, Benes V, Bohn C, Bolotin-Fukuhara M, Bordonn? R, Boyer J, Camasses A, Casamayor A, Casas C, Ch?ret G, Cziepluch C, Daignan-Fornier B, Dang DV, de Haan M, Delius H, Durand P, Fairhead C, Feldmann H, Gaillon L, Kleine K
Nature387(6632 Suppl)98-102(1997 May)

Life with 6000 genes.
Goffeau A, Barrell BG, Bussey H, Davis RW, Dujon B, Feldmann H, Galibert F, Hoheisel JD, Jacq C, Johnston M, Louis EJ, Mewes HW, Murakami Y, Philippsen P, Tettelin H, Oliver SG
Science (New York, N.Y.)274(5287)546, 563-7(1996 Oct)

Data indicate that efficient Vps21 recycling requires both Ypt7 and endosome-vacuole fusion, thus suggesting extended control of a GAP cascade beyond Rab interactions.
Title: Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole.

Finally, three sequential steps of this pathway are delineated: Atg9-dependent exit from the ER en route to autophagy, Ypt1- and core Atgs-mediated pre-autophagsomal-structure organization, and Ypt51-mediated delivery of APs to the vacuole
Title: A Role for Macro-ER-Phagy in ER Quality Control.

The endocytic traffic branches into two routes to reach the vacuole: a Rab5-dependent vacuolar protein sorting pathway and a Rab5-independent AP-3-mediated pathway.
Title: Bifurcation of the endocytic pathway into Rab5-dependent and -independent transport to the vacuole.

Data indicate that Cells lacking both Vps9 and Muk1 closely phenocopy double and triple knock-out strains lacking Rab5 paralogs.
Title: Vps9 family protein Muk1 is the second Rab5 guanosine nucleotide exchange factor in budding yeast.

CORVET (class C core vacuole/endosome tethering) binds to SNAREs and Rab5/Vps21-GTP and can specifically tether Vps21-positive membranes.
Title: The CORVET complex promotes tethering and fusion of Rab5/Vps21-positive membranes.