Slc22a7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.
Shen H, Liu T, Morse BL, Zhao Y, Zhang Y, Qiu X, Chen C, Lewin AC, Wang XT, Liu G, Christopher LJ, Marathe P, Lai Y
Drug metabolism and disposition: the biological fate of chemicals43(7)984-93(2015 Jul)

Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats.
Babelova A, Burckhardt BC, Wegner W, Burckhardt G, Henjakovic M
Journal of diabetes research2015483238(2015)

OAT2 catalyses efflux of glutamate and uptake of orotic acid.
Fork C, Bauer T, Golz S, Geerts A, Weiland J, Del Turco D, Sch?mig E, Gr?ndemann D
The Biochemical journal436(2)305-12(2011 Jun)

Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression.
Chen C, Cheng X, Dieter MZ, Tanaka Y, Klaassen CD
Molecular pharmacology71(4)1159-64(2007 Apr)

Resveratrol improves health and survival of mice on a high-calorie diet.
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA
Nature444(7117)337-42(2006 Nov)

the findings revealed the important role of OAT2 in renal secretion and possible reabsorption of creatinine and suggested a molecular basis for potential species difference in the transporter handling of creatinine
Title: Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.

strongly decreased expression of Oat2 and other transporters in female diabetic ZSF1 rats could possibly impair renal drug excretion, for example, of furosemide
Title: Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats.

Expression of rat OAT2 in HEK (human embryonic kidney)-293 cells stimulates accumulation of the zwitterion trigonelline; subsequently, orotic acid is identified as an excellent and specific substrate of OAT2 from rat.
Title: OAT2 catalyses efflux of glutamate and uptake of orotic acid.

induction of Oatp2 expression in liver of fasted mice may be caused by activation of the cAMP-dependent signaling pathway, with the CRE site (-1808/-1804) and CREB being the cis- and trans-acting factors mediating the induction, respectively
Title: Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression.

OAT2 in rat kidney exhibiting gender differences (F > M) that appear in puberty and are caused by strong androgen inhibition and weak estrogen and progesterone stimulation
Title: Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones.