Slc22a7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc22a7
Entrez Gene ID	89776
Full Name	solute carrier family 22 member 7
Synonyms	Oat2
General protein information	Preferred Names solute carrier family 22 member 7 Names solute carrier family 22 member 7 novel liver transporter organic anion transporter 2 solute carrier family 22 (organic anion transporter), member 7
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 9 Map Location: 9q12
Summary	may act as an organic ion transporter during liver development [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_053537.2	NP_445989.2	solute carrier family 22 member 7

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	SLC22A7	XP_538932.3
Bos taurus (cattle)	SLC22A7	NP_001094517.1
Homo sapiens (human)	SLC22A7	NP_696961.2
Pan troglodytes (chimpanzee)	SLC22A7	XP_001137440.1
Rattus norvegicus (Norway rat)	Slc22a7	NP_445989.2
Danio rerio (zebrafish)	slc22a7a	NP_001077330.1
	LOC699496	XP_002808432.1
Gallus gallus (chicken)	SLC22A7	NP_001186367.1
Mus musculus (house mouse)	Slc22a7	NP_659105.2

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.
Shen H, Liu T, Morse BL, Zhao Y, Zhang Y, Qiu X, Chen C, Lewin AC, Wang XT, Liu G, Christopher LJ, Marathe P, Lai Y
Drug metabolism and disposition: the biological fate of chemicals43(7)984-93(2015 Jul)

Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats.
Babelova A, Burckhardt BC, Wegner W, Burckhardt G, Henjakovic M
Journal of diabetes research2015483238(2015)

OAT2 catalyses efflux of glutamate and uptake of orotic acid.
Fork C, Bauer T, Golz S, Geerts A, Weiland J, Del Turco D, Sch?mig E, Gr?ndemann D
The Biochemical journal436(2)305-12(2011 Jun)

Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression.
Chen C, Cheng X, Dieter MZ, Tanaka Y, Klaassen CD
Molecular pharmacology71(4)1159-64(2007 Apr)

Resveratrol improves health and survival of mice on a high-calorie diet.
Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le Couteur D, Shaw RJ, Navas P, Puigserver P, Ingram DK, de Cabo R, Sinclair DA
Nature444(7117)337-42(2006 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the findings revealed the important role of OAT2 in renal secretion and possible reabsorption of creatinine and suggested a molecular basis for potential species difference in the transporter handling of creatinine
Title: Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.

strongly decreased expression of Oat2 and other transporters in female diabetic ZSF1 rats could possibly impair renal drug excretion, for example, of furosemide
Title: Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats.

Expression of rat OAT2 in HEK (human embryonic kidney)-293 cells stimulates accumulation of the zwitterion trigonelline; subsequently, orotic acid is identified as an excellent and specific substrate of OAT2 from rat.
Title: OAT2 catalyses efflux of glutamate and uptake of orotic acid.

induction of Oatp2 expression in liver of fasted mice may be caused by activation of the cAMP-dependent signaling pathway, with the CRE site (-1808/-1804) and CREB being the cis- and trans-acting factors mediating the induction, respectively
Title: Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression.

OAT2 in rat kidney exhibiting gender differences (F > M) that appear in puberty and are caused by strong androgen inhibition and weak estrogen and progesterone stimulation
Title: Renal expression of organic anion transporter OAT2 in rats and mice is regulated by sex hormones.

The following Slc22a7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc22a7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09827	NM_053537.2 Latest version!	Rattus norvegicus solute carrier family 22 member 7 (Slc22a7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$314.30 $449.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc22a7 ( NM_053537.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445989.2 Rattus norvegicus solute carrier family 22 member 7 (Slc22a7), mRNA.

Price & Availability↑

CloneID	ORa09827
Clone ID Related Accession (Same CDS sequence)	NM_053537.2
Accession Version	NM_053537.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-02
Organism	Rattus norvegicus(Norway rat)
Product	solute carrier family 22 member 7
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AY816233.1. On Jun 10, 2007 this sequence version replaced NM_053537.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY816233.1, L27651.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689597, SAMEA2689598 [ECO:0000348] ##Evidence-Data-END##

ATGGGCTTCG AAGACCTGCT GGACAAGGTG GGCGGCTTTG GGCCCTTCCA ACTTCGGAAT 
CTGGTTCTGA TGGCCCTGCC CCGAATGCTG CTCCCCATGC ACTTTCTCCT GCCCGTCTTC 
ATGGCCGCTG TGCCTGCCCA CCATTGTGCC CTGCCCGGTG CCCCTGCCAA CCTCAGTCAC 
CAGGACTTAT GGCTGGAAGC CCATCTACCC CGGGAGACTG ACGGCAGCTT TAGCTCCTGC 
CTCCGATTTG CCTATCCCCA GACTGTCCCC AATGTCACTT TGGGGACAGA GGTGTCCAAC 
TCTGGGGAGC CTGAGGGTGA GCCCCTCACG GTGCCCTGCT CTCAGGGCTG GGAGTACGAC 
CGCTCAGAAT TCTCCTCCAC CATTGCAACT GAGTGGGATC TTGTGTGTCA GCAGAGAGGA 
CTGAACAAAA TTACGTCCAC CTGCTTCTTC ATTGGTGTGC TGGTGGGAGC CGTGGTGTAT 
GGATACTTGT CTGACAGGTT TGGCAGGCGC CGGCTTCTGC TGGTGGCCTA CGTGAGCTCC 
CTGGTGCTGG GTCTGATGTC TGCAGCCTCC ATCAACTACA TCATGTTCGT AGTCACCCGT 
ACACTCACCG GCTCAGCCCT GGCTGGCTTC ACCATCATTG TGCTCCCACT GGAGTTGGAG 
TGGCTGGATG TGGAGCACCG CACTGTGGCC GGGGTCATCA GCACCGTCTT CTGGTCGGGA 
GGCGTGCTGC TGCTGGCACT GGTGGGCTAC CTGATCCGGA GCTGGCGCTG GCTTCTGCTG 
GCTGCCACCC TGCCGTGTGT CCCAGGCATC ATCAGCATCT GGTGGGTTCC TGAGTCTGCA 
CGGTGGCTTC TAACCCAGGG TCGTGTGGAG GAGGCAAAAA AATACTTGCT GAGCTGTGCC 
AAGCTCAATG GGCGGCCCGT GGGTGAGGGC AGCCTGAGCC AGGAGGCCCT GAACAACGTG 
GTCACCATGG AAAGGGCGTT GCAAAGACCC TCATACTTAG ACCTGTTCCG AACATCTCAG 
CTCCGACATA TCTCACTGTG CTGCATGATG GTGTGGTTTG GAGTGAACTT TTCCTACTAC 
GGCCTGACTC TGGACGTGTC TGGGCTGGGG CTGAACGTGT ACCAGACACA GCTGCTGTTT 
GGGGCTGTGG AGCTCCCCTC CAAAATTATG GTCTACTTCC TTGTGCGCCG TCTGGGACGC 
CGTCTCACGG AGGCTGGGAT GCTGCTGGGC GCTGCTCTGA CCTTTGGCAC CAGCCTGCTG 
GTATCCTTGG AGACTAAGTC ATGGATCACT GCTCTGGTGG TGGTGGGGAA AGCTTTTTCT 
GAAGCTGCTT TTACTACGGC CTACCTGTTC ACGTCCGAGT TGTACCCTAC TGTGCTCAGA 
CAGACAGGAT TGGGACTTAC TGCACTCATG GGCAGGCTAG GGGCCTCTCT GGCCCCACTG 
GCGGCCTTGC TGGATGGAGT GTGGCTGTTG CTGCCCAAAG TTGCTTACGG GGGGATTGCC 
CTGGTGGCTG CCTGCACTGC ACTCCTGCTG CCTGAGACGA AGAAGGCACA GCTGCCAGAG 
ACCATCCAGG ATGTGGAGAG GAAGAGTACC CAGGAGGAAG ATGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445989.2
CDS	14..1621
Translation	MGFEDLLDKVGGFGPFQLRNLVLMALPRMLLPMHFLLPVFMAAVPAHHCALPGAPANLSHQDLWLEAHLPRETDGSFSSCLRFAYPQTVPNVTLGTEVSNSGEPEGEPLTVPCSQGWEYDRSEFSSTIATEWDLVCQQRGLNKITSTCFFIGVLVGAVVYGYLSDRFGRRRLLLVAYVSSLVLGLMSAASINYIMFVVTRTLTGSALAGFTIIVLPLELEWLDVEHRTVAGVISTVFWSGGVLLLALVGYLIRSWRWLLLAATLPCVPGIISIWWVPESARWLLTQGRVEEAKKYLLSCAKLNGRPVGEGSLSQEALNNVVTMERALQRPSYLDLFRTSQLRHISLCCMMVWFGVNFSYYGLTLDVSGLGLNVYQTQLLFGAVELPSKIMVYFLVRRLGRRLTEAGMLLGAALTFGTSLLVSLETKSWITALVVVGKAFSEAAFTTAYLFTSELYPTVLRQTGLGLTALMGRLGASLAPLAALLDGVWLLLPKVAYGGIALVAACTALLLPETKKAQLPETIQDVERKSTQEEDV

Target ORF information:

RefSeq Version	NM_053537.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 22 member 7 (Slc22a7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053537.2

ORF Insert Sequence:

ATGGGCTTCG AAGACCTGCT GGACAAGGTG GGCGGCTTTG GGCCCTTCCA ACTTCGGAAT 
CTGGTTCTGA TGGCCCTGCC CCGAATGCTG CTCCCCATGC ACTTTCTCCT GCCCGTCTTC 
ATGGCCGCTG TGCCTGCCCA CCATTGTGCC CTGCCCGGTG CCCCTGCCAA CCTCAGTCAC 
CAGGACTTAT GGCTGGAAGC CCATCTACCC CGGGAGACTG ACGGCAGCTT TAGCTCCTGC 
CTCCGATTTG CCTATCCCCA GACTGTCCCC AATGTCACTT TGGGGACAGA GGTGTCCAAC 
TCTGGGGAGC CTGAGGGTGA GCCCCTCACG GTGCCCTGCT CTCAGGGCTG GGAGTACGAC 
CGCTCAGAAT TCTCCTCCAC CATTGCAACT GAGTGGGATC TTGTGTGTCA GCAGAGAGGA 
CTGAACAAAA TTACGTCCAC CTGCTTCTTC ATTGGTGTGC TGGTGGGAGC CGTGGTGTAT 
GGATACTTGT CTGACAGGTT TGGCAGGCGC CGGCTTCTGC TGGTGGCCTA CGTGAGCTCC 
CTGGTGCTGG GTCTGATGTC TGCAGCCTCC ATCAACTACA TCATGTTCGT AGTCACCCGT 
ACACTCACCG GCTCAGCCCT GGCTGGCTTC ACCATCATTG TGCTCCCACT GGAGTTGGAG 
TGGCTGGATG TGGAGCACCG CACTGTGGCC GGGGTCATCA GCACCGTCTT CTGGTCGGGA 
GGCGTGCTGC TGCTGGCACT GGTGGGCTAC CTGATCCGGA GCTGGCGCTG GCTTCTGCTG 
GCTGCCACCC TGCCGTGTGT CCCAGGCATC ATCAGCATCT GGTGGGTTCC TGAGTCTGCA 
CGGTGGCTTC TAACCCAGGG TCGTGTGGAG GAGGCAAAAA AATACTTGCT GAGCTGTGCC 
AAGCTCAATG GGCGGCCCGT GGGTGAGGGC AGCCTGAGCC AGGAGGCCCT GAACAACGTG 
GTCACCATGG AAAGGGCGTT GCAAAGACCC TCATACTTAG ACCTGTTCCG AACATCTCAG 
CTCCGACATA TCTCACTGTG CTGCATGATG GTGTGGTTTG GAGTGAACTT TTCCTACTAC 
GGCCTGACTC TGGACGTGTC TGGGCTGGGG CTGAACGTGT ACCAGACACA GCTGCTGTTT 
GGGGCTGTGG AGCTCCCCTC CAAAATTATG GTCTACTTCC TTGTGCGCCG TCTGGGACGC 
CGTCTCACGG AGGCTGGGAT GCTGCTGGGC GCTGCTCTGA CCTTTGGCAC CAGCCTGCTG 
GTATCCTTGG AGACTAAGTC ATGGATCACT GCTCTGGTGG TGGTGGGGAA AGCTTTTTCT 
GAAGCTGCTT TTACTACGGC CTACCTGTTC ACGTCCGAGT TGTACCCTAC TGTGCTCAGA 
CAGACAGGAT TGGGACTTAC TGCACTCATG GGCAGGCTAG GGGCCTCTCT GGCCCCACTG 
GCGGCCTTGC TGGATGGAGT GTGGCTGTTG CTGCCCAAAG TTGCTTACGG GGGGATTGCC 
CTGGTGGCTG CCTGCACTGC ACTCCTGCTG CCTGAGACGA AGAAGGCACA GCTGCCAGAG 
ACCATCCAGG ATGTGGAGAG GAAGAGTACC CAGGAGGAAG ATGTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression.
Drug metabolism and disposition: the biological fate of chemicals43(7)984-93(2015 Jul)
Shen H,Liu T,Morse BL,Zhao Y,Zhang Y,Qiu X,Chen C,Lewin AC,Wang XT,Liu G,Christopher LJ,Marathe P,Lai Y

Sex-differences in renal expression of selected transporters and transcription factors in lean and obese Zucker spontaneously hypertensive fatty rats.
Journal of diabetes research2015483238(2015)
Babelova A,Burckhardt BC,Wegner W,Burckhardt G,Henjakovic M

OAT2 catalyses efflux of glutamate and uptake of orotic acid.
The Biochemical journal436(2)305-12(2011 Jun)
Fork C,Bauer T,Golz S,Geerts A,Weiland J,Del Turco D,Sch?mig E,Gr?ndemann D

Activation of cAMP-dependent signaling pathway induces mouse organic anion transporting polypeptide 2 expression.
Molecular pharmacology71(4)1159-64(2007 Apr)
Chen C,Cheng X,Dieter MZ,Tanaka Y,Klaassen CD

Resveratrol improves health and survival of mice on a high-calorie diet.
Nature444(7117)337-42(2006 Nov)
Baur JA,Pearson KJ,Price NL,Jamieson HA,Lerin C,Kalra A,Prabhu VV,Allard JS,Lopez-Lluch G,Lewis K,Pistell PJ,Poosala S,Becker KG,Boss O,Gwinn D,Wang M,Ramaswamy S,Fishbein KW,Spencer RG,Lakatta EG,Le Couteur D,Shaw RJ,Navas P,Puigserver P,Ingram DK,de Cabo R,Sinclair DA

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

Slc22a7 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報