Nr1i2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis.
Gabbia D, Pozza AD, Albertoni L, Lazzari R, Zigiotto G, Carrara M, Baldo V, Baldovin T, Floreani A, Martin S
World journal of gastroenterology23(42)7519-7530(2017 Nov)

Combining Genomics To Identify the Pathways of Post-Transcriptional Nongenotoxic Signaling and Energy Homeostasis in Livers of Rats Treated with the Pregnane X Receptor Agonist, Pregnenolone Carbonitrile.
Nagahori H, Nakamura K, Sumida K, Ito S, Ohtsuki S
Journal of proteome research16(10)3634-3645(2017 Oct)

Pregnane X Receptor Not Nuclear Factor-kappa B Up-regulates P-glycoprotein Expression in the Brain of Chronic Epileptic Rats Induced by Kainic Acid.
Yu N, Zhang YF, Zhang K, Cheng YF, Ma HY, Di Q
Neurochemical research42(8)2167-2177(2017 Aug)

Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPAR? activities.
Fujino C, Tamura Y, Tange S, Nakajima H, Sanoh S, Watanabe Y, Uramaru N, Kojima H, Yoshinari K, Ohta S, Kitamura S
The Journal of toxicological sciences41(5)677-91(2016)

Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation.
Amer AO, Probert PM, Dunn M, Knight M, Vallance AE, Flecknell PA, Oakley F, Cameron I, White SA, Blain PG, Wright MC
PloS one10(8)e0136173(2015)

Metabolism of methiocarb and carbaryl alters PXR agonist activity.
Title: Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPAR? activities.

Drug-mediated activation of the pregnane X receptor reduced these adverse changes in rats, suggesting that the pregnane X receptor is a viable drug target to reduce ischaemic-type biliary lesions in recipients of liver transplants
Title: Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation.

Following ethyl tertiary-butyl ether administration, PXR is activated along with tumorigenesis and oxidative stress.
Title: Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways.

Results indicate that pregnane X receptor (PXR) represents a flow-activated detoxification system to protect endothelial cells (ECs) against damage by xeno- and endobiotics.
Title: Shear stress activation of nuclear receptor PXR in endothelial detoxification.

PXR in the midbrain may be required for the observed increase in 3alpha-5alpha-THP during proestrus, which has subsequent effects on motivated, reproductive behaviors.
Title: Motivated behaviors and levels of 3?,5?-THP in the midbrain are attenuated by knocking down expression of pregnane xenobiotic receptor in the midbrain ventral tegmental area of proestrous rats.