Bambi cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Bambi
Entrez Gene ID	83837
Full Name	BMP and activin membrane-bound inhibitor
General protein information	Preferred Names BMP and activin membrane-bound inhibitor Names BMP and activin membrane-bound inhibitor homolog BMP and activin membrane-bound inhibitor, homolog kinase-deficient TGFbeta superfamily receptor subunit
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 17 Map Location: 17q12.1

mRNA and Protein(s)

mRNA	Protein	Name
NM_139082.3	NP_620782.1	BMP and activin membrane-bound inhibitor homolog precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	BAMBI	NP_036474.1
Mus musculus (house mouse)	Bambi	NP_080781.1
Rattus norvegicus (Norway rat)	Bambi	NP_620782.1
Gallus gallus (chicken)	BAMBI	NP_001182330.1
Xenopus tropicalis (tropical clawed frog)	bambi	NP_001008194.1
Danio rerio (zebrafish)	bambia	NP_571859.1
	BAMBI	XP_001106773.2
Pan troglodytes (chimpanzee)	BAMBI	XP_001150397.2
Canis lupus familiaris (dog)	BAMBI	XP_544209.1
Bos taurus (cattle)	BAMBI	NP_001039774.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of BAMBI reduces the viability and motility of colon cancer via activating TGF-?/Smad pathway
Yu W, Chai H
Oncology letters14(4)4793-4799(2017 Oct)

BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury.
Yang Y, Guo C, Liao B, Cao J, Liang C, He X
International journal of molecular medicine39(2)423-429(2017 Feb)

TGF-?/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease.
Zhang JC, Chen G, Chen L, Meng ZJ, Xiong XZ, Liu HJ, Jin Y, Tao XN, Wu JH, Sun SW
Scientific reports631911(2016 Aug)

LPS/TLR4 Signaling Enhances TGF-? Response Through Downregulating BAMBI During Prostatic Hyperplasia.
He Y, Ou Z, Chen X, Zu X, Liu L, Li Y, Cao Z, Chen M, Chen Z, Chen H, Qi L, Wang L
Scientific reports627051(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

BAMBI plays a neuroprotective role by decreasing inflammation and activating autophagy in rats with SCI.
Title: BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury.

Angiotensin II enhances lipopolysaccharide-TLR4 pathway signaling and further down-regulates expression of BAMBI through up-regulation of TLR4, which results in facilitation of pro-fibrotic activity of TGF-beta1.
Title: Angiotensin II facilitates fibrogenic effect of TGF-?1 through enhancing the down-regulation of BAMBI caused by LPS: a new pro-fibrotic mechanism of angiotensin II.

Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/beta-catenin signaling
Title: Metformin-mediated Bambi expression in hepatic stellate cells induces prosurvival Wnt/?-catenin signaling.

Regulated Bambi mRNA synthesis may contribute to TGF beta superfamily signaling modulation in several organs, as suggested by its discrete expression switch in male germ cells.
Title: Expression of Bambi is widespread in juvenile and adult rat tissues and is regulated in male germ cells.

The following Bambi gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Bambi cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa02107	NM_139082.3 Latest version!	Rattus norvegicus BMP and activin membrane-bound inhibitor (Bambi), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Bambi ( NM_139082.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_620782.1 Rattus norvegicus BMP and activin membrane-bound inhibitor (Bambi), mRNA.

Price & Availability↑

CloneID	ORa02107
Clone ID Related Accession (Same CDS sequence)	NM_139082.3
Accession Version	NM_139082.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Rattus norvegicus(Norway rat)
Product	BMP and activin membrane-bound inhibitor homolog precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF387513.1. On Jun 10, 2007 this sequence version replaced NM_139082.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF387513.1, BC070516.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGATCGCC ACTCCAGCTA CATCTTCATC TGGCTGCAGT TGGAGCTCTG CGCCATGGCT 
GTGCTGCTCA CCAAAGGCGA GATCAGATGC TACTGTGATG CCGCTCACTG TGTGGCAACT 
GGTTACATGT GTAAGTCCGA GCTTAGTGCC TGCTTCTCCA GACTCCTTGA TCCTCAGAAC 
ACCAATTCCC CACTAACCCA CGGCTGCCTG GACTCACTCG CAAGCACAGC AGACATCTGC 
CGAGCCAAAC AGGCCCAAAA CCACTCTGGT CCCACCATGC CCACTTTGGA ATGCTGTCAT 
GAAGACATGT GCAATTACCG AGGACTGCAT GATGTCCTCT CTCCTCCCAA GAGTGAAGCC 
TCAGGACAAG GAAACAGATA CCAGCATGAC AGCAGCAGAA ACCTCATCAC TAAGGTGCAG 
GAGCTGACTT CCTCCAAAGA ACTGTGGTTC CGTGCAGCCG TGATCGCGGT TCCCATTGCT 
GGCGGACTGA TCTTGGTGCT GCTCATTATG TTGGCCTTGC GAATGCTGCG AAGTGAGAAC 
AAGAGGCTGC AGGATCAGCG GCAGCAGATG CTCTCTCGTT TGCACTACAG CTTCCATGGA 
CACCACTCCA AGAAGGGACA GGTTGCAAAG TTGGACTTAG AGTGCATGGT GCCCGTCAGT 
GGGCAGGAGA ACTGCTGTCT GACCTGCGAC AAAATGAGGC AAGCAGATCT CAGCAACGAG 
AAGATCCTCT CCCTTGTGCA CTGGGGCATG TACAGTGGTC ATGGGAAGCT GGAATTCGTA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_620782.1
CDS	12..794
Translation	MDRHSSYIFIWLQLELCAMAVLLTKGEIRCYCDAAHCVATGYMCKSELSACFSRLLDPQNTNSPLTHGCLDSLASTADICRAKQAQNHSGPTMPTLECCHEDMCNYRGLHDVLSPPKSEASGQGNRYQHDSSRNLITKVQELTSSKELWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHGHHSKKGQVAKLDLECMVPVSGQENCCLTCDKMRQADLSNEKILSLVHWGMYSGHGKLEFV

Target ORF information:

RefSeq Version	NM_139082.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus BMP and activin membrane-bound inhibitor (Bambi), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_139082.3

ORF Insert Sequence:

ATGGATCGCC ACTCCAGCTA CATCTTCATC TGGCTGCAGT TGGAGCTCTG CGCCATGGCT 
GTGCTGCTCA CCAAAGGCGA GATCAGATGC TACTGTGATG CCGCTCACTG TGTGGCAACT 
GGTTACATGT GTAAGTCCGA GCTTAGTGCC TGCTTCTCCA GACTCCTTGA TCCTCAGAAC 
ACCAATTCCC CACTAACCCA CGGCTGCCTG GACTCACTCG CAAGCACAGC AGACATCTGC 
CGAGCCAAAC AGGCCCAAAA CCACTCTGGT CCCACCATGC CCACTTTGGA ATGCTGTCAT 
GAAGACATGT GCAATTACCG AGGACTGCAT GATGTCCTCT CTCCTCCCAA GAGTGAAGCC 
TCAGGACAAG GAAACAGATA CCAGCATGAC AGCAGCAGAA ACCTCATCAC TAAGGTGCAG 
GAGCTGACTT CCTCCAAAGA ACTGTGGTTC CGTGCAGCCG TGATCGCGGT TCCCATTGCT 
GGCGGACTGA TCTTGGTGCT GCTCATTATG TTGGCCTTGC GAATGCTGCG AAGTGAGAAC 
AAGAGGCTGC AGGATCAGCG GCAGCAGATG CTCTCTCGTT TGCACTACAG CTTCCATGGA 
CACCACTCCA AGAAGGGACA GGTTGCAAAG TTGGACTTAG AGTGCATGGT GCCCGTCAGT 
GGGCAGGAGA ACTGCTGTCT GACCTGCGAC AAAATGAGGC AAGCAGATCT CAGCAACGAG 
AAGATCCTCT CCCTTGTGCA CTGGGGCATG TACAGTGGTC ATGGGAAGCT GGAATTCGTA 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of BAMBI reduces the viability and motility of colon cancer via activating TGF-?/Smad pathway
Oncology letters14(4)4793-4799(2017 Oct)
Yu W,Chai H

BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury.
International journal of molecular medicine39(2)423-429(2017 Feb)
Yang Y,Guo C,Liao B,Cao J,Liang C,He X

TGF-?/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease.
Scientific reports631911(2016 Aug)
Zhang JC,Chen G,Chen L,Meng ZJ,Xiong XZ,Liu HJ,Jin Y,Tao XN,Wu JH,Sun SW

LPS/TLR4 Signaling Enhances TGF-? Response Through Downregulating BAMBI During Prostatic Hyperplasia.
Scientific reports627051(2016 May)
He Y,Ou Z,Chen X,Zu X,Liu L,Li Y,Cao Z,Chen M,Chen Z,Chen H,Qi L,Wang L