Fdps cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Fdps
Entrez Gene ID	83791
Full Name	farnesyl diphosphate synthase
Synonyms	Ac2-125,FPS
General protein information	Preferred Names farnesyl diphosphate synthase Names farnesyl pyrophosphate synthase (2E,6E)-farnesyl diphosphate synthase CR 39 FPP synthase FPP synthetase cholesterol-regulated 39 kDa protein dimethylallyltranstransferase farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) farnesyl diphosphate synthetase farnesyl pyrophosphate synthetase geranyltranstransferase testis-specific farnesyl pyrophosphate synthetase
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	catalyzes the conversion of geranyl diphosphate and isopentenyl diphosphate to diphosphate and trans, trans-farnesyl diphosphate in the isoprene biosynthetic pathway [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031840.1	NP_114028.1	farnesyl pyrophosphate synthase

Pathways from BioSystems

Homologies

Drosophila melanogaster (fruit fly)	Fpps	NP_477380.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007104	XP_308653.4
Magnaporthe oryzae (rice blast fungus)	MGG_08649	XP_003711082.1
Kluyveromyces lactis	KLLA0A06732g	XP_451300.1
Eremothecium gossypii	AGOS_AEL122W	NP_984739.1
Schizosaccharomyces pombe (fission yeast)	fps1	NP_593299.1
Canis lupus familiaris (dog)	FDPS	XP_005622781.1
Bos taurus (cattle)	FDPS	NP_803463.1
Mus musculus (house mouse)	Fdps	NP_001240680.1
Rattus norvegicus (Norway rat)	Fdps	NP_114028.1
Danio rerio (zebrafish)	fdps	NP_001020642.1
Xenopus tropicalis (tropical clawed frog)	fdps	NP_001015867.1
Homo sapiens (human)	FDPS	NP_001995.1
Pan troglodytes (chimpanzee)	FDPS	XP_001160391.1
Gallus gallus (chicken)	FDPS	XP_422855.3
Saccharomyces cerevisiae (baker's yeast)	ERG20	NP_012368.1
Neurospora crassa	NCU01175	XP_961541.1
Arabidopsis thaliana (thale cress)	FPS1	NP_199588.1
Arabidopsis thaliana (thale cress)	FPS2	NP_193452.1
Oryza sativa (rice)	Os05g0543400	NP_001056204.1
Oryza sativa (rice)	Os01g0703400	NP_001044000.1

Gene Ontology
Bibliography

Related articles in PubMed

Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced fibrotic responses in vascular smooth muscle cells.
Du CQ, Liu XW, Zeng GZ, Jin HF, Tang LJ
International journal of molecular medicine35(6)1767-72(2015 Jun)

Inhibition of farnesyl pyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis in vitro.
Li Z, Bi X, Wang M, Zhang J, Song J, Shen X, Han J, Fu G, Ye Y
Clinical and experimental immunology176(3)429-37(2014 Jun)

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW
Cell149(6)1393-406(2012 Jun)

Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats.
Li L, Chen GP, Yang Y, Ye Y, Yao L, Hu SJ
Biochemical pharmacology79(3)399-406(2010 Feb)

Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway.
Ye Y, Hu SJ, Li L
FEBS letters583(18)2997-3003(2009 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data indicate that FPPS may play an important role in Ang II-induced fibrotic responses in VSMCs
Title: Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced fibrotic responses in vascular smooth muscle cells.

Inhibition of farnesyl pyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis in vitro.
Title: Inhibition of farnesyl pyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis in vitro.

This is the first report to show that chronic inhibition of farnesyl pyrophosphate synthase attenuates the development of cardiac hypertrophy and fibrosis.
Title: Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats.

inhibition of FPP synthase by alendronate reduces RhoA activation by diminishing geranylgeranylation which prevents Ang II-induced hypertrophic responses in neonatal cardiomyocytes.
Title: Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway.

The following Fdps gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Fdps cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08855	NM_031840.1 Latest version!	Rattus norvegicus farnesyl diphosphate synthase (Fdps), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$188.30 $269.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Fdps ( NM_031840.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114028.1 Rattus norvegicus farnesyl diphosphate synthase (Fdps), mRNA.

Price & Availability↑

CloneID	ORa08855
Clone ID Related Accession (Same CDS sequence)	NM_031840.1
Accession Version	NM_031840.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1062bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	farnesyl pyrophosphate synthase
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M34477.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M34477.1, FQ218556.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN01906347, SAMN01906348 [ECO:0000348] ##Evidence-Data-END##

ATGAATGGGG ACCAGAAACT GGATGTTCAT AACCAAGAAA AGCAGAATTT CATCCAGCAC 
TTCTCCCAGA TTGTCAAGGT GCTGACTGAG GATGAACTGG GACACCCAGA GAAGGGAGAT 
GCTATTACCC GGATCAAAGA GGTCCTGGAG TACAACACTG TAGGAGGCAA GTACAATCGG 
GGTCTGACGG TGGTACAGAC CTTCCAGGAA CTGGTGGAAC CAAGGAAACA GGATGCTGAG 
AGCCTACAGC GGGCCCTGAC GGTGGGCTGG TGTGTAGAAC TGCTCCAGGC TTTCTTCCTC 
GTGTTAGATG ACATCATGGA CTCTTCCCAC ACTCGCCGGG GGCAGATCTG CTGGTATCAG 
AAGCCGGGCA TAGGCTTGGA TGCCATCAAC GATGCTCTGC TTCTGGAAGC CGCTATCTAC 
CGCCTGCTTA AGTTCTACTG CAGGGAGCAG CCCTACTACC TCAACCTGCT GGAGCTCTTT 
CTACAGAGTT CCTATCAGAC TGAGATCGGG CAGACTCTCG ACCTCATCAC AGCACCCCAG 
GGCCAAGTGG ATCTTGGTAG ATACACTGAA AAGAGGTACA AATCTATCGT CAAGTACAAG 
ACAGCTTTCT ACTCTTTCTA CCTGCCTATC GCGGCTGCCA TGTACATGGC TGGAATTGAT 
GGGGAGAAGG AACACGCTAA TGCCCTGAAG ATCCTGCTGG AGATGGGCGA GTTCTTCCAG 
ATCCAGGACG ACTACCTTGA TCTCTTTGGA GACCCCAGTG TGACCGGAAA GGTCGGCACT 
GACATCCAGG ACAACAAATG CAGCTGGCTG GTGGTTCAGT GTCTGCTACG AGCCACTCCT 
CAGCAGCGCC AGATCTTAGA GGAGAATTAT GGGCAGAAGG ACCCAGAAAA AGTGGCGCGG 
GTGAAAGCAC TGTACGAGGA GCTGGATCTG CGGAGTGTGT TCTTCAAGTA CGAGGAAGAC 
AGTTACAACC GCCTCAAGAG TCTCATAGAG CAGTGCTCCG CGCCCCTGCC CCCATCCATC 
TTCCTGGAAC TAGCAAACAA GATCTACAAG CGGAGAAAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114028.1
CDS	158..1219
Translation	MNGDQKLDVHNQEKQNFIQHFSQIVKVLTEDELGHPEKGDAITRIKEVLEYNTVGGKYNRGLTVVQTFQELVEPRKQDAESLQRALTVGWCVELLQAFFLVLDDIMDSSHTRRGQICWYQKPGIGLDAINDALLLEAAIYRLLKFYCREQPYYLNLLELFLQSSYQTEIGQTLDLITAPQGQVDLGRYTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANALKILLEMGEFFQIQDDYLDLFGDPSVTGKVGTDIQDNKCSWLVVQCLLRATPQQRQILEENYGQKDPEKVARVKALYEELDLRSVFFKYEEDSYNRLKSLIEQCSAPLPPSIFLELANKIYKRRK

Target ORF information:

RefSeq Version	NM_031840.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus farnesyl diphosphate synthase (Fdps), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031840.1

ORF Insert Sequence:

ATGAATGGGG ACCAGAAACT GGATGTTCAT AACCAAGAAA AGCAGAATTT CATCCAGCAC 
TTCTCCCAGA TTGTCAAGGT GCTGACTGAG GATGAACTGG GACACCCAGA GAAGGGAGAT 
GCTATTACCC GGATCAAAGA GGTCCTGGAG TACAACACTG TAGGAGGCAA GTACAATCGG 
GGTCTGACGG TGGTACAGAC CTTCCAGGAA CTGGTGGAAC CAAGGAAACA GGATGCTGAG 
AGCCTACAGC GGGCCCTGAC GGTGGGCTGG TGTGTAGAAC TGCTCCAGGC TTTCTTCCTC 
GTGTTAGATG ACATCATGGA CTCTTCCCAC ACTCGCCGGG GGCAGATCTG CTGGTATCAG 
AAGCCGGGCA TAGGCTTGGA TGCCATCAAC GATGCTCTGC TTCTGGAAGC CGCTATCTAC 
CGCCTGCTTA AGTTCTACTG CAGGGAGCAG CCCTACTACC TCAACCTGCT GGAGCTCTTT 
CTACAGAGTT CCTATCAGAC TGAGATCGGG CAGACTCTCG ACCTCATCAC AGCACCCCAG 
GGCCAAGTGG ATCTTGGTAG ATACACTGAA AAGAGGTACA AATCTATCGT CAAGTACAAG 
ACAGCTTTCT ACTCTTTCTA CCTGCCTATC GCGGCTGCCA TGTACATGGC TGGAATTGAT 
GGGGAGAAGG AACACGCTAA TGCCCTGAAG ATCCTGCTGG AGATGGGCGA GTTCTTCCAG 
ATCCAGGACG ACTACCTTGA TCTCTTTGGA GACCCCAGTG TGACCGGAAA GGTCGGCACT 
GACATCCAGG ACAACAAATG CAGCTGGCTG GTGGTTCAGT GTCTGCTACG AGCCACTCCT 
CAGCAGCGCC AGATCTTAGA GGAGAATTAT GGGCAGAAGG ACCCAGAAAA AGTGGCGCGG 
GTGAAAGCAC TGTACGAGGA GCTGGATCTG CGGAGTGTGT TCTTCAAGTA CGAGGAAGAC 
AGTTACAACC GCCTCAAGAG TCTCATAGAG CAGTGCTCCG CGCCCCTGCC CCCATCCATC 
TTCCTGGAAC TAGCAAACAA GATCTACAAG CGGAGAAAGT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Inhibition of farnesyl pyrophosphate synthase attenuates angiotensin II-induced fibrotic responses in vascular smooth muscle cells.
International journal of molecular medicine35(6)1767-72(2015 Jun)
Du CQ,Liu XW,Zeng GZ,Jin HF,Tang LJ

Inhibition of farnesyl pyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis in vitro.
Clinical and experimental immunology176(3)429-37(2014 Jun)
Li Z,Bi X,Wang M,Zhang J,Song J,Shen X,Han J,Fu G,Ye Y

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Cell149(6)1393-406(2012 Jun)
Castello A,Fischer B,Eichelbaum K,Horos R,Beckmann BM,Strein C,Davey NE,Humphreys DT,Preiss T,Steinmetz LM,Krijgsveld J,Hentze MW

Chronic inhibition of farnesyl pyrophosphate synthase attenuates cardiac hypertrophy and fibrosis in spontaneously hypertensive rats.
Biochemical pharmacology79(3)399-406(2010 Feb)
Li L,Chen GP,Yang Y,Ye Y,Yao L,Hu SJ

Inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced hypertrophic responses in rat neonatal cardiomyocytes: involvement of the RhoA/Rho kinase pathway.
FEBS letters583(18)2997-3003(2009 Sep)
Ye Y,Hu SJ,Li L

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Fdps cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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