Nme2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Nme2
Entrez Gene ID	83782
Full Name	NME/NM23 nucleoside diphosphate kinase 2
Synonyms	NDKB,nm23-2,p18-12d
General protein information	Preferred Names NME/NM23 nucleoside diphosphate kinase 2 Names nucleoside diphosphate kinase B NDK B NDP kinase B NDP kinase alpha P18 expressed in non-metastatic cells 2 histidine protein kinase NDKB non-metastatic cells 2, protein (NM23B) expressed in
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q26
Summary	kinase involved in synthesis of nucleoside triphosphates [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031833.2	NP_114021.2	nucleoside diphosphate kinase B

Pathways from BioSystems

Homologies

Bos taurus (cattle)	NME2	NP_001069844.1
Gallus gallus (chicken)	NME2	NP_990378.1
Rattus norvegicus (Norway rat)	Nme2	NP_114021.2
Oryza sativa (rice)	Os07g0492000	NP_001059682.1
Canis lupus familiaris (dog)	NME2	NP_001019809.1
Homo sapiens (human)	NME2	NP_002503.1
Mus musculus (house mouse)	Nme2	NP_032731.1
Danio rerio (zebrafish)	nme2b.2	NP_571002.1
Xenopus tropicalis (tropical clawed frog)	nme2	NP_001005140.1

Gene Ontology
Bibliography

Related articles in PubMed

The maize (Zea mays L.) nucleoside diphosphate kinase1 (ZmNDPK1) gene encodes a human NM23-H2 homologue that binds and stabilizes G-quadruplex DNA.
Kopylov M, Bass HW, Stroupe ME
Biochemistry54(9)1743-57(2015 Mar)

PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-? precursor protein via a tissue-specific proximal regulatory element (PRE).
Lahiri DK, Maloney B, Rogers JT, Ge YW
BMC genomics1468(2013 Jan)

Activity of nucleoside diphosphate kinase ? (NDPK ?) capable of binding to outer mitochondrial membrane accounts for less than 10% of total NDPK activity present in cytoplasm of liver cells.
Lipskaya TY, Voinova VV
Biochemistry. Biokhimiia77(6)593-602(2012 Jun)

Proteomic characterization of the human sperm nucleus.
de Mateo S, Castillo J, Estanyol JM, Ballesc? JL, Oliva R
Proteomics11(13)2714-26(2011 Jul)

Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.
Tan WL, Bhattacharya B, Loh M, Balasubramanian I, Akram M, Dong D, Wong L, Thakkar B, Salto-Tellez M, Soo RA, Fichtner I, Iacopetta B, Soong R
Cancer biology & therapy11(6)599-608(2011 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PuF may regulate the APP gene promoter
Title: PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-? precursor protein via a tissue-specific proximal regulatory element (PRE).

the sites of NDPK binding to the outer mitochondrial membrane are not identical to those of hexokinase and glycerol kinase.
Title: Activity of nucleoside diphosphate kinase ? (NDPK ?) capable of binding to outer mitochondrial membrane accounts for less than 10% of total NDPK activity present in cytoplasm of liver cells.

Nucleoside diphosphate kinase B regulates Gs function by two different mechanisms.
Title: Through scaffolding and catalytic actions nucleoside diphosphate kinase B differentially regulates basal and ?-adrenoceptor-stimulated cAMP synthesis.

Dowen-regulation of expression and function of nucleoside diphosphate kinase B in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity is reported.
Title: Down-regulation of expression and function of nucleoside diphosphate kinase in insulin-secreting beta-cells under in vitro conditions of glucolipotoxicity.

interaction with phocein
Title: Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I.

The following Nme2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Nme2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa08839	NM_031833.2 Latest version!	Rattus norvegicus NME/NM23 nucleoside diphosphate kinase 2 (Nme2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Nme2 ( NM_031833.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_114021.2 Rattus norvegicus NME/NM23 nucleoside diphosphate kinase 2 (Nme2), mRNA.

Price & Availability↑

CloneID	ORa08839
Clone ID Related Accession (Same CDS sequence)	NM_031833.2
Accession Version	NM_031833.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-17
Organism	Rattus norvegicus(Norway rat)
Product	nucleoside diphosphate kinase B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC086599.1. On Nov 22, 2004 this sequence version replaced NM_031833.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC086599.1, CO403871.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCCAACC TCGAGCGTAC CTTCATTGCC ATCAAGCCAG ATGGCGTGCA GCGCGGCCTG 
GTGGGCGAGA TCATCAAGCG ATTCGAGCAG AAGGGGTTCC GCCTGGTGGC CATGAAGTTC 
CTTCGGGCTT CTGAGGAACA CCTGAAGCAG CACTATATTG ACCTGAAAGA CCGTCCTTTC 
TTCCCGGGGC TGGTGAAGTA CATGAACTCA GGGCCTGTGG TGGCCATGGT CTGGGAGGGG 
CTCAATGTGG TGAAAACAGG CCGAGTGATG CTGGGGGAGA CCAATCCAGC TGATTCGAAG 
CCAGGCACCA TTCGTGGGGA TTTCTGCATT CAAGTTGGCA GGAACATCAT TCACGGCAGT 
GATTCAGTGG AGAGTGCCGA GAAAGAGATC GGTCTATGGT TTAAGCCCGA AGAACTGATT 
GACTATAAGT CTTGTGCCCA TGACTGGGTG TATGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_114021.2
CDS	172..630
Translation	MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFKPEELIDYKSCAHDWVYE

Target ORF information:

RefSeq Version	NM_031833.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus NME/NM23 nucleoside diphosphate kinase 2 (Nme2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031833.2

ORF Insert Sequence:

ATGGCCAACC TCGAGCGTAC CTTCATTGCC ATCAAGCCAG ATGGCGTGCA GCGCGGCCTG 
GTGGGCGAGA TCATCAAGCG ATTCGAGCAG AAGGGGTTCC GCCTGGTGGC CATGAAGTTC 
CTTCGGGCTT CTGAGGAACA CCTGAAGCAG CACTATATTG ACCTGAAAGA CCGTCCTTTC 
TTCCCGGGGC TGGTGAAGTA CATGAACTCA GGGCCTGTGG TGGCCATGGT CTGGGAGGGG 
CTCAATGTGG TGAAAACAGG CCGAGTGATG CTGGGGGAGA CCAATCCAGC TGATTCGAAG 
CCAGGCACCA TTCGTGGGGA TTTCTGCATT CAAGTTGGCA GGAACATCAT TCACGGCAGT 
GATTCAGTGG AGAGTGCCGA GAAAGAGATC GGTCTATGGT TTAAGCCCGA AGAACTGATT 
GACTATAAGT CTTGTGCCCA TGACTGGGTG TATGAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The maize (Zea mays L.) nucleoside diphosphate kinase1 (ZmNDPK1) gene encodes a human NM23-H2 homologue that binds and stabilizes G-quadruplex DNA.
Biochemistry54(9)1743-57(2015 Mar)
Kopylov M,Bass HW,Stroupe ME

PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer's amyloid-? precursor protein via a tissue-specific proximal regulatory element (PRE).
BMC genomics1468(2013 Jan)
Lahiri DK,Maloney B,Rogers JT,Ge YW

Activity of nucleoside diphosphate kinase ? (NDPK ?) capable of binding to outer mitochondrial membrane accounts for less than 10% of total NDPK activity present in cytoplasm of liver cells.
Biochemistry. Biokhimiia77(6)593-602(2012 Jun)
Lipskaya TY,Voinova VV

Proteomic characterization of the human sperm nucleus.
Proteomics11(13)2714-26(2011 Jul)
de Mateo S,Castillo J,Estanyol JM,Ballesc? JL,Oliva R

Low cytosine triphosphate synthase 2 expression renders resistance to 5-fluorouracil in colorectal cancer.
Cancer biology & therapy11(6)599-608(2011 Mar)
Tan WL,Bhattacharya B,Loh M,Balasubramanian I,Akram M,Dong D,Wong L,Thakkar B,Salto-Tellez M,Soo RA,Fichtner I,Iacopetta B,Soong R

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Nme2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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