Vdac1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Vdac1
Entrez Gene ID	83529
Full Name	voltage-dependent anion channel 1
General protein information	Preferred Names voltage-dependent anion channel 1 Names voltage-dependent anion-selective channel protein 1 VDAC-1 outer mitochondrial membrane protein porin 1 rVDAC1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q22
Summary	large diameter (2.5-3 nm) channel, permeable to ions and small molecules; molecular component of Ca2+ transport across the mitochondrial membranes [RGD, Jun 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031353.1	NP_112643.1	voltage-dependent anion-selective channel protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	VDAC1	NP_003365.1
Bos taurus (cattle)	VDAC1	NP_776910.2
Gallus gallus (chicken)	VDAC1	NP_001029041.1
Pan troglodytes (chimpanzee)	VDAC1	XP_001151901.2
	VDAC1	XP_001107652.1
Canis lupus familiaris (dog)	VDAC1	XP_531907.1
Mus musculus (house mouse)	Vdac1	NP_035824.1
Danio rerio (zebrafish)	vdac1	NP_001001404.1
Xenopus tropicalis (tropical clawed frog)	vdac1	NP_001016492.1
Rattus norvegicus (Norway rat)	Vdac1	NP_112643.1

Gene Ontology
Bibliography

Related articles in PubMed

WDR26/MIP2 interacts with VDAC1 and regulates VDAC1 expression levels in H9c2 cells.
Jiang L, Wang H, Chen G, Feng Y, Zou J, Liu M, Liu K, Wang N, Zhang H, Wang K, Xiao X
Free radical biology & medicine(2017 Dec)

Gene polymorphisms in the PI3K/AKT/mTOR signaling pathway contribute to prostate cancer susceptibility in Chinese men.
Liu T, Gulinaer A, Shi X, Wang F, An H, Cui W, Li Q
Oncotarget8(37)61305-61317(2017 Sep)

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction.
Ben-Hail D, Begas-Shvartz R, Shalev M, Shteinfer-Kuzmine A, Gruzman A, Reina S, De Pinto V, Shoshan-Barmatz V
The Journal of biological chemistry291(48)24986-25003(2016 Nov)

lncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy.
Li X, Wang H, Yao B, Xu W, Chen J, Zhou X
Scientific reports636340(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study describes novel drug candidates with a defined mechanism of action that involves inhibition of VDAC1 oligomerization, apoptosis, and mitochondrial dysfunction. The compounds VBIT-3 and VBIT-4 offer a therapeutic strategy for treating different diseases associated with enhanced apoptosis and point to VDAC1 as a promising target for therapeutic intervention.
Title: Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction.

VDAC1-interacting anion transport inhibitors inhibited apoptosis via direct interaction with VDAC1 to inhibit its oligomerization and subsequent Cyto c release and apoptosis.
Title: VDAC1-interacting anion transport inhibitors inhibit VDAC1 oligomerization and apoptosis.

Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel, VDAC.
Title: Tubulin tail sequences and post-translational modifications regulate closure of mitochondrial voltage-dependent anion channel (VDAC).

Results indicate that mitochondrial function associated with VDAC1 is decreased in sporadic and experimental Parkinson's disease, and this decrease is associated with alpha-synuclein accumulation and aggregation
Title: Abnormal alpha-synuclein reduces nigral voltage-dependent anion channel 1 in sporadic and experimental Parkinson's disease.

The data obtained argue against VDAC1 and in favor of Cyb5R3 involvement in the activation of redox cyclers in the outer mitochondrial membrane.
Title: External mitochondrial NADH-dependent reductase of redox cyclers: VDAC1 or Cyb5R3?

The following Vdac1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Vdac1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12452	NM_031353.1 Latest version!	Rattus norvegicus voltage-dependent anion channel 1 (Vdac1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Vdac1 ( NM_031353.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112643.1 Rattus norvegicus voltage-dependent anion channel 1 (Vdac1), mRNA.

Price & Availability↑

CloneID	ORa12452
Clone ID Related Accession (Same CDS sequence)	NM_031353.1
Accession Version	NM_031353.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 852bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-20
Organism	Rattus norvegicus(Norway rat)
Product	voltage-dependent anion-selective channel protein 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB039662.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB039662.1, BC060558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: inferred from homology ##RefSeq-Attributes-END##

ATGGCTGTGC CTCCCACATA TGCTGATCTT GGCAAGTCCG CCAGGGATGT CTTCACCAAG 
GGCTACGGCT TTGGCTTAAT AAAACTTGAT TTGAAAACGA AGTCCGAGAA TGGATTGGAA 
TTTACTAGCT CAGGTTCTGC CAACACGGAG ACCACCAAAG TGAACGGCAG TCTGGAAACC 
AAGTACAGAT GGACCGAGTA TGGGCTGACG TTTACTGAGA AGTGGAACAC AGACAACACC 
CTGGGCACTG AGATCACCGT GGAAGACCAG CTTGCTCGTG GACTGAAGCT GACCTTTGAT 
TCATCTTTCT CGCCTAACAC TGGGAAAAAA AATGCTAAAA TCAAGACAGG GTACAAGAGG 
GAGCATATCA ACCTGGGCTG TGATGTGGAC TTTGACATCG CTGGGCCCTC AATCCGGGGC 
GCTCTGGTGC TTGGCTATGA GGGTTGGCTG GCTGGCTACC AGATGAATTT TGAGACCTCG 
AAGTCCCGAG TGACCCAGAG CAACTTTGCA GTTGGCTACA AGACGGACGA ATTCCAGCTT 
CATACTAATG TGAATGATGG GACGGAGTTT GGTGGCTCCA TTTACCAGAA GGTGAACAAG 
AAGTTGGAGA CTGCTGTCAA TCTCGCCTGG ACCGCAGGAA ACAGTAACAC TCGCTTTGGA 
ATAGCAGCCA AGTATCAGGT CGACCCTGAT GCCTGCTTTT CGGCCAAAGT GAACAACTCC 
AGTCTAATTG GCTTAGGGTA CACTCAGACC CTAAAACCAG GTATCAAACT GACACTGTCA 
GCCCTGCTGG ATGGCAAGAA CGTCAATGCG GGTGGCCACA AGCTTGGTTT AGGACTGGAA 
TTTCAAGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112643.1
CDS	67..918
Translation	MAVPPTYADLGKSARDVFTKGYGFGLIKLDLKTKSENGLEFTSSGSANTETTKVNGSLETKYRWTEYGLTFTEKWNTDNTLGTEITVEDQLARGLKLTFDSSFSPNTGKKNAKIKTGYKREHINLGCDVDFDIAGPSIRGALVLGYEGWLAGYQMNFETSKSRVTQSNFAVGYKTDEFQLHTNVNDGTEFGGSIYQKVNKKLETAVNLAWTAGNSNTRFGIAAKYQVDPDACFSAKVNNSSLIGLGYTQTLKPGIKLTLSALLDGKNVNAGGHKLGLGLEFQA

Target ORF information:

RefSeq Version	NM_031353.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus voltage-dependent anion channel 1 (Vdac1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031353.1

ORF Insert Sequence:

ATGGCTGTGC CTCCCACATA TGCTGATCTT GGCAAGTCCG CCAGGGATGT CTTCACCAAG 
GGCTACGGCT TTGGCTTAAT AAAACTTGAT TTGAAAACGA AGTCCGAGAA TGGATTGGAA 
TTTACTAGCT CAGGTTCTGC CAACACGGAG ACCACCAAAG TGAACGGCAG TCTGGAAACC 
AAGTACAGAT GGACCGAGTA TGGGCTGACG TTTACTGAGA AGTGGAACAC AGACAACACC 
CTGGGCACTG AGATCACCGT GGAAGACCAG CTTGCTCGTG GACTGAAGCT GACCTTTGAT 
TCATCTTTCT CGCCTAACAC TGGGAAAAAA AATGCTAAAA TCAAGACAGG GTACAAGAGG 
GAGCATATCA ACCTGGGCTG TGATGTGGAC TTTGACATCG CTGGGCCCTC AATCCGGGGC 
GCTCTGGTGC TTGGCTATGA GGGTTGGCTG GCTGGCTACC AGATGAATTT TGAGACCTCG 
AAGTCCCGAG TGACCCAGAG CAACTTTGCA GTTGGCTACA AGACGGACGA ATTCCAGCTT 
CATACTAATG TGAATGATGG GACGGAGTTT GGTGGCTCCA TTTACCAGAA GGTGAACAAG 
AAGTTGGAGA CTGCTGTCAA TCTCGCCTGG ACCGCAGGAA ACAGTAACAC TCGCTTTGGA 
ATAGCAGCCA AGTATCAGGT CGACCCTGAT GCCTGCTTTT CGGCCAAAGT GAACAACTCC 
AGTCTAATTG GCTTAGGGTA CACTCAGACC CTAAAACCAG GTATCAAACT GACACTGTCA 
GCCCTGCTGG ATGGCAAGAA CGTCAATGCG GGTGGCCACA AGCTTGGTTT AGGACTGGAA 
TTTCAAGCAT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

WDR26/MIP2 interacts with VDAC1 and regulates VDAC1 expression levels in H9c2 cells.
Free radical biology & medicine(2017 Dec)
Jiang L,Wang H,Chen G,Feng Y,Zou J,Liu M,Liu K,Wang N,Zhang H,Wang K,Xiao X

Gene polymorphisms in the PI3K/AKT/mTOR signaling pathway contribute to prostate cancer susceptibility in Chinese men.
Oncotarget8(37)61305-61317(2017 Sep)
Liu T,Gulinaer A,Shi X,Wang F,An H,Cui W,Li Q

Novel Compounds Targeting the Mitochondrial Protein VDAC1 Inhibit Apoptosis and Protect against Mitochondrial Dysfunction.
The Journal of biological chemistry291(48)24986-25003(2016 Nov)
Ben-Hail D,Begas-Shvartz R,Shalev M,Shteinfer-Kuzmine A,Gruzman A,Reina S,De Pinto V,Shoshan-Barmatz V

lncRNA H19/miR-675 axis regulates cardiomyocyte apoptosis by targeting VDAC1 in diabetic cardiomyopathy.
Scientific reports636340(2016 Oct)
Li X,Wang H,Yao B,Xu W,Chen J,Zhou X

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Vdac1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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