Rrad cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rrad
Entrez Gene ID	83521
Full Name	RRAD, Ras related glycolysis inhibitor and calcium channel regulator
General protein information	Preferred Names RRAD, Ras related glycolysis inhibitor and calcium channel regulator Names GTP-binding protein RAD RAD1 Ras-related associated with diabetes ras associated with diabetes
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19p14
Summary	human homolog is a GTP-binding protein [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_006255055.3	XP_006255117.1	GTP-binding protein RAD isoform X1
NM_053338.2	NP_445790.2	GTP-binding protein RAD

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Rrad	NP_062636.2
Rattus norvegicus (Norway rat)	Rrad	NP_445790.2
Bos taurus (cattle)	RRAD	NP_001039378.1
Xenopus tropicalis (tropical clawed frog)	rrad	NP_001016726.1
Pan troglodytes (chimpanzee)	RRAD	XP_001143391.2
	RRAD	XP_001086160.1
Canis lupus familiaris (dog)	RRAD	XP_854048.1
Homo sapiens (human)	RRAD	NP_001122322.1
Gallus gallus (chicken)	RRAD	NP_001264535.1
Danio rerio (zebrafish)	rrad	NP_956092.1

Gene Ontology
Bibliography

Related articles in PubMed

Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor.
Zhang J, Chang L, Chen C, Zhang M, Luo Y, Hamblin M, Villacorta L, Xiong JW, Chen YE, Zhang J, Zhu X
Cardiovascular research91(1)90-8(2011 Jul)

Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase.
Sun Z, Zhang J, Zhang J, Chen C, Du Q, Chang L, Cao C, Zheng M, Garcia-Barrio MT, Chen YE, Xiao RP, Mao J, Zhu X
Biochemical and biophysical research communications409(1)52-7(2011 May)

Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells.
Luo Y, Zhang M, Zhang J, Zhang J, Chen C, Chen YE, Xiong JW, Zhu X
PloS one6(4)e19408(2011 Apr)

Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.
Wang G, Zhu X, Xie W, Han P, Li K, Sun Z, Wang Y, Chen C, Song R, Cao C, Zhang J, Wu C, Liu J, Cheng H
Circulation research106(2)317-27(2010 Feb)

Rad GTPase deficiency leads to cardiac hypertrophy.
Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Br?ning JC, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Day SM, Kahn CR, Chen YE
Circulation116(25)2976-2983(2007 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor in failing hearts.
Title: Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor.

Rad-triggered apoptosis was mediated by the activation of p38 MAPK.
Title: Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase.

Rad is regulated by PDGF through the transcriptional factor Egr-1 in RASMCs
Title: Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells.

Results establish Rad as a novel endogenous regulator of cardiac EC coupling and betaAR signaling and support a parsimonious model in which Rad buffers Ca(v)beta to modulate LCC activity, EC coupling, and betaAR responsiveness.
Title: Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.

Rad is a novel mediator that inhibits cardiac hypertrophy through the CaMKII pathway
Title: Rad GTPase deficiency leads to cardiac hypertrophy.

The following Rrad gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rrad cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09311	NM_053338.2 Latest version!	Rattus norvegicus RRAD, Ras related glycolysis inhibitor and calcium channel regulator (Rrad), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
ORa09311	XM_006255055.3 Latest version!	Rattus norvegicus RRAD, Ras related glycolysis inhibitor and calcium channel regulator (Rrad), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rrad ( NM_053338.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_445790.2 Rattus norvegicus RRAD, Ras related glycolysis inhibitor and calcium channel regulator (Rrad), mRNA.

Price & Availability↑

CloneID	ORa09311
Clone ID Related Accession (Same CDS sequence)	XM_006255055.3 , NM_053338.2
Accession Version	NM_053338.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-20
Organism	Rattus norvegicus(Norway rat)
Product	GTP-binding protein RAD
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FM054321.1, CK602305.1, FM055705.1 and CK840773.1. On Aug 4, 2012 this sequence version replaced NM_053338.1. ##Evidence-Data-START## Transcript exon combination :: U12187.1, EV767675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACCCTGA ATGGAGGCAG CGGAGCGGGC GGCAGCCGTA GCGCGGGCCG GGAGCGCGAC 
CGTCGTCGAG GCAGCACCCC ATGGGGCCCG GCACCCCCAC TGCACCGCAG GAGCATGCCG 
GTGGACGAGC GAGACCTTCA GGCGGCGCTA ACCCCGGGCT CCCTGGCAGC GACTGCAGCT 
GGAACTCGGA CACAGGGGCA GAGGCTGGAC TGGCCTGAAG GCTCCTCCGA TTCGCTCAGT 
TCTGGAGACA GCGGCTCAGA GGATGGCGTT TACAAGGTGC TGCTGCTGGG GGCACCTGGT 
GTGGGCAAGA GCGCTCTGGC GCGCATCTTT GGTGGTATAG AAGACGGACC TGAAGCAGAA 
GCAGCAGGGC ACACATATGA CCGTTCTATC ACTGTGGATG GAGAAGAAGC ATCACTAATG 
GTCTATGACA TTTGGGAACA GGATGGAGGC TGCTGGCTGC CTGGCCACTG CATGGCCATG 
GGGGATGCAT ATGTCATTGT GTACTCAATA ACGGACAAGG GCAGCTTTGA GAAAGCCTCA 
GAACTCCGGG TCCAGCTGCG GCGGGCACGG CAGACAGACA ATGTGCCCAT CATCCTAGTG 
GGCAACAAGA GCGATCTGGT GCGCTCTCGT GAGGTCTCTG TGGATGAGGG CCGGGCCTGC 
GCAGTGGTCT TCGACTGCAA GTTCATCGAG ACCTCCGCAG CACTGCATCA CAACGTCCAG 
GCACTGTTCG AGGGTGTTGT GCGTCAGATA CGCCTGCGCA GGGACAGCAA AGAGGATAAT 
GCTCGTCGAC AAGCTGGCAC TCGACGACGG GAGAGCCTTG GCAAGAAGGC CAAACGCTTT 
CTGGGCCGCA TAGTAGCTCG CAACAGCCGC AAGATGGCCT TTCGTGCCAA GTCCAAGTCC 
TGCCATGACC TCTCTGTTCT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_445790.2
CDS	173..1096
Translation	MTLNGGSGAGGSRSAGRERDRRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGSLAATAAGTRTQGQRLDWPEGSSDSLSSGDSGSEDGVYKVLLLGAPGVGKSALARIFGGIEDGPEAEAAGHTYDRSITVDGEEASLMVYDIWEQDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRRARQTDNVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEDNARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL

Target ORF information:

RefSeq Version	NM_053338.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus RRAD, Ras related glycolysis inhibitor and calcium channel regulator (Rrad), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_053338.2

ORF Insert Sequence:

ATGACCCTGA ATGGAGGCAG CGGAGCGGGC GGCAGCCGTA GCGCGGGCCG GGAGCGCGAC 
CGTCGTCGAG GCAGCACCCC ATGGGGCCCG GCACCCCCAC TGCACCGCAG GAGCATGCCG 
GTGGACGAGC GAGACCTTCA GGCGGCGCTA ACCCCGGGCT CCCTGGCAGC GACTGCAGCT 
GGAACTCGGA CACAGGGGCA GAGGCTGGAC TGGCCTGAAG GCTCCTCCGA TTCGCTCAGT 
TCTGGAGACA GCGGCTCAGA GGATGGCGTT TACAAGGTGC TGCTGCTGGG GGCACCTGGT 
GTGGGCAAGA GCGCTCTGGC GCGCATCTTT GGTGGTATAG AAGACGGACC TGAAGCAGAA 
GCAGCAGGGC ACACATATGA CCGTTCTATC ACTGTGGATG GAGAAGAAGC ATCACTAATG 
GTCTATGACA TTTGGGAACA GGATGGAGGC TGCTGGCTGC CTGGCCACTG CATGGCCATG 
GGGGATGCAT ATGTCATTGT GTACTCAATA ACGGACAAGG GCAGCTTTGA GAAAGCCTCA 
GAACTCCGGG TCCAGCTGCG GCGGGCACGG CAGACAGACA ATGTGCCCAT CATCCTAGTG 
GGCAACAAGA GCGATCTGGT GCGCTCTCGT GAGGTCTCTG TGGATGAGGG CCGGGCCTGC 
GCAGTGGTCT TCGACTGCAA GTTCATCGAG ACCTCCGCAG CACTGCATCA CAACGTCCAG 
GCACTGTTCG AGGGTGTTGT GCGTCAGATA CGCCTGCGCA GGGACAGCAA AGAGGATAAT 
GCTCGTCGAC AAGCTGGCAC TCGACGACGG GAGAGCCTTG GCAAGAAGGC CAAACGCTTT 
CTGGGCCGCA TAGTAGCTCG CAACAGCCGC AAGATGGCCT TTCGTGCCAA GTCCAAGTCC 
TGCCATGACC TCTCTGTTCT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Rrad ( XM_006255055.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006255117.1 Rattus norvegicus RRAD, Ras related glycolysis inhibitor and calcium channel regulator (Rrad), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa09311
Clone ID Related Accession (Same CDS sequence)	XM_006255055.3 , NM_053338.2
Accession Version	XM_006255055.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 924bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	GTP-binding protein RAD isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005118.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006255055.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCCTGA ATGGAGGCAG CGGAGCGGGC GGCAGCCGTA GCGCGGGCCG GGAGCGCGAC 
CGTCGTCGAG GCAGCACCCC ATGGGGCCCG GCACCCCCAC TGCACCGCAG GAGCATGCCG 
GTGGACGAGC GAGACCTTCA GGCGGCGCTA ACCCCGGGCT CCCTGGCAGC GACTGCAGCT 
GGAACTCGGA CACAGGGGCA GAGGCTGGAC TGGCCTGAAG GCTCCTCCGA TTCGCTCAGT 
TCTGGAGACA GCGGCTCAGA GGATGGCGTT TACAAGGTGC TGCTGCTGGG GGCACCTGGT 
GTGGGCAAGA GCGCTCTGGC GCGCATCTTT GGTGGTATAG AAGACGGACC TGAAGCAGAA 
GCAGCAGGGC ACACATATGA CCGTTCTATC ACTGTGGATG GAGAAGAAGC ATCACTAATG 
GTCTATGACA TTTGGGAACA GGATGGAGGC TGCTGGCTGC CTGGCCACTG CATGGCCATG 
GGGGATGCAT ATGTCATTGT GTACTCAATA ACGGACAAGG GCAGCTTTGA GAAAGCCTCA 
GAACTCCGGG TCCAGCTGCG GCGGGCACGG CAGACAGACA ATGTGCCCAT CATCCTAGTG 
GGCAACAAGA GCGATCTGGT GCGCTCTCGT GAGGTCTCTG TGGATGAGGG CCGGGCCTGC 
GCAGTGGTCT TCGACTGCAA GTTCATCGAG ACCTCCGCAG CACTGCATCA CAACGTCCAG 
GCACTGTTCG AGGGTGTTGT GCGTCAGATA CGCCTGCGCA GGGACAGCAA AGAGGATAAT 
GCTCGTCGAC AAGCTGGCAC TCGACGACGG GAGAGCCTTG GCAAGAAGGC CAAACGCTTT 
CTGGGCCGCA TAGTAGCTCG CAACAGCCGC AAGATGGCCT TTCGTGCCAA GTCCAAGTCC 
TGCCATGACC TCTCTGTTCT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006255117.1
CDS	260..1183
Translation	MTLNGGSGAGGSRSAGRERDRRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGSLAATAAGTRTQGQRLDWPEGSSDSLSSGDSGSEDGVYKVLLLGAPGVGKSALARIFGGIEDGPEAEAAGHTYDRSITVDGEEASLMVYDIWEQDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRRARQTDNVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDSKEDNARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL

Target ORF information:

RefSeq Version	XM_006255055.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus RRAD, Ras related glycolysis inhibitor and calcium channel regulator (Rrad), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006255055.3

ORF Insert Sequence:

ATGACCCTGA ATGGAGGCAG CGGAGCGGGC GGCAGCCGTA GCGCGGGCCG GGAGCGCGAC 
CGTCGTCGAG GCAGCACCCC ATGGGGCCCG GCACCCCCAC TGCACCGCAG GAGCATGCCG 
GTGGACGAGC GAGACCTTCA GGCGGCGCTA ACCCCGGGCT CCCTGGCAGC GACTGCAGCT 
GGAACTCGGA CACAGGGGCA GAGGCTGGAC TGGCCTGAAG GCTCCTCCGA TTCGCTCAGT 
TCTGGAGACA GCGGCTCAGA GGATGGCGTT TACAAGGTGC TGCTGCTGGG GGCACCTGGT 
GTGGGCAAGA GCGCTCTGGC GCGCATCTTT GGTGGTATAG AAGACGGACC TGAAGCAGAA 
GCAGCAGGGC ACACATATGA CCGTTCTATC ACTGTGGATG GAGAAGAAGC ATCACTAATG 
GTCTATGACA TTTGGGAACA GGATGGAGGC TGCTGGCTGC CTGGCCACTG CATGGCCATG 
GGGGATGCAT ATGTCATTGT GTACTCAATA ACGGACAAGG GCAGCTTTGA GAAAGCCTCA 
GAACTCCGGG TCCAGCTGCG GCGGGCACGG CAGACAGACA ATGTGCCCAT CATCCTAGTG 
GGCAACAAGA GCGATCTGGT GCGCTCTCGT GAGGTCTCTG TGGATGAGGG CCGGGCCTGC 
GCAGTGGTCT TCGACTGCAA GTTCATCGAG ACCTCCGCAG CACTGCATCA CAACGTCCAG 
GCACTGTTCG AGGGTGTTGT GCGTCAGATA CGCCTGCGCA GGGACAGCAA AGAGGATAAT 
GCTCGTCGAC AAGCTGGCAC TCGACGACGG GAGAGCCTTG GCAAGAAGGC CAAACGCTTT 
CTGGGCCGCA TAGTAGCTCG CAACAGCCGC AAGATGGCCT TTCGTGCCAA GTCCAAGTCC 
TGCCATGACC TCTCTGTTCT CTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Rad GTPase inhibits cardiac fibrosis through connective tissue growth factor.
Cardiovascular research91(1)90-8(2011 Jul)
Zhang J,Chang L,Chen C,Zhang M,Luo Y,Hamblin M,Villacorta L,Xiong JW,Chen YE,Zhang J,Zhu X

Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase.
Biochemical and biophysical research communications409(1)52-7(2011 May)
Sun Z,Zhang J,Zhang J,Chen C,Du Q,Chang L,Cao C,Zheng M,Garcia-Barrio MT,Chen YE,Xiao RP,Mao J,Zhu X

Platelet-derived growth factor induces Rad expression through Egr-1 in vascular smooth muscle cells.
PloS one6(4)e19408(2011 Apr)
Luo Y,Zhang M,Zhang J,Zhang J,Chen C,Chen YE,Xiong JW,Zhu X

Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart.
Circulation research106(2)317-27(2010 Feb)
Wang G,Zhu X,Xie W,Han P,Li K,Sun Z,Wang Y,Chen C,Song R,Cao C,Zhang J,Wu C,Liu J,Cheng H

Rad GTPase deficiency leads to cardiac hypertrophy.
Circulation116(25)2976-2983(2007 Dec)
Chang L,Zhang J,Tseng YH,Xie CQ,Ilany J,Br?ning JC,Sun Z,Zhu X,Cui T,Youker KA,Yang Q,Day SM,Kahn CR,Chen YE

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Rrad cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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