Aplnr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Aplnr
Entrez Gene ID	83518
Full Name	apelin receptor
Synonyms	Agtrl1,Apj
General protein information	Preferred Names apelin receptor Names apelin receptor B78 G-protein coupled receptor APJ GPCR34 angiotensin receptor-like 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 3 Map Location: 3q24

mRNA and Protein(s)

mRNA	Protein	Name
NM_031349.2	NP_112639.1	apelin receptor

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	APLNR	XP_521984.1
Mus musculus (house mouse)	Aplnr	NP_035914.1
Canis lupus familiaris (dog)	APLNR	XP_005631266.1
Homo sapiens (human)	APLNR	NP_005152.1
Rattus norvegicus (Norway rat)	Aplnr	NP_112639.1
Gallus gallus (chicken)	APLNR	XP_001232341.2
	APLNR	NP_001040591.1

Gene Ontology
Bibliography

Related articles in PubMed

Heterodimerization of apelin and opioid receptors and cardiac inotropic and lusitropic effects of apelin in 2K1C hypertension: Role of pERK1/2 and PKC.
Rostamzadeh F, Najafipour H, Yeganeh-Hajahmadi M, Esmaeili-Mahani S, Joukar S, Iranpour M
Life sciences19124-33(2017 Dec)

Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts.
Sharma B, Ho L, Ford GH, Chen HI, Goldstone AB, Woo YJ, Quertermous T, Reversade B, Red-Horse K
Developmental cell42(6)655-666.e3(2017 09)

Effect of the spinal apelin?APJ system on the pathogenesis of chronic constriction injury?induced neuropathic pain in rats.
Xiong Q, He W, Wang H, Zhou J, Zhang Y, He J, Yang C, Zhang B
Molecular medicine reports16(2)1223-1231(2017 Aug)

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.
Ho L, van Dijk M, Chye STJ, Messerschmidt DM, Chng SC, Ong S, Yi LK, Boussata S, Goh GH, Afink GB, Lim CY, Dunn NR, Solter D, Knowles BB, Reversade B
Science (New York, N.Y.)357(6352)707-713(2017 08)

Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling.
Galon-Tilleman H, Yang H, Bednarek MA, Spurlock SM, Paavola KJ, Ko B, To C, Luo J, Tian H, Jermutus L, Grimsby J, Rondinone CM, Konkar A, Kaplan DD
The Journal of biological chemistry292(5)1925-1933(2017 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Apelin- induced recovery of ERK1/2 phosphorylation and Kappa Opioid receptors -APJ dimerization may nominate apelin as a therapeutic goal in treatment of renovascular hypertension.
Title: Heterodimerization of apelin and opioid receptors and cardiac inotropic and lusitropic effects of apelin in 2K1C hypertension: Role of pERK1/2 and PKC.

Apelin-36-[L28C(30kDa-PEG)] provides a starting point for the development of diabetes therapeutics that are devoid of the blood pressure effects associated with canonical APJ activation
Title: Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling.

Electroacupuncture stimulation could alleviate inflammatory pain, at least in part, by restoring apelin and APJ mRNA and protein expression levels, which are downregulated in the complete Freund's adjuvant pain model.
Title: The Effects of Electroacupuncture on the Apelin/APJ System in the Spinal Cord of Rats With Inflammatory Pain.

Apelin receptor and apelin mRNA were significantly increased in the left ventricle following a high fat diet.
Title: The role of apelin in central cardiovascular regulation in rats with post-infarct heart failure maintained on a normal fat or high fat diet.

APJ mRNA levels were similar in placenta and mesometrial triangle at embryonic day 13. In the placenta, APJ expression was increased at E17 versus the E13 level and reduced at E21, whereas in the Meso-tr an opposite modulation was observed.
Title: Apelin Controls Fetal and Neonatal Glucose Homeostasis and Is Altered by Maternal Undernutrition.

The following Aplnr gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Aplnr cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa42479	NM_031349.2 Latest version!	Rattus norvegicus apelin receptor (Aplnr), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$188.30 $269.00

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Aplnr ( NM_031349.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112639.1 Rattus norvegicus apelin receptor (Aplnr), mRNA.

Price & Availability↑

CloneID	ORa42479
Clone ID Related Accession (Same CDS sequence)	NM_031349.2
Accession Version	NM_031349.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1134bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-05
Organism	Rattus norvegicus(Norway rat)
Product	apelin receptor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC072494.1. On Jun 13, 2004 this sequence version replaced NM_031349.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC072494.1 [ECO:0000332] ##Evidence-Data-END##

ATGGAAGATG ATGGTTACAA CTACTACGGG GCTGACAACC AGTCTGAATG TGACTACGCA 
GACTGGACGC CCTCTGGAGC TCTCATCCCT GCCATCTACA TTCTGGTTTT CCTTCTAGGC 
ACCACAGGCA ATGGCCTGGT GCTCTGGACC GTGTTTTGGA GCAGCCGAGA AAAGAGACGC 
TCAGCTGACA TCTTCATTGC CAGCCTGGCT GTGGCTGACT TGACCTTTGT GGTGACTTTG 
CCACTGTGGG CCACTTATAC CTACCGGGAG TTTGACTGGC CTTTTGGAAC CTTCTCTTGC 
AAGCTCAGCA GCTACCTCAT CTTTGTCAAC ATGTACGCCA GTGTCTTTTG CCTCACCGGC 
CTCAGCTTTG ACCGATACCT GGCCATTGTC AGGCCAGTGG CTAACGCTCG ACTAAGGCTG 
CGAGTCAGCG GGGCCGTGGC CACAGCAGTC TTGTGGGTGC TGGCTGCCCT TCTAGCTGTG 
CCCGTCATGG TGTTCCGTTC CACTGACATC CCGGAAAACA GCACCAAGAC CCAGTGCTAC 
ATGGACTACT CTATGGTGGC CACTTCAAAC TCAGAGTGGG CCTGGGAGGT GGGCCTTGGG 
GTGTCCTCCA CTGCTGTGGG CTTTGTGGTG CCCTTCATCA TCATGCTGAC CTGTTACTTC 
TTCATTGCCC AAACCATCGC TGGCCATTTC CGAAAGGAGC GCATCGAGGG CCTGCGGAAG 
AGGCGCCGGC TGCTGAGCAT CATCGTGGTG CTGGTGGTGA CCTTTGCCCT GTGCTGGATG 
CCTTACCACC TGGTGAAGAC TCTCTACATG CTGGGCAATT TGCTGCACTG GCCCTGTGAC 
TTTGACAGCT TCCTCATGAA TGTCTTTCCC TATTGCACCT GCATCAGTTA CGTCAACAGC 
TGCCTCAACC CCTTCCTCTA TGCCTTCTTT GACCCCCGAT TTCGCCGAGC CTGCACCTCC 
ATGCTCTGCT GTGACCAGAG CGGGTGCAAA GGCAGCCCTC ACAGCAGCAG TGCAGAGAAA 
TCTGCCAGTT ATTCTTCTGG GCACAGCCAG GGCCCCGGCC CCAACATGTG CAAGGGAGGA 
GAACCGATGC ATGAGAAATC TATCCCCTAT AGCCAAGAAA CCCTTGTGGA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112639.1
CDS	224..1357
Translation	MEDDGYNYYGADNQSECDYADWTPSGALIPAIYILVFLLGTTGNGLVLWTVFWSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYREFDWPFGTFSCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAVPVMVFRSTDIPENSTKTQCYMDYSMVATSNSEWAWEVGLGVSSTAVGFVVPFIIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGNLLHWPCDFDSFLMNVFPYCTCISYVNSCLNPFLYAFFDPRFRRACTSMLCCDQSGCKGSPHSSSAEKSASYSSGHSQGPGPNMCKGGEPMHEKSIPYSQETLVD

Target ORF information:

RefSeq Version	NM_031349.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus apelin receptor (Aplnr), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031349.2

ORF Insert Sequence:

ATGGAAGATG ATGGTTACAA CTACTACGGG GCTGACAACC AGTCTGAATG TGACTACGCA 
GACTGGACGC CCTCTGGAGC TCTCATCCCT GCCATCTACA TTCTGGTTTT CCTTCTAGGC 
ACCACAGGCA ATGGCCTGGT GCTCTGGACC GTGTTTTGGA GCAGCCGAGA AAAGAGACGC 
TCAGCTGACA TCTTCATTGC CAGCCTGGCT GTGGCTGACT TGACCTTTGT GGTGACTTTG 
CCACTGTGGG CCACTTATAC CTACCGGGAG TTTGACTGGC CTTTTGGAAC CTTCTCTTGC 
AAGCTCAGCA GCTACCTCAT CTTTGTCAAC ATGTACGCCA GTGTCTTTTG CCTCACCGGC 
CTCAGCTTTG ACCGATACCT GGCCATTGTC AGGCCAGTGG CTAACGCTCG ACTAAGGCTG 
CGAGTCAGCG GGGCCGTGGC CACAGCAGTC TTGTGGGTGC TGGCTGCCCT TCTAGCTGTG 
CCCGTCATGG TGTTCCGTTC CACTGACATC CCGGAAAACA GCACCAAGAC CCAGTGCTAC 
ATGGACTACT CTATGGTGGC CACTTCAAAC TCAGAGTGGG CCTGGGAGGT GGGCCTTGGG 
GTGTCCTCCA CTGCTGTGGG CTTTGTGGTG CCCTTCATCA TCATGCTGAC CTGTTACTTC 
TTCATTGCCC AAACCATCGC TGGCCATTTC CGAAAGGAGC GCATCGAGGG CCTGCGGAAG 
AGGCGCCGGC TGCTGAGCAT CATCGTGGTG CTGGTGGTGA CCTTTGCCCT GTGCTGGATG 
CCTTACCACC TGGTGAAGAC TCTCTACATG CTGGGCAATT TGCTGCACTG GCCCTGTGAC 
TTTGACAGCT TCCTCATGAA TGTCTTTCCC TATTGCACCT GCATCAGTTA CGTCAACAGC 
TGCCTCAACC CCTTCCTCTA TGCCTTCTTT GACCCCCGAT TTCGCCGAGC CTGCACCTCC 
ATGCTCTGCT GTGACCAGAG CGGGTGCAAA GGCAGCCCTC ACAGCAGCAG TGCAGAGAAA 
TCTGCCAGTT ATTCTTCTGG GCACAGCCAG GGCCCCGGCC CCAACATGTG CAAGGGAGGA 
GAACCGATGC ATGAGAAATC TATCCCCTAT AGCCAAGAAA CCCTTGTGGA CTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Heterodimerization of apelin and opioid receptors and cardiac inotropic and lusitropic effects of apelin in 2K1C hypertension: Role of pERK1/2 and PKC.
Life sciences19124-33(2017 Dec)
Rostamzadeh F,Najafipour H,Yeganeh-Hajahmadi M,Esmaeili-Mahani S,Joukar S,pour M

Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts.
Developmental cell42(6)655-666.e3(2017 09)
Sharma B,Ho L,Ford GH,Chen HI,Goldstone AB,Woo YJ,Quertermous T,Reversade B,Red-Horse K

Effect of the spinal apelin?APJ system on the pathogenesis of chronic constriction injury?induced neuropathic pain in rats.
Molecular medicine reports16(2)1223-1231(2017 Aug)
Xiong Q,He W,Wang H,Zhou J,Zhang Y,He J,Yang C,Zhang B

ELABELA deficiency promotes preeclampsia and cardiovascular malformations in mice.
Science (New York, N.Y.)357(6352)707-713(2017 08)
Ho L,van Dijk M,Chye STJ,Messerschmidt DM,Chng SC,Ong S,Yi LK,Boussata S,Goh GH,Afink GB,Lim CY,Dunn NR,Solter D,Knowles BB,Reversade B

Apelin-36 Modulates Blood Glucose and Body Weight Independently of Canonical APJ Receptor Signaling.
The Journal of biological chemistry292(5)1925-1933(2017 02)
Galon-Tilleman H,Yang H,Bednarek MA,Spurlock SM,Paavola KJ,Ko B,To C,Luo J,Tian H,Jermutus L,Grimsby J,Rondinone CM,Konkar A,Kaplan DD

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Aplnr cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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