Slc6a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc6a2
Entrez Gene ID	83511
Full Name	solute carrier family 6 member 2
Synonyms	Net
General protein information	Preferred Names solute carrier family 6 member 2 Names sodium-dependent noradrenaline transporter NaCl-dependent norepinephrine transporter neurotransmitter transporter, noradrenal norepinephrine transporter solute carrier family 6 (neurotransmitter transporter), member 2 solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 transmembrane region 4..26 transmembrane region 55..77 transmembrane region 105..123 transmembrane region 136..157
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 19 Map Location: 19p11
Summary	norepinephrine transporter [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031343.1	NP_112633.1	sodium-dependent noradrenaline transporter

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Slc6a2	NP_033235.3
Gallus gallus (chicken)	SLC6A2	NP_990047.1
Caenorhabditis elegans (roundworm)	dat-1	NP_499043.1
	SLC6A2	NP_001028195.1
Rattus norvegicus (Norway rat)	Slc6a2	NP_112633.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007367	XP_308462.4
Homo sapiens (human)	SLC6A2	NP_001165972.1
Drosophila melanogaster (fruit fly)	DAT	NP_523763.2
Pan troglodytes (chimpanzee)	SLC6A2	XP_001167725.1
Bos taurus (cattle)	SLC6A2	NP_777033.1
Canis lupus familiaris (dog)	SLC6A2	NP_001129974.1
Danio rerio (zebrafish)	LOC565776	XP_694138.3
Xenopus tropicalis (tropical clawed frog)	slc6a2	XP_002939272.2

Gene Ontology
Bibliography

Related articles in PubMed

MicroRNAs 29b and 181a down-regulate the expression of the norepinephrine transporter and glucocorticoid receptors in PC12 cells.
Deng M, Tufan T, Raza MU, Jones TC, Zhu MY
Journal of neurochemistry139(2)197-207(2016 10)

Light and electron microscopic analysis of enkephalin-like immunoreactivity in the basolateral amygdala, including evidence for convergence of enkephalin-containing axon terminals and norepinephrine transporter-containing axon terminals onto common targets.
Zhang J, McDonald AJ
Brain research163662-73(2016 Apr)

Differential expression of tyrosine hydroxylase and transporters in the right and left stellate ganglion of socially isolated rats.
Jovanovic P, Spasojevic N, Stefanovic B, Dronjak S
Autonomic neuroscience : basic & clinical18185-9(2014 Apr)

Regional changes in cardiac and stellate ganglion norepinephrine transporter in DOCA-salt hypertension.
Wehrwein EA, Novotny M, Swain GM, Parker LM, Esfahanian M, Spitsbergen JM, Habecker BA, Kreulen DL
Autonomic neuroscience : basic & clinical179(1-2)99-107(2013 Dec)

Regulated norepinephrine transporter interaction with the neurokinin-1 receptor establishes transporter subcellular localization.
Arapulisamy O, Mannangatti P, Jayanthi LD
The Journal of biological chemistry288(40)28599-610(2013 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

miR-181a and miR-29b can function as the negative regulators of norepinephrine transporter and glucocorticoid receptor translation in vitro
Title: MicroRNAs 29b and 181a down-regulate the expression of the norepinephrine transporter and glucocorticoid receptors in PC12 cells.

The findings of this study suggested that ENK and NET terminals in the BLa may interact by targeting common dendrites and by direct interactions between the two types of terminals.
Title: Light and electron microscopic analysis of enkephalin-like immunoreactivity in the basolateral amygdala, including evidence for convergence of enkephalin-containing axon terminals and norepinephrine transporter-containing axon terminals onto common targets.

These results demonstrate asymmetry in noradrenegic genes (Th, NET, and VMAT2) in the right and left stellate ganglia during stress and provide molecular evidence to help explain the difference in response to the stress.
Title: Differential expression of tyrosine hydroxylase and transporters in the right and left stellate ganglion of socially isolated rats.

norepinephrine transporter regulation occurs regionally in the heart and stellate ganglion in the hypertensive rat heart.
Title: Regional changes in cardiac and stellate ganglion norepinephrine transporter in DOCA-salt hypertension.

NK1R forms physical complexes with NET.
Title: Regulated norepinephrine transporter interaction with the neurokinin-1 receptor establishes transporter subcellular localization.

The following Slc6a2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc6a2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa13948	NM_031343.1 Latest version!	Rattus norvegicus solute carrier family 6 member 2 (Slc6a2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc6a2 ( NM_031343.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112633.1 Rattus norvegicus solute carrier family 6 member 2 (Slc6a2), mRNA.

Price & Availability↑

CloneID	ORa13948
Clone ID Related Accession (Same CDS sequence)	NM_031343.1
Accession Version	NM_031343.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1794bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-18
Organism	Rattus norvegicus(Norway rat)
Product	sodium-dependent noradrenaline transporter
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB021971.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB021971.1 [ECO:0000332] ##Evidence-Data-END##

ATGGTGACGC GCACCCGGGA GACTTGGGGC AAGAAGATTG ATTTCCTGCT GTCTGTGGTG 
GGCTTCGCAG TGGACCTGGC CAATGTGTGG CGCTTCCCCT ATCTCTGCTA CAAGAATGGT 
GGTGGTGCCT TCCTGATTCC ATATACACTG TTCCTCATCA TTGCTGGGAT GCCTCTGTTT 
TACATGGAGC TGGCTCTGGG GCAGTTCAAC CGGGAGGGGG CAGCCACAGT GTGGAAGATC 
TGCCCTTTCT TCAAAGGAGT GGGCTATGCT GTGATCCTCA TTGCCCTCTA TGTTGGCTTT 
TACTACAATG TCATCATCGC CTGGTCACTG TACTACCTCT TCGCGTCCTT CACCTTGAAC 
CTGCCCTGGA CCAACTGTGG CCATGCCTGG AACAGCCCCA ACTGTACCGA CCCCAAACTC 
CTCAACGCCT CGGTGCTGGG CGACCATACC AAATACTCCA AATACAAGTT CACACCGGCT 
GCAGAGTTTT ATGAGCGTGG TGTCCTACAC CTTCACGAGA GCAGTGGGAT CCATGACATC 
GGCCTGCCCC AGTGGCAGCT GTTGCTATGC CTGATGGTCG TTATCGTTGT CCTGTATGTC 
AGCCTCTGGA AAGGAGTGAA GACATCGGGA AAGGTTGTCT GGATCACAGC CACCCTGCCT 
TACTTTGTCC TCTTTGTGCT CCTGGTTCAT GGCGTCACTC TGCCTGGTGC TTCCAATGGC 
ATCAACGCCT ACCTGCACAT TGACTTCTAC CGCCTCAAGG AGGCCACGGT ATGGATCGAT 
GCTGCAACCC AAATATTCTT TTCCCTGGGA GCTGGATTTG GAGTCTTGAT TGCATTTGCC 
AGTTACAATA AATTTGACAA CAACTGTTAC AGGGATGCCT TGCTGACCAG CACCATCAAC 
TGTGTTACCA GTTTTATTTC TGGATTTGCC ATTTTCTCCA TCCTTGGTTA CATGGCCCAT 
GAACATAAAG TCAAGATTGA GGATGTCGCC ACTGAAGGAG CTGGCCTTGT ATTTGTCCTG 
TATCCAGAAG CCATTTCTAC TCTGTCGGGA TCCACGTTCT GGGCTGTCCT GTTCTTCCTG 
ATGCTCCTGG CTCTGGGGCT AGATAGCTCA ATGGGAGGCA TGGAGGCAGT CATCACCGGA 
CTGGCTGATG ACTTCCAGGT CCTGAAGCGA CACCGAAAAC TCTTCACATG TGCTGTCACC 
CTCGGTACCT TTCTTCTGGC CATGTTTTGC ATAACGAAGG GAGGGATTTA CGTCCTCACT 
CTGCTGGACA CCTTCGCGGC AGGCACGTCC ATTCTCTTTG CCGTGCTCAT GGAGGCCATT 
GGAGTTTCCT GGTTTTATGG CGTGGACAGG TTCAGCAATG ACATCCAGCA GATGATGGGG 
TTTAAGCCAG GCCTGTACTG GAGACTGTGT TGGAAGTTCG TGAGCCCCGC CTTCCTCCTG 
TTTGTGGTAG TGGTCAGCAT CATCAACTTC AAGCCACTCA CCTATGATGA CTACGTCTAT 
CCTCCTTGGG CCAACTGGGT CGGGTGGGGC ATTGCCCTCT CATCCATGAT CCTGGTACCT 
GCCTACGTCA TCTACAAATT CTTCAGCATA CGGGGCTCCC TTTGGGAGAG AGTGGCCTAC 
GGAATCACCC CGGAGAATGA GCACCACCTA TTGGCTCTAG AAATAGAGCT TTCCAGCCTT 
CAGAGCTTTG TTATTACTTC ATGTCCCATA GATCCTCTTT TGTCGAGTTT TCTTTTCATC 
TCCTGCCAGA AAACCTTGGT GTTTAAGAAG TCAGGTCCAG CACCATTGAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112633.1
CDS	193..1986
Translation	MVTRTRETWGKKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQFNREGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFASFTLNLPWTNCGHAWNSPNCTDPKLLNASVLGDHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLCLMVVIVVLYVSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFYRLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSTINCVTSFISGFAIFSILGYMAHEHKVKIEDVATEGAGLVFVLYPEAISTLSGSTFWAVLFFLMLLALGLDSSMGGMEAVITGLADDFQVLKRHRKLFTCAVTLGTFLLAMFCITKGGIYVLTLLDTFAAGTSILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFKPGLYWRLCWKFVSPAFLLFVVVVSIINFKPLTYDDYVYPPWANWVGWGIALSSMILVPAYVIYKFFSIRGSLWERVAYGITPENEHHLLALEIELSSLQSFVITSCPIDPLLSSFLFISCQKTLVFKKSGPAPLI

Target ORF information:

RefSeq Version	NM_031343.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 6 member 2 (Slc6a2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031343.1

ORF Insert Sequence:

ATGGTGACGC GCACCCGGGA GACTTGGGGC AAGAAGATTG ATTTCCTGCT GTCTGTGGTG 
GGCTTCGCAG TGGACCTGGC CAATGTGTGG CGCTTCCCCT ATCTCTGCTA CAAGAATGGT 
GGTGGTGCCT TCCTGATTCC ATATACACTG TTCCTCATCA TTGCTGGGAT GCCTCTGTTT 
TACATGGAGC TGGCTCTGGG GCAGTTCAAC CGGGAGGGGG CAGCCACAGT GTGGAAGATC 
TGCCCTTTCT TCAAAGGAGT GGGCTATGCT GTGATCCTCA TTGCCCTCTA TGTTGGCTTT 
TACTACAATG TCATCATCGC CTGGTCACTG TACTACCTCT TCGCGTCCTT CACCTTGAAC 
CTGCCCTGGA CCAACTGTGG CCATGCCTGG AACAGCCCCA ACTGTACCGA CCCCAAACTC 
CTCAACGCCT CGGTGCTGGG CGACCATACC AAATACTCCA AATACAAGTT CACACCGGCT 
GCAGAGTTTT ATGAGCGTGG TGTCCTACAC CTTCACGAGA GCAGTGGGAT CCATGACATC 
GGCCTGCCCC AGTGGCAGCT GTTGCTATGC CTGATGGTCG TTATCGTTGT CCTGTATGTC 
AGCCTCTGGA AAGGAGTGAA GACATCGGGA AAGGTTGTCT GGATCACAGC CACCCTGCCT 
TACTTTGTCC TCTTTGTGCT CCTGGTTCAT GGCGTCACTC TGCCTGGTGC TTCCAATGGC 
ATCAACGCCT ACCTGCACAT TGACTTCTAC CGCCTCAAGG AGGCCACGGT ATGGATCGAT 
GCTGCAACCC AAATATTCTT TTCCCTGGGA GCTGGATTTG GAGTCTTGAT TGCATTTGCC 
AGTTACAATA AATTTGACAA CAACTGTTAC AGGGATGCCT TGCTGACCAG CACCATCAAC 
TGTGTTACCA GTTTTATTTC TGGATTTGCC ATTTTCTCCA TCCTTGGTTA CATGGCCCAT 
GAACATAAAG TCAAGATTGA GGATGTCGCC ACTGAAGGAG CTGGCCTTGT ATTTGTCCTG 
TATCCAGAAG CCATTTCTAC TCTGTCGGGA TCCACGTTCT GGGCTGTCCT GTTCTTCCTG 
ATGCTCCTGG CTCTGGGGCT AGATAGCTCA ATGGGAGGCA TGGAGGCAGT CATCACCGGA 
CTGGCTGATG ACTTCCAGGT CCTGAAGCGA CACCGAAAAC TCTTCACATG TGCTGTCACC 
CTCGGTACCT TTCTTCTGGC CATGTTTTGC ATAACGAAGG GAGGGATTTA CGTCCTCACT 
CTGCTGGACA CCTTCGCGGC AGGCACGTCC ATTCTCTTTG CCGTGCTCAT GGAGGCCATT 
GGAGTTTCCT GGTTTTATGG CGTGGACAGG TTCAGCAATG ACATCCAGCA GATGATGGGG 
TTTAAGCCAG GCCTGTACTG GAGACTGTGT TGGAAGTTCG TGAGCCCCGC CTTCCTCCTG 
TTTGTGGTAG TGGTCAGCAT CATCAACTTC AAGCCACTCA CCTATGATGA CTACGTCTAT 
CCTCCTTGGG CCAACTGGGT CGGGTGGGGC ATTGCCCTCT CATCCATGAT CCTGGTACCT 
GCCTACGTCA TCTACAAATT CTTCAGCATA CGGGGCTCCC TTTGGGAGAG AGTGGCCTAC 
GGAATCACCC CGGAGAATGA GCACCACCTA TTGGCTCTAG AAATAGAGCT TTCCAGCCTT 
CAGAGCTTTG TTATTACTTC ATGTCCCATA GATCCTCTTT TGTCGAGTTT TCTTTTCATC 
TCCTGCCAGA AAACCTTGGT GTTTAAGAAG TCAGGTCCAG CACCATTGAT TTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MicroRNAs 29b and 181a down-regulate the expression of the norepinephrine transporter and glucocorticoid receptors in PC12 cells.
Journal of neurochemistry139(2)197-207(2016 10)
Deng M,Tufan T,Raza MU,Jones TC,Zhu MY

Light and electron microscopic analysis of enkephalin-like immunoreactivity in the basolateral amygdala, including evidence for convergence of enkephalin-containing axon terminals and norepinephrine transporter-containing axon terminals onto common targets.
Brain research163662-73(2016 Apr)
Zhang J,McDonald AJ

Differential expression of tyrosine hydroxylase and transporters in the right and left stellate ganglion of socially isolated rats.
Autonomic neuroscience : basic & clinical18185-9(2014 Apr)
Jovanovic P,Spasojevic N,Stefanovic B,Dronjak S

Regional changes in cardiac and stellate ganglion norepinephrine transporter in DOCA-salt hypertension.
Autonomic neuroscience : basic & clinical179(1-2)99-107(2013 Dec)
Wehrwein EA,Novotny M,Swain GM,Parker LM,Esfahanian M,Spitsbergen JM,Habecker BA,Kreulen DL

Regulated norepinephrine transporter interaction with the neurokinin-1 receptor establishes transporter subcellular localization.
The Journal of biological chemistry288(40)28599-610(2013 Oct)
Arapulisamy O,Mannangatti P,Jayanthi LD

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Slc6a2 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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