Ccl5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Ccl5
Entrez Gene ID	81780
Full Name	C-C motif chemokine ligand 5
Synonyms	Rantes,Scya5
General protein information	Preferred Names C-C motif chemokine ligand 5 Names C-C motif chemokine 5 SIS-delta T-cell-specific protein RANTES chemokine (C-C motif) ligand 5 regulated upon activation normal T-cell expressed and secreted small-inducible cytokine A5
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 10 Map Location: 10q26
Summary	may play a role in cellular response to viral infection in testicular somatic cells [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_031116.3	NP_112378.2	C-C motif chemokine 5 precursor

Pathways from BioSystems

Homologies

	CCL5	NP_001028022.1
Homo sapiens (human)	CCL5	NP_002976.2
Gallus gallus (chicken)	CCL5	NP_001039297.1
Bos taurus (cattle)	CCL5	NP_787021.1
Pan troglodytes (chimpanzee)	CCL5	XP_001155572.3
Canis lupus familiaris (dog)	CCL5	NP_001003010.1
Mus musculus (house mouse)	Ccl5	NP_038681.2
Rattus norvegicus (Norway rat)	Ccl5	NP_112378.2

Gene Ontology
Bibliography

Related articles in PubMed

C-C Chemokine Ligand-5 is critical for facilitating macrophage infiltration in the early phase of liver ischemia/reperfusion injury.
Lee CM, Peng HH, Yang P, Liou JT, Liao CC, Day YJ
Scientific reports7(1)3698(2017 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

CCL5 plays a pivotal regulatory role in hepatic fibrosis during nonalcoholic fatty liver disease.
Title: Steatosis induced CCL5 contributes to early-stage liver fibrosis in nonalcoholic fatty liver disease progress.

The inhibition of spinal CCL5 expression may provide a new method to prevent and treat nerve injury-induced neuropathic pain.
Title: Spinal NF-?B and chemokine ligand 5 expression during spinal glial cell activation in a neuropathic pain model.

study provides novel evidence that IL-10 plays an up-regulatory role in the anti-hypertensive activity of CCL5 in SHR VSMCs
Title: IL-10 up-regulates CCL5 expression in vascular smooth muscle cells from spontaneously hypertensive rats.

Expression of RANTES and CCR5 in cardiac allografts may play important roles in chronic rejection.
Title: The significance for chronic rejection of cardiac allograft of regulated upon activation normal T-cell cytokine and its CCR5 receptor.

Mutants of RANTES/CCL5 may also represent an innovative approach to prevent the angiogenesis associated with the formation of atherosclerotic plaque
Title: RANTES/CCL5-induced pro-angiogenic effects depend on CCR1, CCR5 and glycosaminoglycans.

The following Ccl5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Ccl5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa07645	NM_031116.3 Latest version!	Rattus norvegicus C-C motif chemokine ligand 5 (Ccl5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Ccl5 ( NM_031116.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_112378.2 Rattus norvegicus C-C motif chemokine ligand 5 (Ccl5), mRNA.

Price & Availability↑

CloneID	ORa07645
Clone ID Related Accession (Same CDS sequence)	NM_031116.3
Accession Version	NM_031116.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 279bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-28
Organism	Rattus norvegicus(Norway rat)
Product	C-C motif chemokine 5 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC058138.1 and BP467039.1. On Jan 30, 2007 this sequence version replaced NM_031116.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BF562175.1, BC058138.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052297, SAMEA2689594 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGATCT CCACAGCTGC ATCCCTCACC GTCATCCTCG TTGCAGCCGC CCTCTGCACC 
CCCGCACCTG CCTCCCCATA TGGCTCGGAC ACCACTCCCT GCTGCTTTGC CTACCTCTCC 
CTCGCACTGC CCCGTGCCCA CGTGAAGGAG TATTTTTACA CCAGCAGCAA GTGCTCCAAC 
CTTGCAGTCG TCTTTGTCAC TCGAAGGAAC CGCCAAGTGT GTGCCAACCC AGAGAAGAAG 
TGGGTTCAAG AATACATCAA CTATTTGGAG ATGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_112378.2
CDS	43..321
Translation	MKISTAASLTVILVAAALCTPAPASPYGSDTTPCCFAYLSLALPRAHVKEYFYTSSKCSNLAVVFVTRRNRQVCANPEKKWVQEYINYLEMS

Target ORF information:

RefSeq Version	NM_031116.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus C-C motif chemokine ligand 5 (Ccl5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031116.3

ORF Insert Sequence:

ATGAAGATCT CCACAGCTGC ATCCCTCACC GTCATCCTCG TTGCAGCCGC CCTCTGCACC 
CCCGCACCTG CCTCCCCATA TGGCTCGGAC ACCACTCCCT GCTGCTTTGC CTACCTCTCC 
CTCGCACTGC CCCGTGCCCA CGTGAAGGAG TATTTTTACA CCAGCAGCAA GTGCTCCAAC 
CTTGCAGTCG TCTTTGTCAC TCGAAGGAAC CGCCAAGTGT GTGCCAACCC AGAGAAGAAG 
TGGGTTCAAG AATACATCAA CTATTTGGAG ATGAGCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

C-C Chemokine Ligand-5 is critical for facilitating macrophage infiltration in the early phase of liver ischemia/reperfusion injury.
Scientific reports7(1)3698(2017 Jun)
Lee CM,Peng HH,Yang P,Liou JT,Liao CC,Day YJ

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Ccl5 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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