Msn cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Msn
Entrez Gene ID	81521
Full Name	moesin
General protein information	Preferred Names moesin Names moesin membrane-organizing extension spike protein
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: X Map Location: Xq22
Summary	involved in regulating functional associations between the cell surface and the cytoskeleton [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_030863.1	NP_110490.1	moesin

Pathways from BioSystems

Homologies

	MSN	XP_001100546.2
Bos taurus (cattle)	MSN	NP_001039942.1
Mus musculus (house mouse)	Msn	NP_034963.2
Rattus norvegicus (Norway rat)	Msn	NP_110490.1
Drosophila melanogaster (fruit fly)	Moe	NP_001259361.1
Anopheles gambiae (African malaria mosquito)	MOEH_ANOGA	XP_310518.5
Homo sapiens (human)	MSN	NP_002435.1
Canis lupus familiaris (dog)	MSN	XP_848336.1
Caenorhabditis elegans (roundworm)	erm-1	NP_491559.1
Xenopus tropicalis (tropical clawed frog)	msn	XP_002936828.1

Gene Ontology
Bibliography

Related articles in PubMed

X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene.
Lagresle-Peyrou C, Luce S, Ouchani F, Soheili TS, Sadek H, Chouteau M, Durand A, Pic I, Majewski J, Brouzes C, Lambert N, Bohineust A, Verhoeyen E, Cosset FL, Magerus-Chatinet A, Rieux-Laucat F, Gandemer V, Monnier D, Heijmans C, van Gijn M, Dalm VA, Mahlaoui N, Stephan JL, Picard C, Durandy A, Kracker S, Hivroz C, Jabado N, de Saint Basile G, Fischer A, Cavazzana M, Andr?-Schmutz I
The Journal of allergy and clinical immunology138(6)1681-1689.e8(2016 Dec)

Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation.
Miyawaki A, Mitsuhara Y, Orimoto A, Nakayasu Y, Tsunoda S, Obana M, Maeda M, Nakayama H, Yoshioka Y, Tsutsumi Y, Fujio Y
American journal of physiology. Heart and circulatory physiology311(2)H476-86(2016 Aug)

Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability.
Mart?n-Villar E, Borda-d'Agua B, Carrasco-Ramirez P, Renart J, Parsons M, Quintanilla M, Jones GE
Oncogene34(34)4531-44(2015 Aug)

[The transfection of lentiviral siRNA vectors targeting ezrin, radixin and moesin facilitates influenza virus replication in primary pulmonary microvascular endothelial cells].
Wu Y, Zhang S, Zhang C, Xuan Z, Li S, Gao Y, Hu Y
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology31(4)456-61(2015 Apr)

NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane.
Georgescu MM, Cote G, Agarwal NK, White CL 3rd
Neoplasia (New York, N.Y.)16(4)365-74.e1-2(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The expression of moesin was upregulated in cardiomyocytes under inflammation, inducing protrusion formation in a phosphorylation-dependent fashion.
Title: Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation.

Overexpression ezrin, radixin and moesin facilitates influenza virus H1N1 replication in primary pulmonary microvascular endothelial cells.
Title: [The transfection of lentiviral siRNA vectors targeting ezrin, radixin and moesin facilitates influenza virus replication in primary pulmonary microvascular endothelial cells].

These results indicate that ezrin, radixin, and moesin exert a redundant control on platelet derived growth factor-induced vascular smooth muscle cells migration by regulating focal adhesion turn-over and cell adhesion to substrate.
Title: Redundant control of migration and adhesion by ERM proteins in vascular smooth muscle cells.

Found that moesin knock-down does not affect renal Na(+) -K(+) -2Cl(-) co-transporter internalisation but strongly reduces exocytosis of the co-transporter.
Title: Identification of moesin as NKCC2-interacting protein and analysis of its functional role in the NKCC2 apical trafficking.

The ERM (ezrin, radixin, moesin) proteins are novel scaffolds at the level of SOS activity control, which is relevant for both normal Ras function and dysfunction known to occur in several human cancers.
Title: Activation of Ras requires the ERM-dependent link of actin to the plasma membrane.

The following Msn gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Msn cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa12636	NM_030863.1 Latest version!	Rattus norvegicus moesin (Msn), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$342.30 $489.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Msn ( NM_030863.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_110490.1 Rattus norvegicus moesin (Msn), mRNA.

Price & Availability↑

CloneID	ORa12636
Clone ID Related Accession (Same CDS sequence)	NM_030863.1
Accession Version	NM_030863.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1734bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	moesin
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AF004811.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF004811.1, FQ230914.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGCCGAAGA CGATCAGTGT TCGTGTAACC ACCATGGATG CAGAGCTGGA GTTTGCCATT 
CAGCCCAACA CCACTGGCAA GCAGCTGTTT GACCAGGTGG TGAAAACTAT TGGTTTGAGA 
GAAGTTTGGT TCTTTGGTCT GCAGTACCAG GACACAAAAG CTTTCTCTAC TTGGCTGAAA 
CTCAATAAGA AGGTGACTGC ACAGGATGTC CGGAAGGAAA GTCCGTTGCT CTTCAAGTTC 
CGGGCCAAGT TCTATCCAGA GGATGTGTCT GAAGAACTGA TTCAGGATAT CACCCAGCGC 
CTGTTCTTTC TGCAAGTGAA GGAGGGCATT CTCAATGATG ACATTTATTG TCCACCTGAA 
ACCGCTGTGC TCTTGGCGTC CTATGCCGTC CAGTCTAAGT ATGGTGACTT CAACAAGGAA 
GTGCACAAGT CTGGCTACCT GGCTGGAGAT AAGTTGCTTC CCCAAAGAGT CTTGGAGCAG 
CACAAACTCA ACAAGGACCA GTGGGAAGAG CGGATCCAGG TATGGCATGA GGAACACCGG 
GGCATGCTCA GGGAGGATGC TGTCCTGGAA TATCTCAAGA TTGCTCAGGA CCTGGAGATG 
TATGGTGTGA ACTATTTCAG CATCAAGAAC AAGAAAGGCT CAGAGCTGTG GCTGGGTGTG 
GATGCCTTGG GTCTCAACAT CTATGAGCAG AATGACAGAT TGACTCCTAA GATTGGCTTC 
CCTTGGAGTG AAATCAGGAA CATCTCTTTC AATGATAAGA AATTTGTCAT CAAGCCTATT 
GACAAAAAGG CCCCGGACTT TGTGTTCTAT GCTCCTCGGC TTCGGATTAA CAAAAGGATC 
TTGGCCCTGT GCATGGGGAA TCATGAGCTG TACATGCGTC GGCGAAAGCC TGACACCATT 
GAGGTGCAGC AGATGAAGGC CCAGGCTCGA GAAGAGAAGC ACCAGAAGCA GATGGAGCGT 
GCTCTACTGG AAAATGAGAA GAAGAAGCGT GAGCTGGCTG AAAAAGAGAA GGAGAAGATT 
GAACGGGAGA AGGAAGAGCT GATGGAGAAG CTGAAGCAGA TTGAGGAGCA GACCAAGAAG 
GCTCAGCAAG AACTGGAAGA ACAGACCCGC AGGGCCCTAG AACTTGAGCA GGAACGGAAG 
CGTGCCCAGA GTGAGGCTGA AAAGCTGGCC AAGGAGCGTC AAGAAGCTGA AGAAGCCAAG 
GAGGCCCTGC TGCAGGCTTC TCGGGACCAG AAGAAGACTC AGGAACAGCT GGCTTCAGAA 
ATGGCAGAGC TGACAGCACG GGTCTCCCAG TTGGAAATGG CTCGAAAGAA GAAGGAGAGT 
GAGGCTGAGG AATGCCACCA AAAGGCCCAG ATGGTCCAGG AAGACTTGGA GAAGACTCGC 
GCTGAGCTGA AGACAGCCAT GAGTACCCCT CATGTGGCAG AGCCTGCTGA GAATGAACAT 
GATGAGCAGG ATGAGAATGG AGCCGAGGCC AGTGCTGAGC TGCGGGCTGA TGCTATGGCC 
AAGGACCGCA GTGAGGAAGA ACGTACCACT GAGGCAGAGA AGAATGAGCG TGTGCAGAAG 
CATCTTAAGG CCCTTACTTC AGAGCTGGCC AATGCCCGAG ATGAGTCCAA GAAGACTACC 
AATGACATGA TCCATGCTGA GAACATGCGA CTGGGACGAG ACAAATACAA GACCCTGCGC 
CAGATCCGGC AGGGCAATAC CAAACAGCGC ATTGATGAAT TTGAGTCCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_110490.1
CDS	99..1832
Translation	MPKTISVRVTTMDAELEFAIQPNTTGKQLFDQVVKTIGLREVWFFGLQYQDTKAFSTWLKLNKKVTAQDVRKESPLLFKFRAKFYPEDVSEELIQDITQRLFFLQVKEGILNDDIYCPPETAVLLASYAVQSKYGDFNKEVHKSGYLAGDKLLPQRVLEQHKLNKDQWEERIQVWHEEHRGMLREDAVLEYLKIAQDLEMYGVNYFSIKNKKGSELWLGVDALGLNIYEQNDRLTPKIGFPWSEIRNISFNDKKFVIKPIDKKAPDFVFYAPRLRINKRILALCMGNHELYMRRRKPDTIEVQQMKAQAREEKHQKQMERALLENEKKKRELAEKEKEKIEREKEELMEKLKQIEEQTKKAQQELEEQTRRALELEQERKRAQSEAEKLAKERQEAEEAKEALLQASRDQKKTQEQLASEMAELTARVSQLEMARKKKESEAEECHQKAQMVQEDLEKTRAELKTAMSTPHVAEPAENEHDEQDENGAEASAELRADAMAKDRSEEERTTEAEKNERVQKHLKALTSELANARDESKKTTNDMIHAENMRLGRDKYKTLRQIRQGNTKQRIDEFESM

Target ORF information:

RefSeq Version	NM_030863.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus moesin (Msn), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_030863.1

ORF Insert Sequence:

ATGCCGAAGA CGATCAGTGT TCGTGTAACC ACCATGGATG CAGAGCTGGA GTTTGCCATT 
CAGCCCAACA CCACTGGCAA GCAGCTGTTT GACCAGGTGG TGAAAACTAT TGGTTTGAGA 
GAAGTTTGGT TCTTTGGTCT GCAGTACCAG GACACAAAAG CTTTCTCTAC TTGGCTGAAA 
CTCAATAAGA AGGTGACTGC ACAGGATGTC CGGAAGGAAA GTCCGTTGCT CTTCAAGTTC 
CGGGCCAAGT TCTATCCAGA GGATGTGTCT GAAGAACTGA TTCAGGATAT CACCCAGCGC 
CTGTTCTTTC TGCAAGTGAA GGAGGGCATT CTCAATGATG ACATTTATTG TCCACCTGAA 
ACCGCTGTGC TCTTGGCGTC CTATGCCGTC CAGTCTAAGT ATGGTGACTT CAACAAGGAA 
GTGCACAAGT CTGGCTACCT GGCTGGAGAT AAGTTGCTTC CCCAAAGAGT CTTGGAGCAG 
CACAAACTCA ACAAGGACCA GTGGGAAGAG CGGATCCAGG TATGGCATGA GGAACACCGG 
GGCATGCTCA GGGAGGATGC TGTCCTGGAA TATCTCAAGA TTGCTCAGGA CCTGGAGATG 
TATGGTGTGA ACTATTTCAG CATCAAGAAC AAGAAAGGCT CAGAGCTGTG GCTGGGTGTG 
GATGCCTTGG GTCTCAACAT CTATGAGCAG AATGACAGAT TGACTCCTAA GATTGGCTTC 
CCTTGGAGTG AAATCAGGAA CATCTCTTTC AATGATAAGA AATTTGTCAT CAAGCCTATT 
GACAAAAAGG CCCCGGACTT TGTGTTCTAT GCTCCTCGGC TTCGGATTAA CAAAAGGATC 
TTGGCCCTGT GCATGGGGAA TCATGAGCTG TACATGCGTC GGCGAAAGCC TGACACCATT 
GAGGTGCAGC AGATGAAGGC CCAGGCTCGA GAAGAGAAGC ACCAGAAGCA GATGGAGCGT 
GCTCTACTGG AAAATGAGAA GAAGAAGCGT GAGCTGGCTG AAAAAGAGAA GGAGAAGATT 
GAACGGGAGA AGGAAGAGCT GATGGAGAAG CTGAAGCAGA TTGAGGAGCA GACCAAGAAG 
GCTCAGCAAG AACTGGAAGA ACAGACCCGC AGGGCCCTAG AACTTGAGCA GGAACGGAAG 
CGTGCCCAGA GTGAGGCTGA AAAGCTGGCC AAGGAGCGTC AAGAAGCTGA AGAAGCCAAG 
GAGGCCCTGC TGCAGGCTTC TCGGGACCAG AAGAAGACTC AGGAACAGCT GGCTTCAGAA 
ATGGCAGAGC TGACAGCACG GGTCTCCCAG TTGGAAATGG CTCGAAAGAA GAAGGAGAGT 
GAGGCTGAGG AATGCCACCA AAAGGCCCAG ATGGTCCAGG AAGACTTGGA GAAGACTCGC 
GCTGAGCTGA AGACAGCCAT GAGTACCCCT CATGTGGCAG AGCCTGCTGA GAATGAACAT 
GATGAGCAGG ATGAGAATGG AGCCGAGGCC AGTGCTGAGC TGCGGGCTGA TGCTATGGCC 
AAGGACCGCA GTGAGGAAGA ACGTACCACT GAGGCAGAGA AGAATGAGCG TGTGCAGAAG 
CATCTTAAGG CCCTTACTTC AGAGCTGGCC AATGCCCGAG ATGAGTCCAA GAAGACTACC 
AATGACATGA TCCATGCTGA GAACATGCGA CTGGGACGAG ACAAATACAA GACCCTGCGC 
CAGATCCGGC AGGGCAATAC CAAACAGCGC ATTGATGAAT TTGAGTCCAT GTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

X-linked primary immunodeficiency associated with hemizygous mutations in the moesin (MSN) gene.
The Journal of allergy and clinical immunology138(6)1681-1689.e8(2016 Dec)
Lagresle-Peyrou C,Luce S,Ouchani F,Soheili TS,Sadek H,Chouteau M,Durand A,Pic I,Majewski J,Brouzes C,Lambert N,Bohineust A,Verhoeyen E,Cosset FL,Magerus-Chatinet A,Rieux-Laucat F,Gandemer V,Monnier D,Heijmans C,van Gijn M,Dalm VA,Mahlaoui N,Stephan JL,Picard C,Durandy A,Kracker S,Hivroz C,Jabado N,de Saint Basile G,Fischer A,Cavazzana M,Andr?-Schmutz I

Moesin is activated in cardiomyocytes in experimental autoimmune myocarditis and mediates cytoskeletal reorganization with protrusion formation.
American journal of physiology. Heart and circulatory physiology311(2)H476-86(2016 Aug)
Miyawaki A,Mitsuhara Y,Orimoto A,Nakayasu Y,Tsunoda S,Obana M,Maeda M,Nakayama H,Yoshioka Y,Tsutsumi Y,Fujio Y

Podoplanin mediates ECM degradation by squamous carcinoma cells through control of invadopodia stability.
Oncogene34(34)4531-44(2015 Aug)
Mart?n-Villar E,Borda-d'Agua B,Carrasco-Ramirez P,Renart J,Parsons M,Quintanilla M,Jones GE

[The transfection of lentiviral siRNA vectors targeting ezrin, radixin and moesin facilitates influenza virus replication in primary pulmonary microvascular endothelial cells].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology31(4)456-61(2015 Apr)
Wu Y,Zhang S,Zhang C,Xuan Z,Li S,Gao Y,Hu Y

NHERF1/EBP50 controls morphogenesis of 3D colonic glands by stabilizing PTEN and ezrin-radixin-moesin proteins at the apical membrane.
Neoplasia (New York, N.Y.)16(4)365-74.e1-2(2014 Apr)
Georgescu MM,Cote G,Agarwal NK,White CL 3rd