Rab11b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Rab11b
Entrez Gene ID	79434
Full Name	RAB11B, member RAS oncogene family
General protein information	Preferred Names RAB11B, member RAS oncogene family Names ras-related protein Rab-11B
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 7 Map Location: 7q13
Summary	may be involved in osteoclast motility and membrane turnover [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_032617.2	NP_116006.1	ras-related protein Rab-11B

Pathways from BioSystems

Homologies

Homo sapiens (human)	RAB11B	NP_004209.2
Bos taurus (cattle)	RAB11B	NP_001030468.1
Mus musculus (house mouse)	Rab11b	NP_033023.1
Arabidopsis thaliana (thale cress)	RAB11c	NP_172434.1
Pan troglodytes (chimpanzee)	RAB11B	XP_001147785.2
Canis lupus familiaris (dog)	RAB11B	XP_854399.2
Danio rerio (zebrafish)	rab11bb	NP_001002555.1
Saccharomyces cerevisiae (baker's yeast)	YPT32	NP_011305.1
Xenopus tropicalis (tropical clawed frog)	rab11b.1	NP_001011048.1
Gallus gallus (chicken)	RAB11B	NP_001012569.1
Danio rerio (zebrafish)	LOC100536606	XP_003198017.1
	RAB11B	XP_001093925.1
Rattus norvegicus (Norway rat)	Rab11b	NP_116006.1
Oryza sativa (rice)	Os05g0105100	NP_001054408.1

Gene Ontology
Bibliography

Related articles in PubMed

Central role for PICALM in amyloid-? blood-brain barrier transcytosis and clearance.
Zhao Z, Sagare AP, Ma Q, Halliday MR, Kong P, Kisler K, Winkler EA, Ramanathan A, Kanekiyo T, Bu G, Owens NC, Rege SV, Si G, Ahuja A, Zhu D, Miller CA, Schneider JA, Maeda M, Maeda T, Sugawara T, Ichida JK, Zlokovic BV
Nature neuroscience18(7)978-87(2015 Jul)

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Guo Z, Neilson LJ, Zhong H, Murray PS, Zanivan S, Zaidel-Bar R
Science signaling7(354)rs7(2014 Dec)

Identification and characterization of multiple novel Rab-myosin Va interactions.
Lindsay AJ, Jollivet F, Horgan CP, Khan AR, Raposo G, McCaffrey MW, Goud B
Molecular biology of the cell24(21)3420-34(2013 Nov)

Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons.
Hong WC, Amara SG
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(8)2995-3007(2013 Aug)

The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.
Lamothe SM, Zhang S
The Journal of biological chemistry288(21)15075-84(2013 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate that internalized dopamine transporter (DAT) colocalized with GFP-Rab11 and suggest that Rab11 plays an important role in the recycling of DAT following AMPH-induced DAT down-regulation.
Title: Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons.

SGK1,3 enhances the expression level of mature hERG channels by inhibiting Nedd4-2 as well as by promoting Rab11-mediated hERG recycling.
Title: The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.

Results suggest that cholesterol regulates Kv1.5 channel expression by modulating its trafficking through the Rab11-associated recycling endosome.
Title: Cholesterol modulates the recruitment of Kv1.5 channels from Rab11-associated recycling endosome in native atrial myocytes.

This is the first report detailing apical CFTR recycling in a native expression system and to demonstrate that Rab11b regulates apical recycling in polarized epithelial cells.
Title: Rab11b regulates the apical recycling of the cystic fibrosis transmembrane conductance regulator in polarized intestinal epithelial cells.

The following Rab11b gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Rab11b cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa09047	NM_032617.2 Latest version!	Rattus norvegicus RAB11B, member RAS oncogene family (Rab11b), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$139.30 $199.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Rab11b ( NM_032617.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_116006.1 Rattus norvegicus RAB11B, member RAS oncogene family (Rab11b), mRNA.

Price & Availability↑

CloneID	ORa09047
Clone ID Related Accession (Same CDS sequence)	NM_032617.2
Accession Version	NM_032617.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 657bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-18
Organism	Rattus norvegicus(Norway rat)
Product	ras-related protein Rab-11B
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC062041.1. On Dec 20, 2003 this sequence version replaced NM_032617.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC062041.1, FQ213918.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGGGACCC GGGACGACGA GTACGATTAC CTATTCAAAG TGGTGCTTAT TGGGGACTCA 
GGTGTAGGTA AGAGCAACCT GCTGTCACGC TTCACCAGAA ACGAGTTCAA CCTAGAGAGC 
AAGAGCACCA TTGGAGTGGA GTTTGCCACT CGCAGCATTC AGGTGGACGG CAAGACCATC 
AAGGCTCAGA TCTGGGATAC TGCTGGCCAG GAGCGCTACC GTGCCATTAC CTCTGCGTAC 
TACCGTGGTG CAGTGGGTGC ACTGCTGGTA TATGACATTG CCAAGCACTT GACATATGAG 
AATGTGGAGC GCTGGCTGAA GGAGCTGCGG GATCATGCAG ATAGCAACAT TGTTATCATG 
CTGGTGGGCA ACAAGAGCGA CCTGCGCCAT CTTCGGGCTG TGCCCACTGA CGAGGCCCGT 
GCCTTTGCAG AAAAGAACAA CTTGTCCTTC ATTGAGACCT CAGCCTTGGA TTCCACCAAT 
GTAGAGGAAG CATTCAAGAA CATCCTCACA GAAATCTACC GTATTGTGTC ACAGAAGCAA 
ATTGCTGACC GTGCAGCTCA TGATGAGTCC CCTGGCAACA ATGTGGTGGA CATCAGTGTG 
CCACCCACCA CCGATGGACA GAAACCCAAT AAGCTGCAGT GCTGCCAGAA CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_116006.1
CDS	51..707
Translation	MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNNLSFIETSALDSTNVEEAFKNILTEIYRIVSQKQIADRAAHDESPGNNVVDISVPPTTDGQKPNKLQCCQNL

Target ORF information:

RefSeq Version	NM_032617.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus RAB11B, member RAS oncogene family (Rab11b), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_032617.2

ORF Insert Sequence:

ATGGGGACCC GGGACGACGA GTACGATTAC CTATTCAAAG TGGTGCTTAT TGGGGACTCA 
GGTGTAGGTA AGAGCAACCT GCTGTCACGC TTCACCAGAA ACGAGTTCAA CCTAGAGAGC 
AAGAGCACCA TTGGAGTGGA GTTTGCCACT CGCAGCATTC AGGTGGACGG CAAGACCATC 
AAGGCTCAGA TCTGGGATAC TGCTGGCCAG GAGCGCTACC GTGCCATTAC CTCTGCGTAC 
TACCGTGGTG CAGTGGGTGC ACTGCTGGTA TATGACATTG CCAAGCACTT GACATATGAG 
AATGTGGAGC GCTGGCTGAA GGAGCTGCGG GATCATGCAG ATAGCAACAT TGTTATCATG 
CTGGTGGGCA ACAAGAGCGA CCTGCGCCAT CTTCGGGCTG TGCCCACTGA CGAGGCCCGT 
GCCTTTGCAG AAAAGAACAA CTTGTCCTTC ATTGAGACCT CAGCCTTGGA TTCCACCAAT 
GTAGAGGAAG CATTCAAGAA CATCCTCACA GAAATCTACC GTATTGTGTC ACAGAAGCAA 
ATTGCTGACC GTGCAGCTCA TGATGAGTCC CCTGGCAACA ATGTGGTGGA CATCAGTGTG 
CCACCCACCA CCGATGGACA GAAACCCAAT AAGCTGCAGT GCTGCCAGAA CCTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Central role for PICALM in amyloid-? blood-brain barrier transcytosis and clearance.
Nature neuroscience18(7)978-87(2015 Jul)
Zhao Z,Sagare AP,Ma Q,Halliday MR,Kong P,Kisler K,Winkler EA,Ramanathan A,Kanekiyo T,Bu G,Owens NC,Rege SV,Si G,Ahuja A,Zhu D,Miller CA,Schneider JA,Maeda M,Maeda T,Sugawara T,Ichida JK,Zlokovic BV

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Science signaling7(354)rs7(2014 Dec)
Guo Z,Neilson LJ,Zhong H,Murray PS,Zanivan S,Zaidel-Bar R

Identification and characterization of multiple novel Rab-myosin Va interactions.
Molecular biology of the cell24(21)3420-34(2013 Nov)
Lindsay AJ,Jollivet F,Horgan CP,Khan AR,Raposo G,McCaffrey MW,Goud B

Differential targeting of the dopamine transporter to recycling or degradative pathways during amphetamine- or PKC-regulated endocytosis in dopamine neurons.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology27(8)2995-3007(2013 Aug)
Hong WC,Amara SG

The serum- and glucocorticoid-inducible kinases SGK1 and SGK3 regulate hERG channel expression via ubiquitin ligase Nedd4-2 and GTPase Rab11.
The Journal of biological chemistry288(21)15075-84(2013 May)
Lamothe SM,Zhang S

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Rab11b cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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