Slc6a11 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Slc6a11
Entrez Gene ID	79213
Full Name	solute carrier family 6 member 11
Synonyms	Gabt4,Gat3
General protein information	Preferred Names solute carrier family 6 member 11 Names sodium- and chloride-dependent GABA transporter 3 GABA transporter GAT-3 GAT-3 solute carrier family 6 (neurotransmitter transporter), member 11 solute carrier family 6 (neurotransmitter transporter, GABA), member 11
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 4 Map Location: 4q42
Summary	catalyzes sodium and chloride dependent transport of gamma-aminobutyric acid (GABA) to terminate GABA mediated synaptic activity [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_024372.2	NP_077348.1	sodium- and chloride-dependent GABA transporter 3

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	SLC6A11	XP_001152123.1
Gallus gallus (chicken)	SLC6A11	XP_414302.2
Homo sapiens (human)	SLC6A11	NP_055044.1
	SLC6A11	NP_001128424.1
Canis lupus familiaris (dog)	SLC6A11	XP_533741.2
Bos taurus (cattle)	SLC6A11	NP_001193832.1
Mus musculus (house mouse)	Slc6a11	NP_766478.1
Rattus norvegicus (Norway rat)	Slc6a11	NP_077348.1

Gene Ontology
Bibliography

Related articles in PubMed

Astrocytic GABA transporter activity modulates excitatory neurotransmission.
Boddum K, Jensen TP, Magloire V, Kristiansen U, Rusakov DA, Pavlov I, Walker MC
Nature communications713572(2016 Nov)

The proteome of the presynaptic active zone from mouse brain.
Weingarten J, Lassek M, Mueller BF, Rohmer M, Lunger I, Baeumlisberger D, Dudek S, Gogesch P, Karas M, Volknandt W
Molecular and cellular neurosciences59106-18(2014 Mar)

Plasma membrane transporters GAT-1 and GAT-3 contribute to heterogeneity of GABAergic synapses in neocortex.
Melone M, Ciappelloni S, Conti F
Frontiers in neuroanatomy872(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study provides a quantitative analysis of the subcellular distribution of GAT-1 and GAT-3 in cerebral cortex, and a detailed description of their ultrastructural localization at GABAergic synapses.
Title: A quantitative analysis of cellular and synaptic localization of GAT-1 and GAT-3 in rat neocortex.

Gat-3 acts synergistically with Gat-1 in the immature hippocampus to regulate excitability.
Title: Inhibition of different GABA transporter systems is required to attenuate epileptiform activity in the CA3 region of the immature rat hippocampus.

Astrocytic GAT-3 contributes to the regulation of extracellular GABA in the hippocampus in vivo and may play an important role in controlling the excitability of hippocampal cells when network activity is increased.
Title: A functional role for both -aminobutyric acid (GABA) transporter-1 and GABA transporter-3 in the modulation of extracellular GABA and GABAergic tonic conductances in the rat hippocampus.

This study provides evidence that the GAT-3-mediated regulation of extracellular GABA can modulate glutamatergic transmission at the subthalamopallidal synapse in the rat globus pallidus.
Title: GABA transporter subtype 1 and GABA transporter subtype 3 modulate glutamatergic transmission via activation of presynaptic GABA(B) receptors in the rat globus pallidus.

Data indicate that GAT-1 and GAT-3 represent different target sites through which GABA reuptake may subserve complementary regulation of GABAergic transmission in the rat globus pallidus.
Title: Differential localization and function of GABA transporters, GAT-1 and GAT-3, in the rat globus pallidus.

The following Slc6a11 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Slc6a11 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa06970	NM_024372.2 Latest version!	Rattus norvegicus solute carrier family 6 member 11 (Slc6a11), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Slc6a11 ( NM_024372.2 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_077348.1 Rattus norvegicus solute carrier family 6 member 11 (Slc6a11), mRNA.

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CloneID	ORa06970
Clone ID Related Accession (Same CDS sequence)	NM_024372.2
Accession Version	NM_024372.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1884bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-15
Organism	Rattus norvegicus(Norway rat)
Product	sodium- and chloride-dependent GABA transporter 3
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from M95763.1. On Jun 10, 2007 this sequence version replaced NM_024372.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M95763.1, M95738.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGACTGCGG AGCAAGCGCT GCCCCTGGGC AACGGGAAGG CGGCCGAGGA GGCGCGAGGG 
TCCGAGGCGC TGGGCGGCGG CGGCGGGGGC GCGGCGGGGA CGCGCGAGGC GCGCGACAAG 
GCGGTCCACG AGCGCGGTCA CTGGAACAAC AAGGTGGAGT TCGTGTTGAG CGTAGCGGGA 
GAGATCATCG GTCTGGGCAA CGTGTGGCGC TTCCCCTACC TGTGCTACAA GAACGGCGGA 
GGGGCATTCC TGATTCCTTA CGTGGTGTTT TTCATCTGCT GTGGAATCCC CGTCTTCTTC 
CTGGAAACGG CTCTGGGGCA GTTCACGAGC GAGGGCGGCA TCACGTGCTG GAGGAGAGTC 
TGTCCTTTAT TTGAAGGCAT CGGCTATGCA ACACAGGTGA TCGAGGCGCA TCTCAATGTC 
TACTACATCA TCATCCTGGC GTGGGCCATC TTCTACTTAA GCAACTGCTT CACCACCGAG 
CTCCCCTGGG CCACCTGTGG GCATGAGTGG AACACAGAGA AATGTGTGGA GTTCCAGAAG 
CTGAACTTCA GCAACTACAG TCATGTGTCC CTGCAGAACG CAACCTCCCC GGTCATGGAG 
TTCTGGGAAC GCCGGGTCTT GGCTATATCT GATGGCATTG AACACATCGG GAACCTCCGA 
TGGGAGCTGG CACTGTGTCT CCTGGCGGCT TGGACCATCT GCTACTTCTG CATCTGGAAG 
GGTACGAAGT CAACTGGAAA GGTCGTGTAT GTCACTGCAA CCTTCCCCTA CATCATGCTG 
CTGATCCTCC TGATCCGAGG GGTCACGTTG CCGGGTGCCT CGGAAGGCAT CAAGTTCTAC 
CTGTACCCTG ACCTCTCCCG GCTCTCTGAT CCACAGGTGT GGGTGGATGC TGGGACGCAG 
ATCTTTTTCT CCTATGCCAT CTGCCTGGGC TGCCTGACCG CTCTGGGGAG TTACAACAAC 
TATAACAACA ACTGCTACAG GGACTGTATT ATGCTCTGCT GTCTGAACAG TGGCACCAGC 
TTCGTGGCTG GGTTTGCTAT CTTCTCAGTC CTGGGCTTCA TGGCGTACGA GCAGGGCGTG 
CCTATTGCTG AGGTGGCAGA ATCAGGTCCT GGACTGGCTT TCATCGCCTA CCCCAAGGCT 
GTCACTATGA TGCCCCTGTC CCCATTGTGG GCCACCCTGT TCTTCATGAT GCTCATCTTC 
CTGGGCCTGG ACAGTCAGTT TGTGTGTGTG GAGAGCCTTG TGACAGCCGT GGTTGACATG 
TACCCCAAGG TCTTCCGGCG GGGCTACCGG CGAGAACTGC TCATCCTGGC CCTGTCCATT 
GTCTCTTATT TCCTAGGCCT GGTGATGCTG ACAGAGGGAG GCATGTACAT TTTCCAGCTT 
TTTGACTCAT ACGCCGCCAG TGGCATGTGC TTGCTCTTCG TGGCCATCTT TGAGTGTGTC 
TGCATCGGCT GGGTGTATGG AAGTAACAGG TTCTATGACA ATATTGAGGA CATGATTGGA 
TACCGGCCAC TGTCACTCAT CAAGTGGTGC TGGAAAGTTG TGACCCCTGG GATCTGTGCG 
GGCATCTTCA TCTTCTTTCT GGTCAAGTAC AAGCCGCTCA AGTACAACAA TGTGTACACA 
TATCCTGCTT GGGGCTACGG CATTGGCTGG CTCATGGCTC TGTCCTCCAT GCTGTGCATC 
CCGCTCTGGA TCTTCATCAA GCTGTGGAAG ACAGAGGGCA CCCTGCCCGA GAAATTACAG 
AAGTTGACAG TCCCCAGCGC TGATCTGAAA ATGAGGGGCA AGCTTGGGGC CAGCCCACGG 
ATGGTGACCG TTAATGACTG TGAGGCCAAG GTCAAAGGCG ACGGTACCAT CTCTGCCATC 
ACAGAGAAGG AGACGCACTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077348.1
CDS	13..1896
Translation	MTAEQALPLGNGKAAEEARGSEALGGGGGGAAGTREARDKAVHERGHWNNKVEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFLIPYVVFFICCGIPVFFLETALGQFTSEGGITCWRRVCPLFEGIGYATQVIEAHLNVYYIIILAWAIFYLSNCFTTELPWATCGHEWNTEKCVEFQKLNFSNYSHVSLQNATSPVMEFWERRVLAISDGIEHIGNLRWELALCLLAAWTICYFCIWKGTKSTGKVVYVTATFPYIMLLILLIRGVTLPGASEGIKFYLYPDLSRLSDPQVWVDAGTQIFFSYAICLGCLTALGSYNNYNNNCYRDCIMLCCLNSGTSFVAGFAIFSVLGFMAYEQGVPIAEVAESGPGLAFIAYPKAVTMMPLSPLWATLFFMMLIFLGLDSQFVCVESLVTAVVDMYPKVFRRGYRRELLILALSIVSYFLGLVMLTEGGMYIFQLFDSYAASGMCLLFVAIFECVCIGWVYGSNRFYDNIEDMIGYRPLSLIKWCWKVVTPGICAGIFIFFLVKYKPLKYNNVYTYPAWGYGIGWLMALSSMLCIPLWIFIKLWKTEGTLPEKLQKLTVPSADLKMRGKLGASPRMVTVNDCEAKVKGDGTISAITEKETHF

Target ORF information:

RefSeq Version	NM_024372.2
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus solute carrier family 6 member 11 (Slc6a11), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024372.2

ORF Insert Sequence:

ATGACTGCGG AGCAAGCGCT GCCCCTGGGC AACGGGAAGG CGGCCGAGGA GGCGCGAGGG 
TCCGAGGCGC TGGGCGGCGG CGGCGGGGGC GCGGCGGGGA CGCGCGAGGC GCGCGACAAG 
GCGGTCCACG AGCGCGGTCA CTGGAACAAC AAGGTGGAGT TCGTGTTGAG CGTAGCGGGA 
GAGATCATCG GTCTGGGCAA CGTGTGGCGC TTCCCCTACC TGTGCTACAA GAACGGCGGA 
GGGGCATTCC TGATTCCTTA CGTGGTGTTT TTCATCTGCT GTGGAATCCC CGTCTTCTTC 
CTGGAAACGG CTCTGGGGCA GTTCACGAGC GAGGGCGGCA TCACGTGCTG GAGGAGAGTC 
TGTCCTTTAT TTGAAGGCAT CGGCTATGCA ACACAGGTGA TCGAGGCGCA TCTCAATGTC 
TACTACATCA TCATCCTGGC GTGGGCCATC TTCTACTTAA GCAACTGCTT CACCACCGAG 
CTCCCCTGGG CCACCTGTGG GCATGAGTGG AACACAGAGA AATGTGTGGA GTTCCAGAAG 
CTGAACTTCA GCAACTACAG TCATGTGTCC CTGCAGAACG CAACCTCCCC GGTCATGGAG 
TTCTGGGAAC GCCGGGTCTT GGCTATATCT GATGGCATTG AACACATCGG GAACCTCCGA 
TGGGAGCTGG CACTGTGTCT CCTGGCGGCT TGGACCATCT GCTACTTCTG CATCTGGAAG 
GGTACGAAGT CAACTGGAAA GGTCGTGTAT GTCACTGCAA CCTTCCCCTA CATCATGCTG 
CTGATCCTCC TGATCCGAGG GGTCACGTTG CCGGGTGCCT CGGAAGGCAT CAAGTTCTAC 
CTGTACCCTG ACCTCTCCCG GCTCTCTGAT CCACAGGTGT GGGTGGATGC TGGGACGCAG 
ATCTTTTTCT CCTATGCCAT CTGCCTGGGC TGCCTGACCG CTCTGGGGAG TTACAACAAC 
TATAACAACA ACTGCTACAG GGACTGTATT ATGCTCTGCT GTCTGAACAG TGGCACCAGC 
TTCGTGGCTG GGTTTGCTAT CTTCTCAGTC CTGGGCTTCA TGGCGTACGA GCAGGGCGTG 
CCTATTGCTG AGGTGGCAGA ATCAGGTCCT GGACTGGCTT TCATCGCCTA CCCCAAGGCT 
GTCACTATGA TGCCCCTGTC CCCATTGTGG GCCACCCTGT TCTTCATGAT GCTCATCTTC 
CTGGGCCTGG ACAGTCAGTT TGTGTGTGTG GAGAGCCTTG TGACAGCCGT GGTTGACATG 
TACCCCAAGG TCTTCCGGCG GGGCTACCGG CGAGAACTGC TCATCCTGGC CCTGTCCATT 
GTCTCTTATT TCCTAGGCCT GGTGATGCTG ACAGAGGGAG GCATGTACAT TTTCCAGCTT 
TTTGACTCAT ACGCCGCCAG TGGCATGTGC TTGCTCTTCG TGGCCATCTT TGAGTGTGTC 
TGCATCGGCT GGGTGTATGG AAGTAACAGG TTCTATGACA ATATTGAGGA CATGATTGGA 
TACCGGCCAC TGTCACTCAT CAAGTGGTGC TGGAAAGTTG TGACCCCTGG GATCTGTGCG 
GGCATCTTCA TCTTCTTTCT GGTCAAGTAC AAGCCGCTCA AGTACAACAA TGTGTACACA 
TATCCTGCTT GGGGCTACGG CATTGGCTGG CTCATGGCTC TGTCCTCCAT GCTGTGCATC 
CCGCTCTGGA TCTTCATCAA GCTGTGGAAG ACAGAGGGCA CCCTGCCCGA GAAATTACAG 
AAGTTGACAG TCCCCAGCGC TGATCTGAAA ATGAGGGGCA AGCTTGGGGC CAGCCCACGG 
ATGGTGACCG TTAATGACTG TGAGGCCAAG GTCAAAGGCG ACGGTACCAT CTCTGCCATC 
ACAGAGAAGG AGACGCACTT CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Astrocytic GABA transporter activity modulates excitatory neurotransmission.
Nature communications713572(2016 Nov)
Boddum K,Jensen TP,Magloire V,Kristiansen U,Rusakov DA,Pavlov I,Walker MC

The proteome of the presynaptic active zone from mouse brain.
Molecular and cellular neurosciences59106-18(2014 Mar)
Weingarten J,Lassek M,Mueller BF,Rohmer M,Lunger I,Baeumlisberger D,Dudek S,Gogesch P,Karas M,Volknandt W

Plasma membrane transporters GAT-1 and GAT-3 contribute to heterogeneity of GABAergic synapses in neocortex.
Frontiers in neuroanatomy872(2014)
Melone M,Ciappelloni S,Conti F

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Slc6a11 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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