Crtc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Crtc1
Entrez Gene ID	684527
Full Name	CREB regulated transcription coactivator 1
Synonyms	Mect1,TORC-1,TORC1
General protein information	Preferred Names CREB regulated transcription coactivator 1 Names CREB-regulated transcription coactivator 1 mucoepidermoid carcinoma translocated 1 mucoepidermoid carcinoma translocated protein 1 homolog transducer of CREB protein 1 transducer of regulated cAMP response element-binding protein 1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 16 Map Location: 16p14

mRNA and Protein(s)

mRNA	Protein	Name
XM_006252936.3	XP_006252998.1	CREB-regulated transcription coactivator 1 isoform X1
NM_001047115.1	NP_001040580.1	CREB-regulated transcription coactivator 1

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Crtc1	NP_001004062.1
Canis lupus familiaris (dog)	CRTC1	XP_005632740.1
Danio rerio (zebrafish)	LOC101886240	XP_005172890.1
Xenopus tropicalis (tropical clawed frog)	crtc1	XP_002940252.1
	CRTC1	XP_001115541.1
Pan troglodytes (chimpanzee)	CRTC1	XP_003316262.1
Rattus norvegicus (Norway rat)	Crtc1	NP_001040580.1
Homo sapiens (human)	CRTC1	NP_001091952.1
Bos taurus (cattle)	CRTC1	NP_001193248.1
Gallus gallus (chicken)	CRTC1	XP_003642931.1

Gene Ontology
Bibliography

Related articles in PubMed

Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents.
Laguesse S, Morisot N, Phamluong K, Ron D
Addiction biology22(6)1856-1869(2017 Nov)

Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease.
Wilson EN, Abela AR, Do Carmo S, Allard S, Marks AR, Welikovitch LA, Ducatenzeiler A, Chudasama Y, Cuello AC
Cerebral cortex (New York, N.Y. : 1991)27(2)1501-1511(2017 Feb)

Balance between cAMP and Ca(2+) signals regulates expression levels of pituitary adenylate cyclase-activating polypeptide gene in neurons.
Fukuchi M, Kuwana Y, Tabuchi A, Tsuda M
Genes to cells : devoted to molecular & cellular mechanisms21(8)921-9(2016 Aug)

CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy.
Dubey D, Porter BE
Neuroscience32057-68(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Impaired nuclear translocation in mutated amyloid precursor protein transgenic rat model of Alzheimer disease suggests its contribution to hippocampal-dependent learning and memory.
Title: Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease.

depolarization (which produced a robust increase in Ca(2+) signals) together with cAMP signaling resulted in a synergistic induction of Pacap mRNA through calcineurin and its substrate, cAMP-response element-binding protein (CREB)-regulated transcription coactivator 1.
Title: Balance between cAMP and Ca(2+) signals regulates expression levels of pituitary adenylate cyclase-activating polypeptide gene in neurons.

Our results provide evidence that CREB cofactor CRTC1 translocates into the nucleus of a distinct subset of hippocampal neurons during and following status epilepticus
Title: CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy.

The NR2B-CREB-CRTC1 signaling pathway may play a crucial role in circadian rhythm of pain
Title: Regulation of the NR2B-CREB-CRTC1 Signaling Pathway Contributes to Circadian Pain in Murine Model of Chronic Constriction Injury.

Results indicate that overexpressing SIK1 can phosphorylate CRTC1 and CRTC2 in the norepinephrine (NE)-stimulated pinealocytes. Howeve, the endogenous SIK1 does not appear to be the main regulator of their phosphorylation and intracellular localization.
Title: The adrenergic-regulated CRTC1 and CRTC2 phosphorylation and cellular distribution is independent of endogenous SIK1 in the male rat pinealocyte.

The following Crtc1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Crtc1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
ORa10129	NM_001047115.1 Latest version!	Rattus norvegicus CREB regulated transcription coactivator 1 (Crtc1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$370.30 $529.00
ORa37261	XM_006252936.3 Latest version!	Rattus norvegicus CREB regulated transcription coactivator 1 (Crtc1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Crtc1 ( NM_001047115.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001040580.1 Rattus norvegicus CREB regulated transcription coactivator 1 (Crtc1), mRNA.

Price & Availability↑

CloneID	ORa10129
Clone ID Related Accession (Same CDS sequence)	NM_001047115.1
Accession Version	NM_001047115.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1893bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Rattus norvegicus(Norway rat)
Product	CREB-regulated transcription coactivator 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from DQ538521.1. On Sep 7, 2006 this sequence version replaced XM_001070837.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ538521.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGACTT CGAACAATCC GCGGAAATTT AGCGAGAAGA TCGCACTGCA CAACCAGAAG 
CAGGCGGAGG AGACGGCGGC CTTCGAGGAG GTCATGAAGG ACCTGAGCCT GACGCGAGCC 
GCGCGGCTTC AACTGCAGAA GTCGCAGTAT CTCCAACTGG GCCCCAGCCG TGGTCAGTAC 
TATGGCGGGT CCCTGCCCAA CGTGAACCAG ATTGGAAGTA GCAGCATGGA CCTCTCCTTC 
CAGACCCCCT TTCAGTCCTC AGGCCTGGAC ACCAGTCGGA CCACACGACA TCATGGGCTT 
GTGGACAGAG TATATCGTGA GCGTGGCAGA CTTGGCTCCC CGCACCGCCG TCCCCTGTCA 
GTAGACAAGC ATGGGCGACA GGCCGACAGC TGCCCCTATG GCACCGTGTA CCTCTCGCCT 
CCTGCGGACA CCAGCTGGAG GAGGACCAAC TCTGACTCTG CCCTGCACCA GAGCACAATG 
ACACCCACCC AGGCAGAATC CTTCACAGGC GGGCCCCAGG ATGCGCACCA GAAGAGAGTC 
TTACTGCTCA CAGTCCCAGG AATGGAGGAG ACCGGATCCG AGACAGACAA GACCCTTTCT 
AAGCAGTCAT GGGACTCAAA GAAGGCGGGT TCCAGGCCCA AGTCCTGCGA AGTCCCTGGA 
ATCAACATCT TTCCATCTGC AGACCAGGAG AACACAGCAG CCCTGATCCC TGCTACCCAC 
AACACAGGAG GCTCCCTTCC TGACCTCAGC ACCATCCACT TCCCCTCCCC ACTGCCGACC 
CCACTGGACC CCGAGGAGCC TCCATTCCCT GCTCTCACCA GCTCCGGCAG CACCGGCAGC 
CTGGCTCATC TAGGCGTTGG CGGCACAGGC CAGGGTATGA ACACCCCCAG CTCTTCTCCA 
CAGCGCCGGC CAGCAGTCGT CAGCCCCCTG TCCCTGAGCA CAGAGGCCAG GCGGCAGCAG 
GCCCAGCAGG TGCCACCCAC CCTGTCTCCA CTGTCACCCA TCACTCAGGC CGTGGCCATG 
GATGCCCTGT CGTTGGAGCA GCAGCTGCCC TACGCCTTCT TCACCCAGGC CGGCTCACAG 
CAGCCTCCCC CGCAGCCCCA GCCACCGCCC CCACCTCCGC CTGTATCTCA ACAGCAGCCA 
CCACCCCCAC AAGTGTCTGT GGGGCTCCCC CAGGGTGGCC CACTGCTGCC CAGTGCCAGC 
CTGACTCGGG GGCCCCAGCT GCCACCACTC GCAGTCACTG TACCATCCAC TCTTCCCCAG 
TCACCTACAG AGAGCCCAGG CCAGCCACCA ATGGGGATTG ATGTCACCTC GGCACCAGCT 
CTGCAGTACC GCACGGGTGC AGGGTCACCA GCCACCCAGT CCCCCACCTC ACCGGTCTCC 
AACCAAGGCT TCTCCCCCGG AAGCTCCCCA CAGCACACGT CCACGCTGGG CAGCGTGTTT 
GGGGATGCGT ACTATGAGCA GCAGATGACA GCCAGGCAGG CCAATGCTCT GTCCCGCCAG 
CTGGAGCAGT TCAACATGAT GGAAAATGCC ATCAGCTCCA GCAGCCTGTA CAACCCAGGT 
TCCACACTCA ACTACTCCCA GGCTGCCATG ATGGGTCTGA GCGGGAGCCA CGGAGGCCTT 
CAGGACCCAC AGCAACTCGG CTACGCAGGC CATGGCGGAA TCCCCAACAT CATCCTCACC 
GTGACAGGGG AGTCACCCCC GAGCCTCTCT AAGGAACTGA GCAGCACACT GGCAGGGGTC 
AGTGATGTCA GCTTTGATTC GGACCACCAG TTTCCACTGG ACGAGCTGAA AATTGATCCC 
CTGACCCTGG ACGGACTTCA TATGTTGAAT GACCCTGACA TGGTCCTCGC TGACCCAGCT 
ACCGAGGACA CCTTCCGAAT GGACCGCCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001040580.1
CDS	1..1893
Translation	MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSSSMDLSFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTVYLSPPADTSWRRTNSDSALHQSTMTPTQAESFTGGPQDAHQKRVLLLTVPGMEETGSETDKTLSKQSWDSKKAGSRPKSCEVPGINIFPSADQENTAALIPATHNTGGSLPDLSTIHFPSPLPTPLDPEEPPFPALTSSGSTGSLAHLGVGGTGQGMNTPSSSPQRRPAVVSPLSLSTEARRQQAQQVPPTLSPLSPITQAVAMDALSLEQQLPYAFFTQAGSQQPPPQPQPPPPPPPVSQQQPPPPQVSVGLPQGGPLLPSASLTRGPQLPPLAVTVPSTLPQSPTESPGQPPMGIDVTSAPALQYRTGAGSPATQSPTSPVSNQGFSPGSSPQHTSTLGSVFGDAYYEQQMTARQANALSRQLEQFNMMENAISSSSLYNPGSTLNYSQAAMMGLSGSHGGLQDPQQLGYAGHGGIPNIILTVTGESPPSLSKELSSTLAGVSDVSFDSDHQFPLDELKIDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL

Target ORF information:

RefSeq Version	NM_001047115.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CREB regulated transcription coactivator 1 (Crtc1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001047115.1

ORF Insert Sequence:

ATGGCGACTT CGAACAATCC GCGGAAATTT AGCGAGAAGA TCGCACTGCA CAACCAGAAG 
CAGGCGGAGG AGACGGCGGC CTTCGAGGAG GTCATGAAGG ACCTGAGCCT GACGCGAGCC 
GCGCGGCTTC AACTGCAGAA GTCGCAGTAT CTCCAACTGG GCCCCAGCCG TGGTCAGTAC 
TATGGCGGGT CCCTGCCCAA CGTGAACCAG ATTGGAAGTA GCAGCATGGA CCTCTCCTTC 
CAGACCCCCT TTCAGTCCTC AGGCCTGGAC ACCAGTCGGA CCACACGACA TCATGGGCTT 
GTGGACAGAG TATATCGTGA GCGTGGCAGA CTTGGCTCCC CGCACCGCCG TCCCCTGTCA 
GTAGACAAGC ATGGGCGACA GGCCGACAGC TGCCCCTATG GCACCGTGTA CCTCTCGCCT 
CCTGCGGACA CCAGCTGGAG GAGGACCAAC TCTGACTCTG CCCTGCACCA GAGCACAATG 
ACACCCACCC AGGCAGAATC CTTCACAGGC GGGCCCCAGG ATGCGCACCA GAAGAGAGTC 
TTACTGCTCA CAGTCCCAGG AATGGAGGAG ACCGGATCCG AGACAGACAA GACCCTTTCT 
AAGCAGTCAT GGGACTCAAA GAAGGCGGGT TCCAGGCCCA AGTCCTGCGA AGTCCCTGGA 
ATCAACATCT TTCCATCTGC AGACCAGGAG AACACAGCAG CCCTGATCCC TGCTACCCAC 
AACACAGGAG GCTCCCTTCC TGACCTCAGC ACCATCCACT TCCCCTCCCC ACTGCCGACC 
CCACTGGACC CCGAGGAGCC TCCATTCCCT GCTCTCACCA GCTCCGGCAG CACCGGCAGC 
CTGGCTCATC TAGGCGTTGG CGGCACAGGC CAGGGTATGA ACACCCCCAG CTCTTCTCCA 
CAGCGCCGGC CAGCAGTCGT CAGCCCCCTG TCCCTGAGCA CAGAGGCCAG GCGGCAGCAG 
GCCCAGCAGG TGCCACCCAC CCTGTCTCCA CTGTCACCCA TCACTCAGGC CGTGGCCATG 
GATGCCCTGT CGTTGGAGCA GCAGCTGCCC TACGCCTTCT TCACCCAGGC CGGCTCACAG 
CAGCCTCCCC CGCAGCCCCA GCCACCGCCC CCACCTCCGC CTGTATCTCA ACAGCAGCCA 
CCACCCCCAC AAGTGTCTGT GGGGCTCCCC CAGGGTGGCC CACTGCTGCC CAGTGCCAGC 
CTGACTCGGG GGCCCCAGCT GCCACCACTC GCAGTCACTG TACCATCCAC TCTTCCCCAG 
TCACCTACAG AGAGCCCAGG CCAGCCACCA ATGGGGATTG ATGTCACCTC GGCACCAGCT 
CTGCAGTACC GCACGGGTGC AGGGTCACCA GCCACCCAGT CCCCCACCTC ACCGGTCTCC 
AACCAAGGCT TCTCCCCCGG AAGCTCCCCA CAGCACACGT CCACGCTGGG CAGCGTGTTT 
GGGGATGCGT ACTATGAGCA GCAGATGACA GCCAGGCAGG CCAATGCTCT GTCCCGCCAG 
CTGGAGCAGT TCAACATGAT GGAAAATGCC ATCAGCTCCA GCAGCCTGTA CAACCCAGGT 
TCCACACTCA ACTACTCCCA GGCTGCCATG ATGGGTCTGA GCGGGAGCCA CGGAGGCCTT 
CAGGACCCAC AGCAACTCGG CTACGCAGGC CATGGCGGAA TCCCCAACAT CATCCTCACC 
GTGACAGGGG AGTCACCCCC GAGCCTCTCT AAGGAACTGA GCAGCACACT GGCAGGGGTC 
AGTGATGTCA GCTTTGATTC GGACCACCAG TTTCCACTGG ACGAGCTGAA AATTGATCCC 
CTGACCCTGG ACGGACTTCA TATGTTGAAT GACCCTGACA TGGTCCTCGC TGACCCAGCT 
ACCGAGGACA CCTTCCGAAT GGACCGCCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Crtc1 ( XM_006252936.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006252998.1 Rattus norvegicus CREB regulated transcription coactivator 1 (Crtc1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	ORa37261
Clone ID Related Accession (Same CDS sequence)	XM_006252936.3
Accession Version	XM_006252936.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1806bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	CREB-regulated transcription coactivator 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005115.4) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006252936.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGACTT CGAACAATCC GCGGAAATTT AGCGAGAAGA TCGCACTGCA CAACCAGAAG 
CAGGCGGAGG AGACGGCGGC CTTCGAGGAG GTCATGAAGG ACCTGAGCCT GACGCGAGCC 
GCGCGGCTTC AACTGCAGAA GTCGCAGTAT CTCCAACTGG GCCCCAGCCG TGGTCAGTAC 
TATGGCGGGT CCCTGCCCAA CGTGAACCAG ATTGGAAGTA GCAGCATGGA CCTCTCCTTC 
CAGACCCCCT TTCAGTCCTC AGGCCTGGAC ACCAGTCGGA CCACACGACA TCATGGGCTT 
GTGGACAGAG TATATCGTGA GCGTGGCAGA CTTGGCTCCC CACACCGCCG TCCCCTGTCA 
GTAGACAAGC ATGGGCGACA GGCCGACAGC TGCCCCTATG GCACCGTGTA CCTCTCGCCT 
CCTGCGGACA CCAGCTGGAG GAGGACCAAC TCTGACTCTG CCCTGCACCA GAGCACAATG 
ACACCCACCC AGGCAGAATC CTTCACAGGC GGGCCCCAGG ATGCGCACCA GAAGAGAGTC 
TTACTGCTCA CAGTCCCAGG AATGGAGGAG ACCGGATCCG AGACAGACAA GACCCTTTCT 
AAGCAGTCAT GGGACTCAAA GAAGGCGGGT TCCAGGCCCA AGTCCTGCGA AGTCCCTGGA 
ATCAACATCT TTCCATCTGC AGACCAGGAG AACACAGCAG CCCTGATCCC TGCTACCCAC 
AACACAGGAG GCTCCCTTCC TGACCTCAGC ACCATCCACT TCCCCTCCCC ACTGCCGACC 
CCACTGGACC CCGAGGAGCC TCCATTCCCT GCTCTCACCA GCTCCGGCAG CACCGGCAGC 
CTGGCTCATC TAGGCGTTGG CGGCACAGGC CAGGGTATGA ACACCCCCAG CTCTTCTCCA 
CAGCGCCGGC CAGCAGTCGT CAGCCCCCTG TCCCTGAGCA CAGAGGCCAG GCGGCAGCAG 
GCCCAGCAGG TGCCACCCAC CCTGTCTCCA CTGTCACCCA TCACTCAGGC CGTGGCCATG 
GATGCCCTGT CGTTGGAGCA GCAGCTGCCC TACGCCTTCT TCACCCAGGC CGGCTCACAG 
CAGCCTCCCC CGCAGCCCCA GCCACCGCCC CCACCTCCGC CTGTATCTCA ACAGCAGCCA 
CCACCCCCAC AAGTGTCTGT GGGGCTCCCC CAGGGTGGCC CACTGCTGCC CAGTGCCAGC 
CTGACTCGGG GGCCCCAGCT GCCACCACTC GCAGTCACTG TACCATCCAC TCTTCCCCAG 
TCACCTACAG AGAGCCCAGG CCAGCCACCA ATGGGGATTG ATGTCACCTC GGCACCAGCT 
CTGCAGTACC GCACGGGTGC AGGGTCACCA GCCACCCAGT CCCCCACCTC ACCGGTCTCC 
AACCAAGGCT TCTCCCCCGG AAGCTCCCCA CAGCTGGAGC AGTTCAACAT GATGGAAAAT 
GCCATCAGCT CCAGCAGCCT GTACAACCCA GGTTCCACAC TCAACTACTC CCAGGCTGCC 
ATGATGGGTC TGAGCGGGAG CCACGGAGGC CTTCAGGACC CACAGCAACT CGGCTACGCA 
GGCCATGGCG GAATCCCCAA CATCATCCTC ACCGTGACAG GGGAGTCACC CCCGAGCCTC 
TCTAAGGAAC TGAGCAGCAC ACTGGCAGGG GTCAGTGATG TCAGCTTTGA TTCGGACCAC 
CAGTTTCCAC TGGACGAGCT GAAAATTGAT CCCCTGACCC TGGACGGACT TCATATGTTG 
AATGACCCTG ACATGGTCCT CGCTGACCCA GCTACCGAGG ACACCTTCCG AATGGACCGC 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006252998.1
CDS	81..1886
Translation	MATSNNPRKFSEKIALHNQKQAEETAAFEEVMKDLSLTRAARLQLQKSQYLQLGPSRGQYYGGSLPNVNQIGSSSMDLSFQTPFQSSGLDTSRTTRHHGLVDRVYRERGRLGSPHRRPLSVDKHGRQADSCPYGTVYLSPPADTSWRRTNSDSALHQSTMTPTQAESFTGGPQDAHQKRVLLLTVPGMEETGSETDKTLSKQSWDSKKAGSRPKSCEVPGINIFPSADQENTAALIPATHNTGGSLPDLSTIHFPSPLPTPLDPEEPPFPALTSSGSTGSLAHLGVGGTGQGMNTPSSSPQRRPAVVSPLSLSTEARRQQAQQVPPTLSPLSPITQAVAMDALSLEQQLPYAFFTQAGSQQPPPQPQPPPPPPPVSQQQPPPPQVSVGLPQGGPLLPSASLTRGPQLPPLAVTVPSTLPQSPTESPGQPPMGIDVTSAPALQYRTGAGSPATQSPTSPVSNQGFSPGSSPQLEQFNMMENAISSSSLYNPGSTLNYSQAAMMGLSGSHGGLQDPQQLGYAGHGGIPNIILTVTGESPPSLSKELSSTLAGVSDVSFDSDHQFPLDELKIDPLTLDGLHMLNDPDMVLADPATEDTFRMDRL

Target ORF information:

RefSeq Version	XM_006252936.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus CREB regulated transcription coactivator 1 (Crtc1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006252936.3

ORF Insert Sequence:

ATGGCGACTT CGAACAATCC GCGGAAATTT AGCGAGAAGA TCGCACTGCA CAACCAGAAG 
CAGGCGGAGG AGACGGCGGC CTTCGAGGAG GTCATGAAGG ACCTGAGCCT GACGCGAGCC 
GCGCGGCTTC AACTGCAGAA GTCGCAGTAT CTCCAACTGG GCCCCAGCCG TGGTCAGTAC 
TATGGCGGGT CCCTGCCCAA CGTGAACCAG ATTGGAAGTA GCAGCATGGA CCTCTCCTTC 
CAGACCCCCT TTCAGTCCTC AGGCCTGGAC ACCAGTCGGA CCACACGACA TCATGGGCTT 
GTGGACAGAG TATATCGTGA GCGTGGCAGA CTTGGCTCCC CACACCGCCG TCCCCTGTCA 
GTAGACAAGC ATGGGCGACA GGCCGACAGC TGCCCCTATG GCACCGTGTA CCTCTCGCCT 
CCTGCGGACA CCAGCTGGAG GAGGACCAAC TCTGACTCTG CCCTGCACCA GAGCACAATG 
ACACCCACCC AGGCAGAATC CTTCACAGGC GGGCCCCAGG ATGCGCACCA GAAGAGAGTC 
TTACTGCTCA CAGTCCCAGG AATGGAGGAG ACCGGATCCG AGACAGACAA GACCCTTTCT 
AAGCAGTCAT GGGACTCAAA GAAGGCGGGT TCCAGGCCCA AGTCCTGCGA AGTCCCTGGA 
ATCAACATCT TTCCATCTGC AGACCAGGAG AACACAGCAG CCCTGATCCC TGCTACCCAC 
AACACAGGAG GCTCCCTTCC TGACCTCAGC ACCATCCACT TCCCCTCCCC ACTGCCGACC 
CCACTGGACC CCGAGGAGCC TCCATTCCCT GCTCTCACCA GCTCCGGCAG CACCGGCAGC 
CTGGCTCATC TAGGCGTTGG CGGCACAGGC CAGGGTATGA ACACCCCCAG CTCTTCTCCA 
CAGCGCCGGC CAGCAGTCGT CAGCCCCCTG TCCCTGAGCA CAGAGGCCAG GCGGCAGCAG 
GCCCAGCAGG TGCCACCCAC CCTGTCTCCA CTGTCACCCA TCACTCAGGC CGTGGCCATG 
GATGCCCTGT CGTTGGAGCA GCAGCTGCCC TACGCCTTCT TCACCCAGGC CGGCTCACAG 
CAGCCTCCCC CGCAGCCCCA GCCACCGCCC CCACCTCCGC CTGTATCTCA ACAGCAGCCA 
CCACCCCCAC AAGTGTCTGT GGGGCTCCCC CAGGGTGGCC CACTGCTGCC CAGTGCCAGC 
CTGACTCGGG GGCCCCAGCT GCCACCACTC GCAGTCACTG TACCATCCAC TCTTCCCCAG 
TCACCTACAG AGAGCCCAGG CCAGCCACCA ATGGGGATTG ATGTCACCTC GGCACCAGCT 
CTGCAGTACC GCACGGGTGC AGGGTCACCA GCCACCCAGT CCCCCACCTC ACCGGTCTCC 
AACCAAGGCT TCTCCCCCGG AAGCTCCCCA CAGCTGGAGC AGTTCAACAT GATGGAAAAT 
GCCATCAGCT CCAGCAGCCT GTACAACCCA GGTTCCACAC TCAACTACTC CCAGGCTGCC 
ATGATGGGTC TGAGCGGGAG CCACGGAGGC CTTCAGGACC CACAGCAACT CGGCTACGCA 
GGCCATGGCG GAATCCCCAA CATCATCCTC ACCGTGACAG GGGAGTCACC CCCGAGCCTC 
TCTAAGGAAC TGAGCAGCAC ACTGGCAGGG GTCAGTGATG TCAGCTTTGA TTCGGACCAC 
CAGTTTCCAC TGGACGAGCT GAAAATTGAT CCCCTGACCC TGGACGGACT TCATATGTTG 
AATGACCCTG ACATGGTCCT CGCTGACCCA GCTACCGAGG ACACCTTCCG AATGGACCGC 
CTGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Region specific activation of the AKT and mTORC1 pathway in response to excessive alcohol intake in rodents.
Addiction biology22(6)1856-1869(2017 Nov)
Laguesse S,Morisot N,Phamluong K,Ron D

Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease.
Cerebral cortex (New York, N.Y. : 1991)27(2)1501-1511(2017 Feb)
Wilson EN,Abela AR,Do Carmo S,Allard S,Marks AR,Welikovitch LA,Ducatenzeiler A,Chudasama Y,Cuello AC

Balance between cAMP and Ca(2+) signals regulates expression levels of pituitary adenylate cyclase-activating polypeptide gene in neurons.
Genes to cells : devoted to molecular & cellular mechanisms21(8)921-9(2016 Aug)
Fukuchi M,Kuwana Y,Tabuchi A,Tsuda M

CRTC1 nuclear localization in the hippocampus of the pilocarpine-induced status epilepticus model of temporal lobe epilepsy.
Neuroscience32057-68(2016 Apr)
Dubey D,Porter BE

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Crtc1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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