Kcnh1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnh1
Entrez Gene ID	65198
Full Name	potassium voltage-gated channel subfamily H member 1
General protein information	Preferred Names potassium voltage-gated channel subfamily H member 1 Names potassium voltage-gated channel subfamily H member 1 EAG channel 1 EAG1 ether-a-go-go potassium channel 1 potassium channel, voltage gated eag related subfamily H, member 1 potassium voltage-gated channel, subfamily H (eag-related), member 1 r-eag voltage-gated potassium channel subunit Kv10.1
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 13 Map Location: 13q27
Summary	pore forming subunit of voltage gated potassium channel [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
XM_017598933.1	XP_017454422.1	potassium voltage-gated channel subfamily H member 1 isoform X1
NM_031742.1	NP_113930.1	potassium voltage-gated channel subfamily H member 1
XM_006250491.3	XP_006250553.1	potassium voltage-gated channel subfamily H member 1 isoform X2

Pathways from BioSystems

Homologies

Rattus norvegicus (Norway rat)	Kcnh1	NP_113930.1
Xenopus tropicalis (tropical clawed frog)	kcnh1	XP_002934755.2
Canis lupus familiaris (dog)	LOC490277	XP_005623012.1
Mus musculus (house mouse)	Kcnh1	NP_001033696.1
Gallus gallus (chicken)	KCNH1	XP_419440.4
Homo sapiens (human)	KCNH1	NP_758872.1
Pan troglodytes (chimpanzee)	KCNH1	XP_001169423.2
	KCNH1	XP_001109251.1
Danio rerio (zebrafish)	kcnh1b	NP_001265743.1
Bos taurus (cattle)	KCNH1	NP_776797.1
Danio rerio (zebrafish)	kcnh1a	NP_001038396.1
Oryza sativa (rice)	Os01g0756700	NP_001044290.1

Gene Ontology
Bibliography

Related articles in PubMed

Structure of the voltage-gated K? channel Eag1 reveals an alternative voltage sensing mechanism.
Whicher JR, MacKinnon R
Science (New York, N.Y.)353(6300)664-9(2016 Aug)

Calmodulin Regulates Human Ether ? Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain.
L?rinczi E, Helliwell M, Finch A, Stansfeld PJ, Davies NW, Mahaut-Smith M, Muskett FW, Mitcheson JS
The Journal of biological chemistry291(34)17907-18(2016 08)

Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations.
Han B, He K, Cai C, Tang Y, Yang L, Heinemann SH, Hoshi T, Hou S
Scientific reports623417(2016 Mar)

KV 10.1 opposes activity-dependent increase in Ca?? influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse.
Mortensen LS, Schmidt H, Farsi Z, Barrantes-Freer A, Rubio ME, Ufartes R, Eilers J, Sakaba T, St?hmer W, Pardo LA
The Journal of physiology593(1)181-96(2015 01)

The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains.
Lin TF, Lin IW, Chen SC, Wu HH, Yang CS, Fang HY, Chiu MM, Jeng CJ
The Journal of biological chemistry289(33)22815-34(2014 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study determined the single-particle cryo-electron microscopy structure of mammalian K(v)10.1, or Eag1, bound to the channel inhibitor calmodulin, at 3.78 angstrom resolution.
Title: Structure of the voltage-gated K? channel Eag1 reveals an alternative voltage sensing mechanism.

both the N-terminal and the C-terminal recognition domains are required to sustain the subfamily-specific assembly of rat Eag1 and human Erg.
Title: The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains.

Our findings suggest that Eag1 and Eag2 K+ channels may modulate membrane excitability in both the dendrosomatic and the axonal compartments and that Eag1 may additionally regulate neurotransmitter release and postsynaptic signaling
Title: The punctate localization of rat Eag1 K+ channels is conferred by the proximal post-CNBHD region.

Anti-Eag1 does not modify effects in the startle reflex but does restore startle amplitude decrease after dentate gyrus surgery.
Title: Hippocampal ether-?-go-go1 potassium channels blockade: effects in the startle reflex and prepulse inhibition.

14-3-3theta; is a binding partner of rEag1 and may modulate the functional expression of the K(+) channel in neurons.
Title: 14-3-3? is a binding partner of rat Eag1 potassium channels.

The following Kcnh1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnh1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa08633	NM_031742.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily H member 1 (Kcnh1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$566.30 $809.00
ORa35752	XM_006250491.3 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily H member 1 (Kcnh1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
ORa58154	XM_017598933.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily H member 1 (Kcnh1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnh1 ( NM_031742.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113930.1 Rattus norvegicus potassium voltage-gated channel subfamily H member 1 (Kcnh1), mRNA.

Price & Availability↑

CloneID	ORa08633
Clone ID Related Accession (Same CDS sequence)	NM_031742.1
Accession Version	NM_031742.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2889bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-20
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily H member 1
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from Z34264.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: Z34264.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2689595, SAMN04563758 [ECO:0000348] ##Evidence-Data-END##

ATGACCATGG CTGGCGGCCG GCGGGGACTA GTGGCCCCGC AGAACACATT TCTGGAGAAC 
ATCGTGCGGC GGTCCAACGA CACTAATTTT GTGTTGGGGA ATGCCCAGAT CGTGGACTGG 
CCCATCGTGT ACAGCAATGA TGGATTCTGC AAGCTGTCTG GCTACCACCG AGCGGAAGTG 
ATGCAAAAGA GTAGCGCCTG CAGTTTTATG TATGGAGAGC TGACCGACAA GGACACGGTT 
GAAAAGGTTC GCCAGACCTT TGAGAACTAC GAGATGAACT CCTTCGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTTTTT GTGAAGATCG CTCCAATCAG GAACGAACAG 
GATAAAGTGG TTCTGTTCCT TTGCACTTTC AGTGACATAA CGGCATTCAA GCAGCCCATT 
GAGGACGACT CCTGCAAAGG TTGGGGGAAG TTTGCTCGAC TGACGAGAGC TCTGACAAGC 
AGCAGGGGAG TCCTGCAGCA GCTGGCCCCC AGTGTGCAGA AGGGTGAGAA TGTTCACAAG 
CACTCGCGCC TGGCAGAGGT CCTGCAGCTG GGTTCAGACA TCCTCCCCCA GTACAAGCAA 
GAGGCGCCAA AGACACCCCC TCACATCATC CTACACTACT GTGTCTTTAA GACCACATGG 
GATTGGATCA TCTTGATCCT GACCTTCTAC ACAGCCATCC TGGTCCCTTA CAACGTCTCC 
TTTAAAACCA GGCAGAATAA CGTGGCCTGG CTGGTGGTGG ACAGCATCGT GGATGTCATC 
TTTTTGGTGG ACATTGTCTT GAATTTTCAC ACCACCTTTG TCGGGCCAGC GGGGGAAGTG 
ATCTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATCGACCTT 
CTCTCCTGTT TGCCATATGA CGTCATCAAC GCTTTTGAGA ACGTGGATGA GGGCATCAGC 
AGCCTGTTCA GTTCTCTGAA AGTCGTGCGG CTGCTCCGTC TCGGACGAGT GGCCCGCAAG 
CTGGACCATT ATATCGAGTA CGGAGCGGCG GTACTGGTCC TGCTGGTGTG CGTGTTCGGG 
CTGGCTGCCC ACTGGATGGC CTGCATCTGG TACAGCATTG GGGATTATGA GATCTTTGAT 
GAAGACACCA AGACCATCCG TAACAACAGC TGGCTCTACC AACTGGCATT GGACATTGGC 
ACTCCATACC AGTTTAATGG GTCTGGTTCG GGGAAGTGGG AAGGCGGGCC AAGCAAGAAC 
TCCGTATACA TTTCCTCGCT GTACTTCACC ATGACAAGTC TCACCAGTGT GGGCTTTGGT 
AACATCGCCC CATCCACAGA CATCGAGAAG ATCTTCGCCG TAGCCATCAT GATGATTGGC 
TCCCTTCTGT ATGCCACCAT CTTTGGGAAT GTGACGACCA TTTTCCAGCA GATGTATGCC 
AACACCAACA GGTATCATGA GATGCTCAAC AGCGTCCGGG ATTTCCTGAA GCTCTACCAG 
GTGCCCAAGG GGCTGAGCGA GCGGGTCATG GACTACATTG TGTCTACCTG GTCCATGTCC 
CGCGGCATCG ACACGGAGAA GGTCCTGCAA ATCTGCCCCA AGGACATGCG AGCTGACATT 
TGCGTACACC TGAACCGAAA AGTGTTCAAA GAACACCCCG CCTTCCGGCT GGCCAGCGAT 
GGTTGCCTGA GGGCCTTGGC CATGGAGTTC CAGACAGTAC ACTGCGCCCC AGGGGACCTC 
ATCTATCACG CCGGGGAGAG TGTGGACAGC CTCTGCTTCG TGGTCTCGGG CTCCCTGGAG 
GTGATCCAGG ATGATGAGGT GGTGGCCATC CTAGGGAAAG GAGATGTGTT TGGGGATGTT 
TTCTGGAAGG AGGCTACCCT TGCACAGTCC TGCGCTAATG TCCGGGCCTT GACCTACTGT 
GACCTGCACG TGATCAAGAG GGATGCCCTG CAGAAAGTGC TAGAATTCTA CACAGCCTTC 
TCCCACTCCT TCTCCCGGAA CCTGATTCTC ACCTACAATC TGAGGAAGAG GATTGTGTTC 
CGGAAGATCA GCGACGTGAA ACGAGAAGAA GAGGAGAGGA TGAAACGGAA GAACGAGGCC 
CCCCTTATCC TGCCTCCTGA CCACCCTGTC AGGAGGCTCT TCCAAAGGTT CCGCCAGCAG 
AAAGAAGCCA GGCTGGCAGC CGAGAGAGGT GGCCGGGACC TGGATGACCT GGATGTAGAG 
AAGGGCAATG CCCTCACGGA CCATACCTCA GCCAACCACA GCCTGGTGAA GGCCAGTGTG 
GTCACGGTGC GTGAGAGTCC CGCCACGCCT GTGTCCTTCC AGGCAGCCTC CACCTCCACA 
GTGTCAGACC ACGCCAAGCT GCATGCACCG GGATCTGAGT GCCTAGGTCC CAAGGCAGGC 
GGTGGCGACC CTGCCAAGCG CAAAGGCTGG GCCCGGTTCA AAGATGCCTG TGGGAAGGGT 
GAGGATTGGA ACAAGGTGTC CAAGGCAGAG TCCATGGAGA CGCTTCCCGA GAGGACAAAG 
GCATCGGGCG AGGCCACGCT GAAGAAGACA GACTCCTGTG ACAGTGGAAT CACCAAGAGT 
GACCTGCGCT TGGACAATGT GGGTGAGGCC AGGAGTCCCC AGGACCGGAG CCCCATCTTG 
GCCGAGGTCA AGCATTCTTT CTACCCCATC CCCGAGCAGA CACTGCAGGC CACAGTGCTG 
GAGGTGAAGC ATGAGCTGAA GGAAGACATC AAGGCCTTGA ATGCCAAAAT GACCTCCATT 
GAGAAGCAGC TGTCTGAGAT CCTCAGGATA CTCATGTCCA GAGGGTCCTC CCAGTCTCCG 
CAGGACACGT GTGAGGTCTC CAGGCCCCAG TCCCCAGAGT CAGACAGAGA CATTTTTGGG 
GCAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113930.1
CDS	210..3098
Translation	MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSACSFMYGELTDKDTVEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLALDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNALTDHTSANHSLVKASVVTVRESPATPVSFQAASTSTVSDHAKLHAPGSECLGPKAGGGDPAKRKGWARFKDACGKGEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVKHELKEDIKALNAKMTSIEKQLSEILRILMSRGSSQSPQDTCEVSRPQSPESDRDIFGAS

Target ORF information:

RefSeq Version	NM_031742.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily H member 1 (Kcnh1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031742.1

ORF Insert Sequence:

ATGACCATGG CTGGCGGCCG GCGGGGACTA GTGGCCCCGC AGAACACATT TCTGGAGAAC 
ATCGTGCGGC GGTCCAACGA CACTAATTTT GTGTTGGGGA ATGCCCAGAT CGTGGACTGG 
CCCATCGTGT ACAGCAATGA TGGATTCTGC AAGCTGTCTG GCTACCACCG AGCGGAAGTG 
ATGCAAAAGA GTAGCGCCTG CAGTTTTATG TATGGAGAGC TGACCGACAA GGACACGGTT 
GAAAAGGTTC GCCAGACCTT TGAGAACTAC GAGATGAACT CCTTCGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTTTTT GTGAAGATCG CTCCAATCAG GAACGAACAG 
GATAAAGTGG TTCTGTTCCT TTGCACTTTC AGTGACATAA CGGCATTCAA GCAGCCCATT 
GAGGACGACT CCTGCAAAGG TTGGGGGAAG TTTGCTCGAC TGACGAGAGC TCTGACAAGC 
AGCAGGGGAG TCCTGCAGCA GCTGGCCCCC AGTGTGCAGA AGGGTGAGAA TGTTCACAAG 
CACTCGCGCC TGGCAGAGGT CCTGCAGCTG GGTTCAGACA TCCTCCCCCA GTACAAGCAA 
GAGGCGCCAA AGACACCCCC TCACATCATC CTACACTACT GTGTCTTTAA GACCACATGG 
GATTGGATCA TCTTGATCCT GACCTTCTAC ACAGCCATCC TGGTCCCTTA CAACGTCTCC 
TTTAAAACCA GGCAGAATAA CGTGGCCTGG CTGGTGGTGG ACAGCATCGT GGATGTCATC 
TTTTTGGTGG ACATTGTCTT GAATTTTCAC ACCACCTTTG TCGGGCCAGC GGGGGAAGTG 
ATCTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATCGACCTT 
CTCTCCTGTT TGCCATATGA CGTCATCAAC GCTTTTGAGA ACGTGGATGA GGGCATCAGC 
AGCCTGTTCA GTTCTCTGAA AGTCGTGCGG CTGCTCCGTC TCGGACGAGT GGCCCGCAAG 
CTGGACCATT ATATCGAGTA CGGAGCGGCG GTACTGGTCC TGCTGGTGTG CGTGTTCGGG 
CTGGCTGCCC ACTGGATGGC CTGCATCTGG TACAGCATTG GGGATTATGA GATCTTTGAT 
GAAGACACCA AGACCATCCG TAACAACAGC TGGCTCTACC AACTGGCATT GGACATTGGC 
ACTCCATACC AGTTTAATGG GTCTGGTTCG GGGAAGTGGG AAGGCGGGCC AAGCAAGAAC 
TCCGTATACA TTTCCTCGCT GTACTTCACC ATGACAAGTC TCACCAGTGT GGGCTTTGGT 
AACATCGCCC CATCCACAGA CATCGAGAAG ATCTTCGCCG TAGCCATCAT GATGATTGGC 
TCCCTTCTGT ATGCCACCAT CTTTGGGAAT GTGACGACCA TTTTCCAGCA GATGTATGCC 
AACACCAACA GGTATCATGA GATGCTCAAC AGCGTCCGGG ATTTCCTGAA GCTCTACCAG 
GTGCCCAAGG GGCTGAGCGA GCGGGTCATG GACTACATTG TGTCTACCTG GTCCATGTCC 
CGCGGCATCG ACACGGAGAA GGTCCTGCAA ATCTGCCCCA AGGACATGCG AGCTGACATT 
TGCGTACACC TGAACCGAAA AGTGTTCAAA GAACACCCCG CCTTCCGGCT GGCCAGCGAT 
GGTTGCCTGA GGGCCTTGGC CATGGAGTTC CAGACAGTAC ACTGCGCCCC AGGGGACCTC 
ATCTATCACG CCGGGGAGAG TGTGGACAGC CTCTGCTTCG TGGTCTCGGG CTCCCTGGAG 
GTGATCCAGG ATGATGAGGT GGTGGCCATC CTAGGGAAAG GAGATGTGTT TGGGGATGTT 
TTCTGGAAGG AGGCTACCCT TGCACAGTCC TGCGCTAATG TCCGGGCCTT GACCTACTGT 
GACCTGCACG TGATCAAGAG GGATGCCCTG CAGAAAGTGC TAGAATTCTA CACAGCCTTC 
TCCCACTCCT TCTCCCGGAA CCTGATTCTC ACCTACAATC TGAGGAAGAG GATTGTGTTC 
CGGAAGATCA GCGACGTGAA ACGAGAAGAA GAGGAGAGGA TGAAACGGAA GAACGAGGCC 
CCCCTTATCC TGCCTCCTGA CCACCCTGTC AGGAGGCTCT TCCAAAGGTT CCGCCAGCAG 
AAAGAAGCCA GGCTGGCAGC CGAGAGAGGT GGCCGGGACC TGGATGACCT GGATGTAGAG 
AAGGGCAATG CCCTCACGGA CCATACCTCA GCCAACCACA GCCTGGTGAA GGCCAGTGTG 
GTCACGGTGC GTGAGAGTCC CGCCACGCCT GTGTCCTTCC AGGCAGCCTC CACCTCCACA 
GTGTCAGACC ACGCCAAGCT GCATGCACCG GGATCTGAGT GCCTAGGTCC CAAGGCAGGC 
GGTGGCGACC CTGCCAAGCG CAAAGGCTGG GCCCGGTTCA AAGATGCCTG TGGGAAGGGT 
GAGGATTGGA ACAAGGTGTC CAAGGCAGAG TCCATGGAGA CGCTTCCCGA GAGGACAAAG 
GCATCGGGCG AGGCCACGCT GAAGAAGACA GACTCCTGTG ACAGTGGAAT CACCAAGAGT 
GACCTGCGCT TGGACAATGT GGGTGAGGCC AGGAGTCCCC AGGACCGGAG CCCCATCTTG 
GCCGAGGTCA AGCATTCTTT CTACCCCATC CCCGAGCAGA CACTGCAGGC CACAGTGCTG 
GAGGTGAAGC ATGAGCTGAA GGAAGACATC AAGGCCTTGA ATGCCAAAAT GACCTCCATT 
GAGAAGCAGC TGTCTGAGAT CCTCAGGATA CTCATGTCCA GAGGGTCCTC CCAGTCTCCG 
CAGGACACGT GTGAGGTCTC CAGGCCCCAG TCCCCAGAGT CAGACAGAGA CATTTTTGGG 
GCAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnh1 ( XM_006250491.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_006250553.1 Rattus norvegicus potassium voltage-gated channel subfamily H member 1 (Kcnh1), transcript variant X2, mRNA.

Price & Availability↑

CloneID	ORa35752
Clone ID Related Accession (Same CDS sequence)	XM_006250491.3
Accession Version	XM_006250491.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2889bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily H member 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jul 26, 2016 this sequence version replaced XM_006250491.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCATGG CTGGCGGCCG GCGGGGACTA GTGGCCCCGC AGAACACATT TCTGGAGAAC 
ATCGTGCGGC GGTCCAACGA CACTAATTTT GTGTTGGGGA ATGCCCAGAT CGTGGACTGG 
CCCATCGTGT ACAGCAATGA TGGATTCTGC AAGCTGTCTG GCTACCACCG AGCGGAAGTG 
ATGCAAAAGA GTAGCGCCTG CAGTTTTATG TATGGAGAGC TGACCGACAA GGACACGGTT 
GAAAAGGTTC GCCAGACCTT TGAGAACTAC GAGATGAACT CCTTCGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTTTTT GTGAAGATCG CTCCAATCAG GAACGAACAG 
GATAAAGTGG TTCTGTTCCT TTGCACTTTC AGTGACATAA CGGCATTCAA GCAGCCCATT 
GAGGACGACT CCTGCAAAGG TTGGGGGAAG TTTGCTCGAC TGACGAGAGC TCTGACAAGC 
AGCAGGGGAG TCCTGCAGCA GCTGGCCCCC AGTGTGCAGA AGGGTGAGAA TGTTCACAAG 
CACTCGCGCC TGGCAGAGGT CCTGCAGCTG GGTTCAGACA TCCTCCCCCA GTACAAGCAA 
GAGGCGCCAA AGACACCCCC TCACATCATC CTACACTACT GTGTCTTTAA GACCACATGG 
GATTGGATCA TCTTGATCCT GACCTTCTAC ACAGCCATCC TGGTCCCTTA CAACGTCTCC 
TTTAAAACCA GGCAGAATAA CGTGGCCTGG CTGGTGGTGG ACAGCATCGT GGATGTCATC 
TTTTTGGTGG ACATTGTCTT GAATTTTCAC ACCACCTTTG TCGGGCCAGC GGGGGAAGTG 
ATCTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATCGACCTT 
CTCTCCTGTT TGCCATATGA CGTCATCAAC GCTTTTGAGA ACGTGGATGA GGGCATCAGC 
AGCCTGTTCA GTTCTCTGAA AGTCGTGCGG CTGCTCCGTC TCGGACGAGT GGCCCGCAAG 
CTGGACCATT ATATCGAGTA CGGAGCGGCG GTACTGGTCC TGCTGGTGTG CGTGTTCGGG 
CTGGCTGCCC ACTGGATGGC CTGCATCTGG TACAGCATTG GGGACTATGA GATCTTTGAT 
GAAGACACCA AGACCATCCG TAACAACAGC TGGCTCTACC AACTGGCATT GGACATTGGC 
ACTCCATACC AGTTTAATGG GTCTGGTTCG GGGAAGTGGG AAGGCGGGCC AAGCAAGAAC 
TCCGTATACA TTTCCTCGCT GTACTTCACC ATGACAAGTC TCACCAGTGT GGGCTTTGGT 
AACATCGCCC CATCCACAGA CATCGAGAAG ATCTTCGCCG TAGCCATCAT GATGATTGGC 
TCCCTTCTGT ATGCCACCAT CTTTGGGAAT GTGACGACCA TTTTCCAGCA GATGTATGCC 
AACACCAACA GGTATCATGA GATGCTCAAC AGCGTCCGGG ATTTCCTGAA GCTCTACCAG 
GTGCCCAAGG GGCTGAGCGA GCGGGTCATG GACTACATTG TGTCTACCTG GTCCATGTCC 
CGCGGCATCG ACACGGAGAA GGTCCTGCAA ATCTGCCCCA AGGACATGCG AGCTGACATT 
TGCGTACACC TGAACCGAAA AGTGTTCAAA GAACACCCCG CCTTCCGGCT GGCCAGCGAT 
GGTTGCCTGA GGGCCTTGGC CATGGAGTTC CAGACAGTAC ACTGCGCCCC AGGGGACCTC 
ATCTATCACG CCGGGGAGAG TGTGGACAGC CTCTGCTTCG TGGTCTCGGG CTCCCTGGAG 
GTGATCCAGG ATGATGAGGT GGTGGCCATC CTAGGGAAAG GAGATGTGTT TGGGGATGTT 
TTCTGGAAGG AGGCTACCCT TGCACAGTCC TGCGCTAATG TCCGGGCCTT GACCTACTGT 
GACCTGCACG TGATCAAGAG GGATGCCCTG CAGAAAGTGC TAGAATTCTA CACAGCCTTC 
TCCCACTCCT TCTCCCGGAA CCTGATTCTC ACCTACAATC TGAGGAAGAG GATTGTGTTC 
CGGAAGATCA GCGACGTGAA ACGAGAAGAA GAGGAGAGGA TGAAACGGAA GAACGAGGCC 
CCCCTTATCC TGCCTCCTGA CCACCCTGTC AGGAGGCTCT TCCAAAGGTT CCGCCAGCAG 
AAAGAAGCCA GGCTGGCAGC CGAGAGAGGT GGCCGGGACC TGGATGACCT GGATGTAGAG 
AAGGGCAATG CCCTCACGGA CCATACCTCA GCCAACCACA GCCTGGTGAA GGCCAGTGTG 
GTCACGGTGC GTGAGAGTCC CGCCACGCCT GTGTCCTTCC AGGCAGCCTC CACCTCCACA 
GTGTCAGACC ACGCCAAGCT GCATGCACCG GGATCTGAGT GCCTAGGTCC CAAGGCAGGC 
GGTGGCGACC CTGCCAAGCG CAAAGGCTGG GCCCGGTTCA AAGATGCCTG TGGGAAGGGT 
GAGGATTGGA ACAAGGTGTC CAAGGCAGAG TCCATGGAGA CGCTTCCCGA GAGGACAAAG 
GCATCGGGCG AGGCCACGCT GAAGAAGACA GACTCCTGTG ACAGTGGAAT CACCAAGAGT 
GACCTGCGCT TGGACAATGT GGGTGAGGCC AGGAGTCCCC AGGACCGGAG CCCCATCTTG 
GCCGAGGTCA AGCATTCTTT CTACCCCATC CCCGAGCAGA CACTGCAGGC CACAGTGCTG 
GAGGTGAAGC ATGAGCTGAA GGAAGACATC AAGGCCTTGA ATGCCAAAAT GACCTCCATT 
GAGAAGCAGC TGTCTGAGAT CCTCAGGATA CTCATGTCCA GAGGGTCCTC CCAGTCTCCG 
CAGGACACGT GTGAGGTCTC CAGGCCCCAG TCCCCAGAGT CAGACAGAGA CATTTTTGGG 
GCAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006250553.1
CDS	234..3122
Translation	MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSACSFMYGELTDKDTVEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLALDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNALTDHTSANHSLVKASVVTVRESPATPVSFQAASTSTVSDHAKLHAPGSECLGPKAGGGDPAKRKGWARFKDACGKGEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVKHELKEDIKALNAKMTSIEKQLSEILRILMSRGSSQSPQDTCEVSRPQSPESDRDIFGAS

Target ORF information:

RefSeq Version	XM_006250491.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily H member 1 (Kcnh1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006250491.3

ORF Insert Sequence:

ATGACCATGG CTGGCGGCCG GCGGGGACTA GTGGCCCCGC AGAACACATT TCTGGAGAAC 
ATCGTGCGGC GGTCCAACGA CACTAATTTT GTGTTGGGGA ATGCCCAGAT CGTGGACTGG 
CCCATCGTGT ACAGCAATGA TGGATTCTGC AAGCTGTCTG GCTACCACCG AGCGGAAGTG 
ATGCAAAAGA GTAGCGCCTG CAGTTTTATG TATGGAGAGC TGACCGACAA GGACACGGTT 
GAAAAGGTTC GCCAGACCTT TGAGAACTAC GAGATGAACT CCTTCGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTTTTT GTGAAGATCG CTCCAATCAG GAACGAACAG 
GATAAAGTGG TTCTGTTCCT TTGCACTTTC AGTGACATAA CGGCATTCAA GCAGCCCATT 
GAGGACGACT CCTGCAAAGG TTGGGGGAAG TTTGCTCGAC TGACGAGAGC TCTGACAAGC 
AGCAGGGGAG TCCTGCAGCA GCTGGCCCCC AGTGTGCAGA AGGGTGAGAA TGTTCACAAG 
CACTCGCGCC TGGCAGAGGT CCTGCAGCTG GGTTCAGACA TCCTCCCCCA GTACAAGCAA 
GAGGCGCCAA AGACACCCCC TCACATCATC CTACACTACT GTGTCTTTAA GACCACATGG 
GATTGGATCA TCTTGATCCT GACCTTCTAC ACAGCCATCC TGGTCCCTTA CAACGTCTCC 
TTTAAAACCA GGCAGAATAA CGTGGCCTGG CTGGTGGTGG ACAGCATCGT GGATGTCATC 
TTTTTGGTGG ACATTGTCTT GAATTTTCAC ACCACCTTTG TCGGGCCAGC GGGGGAAGTG 
ATCTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATCGACCTT 
CTCTCCTGTT TGCCATATGA CGTCATCAAC GCTTTTGAGA ACGTGGATGA GGGCATCAGC 
AGCCTGTTCA GTTCTCTGAA AGTCGTGCGG CTGCTCCGTC TCGGACGAGT GGCCCGCAAG 
CTGGACCATT ATATCGAGTA CGGAGCGGCG GTACTGGTCC TGCTGGTGTG CGTGTTCGGG 
CTGGCTGCCC ACTGGATGGC CTGCATCTGG TACAGCATTG GGGACTATGA GATCTTTGAT 
GAAGACACCA AGACCATCCG TAACAACAGC TGGCTCTACC AACTGGCATT GGACATTGGC 
ACTCCATACC AGTTTAATGG GTCTGGTTCG GGGAAGTGGG AAGGCGGGCC AAGCAAGAAC 
TCCGTATACA TTTCCTCGCT GTACTTCACC ATGACAAGTC TCACCAGTGT GGGCTTTGGT 
AACATCGCCC CATCCACAGA CATCGAGAAG ATCTTCGCCG TAGCCATCAT GATGATTGGC 
TCCCTTCTGT ATGCCACCAT CTTTGGGAAT GTGACGACCA TTTTCCAGCA GATGTATGCC 
AACACCAACA GGTATCATGA GATGCTCAAC AGCGTCCGGG ATTTCCTGAA GCTCTACCAG 
GTGCCCAAGG GGCTGAGCGA GCGGGTCATG GACTACATTG TGTCTACCTG GTCCATGTCC 
CGCGGCATCG ACACGGAGAA GGTCCTGCAA ATCTGCCCCA AGGACATGCG AGCTGACATT 
TGCGTACACC TGAACCGAAA AGTGTTCAAA GAACACCCCG CCTTCCGGCT GGCCAGCGAT 
GGTTGCCTGA GGGCCTTGGC CATGGAGTTC CAGACAGTAC ACTGCGCCCC AGGGGACCTC 
ATCTATCACG CCGGGGAGAG TGTGGACAGC CTCTGCTTCG TGGTCTCGGG CTCCCTGGAG 
GTGATCCAGG ATGATGAGGT GGTGGCCATC CTAGGGAAAG GAGATGTGTT TGGGGATGTT 
TTCTGGAAGG AGGCTACCCT TGCACAGTCC TGCGCTAATG TCCGGGCCTT GACCTACTGT 
GACCTGCACG TGATCAAGAG GGATGCCCTG CAGAAAGTGC TAGAATTCTA CACAGCCTTC 
TCCCACTCCT TCTCCCGGAA CCTGATTCTC ACCTACAATC TGAGGAAGAG GATTGTGTTC 
CGGAAGATCA GCGACGTGAA ACGAGAAGAA GAGGAGAGGA TGAAACGGAA GAACGAGGCC 
CCCCTTATCC TGCCTCCTGA CCACCCTGTC AGGAGGCTCT TCCAAAGGTT CCGCCAGCAG 
AAAGAAGCCA GGCTGGCAGC CGAGAGAGGT GGCCGGGACC TGGATGACCT GGATGTAGAG 
AAGGGCAATG CCCTCACGGA CCATACCTCA GCCAACCACA GCCTGGTGAA GGCCAGTGTG 
GTCACGGTGC GTGAGAGTCC CGCCACGCCT GTGTCCTTCC AGGCAGCCTC CACCTCCACA 
GTGTCAGACC ACGCCAAGCT GCATGCACCG GGATCTGAGT GCCTAGGTCC CAAGGCAGGC 
GGTGGCGACC CTGCCAAGCG CAAAGGCTGG GCCCGGTTCA AAGATGCCTG TGGGAAGGGT 
GAGGATTGGA ACAAGGTGTC CAAGGCAGAG TCCATGGAGA CGCTTCCCGA GAGGACAAAG 
GCATCGGGCG AGGCCACGCT GAAGAAGACA GACTCCTGTG ACAGTGGAAT CACCAAGAGT 
GACCTGCGCT TGGACAATGT GGGTGAGGCC AGGAGTCCCC AGGACCGGAG CCCCATCTTG 
GCCGAGGTCA AGCATTCTTT CTACCCCATC CCCGAGCAGA CACTGCAGGC CACAGTGCTG 
GAGGTGAAGC ATGAGCTGAA GGAAGACATC AAGGCCTTGA ATGCCAAAAT GACCTCCATT 
GAGAAGCAGC TGTCTGAGAT CCTCAGGATA CTCATGTCCA GAGGGTCCTC CCAGTCTCCG 
CAGGACACGT GTGAGGTCTC CAGGCCCCAG TCCCCAGAGT CAGACAGAGA CATTTTTGGG 
GCAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnh1 ( XM_017598933.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> XP_017454422.1 Rattus norvegicus potassium voltage-gated channel subfamily H member 1 (Kcnh1), transcript variant X1, mRNA.

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CloneID	ORa58154
Clone ID Related Accession (Same CDS sequence)	XM_017598933.1
Accession Version	XM_017598933.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2970bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-07-25
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily H member 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_005112.4) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Rattus norvegicus Annotation Release 106 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.1 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGACCATGG CTGGCGGCCG GCGGGGACTA GTGGCCCCGC AGAACACATT TCTGGAGAAC 
ATCGTGCGGC GGTCCAACGA CACTAATTTT GTGTTGGGGA ATGCCCAGAT CGTGGACTGG 
CCCATCGTGT ACAGCAATGA TGGATTCTGC AAGCTGTCTG GCTACCACCG AGCGGAAGTG 
ATGCAAAAGA GTAGCGCCTG CAGTTTTATG TATGGAGAGC TGACCGACAA GGACACGGTT 
GAAAAGGTTC GCCAGACCTT TGAGAACTAC GAGATGAACT CCTTCGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTTTTT GTGAAGATCG CTCCAATCAG GAACGAACAG 
GATAAAGTGG TTCTGTTCCT TTGCACTTTC AGTGACATAA CGGCATTCAA GCAGCCCATT 
GAGGACGACT CCTGCAAAGG TTGGGGGAAG TTTGCTCGAC TGACGAGAGC TCTGACAAGC 
AGCAGGGGAG TCCTGCAGCA GCTGGCCCCC AGTGTGCAGA AGGGTGAGAA TGTTCACAAG 
CACTCGCGCC TGGCAGAGGT CCTGCAGCTG GGTTCAGACA TCCTCCCCCA GTACAAGCAA 
GAGGCGCCAA AGACACCCCC TCACATCATC CTACACTACT GTGTCTTTAA GACCACATGG 
GATTGGATCA TCTTGATCCT GACCTTCTAC ACAGCCATCC TGGTCCCTTA CAACGTCTCC 
TTTAAAACCA GGCAGAATAA CGTGGCCTGG CTGGTGGTGG ACAGCATCGT GGATGTCATC 
TTTTTGGTGG ACATTGTCTT GAATTTTCAC ACCACCTTTG TCGGGCCAGC GGGGGAAGTG 
ATCTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATCGACCTT 
CTCTCCTGTT TGCCATATGA CGTCATCAAC GCTTTTGAGA ACGTGGATGA GGTTAGTGCC 
TTTATGGGTG ATCCAGGGAA GATTGGTTTT GCTGATCAGA TCCCACCACC ACTGGAGGGG 
AGAGAGAGTC AGGGCATCAG CAGCCTGTTC AGTTCTCTGA AAGTCGTGCG GCTGCTCCGT 
CTCGGACGAG TGGCCCGCAA GCTGGACCAT TATATCGAGT ACGGAGCGGC GGTACTGGTC 
CTGCTGGTGT GCGTGTTCGG GCTGGCTGCC CACTGGATGG CCTGCATCTG GTACAGCATT 
GGGGACTATG AGATCTTTGA TGAAGACACC AAGACCATCC GTAACAACAG CTGGCTCTAC 
CAACTGGCAT TGGACATTGG CACTCCATAC CAGTTTAATG GGTCTGGTTC GGGGAAGTGG 
GAAGGCGGGC CAAGCAAGAA CTCCGTATAC ATTTCCTCGC TGTACTTCAC CATGACAAGT 
CTCACCAGTG TGGGCTTTGG TAACATCGCC CCATCCACAG ACATCGAGAA GATCTTCGCC 
GTAGCCATCA TGATGATTGG CTCCCTTCTG TATGCCACCA TCTTTGGGAA TGTGACGACC 
ATTTTCCAGC AGATGTATGC CAACACCAAC AGGTATCATG AGATGCTCAA CAGCGTCCGG 
GATTTCCTGA AGCTCTACCA GGTGCCCAAG GGGCTGAGCG AGCGGGTCAT GGACTACATT 
GTGTCTACCT GGTCCATGTC CCGCGGCATC GACACGGAGA AGGTCCTGCA AATCTGCCCC 
AAGGACATGC GAGCTGACAT TTGCGTACAC CTGAACCGAA AAGTGTTCAA AGAACACCCC 
GCCTTCCGGC TGGCCAGCGA TGGTTGCCTG AGGGCCTTGG CCATGGAGTT CCAGACAGTA 
CACTGCGCCC CAGGGGACCT CATCTATCAC GCCGGGGAGA GTGTGGACAG CCTCTGCTTC 
GTGGTCTCGG GCTCCCTGGA GGTGATCCAG GATGATGAGG TGGTGGCCAT CCTAGGGAAA 
GGAGATGTGT TTGGGGATGT TTTCTGGAAG GAGGCTACCC TTGCACAGTC CTGCGCTAAT 
GTCCGGGCCT TGACCTACTG TGACCTGCAC GTGATCAAGA GGGATGCCCT GCAGAAAGTG 
CTAGAATTCT ACACAGCCTT CTCCCACTCC TTCTCCCGGA ACCTGATTCT CACCTACAAT 
CTGAGGAAGA GGATTGTGTT CCGGAAGATC AGCGACGTGA AACGAGAAGA AGAGGAGAGG 
ATGAAACGGA AGAACGAGGC CCCCCTTATC CTGCCTCCTG ACCACCCTGT CAGGAGGCTC 
TTCCAAAGGT TCCGCCAGCA GAAAGAAGCC AGGCTGGCAG CCGAGAGAGG TGGCCGGGAC 
CTGGATGACC TGGATGTAGA GAAGGGCAAT GCCCTCACGG ACCATACCTC AGCCAACCAC 
AGCCTGGTGA AGGCCAGTGT GGTCACGGTG CGTGAGAGTC CCGCCACGCC TGTGTCCTTC 
CAGGCAGCCT CCACCTCCAC AGTGTCAGAC CACGCCAAGC TGCATGCACC GGGATCTGAG 
TGCCTAGGTC CCAAGGCAGG CGGTGGCGAC CCTGCCAAGC GCAAAGGCTG GGCCCGGTTC 
AAAGATGCCT GTGGGAAGGG TGAGGATTGG AACAAGGTGT CCAAGGCAGA GTCCATGGAG 
ACGCTTCCCG AGAGGACAAA GGCATCGGGC GAGGCCACGC TGAAGAAGAC AGACTCCTGT 
GACAGTGGAA TCACCAAGAG TGACCTGCGC TTGGACAATG TGGGTGAGGC CAGGAGTCCC 
CAGGACCGGA GCCCCATCTT GGCCGAGGTC AAGCATTCTT TCTACCCCAT CCCCGAGCAG 
ACACTGCAGG CCACAGTGCT GGAGGTGAAG CATGAGCTGA AGGAAGACAT CAAGGCCTTG 
AATGCCAAAA TGACCTCCAT TGAGAAGCAG CTGTCTGAGA TCCTCAGGAT ACTCATGTCC 
AGAGGGTCCT CCCAGTCTCC GCAGGACACG TGTGAGGTCT CCAGGCCCCA GTCCCCAGAG 
TCAGACAGAG ACATTTTTGG GGCAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_017454422.1
CDS	234..3203
Translation	MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKSSACSFMYGELTDKDTVEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLALDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNALTDHTSANHSLVKASVVTVRESPATPVSFQAASTSTVSDHAKLHAPGSECLGPKAGGGDPAKRKGWARFKDACGKGEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVKHELKEDIKALNAKMTSIEKQLSEILRILMSRGSSQSPQDTCEVSRPQSPESDRDIFGAS

Target ORF information:

RefSeq Version	XM_017598933.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily H member 1 (Kcnh1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017598933.1

ORF Insert Sequence:

ATGACCATGG CTGGCGGCCG GCGGGGACTA GTGGCCCCGC AGAACACATT TCTGGAGAAC 
ATCGTGCGGC GGTCCAACGA CACTAATTTT GTGTTGGGGA ATGCCCAGAT CGTGGACTGG 
CCCATCGTGT ACAGCAATGA TGGATTCTGC AAGCTGTCTG GCTACCACCG AGCGGAAGTG 
ATGCAAAAGA GTAGCGCCTG CAGTTTTATG TATGGAGAGC TGACCGACAA GGACACGGTT 
GAAAAGGTTC GCCAGACCTT TGAGAACTAC GAGATGAACT CCTTCGAAAT TCTGATGTAC 
AAGAAGAACA GGACACCTGT GTGGTTTTTT GTGAAGATCG CTCCAATCAG GAACGAACAG 
GATAAAGTGG TTCTGTTCCT TTGCACTTTC AGTGACATAA CGGCATTCAA GCAGCCCATT 
GAGGACGACT CCTGCAAAGG TTGGGGGAAG TTTGCTCGAC TGACGAGAGC TCTGACAAGC 
AGCAGGGGAG TCCTGCAGCA GCTGGCCCCC AGTGTGCAGA AGGGTGAGAA TGTTCACAAG 
CACTCGCGCC TGGCAGAGGT CCTGCAGCTG GGTTCAGACA TCCTCCCCCA GTACAAGCAA 
GAGGCGCCAA AGACACCCCC TCACATCATC CTACACTACT GTGTCTTTAA GACCACATGG 
GATTGGATCA TCTTGATCCT GACCTTCTAC ACAGCCATCC TGGTCCCTTA CAACGTCTCC 
TTTAAAACCA GGCAGAATAA CGTGGCCTGG CTGGTGGTGG ACAGCATCGT GGATGTCATC 
TTTTTGGTGG ACATTGTCTT GAATTTTCAC ACCACCTTTG TCGGGCCAGC GGGGGAAGTG 
ATCTCTGACC CCAAACTTAT CCGCATGAAC TACCTGAAGA CGTGGTTTGT GATCGACCTT 
CTCTCCTGTT TGCCATATGA CGTCATCAAC GCTTTTGAGA ACGTGGATGA GGTTAGTGCC 
TTTATGGGTG ATCCAGGGAA GATTGGTTTT GCTGATCAGA TCCCACCACC ACTGGAGGGG 
AGAGAGAGTC AGGGCATCAG CAGCCTGTTC AGTTCTCTGA AAGTCGTGCG GCTGCTCCGT 
CTCGGACGAG TGGCCCGCAA GCTGGACCAT TATATCGAGT ACGGAGCGGC GGTACTGGTC 
CTGCTGGTGT GCGTGTTCGG GCTGGCTGCC CACTGGATGG CCTGCATCTG GTACAGCATT 
GGGGACTATG AGATCTTTGA TGAAGACACC AAGACCATCC GTAACAACAG CTGGCTCTAC 
CAACTGGCAT TGGACATTGG CACTCCATAC CAGTTTAATG GGTCTGGTTC GGGGAAGTGG 
GAAGGCGGGC CAAGCAAGAA CTCCGTATAC ATTTCCTCGC TGTACTTCAC CATGACAAGT 
CTCACCAGTG TGGGCTTTGG TAACATCGCC CCATCCACAG ACATCGAGAA GATCTTCGCC 
GTAGCCATCA TGATGATTGG CTCCCTTCTG TATGCCACCA TCTTTGGGAA TGTGACGACC 
ATTTTCCAGC AGATGTATGC CAACACCAAC AGGTATCATG AGATGCTCAA CAGCGTCCGG 
GATTTCCTGA AGCTCTACCA GGTGCCCAAG GGGCTGAGCG AGCGGGTCAT GGACTACATT 
GTGTCTACCT GGTCCATGTC CCGCGGCATC GACACGGAGA AGGTCCTGCA AATCTGCCCC 
AAGGACATGC GAGCTGACAT TTGCGTACAC CTGAACCGAA AAGTGTTCAA AGAACACCCC 
GCCTTCCGGC TGGCCAGCGA TGGTTGCCTG AGGGCCTTGG CCATGGAGTT CCAGACAGTA 
CACTGCGCCC CAGGGGACCT CATCTATCAC GCCGGGGAGA GTGTGGACAG CCTCTGCTTC 
GTGGTCTCGG GCTCCCTGGA GGTGATCCAG GATGATGAGG TGGTGGCCAT CCTAGGGAAA 
GGAGATGTGT TTGGGGATGT TTTCTGGAAG GAGGCTACCC TTGCACAGTC CTGCGCTAAT 
GTCCGGGCCT TGACCTACTG TGACCTGCAC GTGATCAAGA GGGATGCCCT GCAGAAAGTG 
CTAGAATTCT ACACAGCCTT CTCCCACTCC TTCTCCCGGA ACCTGATTCT CACCTACAAT 
CTGAGGAAGA GGATTGTGTT CCGGAAGATC AGCGACGTGA AACGAGAAGA AGAGGAGAGG 
ATGAAACGGA AGAACGAGGC CCCCCTTATC CTGCCTCCTG ACCACCCTGT CAGGAGGCTC 
TTCCAAAGGT TCCGCCAGCA GAAAGAAGCC AGGCTGGCAG CCGAGAGAGG TGGCCGGGAC 
CTGGATGACC TGGATGTAGA GAAGGGCAAT GCCCTCACGG ACCATACCTC AGCCAACCAC 
AGCCTGGTGA AGGCCAGTGT GGTCACGGTG CGTGAGAGTC CCGCCACGCC TGTGTCCTTC 
CAGGCAGCCT CCACCTCCAC AGTGTCAGAC CACGCCAAGC TGCATGCACC GGGATCTGAG 
TGCCTAGGTC CCAAGGCAGG CGGTGGCGAC CCTGCCAAGC GCAAAGGCTG GGCCCGGTTC 
AAAGATGCCT GTGGGAAGGG TGAGGATTGG AACAAGGTGT CCAAGGCAGA GTCCATGGAG 
ACGCTTCCCG AGAGGACAAA GGCATCGGGC GAGGCCACGC TGAAGAAGAC AGACTCCTGT 
GACAGTGGAA TCACCAAGAG TGACCTGCGC TTGGACAATG TGGGTGAGGC CAGGAGTCCC 
CAGGACCGGA GCCCCATCTT GGCCGAGGTC AAGCATTCTT TCTACCCCAT CCCCGAGCAG 
ACACTGCAGG CCACAGTGCT GGAGGTGAAG CATGAGCTGA AGGAAGACAT CAAGGCCTTG 
AATGCCAAAA TGACCTCCAT TGAGAAGCAG CTGTCTGAGA TCCTCAGGAT ACTCATGTCC 
AGAGGGTCCT CCCAGTCTCC GCAGGACACG TGTGAGGTCT CCAGGCCCCA GTCCCCAGAG 
TCAGACAGAG ACATTTTTGG GGCAAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Structure of the voltage-gated K? channel Eag1 reveals an alternative voltage sensing mechanism.
Science (New York, N.Y.)353(6300)664-9(2016 Aug)
Whicher JR,MacKinnon R

Calmodulin Regulates Human Ether ? Go-Go 1 (hEAG1) Potassium Channels through Interactions of the Eag Domain with the Cyclic Nucleotide Binding Homology Domain.
The Journal of biological chemistry291(34)17907-18(2016 08)
L?rinczi E,Helliwell M,Finch A,Stansfeld PJ,Davies NW,Mahaut-Smith M,Muskett FW,Mitcheson JS

Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations.
Scientific reports623417(2016 Mar)
Han B,He K,Cai C,Tang Y,Yang L,Heinemann SH,Hoshi T,Hou S

KV 10.1 opposes activity-dependent increase in Ca?? influx into the presynaptic terminal of the parallel fibre-Purkinje cell synapse.
The Journal of physiology593(1)181-96(2015 01)
Mortensen LS,Schmidt H,Farsi Z,Barrantes-Freer A,Rubio ME,Ufartes R,Eilers J,Sakaba T,St?hmer W,Pardo LA

The subfamily-specific assembly of Eag and Erg K+ channels is determined by both the amino and the carboxyl recognition domains.
The Journal of biological chemistry289(33)22815-34(2014 Aug)
Lin TF,Lin IW,Chen SC,Wu HH,Yang CS,Fang HY,Chiu MM,Jeng CJ

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Kcnh1 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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