Kcnd3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene
Clones
gRNAs

Summary

Gene Symbol	Kcnd3
Entrez Gene ID	65195
Full Name	potassium voltage-gated channel subfamily D member 3
Synonyms	Kv4.3
General protein information	Preferred Names potassium voltage-gated channel subfamily D member 3 Names potassium voltage-gated channel subfamily D member 3 potassium channel, voltage-gated Shal-related subfamily D, member 3 potassium voltage gated channel, Shal-related family, member 3 potassium voltage-gated channel, Shal-related subfamily, member 3 voltage-gated potassium channel subunit Kv4.3
Gene Type	protein-coding
Organism	Rattus norvegicus(Norway rat)
Genome	Chromosome: 2 Map Location: 2q34
Summary	voltage-gated K+ channel that generates an A type K+ current [RGD, Feb 2006].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001270962.1	NP_001257891.1	potassium voltage-gated channel subfamily D member 3 isoform 1 precursor
NM_031739.3	NP_113927.2	potassium voltage-gated channel subfamily D member 3 isoform 3 precursor
NM_001270963.1	NP_001257892.1	potassium voltage-gated channel subfamily D member 3 isoform 2 precursor

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KCND3	XP_005630924.1
Gallus gallus (chicken)	KCND3	NP_989657.1
	KCND3	XP_002801745.1
Mus musculus (house mouse)	Kcnd3	NP_064315.1
Rattus norvegicus (Norway rat)	Kcnd3	NP_001257891.1
Bos taurus (cattle)	KCND3	NP_001178307.1
Pan troglodytes (chimpanzee)	KCND3	XP_003308377.1
Danio rerio (zebrafish)	kcnd3	NP_956096.1
Xenopus tropicalis (tropical clawed frog)	kcnd3	NP_001096411.1
Homo sapiens (human)	KCND3	NP_004971.2

Gene Ontology
Bibliography

Related articles in PubMed

Down-regulation of Kv4.3 channels and a-type K
Viatchenko-Karpinski V, Ling J, Gu JG
Molecular pain141744806917750995(2018 Jan-Dec)

The activation of
Liu X, Shi S, Yang H, Qu C, Chen Y, Liang J, Yang B
American journal of physiology. Cell physiology313(2)C187-C196(2017 Aug)

Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity.
Shiina Y, Muto T, Zhang Z, Baihaqie A, Yoshizawa T, Lee HI, Park E, Tsukiji S, Takimoto K
Scientific reports626290(2016 May)

Role of Kv4.3 in Vibration-Induced Muscle Pain in the Rat.
Conner LB, Alvarez P, Bogen O, Levine JD
The journal of pain : official journal of the American Pain Society17(4)444-50(2016 Apr)

Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function.
You T, Mao W, Cai B, Li F, Xu H
International journal of molecular medicine36(1)309-15(2015 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

NMDA reduced both currents in a concentration-dependent manner, whereas there was no significant impact on the currents when perfused with MK-801. MDD rats exhibited significantly more fibrosis areas in heart tissue and reduced expression of Kv4.2, Kv4.3, and Cav1.2.
Title: The activation of

This study demonstated that that Kv4.3 is involved in vibration-induced muscle pain and explored whether changes in Kv4.3 expression in nociceptors contributes to the mechanical hyperalgesia in a model of hand-arm vibration syndrome in the rat.
Title: Role of Kv4.3 in Vibration-Induced Muscle Pain in the Rat.

KChIP1 plays a neuroprotective role against 4-AP acute induced cell death in primary hippocampal cells through regulation of Kv 4.3 and GABA transmission but this is lost after long term exposure.
Title: Neuroprotective or neurotoxic effects of 4-aminopyridine mediated by KChIP1 regulation through adjustment of Kv 4.3 potassium channels expression and GABA-mediated transmission in primary hippocampal cells.

These results indicate that Kv4.3 is likely the target of discrepin and highlight the importance of the basic residue K13, located in the alpha-helix of the toxin, for current blockage.
Title: Interaction of the scorpion toxin discrepin with Kv4.3 channels and A-type K(+) channels in cerebellum granular cells.

This study demonistrared that the expression and function of Kv4.3 channels in neurons of the rat bed nucleus of the stria terminalis.
Title: Distribution and functional expression of Kv4 family ? subunits and associated KChIP ? subunits in the bed nucleus of the stria terminalis.

The following Kcnd3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the Kcnd3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
ORa08627	NM_031739.3 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily D member 3 (Kcnd3), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$356.30 $509.00
ORa09995	NM_001270962.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily D member 3 (Kcnd3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
ORa10002	NM_001270963.1 Latest version!	Rattus norvegicus potassium voltage-gated channel subfamily D member 3 (Kcnd3), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00

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Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

Kcnd3 ( NM_031739.3 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_113927.2 Rattus norvegicus potassium voltage-gated channel subfamily D member 3 (Kcnd3), transcript variant 3, mRNA.

Price & Availability↑

CloneID	ORa08627
Clone ID Related Accession (Same CDS sequence)	NM_031739.3
Accession Version	NM_031739.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1836bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily D member 3 isoform 3 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07012774.1 and AABR07012775.1. On Aug 16, 2012 this sequence version replaced NM_031739.2. Transcript Variant: This variant (3, also known as Kv4.3S and Kv4.3b) lacks an in-frame exon in the 3' coding region, and lacks a segment in the 3' coding region, which results in a frameshift compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L48619.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMD00052296, SAMD00052297 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCAG GAGTTGCAGC CTGGCTGCCT TTTGCCCGGG CTGCGGCCAT TGGGTGGATG 
CCAGTGGCCA ACTGCCCCAT GCCCCTAGCT CCAGCCGACA AGAACAAGCG GCAAGATGAG 
CTAATCGTCC TCAACGTGAG TGGCCGTCGG TTCCAGACCT GGAGGACCAC TCTGGAGCGC 
TATCCCGACA CCCTGCTGGG TAGCACAGAG AAGGAGTTCT TCTTCAACGA GGACACCAAG 
GAGTACTTCT TTGACCGTGA CCCGGAAGTG TTCCGTTGTG TGCTCAACTT CTACCGCACT 
GGGAAGCTGC ACTACCCACG CTATGAATGC ATCTCTGCCT ACGACGATGA GCTGGCCTTC 
TATGGCATCC TCCCTGAGAT CATTGGCGAC TGCTGCTATG AGGAGTACAA AGACCGCAAG 
CGGGAGAACG CTGAGCGGCT CATGGATGAC AATGAGTCTG AGAACAACCA GGAGTCCATG 
CCCTCCCTCA GCTTCCGCCA GACCATGTGG CGGGCCTTCG AGAACCCACA CACCAGCACC 
CTGGCACTGG TCTTCTACTA CGTGACAGGC TTCTTCATTG CGGTCTCGGT GATCACCAAC 
GTGGTGGAGA CGGTGCCATG CGGCACGGTG CCTGGGAGCA AGGAACTGCC GTGTGGAGAG 
CGCTACTCCG TGGCTTTCTT CTGCCTGGAC ACTGCGTGTG TCATGATCTT CACGGTGGAG 
TACCTCCTCC GACTCTTCGC GGCACCCAGC AGGTACCGCT TCATCCGCAG TGTGATGAGC 
ATCATCGACG TGGTGGCCAT CATGCCCTAT TACATTGGCC TGGTCATGAC CAACAACGAG 
GACGTGTCCG GGGCATTTGT CACACTCCGG GTCTTCCGCG TCTTCAGGAT CTTCAAGTTC 
TCCCGACATT CCCAGGGCCT ACGGATCCTA GGCTACACCC TGAAGAGCTG TGCCTCAGAA 
CTAGGCTTTC TTCTCTTCTC CCTCACCATG GCCATCATCA TCTTTGCCAC TGTGATGTTT 
TATGCTGAGA AGGGCTCCTC CGCCAGCAAG TTCACAAGCA TCCCTGCGTC TTTCTGGTAC 
ACCATAGTCA CCATGACAAC ACTGGGGTAT GGAGACATGG TGCCTAAGAC AATTGCTGGG 
AAGATATTTG GCTCCATCTG CTCCCTAAGC GGCGTCCTGG TCATTGCTCT GCCAGTCCCC 
GTCATAGTCT CCAACTTTAG CAGGATCTAC CATCAGAACC AGAGAGCAGA TAAACGCAGG 
GCACAGAAGA AGGCCCGCCT TGCCAGAATC CGTGTGGCCA AAACAGGGAG CTCCAATGCC 
TACCTGCACA GCAAGCGCAA TGGACTCCTC AATGAAGCTC TGGAGCTGAC CGGCACCCCA 
GAAGAGGAGC ACATGGGCAA GACCACGTCA CTCATCGAGA GCCAGCACCA CCACCTGCTA 
CACTGCTTAG AAAAGACCAC TAACCACGAG TTTATTGATG AGCAGATGTT TGAGCAGAAC 
TGCATGGAGA GCTCAATGCA GAACTACCCA TCCACCAGAA GCCCTTCTCT GTCCAGCCAC 
TCGGGCCTCA CCACCACCTG CTGCTCCCGC CGTAGCAAGA AGACCACGCA CCTGCCCAAC 
TCCAACCTGC CGGCCACCCG CCTGCGCAGC ATGCAAGAGC TCAGCACCAT CCACATCCAG 
GGCAGTGAGC AGCCCTCCCT CACCACTAGT CGCTCCAGCC TTAATTTGAA AGCAGACGAC 
GGACTGAGAC CAAACTGCAA AACACAAGAC CAAGAGCAGC CCAGAGGCCG AGTCGTCACA 
TGCAAACAGG AAGAAATTAT AACACTGTGT ATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_113927.2
CDS	93..1928
Translation	MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNESENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHSGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTQDQEQPRGRVVTCKQEEIITLCI

Target ORF information:

RefSeq Version	NM_031739.3
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily D member 3 (Kcnd3), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_031739.3

ORF Insert Sequence:

ATGGCGGCAG GAGTTGCAGC CTGGCTGCCT TTTGCCCGGG CTGCGGCCAT TGGGTGGATG 
CCAGTGGCCA ACTGCCCCAT GCCCCTAGCT CCAGCCGACA AGAACAAGCG GCAAGATGAG 
CTAATCGTCC TCAACGTGAG TGGCCGTCGG TTCCAGACCT GGAGGACCAC TCTGGAGCGC 
TATCCCGACA CCCTGCTGGG TAGCACAGAG AAGGAGTTCT TCTTCAACGA GGACACCAAG 
GAGTACTTCT TTGACCGTGA CCCGGAAGTG TTCCGTTGTG TGCTCAACTT CTACCGCACT 
GGGAAGCTGC ACTACCCACG CTATGAATGC ATCTCTGCCT ACGACGATGA GCTGGCCTTC 
TATGGCATCC TCCCTGAGAT CATTGGCGAC TGCTGCTATG AGGAGTACAA AGACCGCAAG 
CGGGAGAACG CTGAGCGGCT CATGGATGAC AATGAGTCTG AGAACAACCA GGAGTCCATG 
CCCTCCCTCA GCTTCCGCCA GACCATGTGG CGGGCCTTCG AGAACCCACA CACCAGCACC 
CTGGCACTGG TCTTCTACTA CGTGACAGGC TTCTTCATTG CGGTCTCGGT GATCACCAAC 
GTGGTGGAGA CGGTGCCATG CGGCACGGTG CCTGGGAGCA AGGAACTGCC GTGTGGAGAG 
CGCTACTCCG TGGCTTTCTT CTGCCTGGAC ACTGCGTGTG TCATGATCTT CACGGTGGAG 
TACCTCCTCC GACTCTTCGC GGCACCCAGC AGGTACCGCT TCATCCGCAG TGTGATGAGC 
ATCATCGACG TGGTGGCCAT CATGCCCTAT TACATTGGCC TGGTCATGAC CAACAACGAG 
GACGTGTCCG GGGCATTTGT CACACTCCGG GTCTTCCGCG TCTTCAGGAT CTTCAAGTTC 
TCCCGACATT CCCAGGGCCT ACGGATCCTA GGCTACACCC TGAAGAGCTG TGCCTCAGAA 
CTAGGCTTTC TTCTCTTCTC CCTCACCATG GCCATCATCA TCTTTGCCAC TGTGATGTTT 
TATGCTGAGA AGGGCTCCTC CGCCAGCAAG TTCACAAGCA TCCCTGCGTC TTTCTGGTAC 
ACCATAGTCA CCATGACAAC ACTGGGGTAT GGAGACATGG TGCCTAAGAC AATTGCTGGG 
AAGATATTTG GCTCCATCTG CTCCCTAAGC GGCGTCCTGG TCATTGCTCT GCCAGTCCCC 
GTCATAGTCT CCAACTTTAG CAGGATCTAC CATCAGAACC AGAGAGCAGA TAAACGCAGG 
GCACAGAAGA AGGCCCGCCT TGCCAGAATC CGTGTGGCCA AAACAGGGAG CTCCAATGCC 
TACCTGCACA GCAAGCGCAA TGGACTCCTC AATGAAGCTC TGGAGCTGAC CGGCACCCCA 
GAAGAGGAGC ACATGGGCAA GACCACGTCA CTCATCGAGA GCCAGCACCA CCACCTGCTA 
CACTGCTTAG AAAAGACCAC TAACCACGAG TTTATTGATG AGCAGATGTT TGAGCAGAAC 
TGCATGGAGA GCTCAATGCA GAACTACCCA TCCACCAGAA GCCCTTCTCT GTCCAGCCAC 
TCGGGCCTCA CCACCACCTG CTGCTCCCGC CGTAGCAAGA AGACCACGCA CCTGCCCAAC 
TCCAACCTGC CGGCCACCCG CCTGCGCAGC ATGCAAGAGC TCAGCACCAT CCACATCCAG 
GGCAGTGAGC AGCCCTCCCT CACCACTAGT CGCTCCAGCC TTAATTTGAA AGCAGACGAC 
GGACTGAGAC CAAACTGCAA AACACAAGAC CAAGAGCAGC CCAGAGGCCG AGTCGTCACA 
TGCAAACAGG AAGAAATTAT AACACTGTGT ATTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnd3 ( NM_001270962.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001257891.1 Rattus norvegicus potassium voltage-gated channel subfamily D member 3 (Kcnd3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	ORa09995
Clone ID Related Accession (Same CDS sequence)	NM_001270962.1
Accession Version	NM_001270962.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1968bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily D member 3 isoform 1 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07012774.1 and AABR07012775.1. Transcript Variant: This variant (1, also known as Kv4.3L and Kv4.3c) represents the longest transcript and encodes the longest isoform (1). Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: AB003587.1, AF334791.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCAG GAGTTGCAGC CTGGCTGCCT TTTGCCCGGG CTGCGGCCAT TGGGTGGATG 
CCAGTGGCCA ACTGCCCCAT GCCCCTAGCT CCAGCCGACA AGAACAAGCG GCAAGATGAG 
CTAATCGTCC TCAACGTGAG TGGCCGTCGG TTCCAGACCT GGAGGACCAC TCTGGAGCGC 
TATCCCGACA CCCTGCTGGG TAGCACAGAG AAGGAGTTCT TCTTCAACGA GGACACCAAG 
GAGTACTTCT TTGACCGTGA CCCGGAAGTG TTCCGTTGTG TGCTCAACTT CTACCGCACT 
GGGAAGCTGC ACTACCCACG CTATGAATGC ATCTCTGCCT ACGACGATGA GCTGGCCTTC 
TATGGCATCC TCCCTGAGAT CATTGGCGAC TGCTGCTATG AGGAGTACAA AGACCGCAAG 
CGGGAGAACG CTGAGCGGCT CATGGATGAC AATGAGTCTG AGAACAACCA GGAGTCCATG 
CCCTCCCTCA GCTTCCGCCA GACCATGTGG CGGGCCTTCG AGAACCCACA CACCAGCACC 
CTGGCACTGG TCTTCTACTA CGTGACAGGC TTCTTCATTG CGGTCTCGGT GATCACCAAC 
GTGGTGGAGA CGGTGCCATG CGGCACGGTG CCTGGGAGCA AGGAACTGCC GTGTGGAGAG 
CGCTACTCCG TGGCTTTCTT CTGCCTGGAC ACTGCGTGTG TCATGATCTT CACGGTGGAG 
TACCTCCTCC GACTCTTCGC GGCACCCAGC AGGTACCGCT TCATCCGCAG TGTGATGAGC 
ATCATCGACG TGGTGGCCAT CATGCCCTAT TACATTGGCC TGGTCATGAC CAACAACGAG 
GACGTGTCCG GGGCATTTGT CACACTCCGG GTCTTCCGCG TCTTCAGGAT CTTCAAGTTC 
TCCCGACATT CCCAGGGCCT ACGGATCCTA GGCTACACCC TGAAGAGCTG TGCCTCAGAA 
CTAGGCTTTC TTCTCTTCTC CCTCACCATG GCCATCATCA TCTTTGCCAC TGTGATGTTT 
TATGCTGAGA AGGGCTCCTC CGCCAGCAAG TTCACAAGCA TCCCTGCGTC TTTCTGGTAC 
ACCATAGTCA CCATGACAAC ACTGGGGTAT GGAGACATGG TGCCTAAGAC AATTGCTGGG 
AAGATATTTG GCTCCATCTG CTCCCTAAGC GGCGTCCTGG TCATTGCTCT GCCAGTCCCC 
GTCATAGTCT CCAACTTTAG CAGGATCTAC CATCAGAACC AGAGAGCAGA TAAACGCAGG 
GCACAGAAGA AGGCCCGCCT TGCCAGAATC CGTGTGGCCA AAACAGGGAG CTCCAATGCC 
TACCTGCACA GCAAGCGCAA TGGACTCCTC AATGAAGCTC TGGAGCTGAC CGGCACCCCA 
GAAGAGGAGC ACATGGGCAA GACCACGTCA CTCATCGAGA GCCAGCACCA CCACCTGCTA 
CACTGCTTAG AAAAGACCAC TGGGTTATCC TATCTTGTGG ATGATCCCCT GTTGTCTGTA 
CGAACCTCCA CCATCAAGAA CCACGAGTTT ATTGATGAGC AGATGTTTGA GCAGAACTGC 
ATGGAGAGCT CAATGCAGAA CTACCCATCC ACCAGAAGCC CTTCTCTGTC CAGCCACTCG 
GGCCTCACCA CCACCTGCTG CTCCCGCCGT AGCAAGAAGA CCACGCACCT GCCCAACTCC 
AACCTGCCGG CCACCCGCCT GCGCAGCATG CAAGAGCTCA GCACCATCCA CATCCAGGGC 
AGTGAGCAGC CCTCCCTCAC CACTAGTCGC TCCAGCCTTA ATTTGAAAGC AGACGACGGA 
CTGAGACCAA ACTGCAAAAC ATCCCAGATT ACAACAGCCA TCATCAGCAT CCCTACTCCC 
CCAGCTCTAA CCCCAGAGGG AGAAAGTCGG CCACCCCCTG CCAGCCCAGG TCCCAACACG 
AACATTCCTT CCATAACCAG CAATGTTGTC AAGGTCTCTG CCTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257891.1
CDS	93..2060
Translation	MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNESENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTGLSYLVDDPLLSVRTSTIKNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHSGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSITSNVVKVSAL

Target ORF information:

RefSeq Version	NM_001270962.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily D member 3 (Kcnd3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270962.1

ORF Insert Sequence:

ATGGCGGCAG GAGTTGCAGC CTGGCTGCCT TTTGCCCGGG CTGCGGCCAT TGGGTGGATG 
CCAGTGGCCA ACTGCCCCAT GCCCCTAGCT CCAGCCGACA AGAACAAGCG GCAAGATGAG 
CTAATCGTCC TCAACGTGAG TGGCCGTCGG TTCCAGACCT GGAGGACCAC TCTGGAGCGC 
TATCCCGACA CCCTGCTGGG TAGCACAGAG AAGGAGTTCT TCTTCAACGA GGACACCAAG 
GAGTACTTCT TTGACCGTGA CCCGGAAGTG TTCCGTTGTG TGCTCAACTT CTACCGCACT 
GGGAAGCTGC ACTACCCACG CTATGAATGC ATCTCTGCCT ACGACGATGA GCTGGCCTTC 
TATGGCATCC TCCCTGAGAT CATTGGCGAC TGCTGCTATG AGGAGTACAA AGACCGCAAG 
CGGGAGAACG CTGAGCGGCT CATGGATGAC AATGAGTCTG AGAACAACCA GGAGTCCATG 
CCCTCCCTCA GCTTCCGCCA GACCATGTGG CGGGCCTTCG AGAACCCACA CACCAGCACC 
CTGGCACTGG TCTTCTACTA CGTGACAGGC TTCTTCATTG CGGTCTCGGT GATCACCAAC 
GTGGTGGAGA CGGTGCCATG CGGCACGGTG CCTGGGAGCA AGGAACTGCC GTGTGGAGAG 
CGCTACTCCG TGGCTTTCTT CTGCCTGGAC ACTGCGTGTG TCATGATCTT CACGGTGGAG 
TACCTCCTCC GACTCTTCGC GGCACCCAGC AGGTACCGCT TCATCCGCAG TGTGATGAGC 
ATCATCGACG TGGTGGCCAT CATGCCCTAT TACATTGGCC TGGTCATGAC CAACAACGAG 
GACGTGTCCG GGGCATTTGT CACACTCCGG GTCTTCCGCG TCTTCAGGAT CTTCAAGTTC 
TCCCGACATT CCCAGGGCCT ACGGATCCTA GGCTACACCC TGAAGAGCTG TGCCTCAGAA 
CTAGGCTTTC TTCTCTTCTC CCTCACCATG GCCATCATCA TCTTTGCCAC TGTGATGTTT 
TATGCTGAGA AGGGCTCCTC CGCCAGCAAG TTCACAAGCA TCCCTGCGTC TTTCTGGTAC 
ACCATAGTCA CCATGACAAC ACTGGGGTAT GGAGACATGG TGCCTAAGAC AATTGCTGGG 
AAGATATTTG GCTCCATCTG CTCCCTAAGC GGCGTCCTGG TCATTGCTCT GCCAGTCCCC 
GTCATAGTCT CCAACTTTAG CAGGATCTAC CATCAGAACC AGAGAGCAGA TAAACGCAGG 
GCACAGAAGA AGGCCCGCCT TGCCAGAATC CGTGTGGCCA AAACAGGGAG CTCCAATGCC 
TACCTGCACA GCAAGCGCAA TGGACTCCTC AATGAAGCTC TGGAGCTGAC CGGCACCCCA 
GAAGAGGAGC ACATGGGCAA GACCACGTCA CTCATCGAGA GCCAGCACCA CCACCTGCTA 
CACTGCTTAG AAAAGACCAC TGGGTTATCC TATCTTGTGG ATGATCCCCT GTTGTCTGTA 
CGAACCTCCA CCATCAAGAA CCACGAGTTT ATTGATGAGC AGATGTTTGA GCAGAACTGC 
ATGGAGAGCT CAATGCAGAA CTACCCATCC ACCAGAAGCC CTTCTCTGTC CAGCCACTCG 
GGCCTCACCA CCACCTGCTG CTCCCGCCGT AGCAAGAAGA CCACGCACCT GCCCAACTCC 
AACCTGCCGG CCACCCGCCT GCGCAGCATG CAAGAGCTCA GCACCATCCA CATCCAGGGC 
AGTGAGCAGC CCTCCCTCAC CACTAGTCGC TCCAGCCTTA ATTTGAAAGC AGACGACGGA 
CTGAGACCAA ACTGCAAAAC ATCCCAGATT ACAACAGCCA TCATCAGCAT CCCTACTCCC 
CCAGCTCTAA CCCCAGAGGG AGAAAGTCGG CCACCCCCTG CCAGCCCAGG TCCCAACACG 
AACATTCCTT CCATAACCAG CAATGTTGTC AAGGTCTCTG CCTTGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

Kcnd3 ( NM_001270963.1 ) cDNA ORF clone, Rattus norvegicus(Norway rat) -> NP_001257892.1 Rattus norvegicus potassium voltage-gated channel subfamily D member 3 (Kcnd3), transcript variant 2, mRNA.

Price & Availability↑

CloneID	ORa10002
Clone ID Related Accession (Same CDS sequence)	NM_001270963.1
Accession Version	NM_001270963.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1911bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Rattus norvegicus(Norway rat)
Product	potassium voltage-gated channel subfamily D member 3 isoform 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AABR07012774.1 and AABR07012775.1. Transcript Variant: This variant (2, also known as Kv4.3M and Kv4.3a) lacks an in-frame exon in the 3' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1. Sequence Note: The RefSeq transcript was derived from the reference genome assembly. The genomic coordinates were determined from transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## CDS exon combination :: U75448.1 [ECO:0000331] RNAseq introns :: single sample supports all introns SAMD00052296, SAMD00052297 [ECO:0000348] ##Evidence-Data-END##

ATGGCGGCAG GAGTTGCAGC CTGGCTGCCT TTTGCCCGGG CTGCGGCCAT TGGGTGGATG 
CCAGTGGCCA ACTGCCCCAT GCCCCTAGCT CCAGCCGACA AGAACAAGCG GCAAGATGAG 
CTAATCGTCC TCAACGTGAG TGGCCGTCGG TTCCAGACCT GGAGGACCAC TCTGGAGCGC 
TATCCCGACA CCCTGCTGGG TAGCACAGAG AAGGAGTTCT TCTTCAACGA GGACACCAAG 
GAGTACTTCT TTGACCGTGA CCCGGAAGTG TTCCGTTGTG TGCTCAACTT CTACCGCACT 
GGGAAGCTGC ACTACCCACG CTATGAATGC ATCTCTGCCT ACGACGATGA GCTGGCCTTC 
TATGGCATCC TCCCTGAGAT CATTGGCGAC TGCTGCTATG AGGAGTACAA AGACCGCAAG 
CGGGAGAACG CTGAGCGGCT CATGGATGAC AATGAGTCTG AGAACAACCA GGAGTCCATG 
CCCTCCCTCA GCTTCCGCCA GACCATGTGG CGGGCCTTCG AGAACCCACA CACCAGCACC 
CTGGCACTGG TCTTCTACTA CGTGACAGGC TTCTTCATTG CGGTCTCGGT GATCACCAAC 
GTGGTGGAGA CGGTGCCATG CGGCACGGTG CCTGGGAGCA AGGAACTGCC GTGTGGAGAG 
CGCTACTCCG TGGCTTTCTT CTGCCTGGAC ACTGCGTGTG TCATGATCTT CACGGTGGAG 
TACCTCCTCC GACTCTTCGC GGCACCCAGC AGGTACCGCT TCATCCGCAG TGTGATGAGC 
ATCATCGACG TGGTGGCCAT CATGCCCTAT TACATTGGCC TGGTCATGAC CAACAACGAG 
GACGTGTCCG GGGCATTTGT CACACTCCGG GTCTTCCGCG TCTTCAGGAT CTTCAAGTTC 
TCCCGACATT CCCAGGGCCT ACGGATCCTA GGCTACACCC TGAAGAGCTG TGCCTCAGAA 
CTAGGCTTTC TTCTCTTCTC CCTCACCATG GCCATCATCA TCTTTGCCAC TGTGATGTTT 
TATGCTGAGA AGGGCTCCTC CGCCAGCAAG TTCACAAGCA TCCCTGCGTC TTTCTGGTAC 
ACCATAGTCA CCATGACAAC ACTGGGGTAT GGAGACATGG TGCCTAAGAC AATTGCTGGG 
AAGATATTTG GCTCCATCTG CTCCCTAAGC GGCGTCCTGG TCATTGCTCT GCCAGTCCCC 
GTCATAGTCT CCAACTTTAG CAGGATCTAC CATCAGAACC AGAGAGCAGA TAAACGCAGG 
GCACAGAAGA AGGCCCGCCT TGCCAGAATC CGTGTGGCCA AAACAGGGAG CTCCAATGCC 
TACCTGCACA GCAAGCGCAA TGGACTCCTC AATGAAGCTC TGGAGCTGAC CGGCACCCCA 
GAAGAGGAGC ACATGGGCAA GACCACGTCA CTCATCGAGA GCCAGCACCA CCACCTGCTA 
CACTGCTTAG AAAAGACCAC TAACCACGAG TTTATTGATG AGCAGATGTT TGAGCAGAAC 
TGCATGGAGA GCTCAATGCA GAACTACCCA TCCACCAGAA GCCCTTCTCT GTCCAGCCAC 
TCGGGCCTCA CCACCACCTG CTGCTCCCGC CGTAGCAAGA AGACCACGCA CCTGCCCAAC 
TCCAACCTGC CGGCCACCCG CCTGCGCAGC ATGCAAGAGC TCAGCACCAT CCACATCCAG 
GGCAGTGAGC AGCCCTCCCT CACCACTAGT CGCTCCAGCC TTAATTTGAA AGCAGACGAC 
GGACTGAGAC CAAACTGCAA AACATCCCAG ATTACAACAG CCATCATCAG CATCCCTACT 
CCCCCAGCTC TAACCCCAGA GGGAGAAAGT CGGCCACCCC CTGCCAGCCC AGGTCCCAAC 
ACGAACATTC CTTCCATAAC CAGCAATGTT GTCAAGGTCT CTGCCTTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001257892.1
CDS	93..2003
Translation	MAAGVAAWLPFARAAAIGWMPVANCPMPLAPADKNKRQDELIVLNVSGRRFQTWRTTLERYPDTLLGSTEKEFFFNEDTKEYFFDRDPEVFRCVLNFYRTGKLHYPRYECISAYDDELAFYGILPEIIGDCCYEEYKDRKRENAERLMDDNESENNQESMPSLSFRQTMWRAFENPHTSTLALVFYYVTGFFIAVSVITNVVETVPCGTVPGSKELPCGERYSVAFFCLDTACVMIFTVEYLLRLFAAPSRYRFIRSVMSIIDVVAIMPYYIGLVMTNNEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKGSSASKFTSIPASFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQNQRADKRRAQKKARLARIRVAKTGSSNAYLHSKRNGLLNEALELTGTPEEEHMGKTTSLIESQHHHLLHCLEKTTNHEFIDEQMFEQNCMESSMQNYPSTRSPSLSSHSGLTTTCCSRRSKKTTHLPNSNLPATRLRSMQELSTIHIQGSEQPSLTTSRSSLNLKADDGLRPNCKTSQITTAIISIPTPPALTPEGESRPPPASPGPNTNIPSITSNVVKVSAL

Target ORF information:

RefSeq Version	NM_001270963.1
Organism	Rattus norvegicus(Norway rat)
Definition	Rattus norvegicus potassium voltage-gated channel subfamily D member 3 (Kcnd3), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001270963.1

ORF Insert Sequence:

ATGGCGGCAG GAGTTGCAGC CTGGCTGCCT TTTGCCCGGG CTGCGGCCAT TGGGTGGATG 
CCAGTGGCCA ACTGCCCCAT GCCCCTAGCT CCAGCCGACA AGAACAAGCG GCAAGATGAG 
CTAATCGTCC TCAACGTGAG TGGCCGTCGG TTCCAGACCT GGAGGACCAC TCTGGAGCGC 
TATCCCGACA CCCTGCTGGG TAGCACAGAG AAGGAGTTCT TCTTCAACGA GGACACCAAG 
GAGTACTTCT TTGACCGTGA CCCGGAAGTG TTCCGTTGTG TGCTCAACTT CTACCGCACT 
GGGAAGCTGC ACTACCCACG CTATGAATGC ATCTCTGCCT ACGACGATGA GCTGGCCTTC 
TATGGCATCC TCCCTGAGAT CATTGGCGAC TGCTGCTATG AGGAGTACAA AGACCGCAAG 
CGGGAGAACG CTGAGCGGCT CATGGATGAC AATGAGTCTG AGAACAACCA GGAGTCCATG 
CCCTCCCTCA GCTTCCGCCA GACCATGTGG CGGGCCTTCG AGAACCCACA CACCAGCACC 
CTGGCACTGG TCTTCTACTA CGTGACAGGC TTCTTCATTG CGGTCTCGGT GATCACCAAC 
GTGGTGGAGA CGGTGCCATG CGGCACGGTG CCTGGGAGCA AGGAACTGCC GTGTGGAGAG 
CGCTACTCCG TGGCTTTCTT CTGCCTGGAC ACTGCGTGTG TCATGATCTT CACGGTGGAG 
TACCTCCTCC GACTCTTCGC GGCACCCAGC AGGTACCGCT TCATCCGCAG TGTGATGAGC 
ATCATCGACG TGGTGGCCAT CATGCCCTAT TACATTGGCC TGGTCATGAC CAACAACGAG 
GACGTGTCCG GGGCATTTGT CACACTCCGG GTCTTCCGCG TCTTCAGGAT CTTCAAGTTC 
TCCCGACATT CCCAGGGCCT ACGGATCCTA GGCTACACCC TGAAGAGCTG TGCCTCAGAA 
CTAGGCTTTC TTCTCTTCTC CCTCACCATG GCCATCATCA TCTTTGCCAC TGTGATGTTT 
TATGCTGAGA AGGGCTCCTC CGCCAGCAAG TTCACAAGCA TCCCTGCGTC TTTCTGGTAC 
ACCATAGTCA CCATGACAAC ACTGGGGTAT GGAGACATGG TGCCTAAGAC AATTGCTGGG 
AAGATATTTG GCTCCATCTG CTCCCTAAGC GGCGTCCTGG TCATTGCTCT GCCAGTCCCC 
GTCATAGTCT CCAACTTTAG CAGGATCTAC CATCAGAACC AGAGAGCAGA TAAACGCAGG 
GCACAGAAGA AGGCCCGCCT TGCCAGAATC CGTGTGGCCA AAACAGGGAG CTCCAATGCC 
TACCTGCACA GCAAGCGCAA TGGACTCCTC AATGAAGCTC TGGAGCTGAC CGGCACCCCA 
GAAGAGGAGC ACATGGGCAA GACCACGTCA CTCATCGAGA GCCAGCACCA CCACCTGCTA 
CACTGCTTAG AAAAGACCAC TAACCACGAG TTTATTGATG AGCAGATGTT TGAGCAGAAC 
TGCATGGAGA GCTCAATGCA GAACTACCCA TCCACCAGAA GCCCTTCTCT GTCCAGCCAC 
TCGGGCCTCA CCACCACCTG CTGCTCCCGC CGTAGCAAGA AGACCACGCA CCTGCCCAAC 
TCCAACCTGC CGGCCACCCG CCTGCGCAGC ATGCAAGAGC TCAGCACCAT CCACATCCAG 
GGCAGTGAGC AGCCCTCCCT CACCACTAGT CGCTCCAGCC TTAATTTGAA AGCAGACGAC 
GGACTGAGAC CAAACTGCAA AACATCCCAG ATTACAACAG CCATCATCAG CATCCCTACT 
CCCCCAGCTC TAACCCCAGA GGGAGAAAGT CGGCCACCCC CTGCCAGCCC AGGTCCCAAC 
ACGAACATTC CTTCCATAAC CAGCAATGTT GTCAAGGTCT CTGCCTTGTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Down-regulation of Kv4.3 channels and a-type K
Molecular pain141744806917750995(2018 Jan-Dec)
Viatchenko-Karpinski V,Ling J,Gu JG

The activation of
American journal of physiology. Cell physiology313(2)C187-C196(2017 Aug)
Liu X,Shi S,Yang H,Qu C,Chen Y,Liang J,Yang B

Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity.
Scientific reports626290(2016 May)
Shiina Y,Muto T,Zhang Z,Baihaqie A,Yoshizawa T,Lee HI,Park E,Tsukiji S,Takimoto K

Role of Kv4.3 in Vibration-Induced Muscle Pain in the Rat.
The journal of pain : official journal of the American Pain Society17(4)444-50(2016 Apr)
Conner LB,Alvarez P,Bogen O,Levine JD

Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function.
International journal of molecular medicine36(1)309-15(2015 Jul)
You T,Mao W,Cai B,Li F,Xu H

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Kcnd3 cDNA ORF clone, Rattus norvegicus(Norway rat)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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