Kcnd2 cDNA ORF clone, Rattus norvegicus(Norway rat)

The activation of
Liu X, Shi S, Yang H, Qu C, Chen Y, Liang J, Yang B
American journal of physiology. Cell physiology313(2)C187-C196(2017 Aug)

Reduced expression of IA channels is associated with post-ischemic seizures.
Lei Z, Zhang H, Liang Y, Xu ZC
Epilepsy research12440-8(2016 Aug)

MiR-223-3p as a Novel MicroRNA Regulator of Expression of Voltage-Gated K+ Channel Kv4.2 in Acute Myocardial Infarction.
Liu X, Zhang Y, Du W, Liang H, He H, Zhang L, Pan Z, Li X, Xu C, Zhou Y, Wang L, Qian M, Liu T, Yin H, Lu Y, Yang B, Shan H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(1)102-14(2016)

Estrogen suppresses epileptiform activity by enhancing Kv4.2-mediated transient outward potassium currents in primary hippocampal neurons.
Zhang Y, Huang Y, Liu X, Wang G, Wang X, Wang Y
International journal of molecular medicine36(3)865-72(2015 Sep)

NMDA reduced both currents in a concentration-dependent manner, whereas there was no significant impact on the currents when perfused with MK-801. MDD rats exhibited significantly more fibrosis areas in heart tissue and reduced expression of Kv4.2, Kv4.3, and Cav1.2.
Title: The activation of

Results showed: (i) seizures are associated with more brain damage and neuronal damage is not the major contributor of seizure generation in ischemic rats; (ii) the expression of IA channel subunit Kv4.2 is selectively reduced in ischemic rats with spontaneous behavioral seizures; (iii) The reduction of Kv4.2 may be associated with the long-term increased seizure susceptibility of ischemic rats.
Title: Reduced expression of IA channels is associated with post-ischemic seizures.

Data show that voltage-gated K+ channel Kv4.2 as a target gene of microRNA miR-223-3p.
Title: MiR-223-3p as a Novel MicroRNA Regulator of Expression of Voltage-Gated K+ Channel Kv4.2 in Acute Myocardial Infarction.

17betaestradiol suppresses epileptiform activity by enhancing Kv4.2-mediated transient outward potassium currents in primary hippocampal neurons.
Title: Estrogen suppresses epileptiform activity by enhancing Kv4.2-mediated transient outward potassium currents in primary hippocampal neurons.

The study provides the first piece of evidence for the role of H2S in regulating Ito potassium channels and also the specific motif in an ion channel labile for H2S regulation.
Title: Hydrogen Sulfide Targets the Cys320/Cys529 Motif in Kv4.2 to Inhibit the Ito Potassium Channels in Cardiomyocytes and Regularizes Fatal Arrhythmia in Myocardial Infarction.